Methyl Chloride

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  • Identifiers

    CAS number
    74-87-3

    Molecular formula
    CH3Cl

    SMILES
    CCl

    Safety labels

    Flammable
    Flammable

    Compressed Gas
    Compressed Gas

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Ethereal 58.41%
    Alcoholic 51.31%
    Solvent 43.43%
    Fermented 39.34%
    Sweet 37.5%
    Gassy 37.48%
    Musty 32.77%
    Pungent 28.64%
    Fishy 27.9%
    Winey 26.53%

     

    Flavor
    Egg 35.48%
    Sulfur 35.48%
    Fishy 34.7%
    Garlic 33.62%
    Gasoline 31.67%
    Rotten 28.72%
    Decomposing cabbage 27.56%
    Sulfurous 24.77%
    Onion 22.54%
    Fruity 21.94%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 10.0 [ppm]. Odor threshold from AIHA is >10 ppm
    • Odor recognition in air: 1.00x10+1 ppm (chemically pure)
    • Odor ... not noticeable at dangerous concentrations.
    • Odor Threshold (air) 21 mg/cu m

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    9.45 (weak base)

    Molecular weight
    50.49 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -143 °F (NTP, 1992)
    • -97.6 °C
    • -97 °C
    • -144 °F

    Boiling point

    • -11.6 °F at 760 mmHg (NTP, 1992)
    • -23.7 °C
    • -12 °F

    Flash point

    • -46.28 ˚C est.
    • -49.9 °F (NTP, 1992)
    • -45.6 °C
    • -50 °F (closed cup)
    • <32 °F
    • Flammable gas
    • -49.0 °F
    • NA (Gas)

    Solubility expt.

    • Slightly soluble (NTP, 1992)
    • In water, 5040 mg/L at 25 °C
    • Solubility at 20 °C (mL/100 mL): benzene 4723, carbon tetrachloride 3756, glacial acetic acid 3679, ethanol 3740; miscible with chloroform, ether
    • Soluble in ethanol; miscible with ethyl ether, acetone, benzene and chloroform
    • Solubility in water, g/100ml at 25 °C: 0.5
    • 0.5%

  • Synonyms

    • Chloromethane
    • METHYL CHLORIDE
    • 74-87-3
    • Methane, chloro-
    • Monochloromethane
    • Methylchloride
    • Artic
    • Methylchlorid
    • CH3Cl
    • Clorometano
    • Freon 40
    • Chloor-methaan
    • Metylu chlorek
    • Caswell No. 557
    • Chlor-methan
    • Cloruro di metile
    • Refrigerant R40
    • Chlorure de methyle
    • RCRA waste number U045
    • CCRIS 1124
    • HSDB 883
    • R 40
    • MeCl
    • EINECS 200-817-4
    • UN1063
    • EPA Pesticide Chemical Code 053202
    • UNII-A6R43525YO
    • AI3-01707
    • A6R43525YO
    • METHYL CHLORIDE [II]
    • METHYL CHLORIDE [MI]
    • METHYL CHLORIDE [HSDB]
    • METHYL CHLORIDE [IARC]
    • DTXSID0021541
    • METHYL CHLORIDE [MART.]
    • CHEBI:36014
    • EC 200-817-4
    • UN 1063
    • R-40
    • METHYL CHLORIDE (II)
    • METHYL CHLORIDE (IARC)
    • METHYL CHLORIDE (MART.)
    • Clorometano [Italian]
    • Chlor-methan [German]
    • Chlorocarbon
    • Methylchlorid [German]
    • Methyl Chloride (ca. 5.7% in Tetrahydrofuran, ca. 1mol/L)
    • Chloor-methaan [Dutch]
    • Metylu chlorek [Polish]
    • MFCD00000872
    • Chloride, Methyl
    • Cloruro di metile [Italian]
    • Chlorure de methyle [French]
    • Merrifield's peptide resin, 50-100 mesh
    • RCRA waste no. U045
    • carbon-chlorine
    • chloro-methane
    • methyl-chloride
    • Chloro Methyl group
    • Cl-Me
    • a rt i c
    • Chloromethane 99.9%
    • Chloromethane, >=99.5%
    • 2108-20-5
    • R 40 (REFRIGERANT)
    • REFRIGERANT GAS R-40
    • CHEMBL117545
    • DTXCID701541
    • HCC 40
    • Methyl chloride (ACGIH:OSHA)
    • BBFYMZCRBPASGM-UHFFFAOYSA-N
    • LKYXEULZVGJVTG-UHFFFAOYSA-N
    • DTXSID101316851
    • Chloromethane 100 microg/mL in Methanol
    • Methyl chloride, or Refrigerant gas R 40
    • Merrifield's peptide resin, 200-400 mesh
    • Chloromethane on Rasta Resin, 50-100 mesh
    • M2813
    • NS00019473
    • C19446
    • Q422709
    • Chloromethane 1M, in tert-butyl methyl ether, anhydrous
    • Methyl chloride, or Refrigerant gas R 40 [UN1063] [Flammable gas]
    • 200-817-4
    • JandaJel(TM)-Cl, 100-200 mesh, extent of labeling: 0.8-1.2 mmol/g Cl loading, 2 % cross-linked
    • JandaJel(TM)-Cl, 200-400 mesh, extent of labeling: 0.45-0.70 mmol/g Cl loading, 2 % cross-linked
    • JandaJel(TM)-Cl, 50-100 mesh, extent of labeling: 0.45-0.70 mmol/g Cl loading, 2 % cross-linked
    • Merrifield's peptide resin, 100-200 mesh, extent of labeling: 3.5-4.5 mmol/g Cl- loading, 1 % cross-linked
    • Merrifield's peptide resin, 200-400 mesh, extent of labeling: 1.0-1.5 mmol/g Cl- loading, 2 % cross-linked
    • Merrifield's peptide resin, 200-400 mesh, extent of labeling: 1.5-2.0 mmol/g Cl- loading, 1 % cross-linked
    • Merrifield's peptide resin, 200-400 mesh, extent of labeling: 2.0-2.5 mmol/g Cl- loading, 2 % cross-linked
    • Merrifield's peptide resin, 200-400 mesh, extent of labeling: 3.0-3.5 mmol/g Cl- loading, 1 % cross-linked
    • Merrifield's peptide resin, 200-400 mesh, extent of labeling: 3.5-4.5 mmol/g Cl- loading, 1 % cross-linked
    • Merrifield's peptide resin, 50-100 mesh, extent of labeling: 2.5-4.0 mmol/g Cl- loading, 1 % cross-linked with divinylbenzene
    • Merrifield's peptide resin, 70-90 mesh, extent of labeling: 1.0-1.5 mmol/g Cl- loading, 1 % cross-linked
    • Merrifield's peptide resin, 70-90 mesh, extent of labeling: 1.5-2.0 mmol/g Cl- loading, 1 % cross-linked
    • StratoSpheres(TM) PL-CMS resin, 100-200 mesh, extent of labeling: 1.0 mmol/g loading, 1 % cross-linked
    • StratoSpheres(TM) PL-CMS resin, 100-200 mesh, extent of labeling: 2.0 mmol/g loading, 1 % cross-linked
    • StratoSpheres(TM) PL-CMS resin, 200-400 mesh, extent of labeling: 1.0 mmol/g loading, 1 % cross-linked
    • StratoSpheres(TM) PL-CMS resin, 30-40 mesh, extent of labeling: 1.0 mmol/g loading, 1 % cross-linked
    • StratoSpheres(TM) PL-CMS resin, 30-40 mesh, extent of labeling: 2.0 mmol/g loading, 1 % cross-linked
    • StratoSpheres(TM) PL-CMS resin, 50-100 mesh, extent of labeling: 2.0 mmol/g loading, 1 % cross-linked
    • StratoSpheres(TM) PL-CMS resin, 50-100 mesh, extent of labeling: 4.0 mmol/g loading, 1 % cross-linked

  • Applications

    Methyl Chloride (CAS 74-87-3) is primarily used as a methylating agent and chemical intermediate in organic synthesis, enabling the introduction of a methyl group and the production of various chloromethyl derivatives and other chlorinated organics. It also serves as a solvent and processing medium for selective syntheses and purification steps in industrial manufacturing. Historically, methyl chloride has been employed as a blowing agent to produce polyurethane and other polymer foams. It has been used as a propellant in certain aerosol formulations and as a feedstock for chloromethylation chemistries that supply coatings, adhesives, electronics, and related products. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 189.83
    methanol 242.61
    isopropanol 138.01
    water 10.04
    ethyl acetate 106.79
    n-propanol 153.78
    acetone 217.27
    n-butanol 141.16
    acetonitrile 227.46
    DMF 294.93
    toluene 82.34
    isobutanol 111.12
    1,4-dioxane 229.73
    methyl acetate 129.24
    THF 291.1
    2-butanone 152.27
    n-pentanol 84.75
    sec-butanol 121.53
    n-hexane 41.62
    ethylene glycol 86.86
    NMP 360.73
    cyclohexane 112.16
    DMSO 292.32
    n-butyl acetate 124.58
    n-octanol 57.91
    chloroform 550.44
    n-propyl acetate 75.51
    acetic acid 424.41
    dichloromethane 415.37
    cyclohexanone 266.22
    propylene glycol 68.83
    isopropyl acetate 57.61
    DMAc 206.35
    2-ethoxyethanol 101.32
    isopentanol 94.58
    n-heptane 72.63
    ethyl formate 101.95
    1,2-dichloroethane 221.6
    n-hexanol 105.63
    2-methoxyethanol 201.82
    isobutyl acetate 48.07
    tetrachloromethane 209.19
    n-pentyl acetate 73.25
    transcutol 251.09
    n-heptanol 63.1
    ethylbenzene 37.85
    MIBK 50.41
    2-propoxyethanol 132.18
    tert-butanol 152.55
    MTBE 90.25
    2-butoxyethanol 92.4
    propionic acid 182.57
    o-xylene 61.49
    formic acid 178.32
    diethyl ether 116.08
    m-xylene 48.15
    p-xylene 62.94
    chlorobenzene 156.36
    dimethyl carbonate 44.31
    n-octane 21.6
    formamide 179.18
    cyclopentanone 294.3
    2-pentanone 103.79
    anisole 75.83
    cyclopentyl methyl ether 145.99
    gamma-butyrolactone 300.0
    1-methoxy-2-propanol 126.7
    pyridine 294.16
    3-pentanone 96.18
    furfural 300.96
    n-dodecane 12.87
    diethylene glycol 119.92
    diisopropyl ether 32.98
    tert-amyl alcohol 123.72
    acetylacetone 98.79
    n-hexadecane 14.25
    acetophenone 85.24
    methyl propionate 93.43
    isopentyl acetate 91.94
    trichloroethylene 445.13
    n-nonanol 49.14
    cyclohexanol 184.09
    benzyl alcohol 80.9
    2-ethylhexanol 82.71
    isooctanol 51.55
    dipropyl ether 110.08
    1,2-dichlorobenzene 139.17
    ethyl lactate 45.66
    propylene carbonate 153.65
    n-methylformamide 174.4
    2-pentanol 90.3
    n-pentane 52.4
    1-propoxy-2-propanol 120.39
    1-methoxy-2-propyl acetate 82.44
    2-(2-methoxypropoxy) propanol 73.81
    mesitylene 32.14
    ε-caprolactone 190.67
    p-cymene 55.41
    epichlorohydrin 220.08
    1,1,1-trichloroethane 276.43
    2-aminoethanol 116.1
    morpholine-4-carbaldehyde 252.68
    sulfolane 329.63
    2,2,4-trimethylpentane 21.64
    2-methyltetrahydrofuran 240.67
    n-hexyl acetate 83.99
    isooctane 12.26
    2-(2-butoxyethoxy)ethanol 96.53
    sec-butyl acetate 44.24
    tert-butyl acetate 58.6
    decalin 26.54
    glycerin 107.45
    diglyme 193.1
    acrylic acid 207.11
    isopropyl myristate 38.34
    n-butyric acid 197.13
    acetyl acetate 81.65
    di(2-ethylhexyl) phthalate 41.99
    ethyl propionate 61.48
    nitromethane 331.96
    1,2-diethoxyethane 104.5
    benzonitrile 142.13
    trioctyl phosphate 33.89
    1-bromopropane 164.76
    gamma-valerolactone 263.88
    n-decanol 37.1
    triethyl phosphate 53.66
    4-methyl-2-pentanol 41.43
    propionitrile 168.9
    vinylene carbonate 159.36
    1,1,2-trichlorotrifluoroethane 257.75
    DMS 65.59
    cumene 30.52
    2-octanol 44.74
    2-hexanone 76.52
    octyl acetate 49.66
    limonene 92.53
    1,2-dimethoxyethane 150.75
    ethyl orthosilicate 52.93
    tributyl phosphate 39.72
    diacetone alcohol 78.5
    N,N-dimethylaniline 63.7
    acrylonitrile 215.95
    aniline 139.93
    1,3-propanediol 135.73
    bromobenzene 144.49
    dibromomethane 324.02
    1,1,2,2-tetrachloroethane 352.31
    2-methyl-cyclohexyl acetate 70.48
    tetrabutyl urea 60.21
    diisobutyl methanol 54.22
    2-phenylethanol 82.61
    styrene 59.2
    dioctyl adipate 59.92
    dimethyl sulfate 81.9
    ethyl butyrate 95.74
    methyl lactate 65.53
    butyl lactate 60.88
    diethyl carbonate 66.96
    propanediol butyl ether 76.65
    triethyl orthoformate 73.88
    p-tert-butyltoluene 52.88
    methyl 4-tert-butylbenzoate 79.73
    morpholine 252.89
    tert-butylamine 114.72
    n-dodecanol 31.26
    dimethoxymethane 114.46
    ethylene carbonate 123.37
    cyrene 82.55
    2-ethoxyethyl acetate 76.42
    2-ethylhexyl acetate 85.94
    1,2,4-trichlorobenzene 161.07
    4-methylpyridine 218.78
    dibutyl ether 70.62
    2,6-dimethyl-4-heptanol 54.22
    DEF 146.55
    dimethyl isosorbide 120.22
    tetrachloroethylene 337.31
    eugenol 81.61
    triacetin 79.22
    span 80 89.22
    1,4-butanediol 55.63
    1,1-dichloroethane 229.96
    2-methyl-1-pentanol 66.0
    methyl formate 128.09
    2-methyl-1-butanol 102.93
    n-decane 20.77
    butyronitrile 157.66
    3,7-dimethyl-1-octanol 53.12
    1-chlorooctane 53.33
    1-chlorotetradecane 24.16
    n-nonane 23.04
    undecane 15.49
    tert-butylcyclohexane 24.09
    cyclooctane 31.57
    cyclopentanol 202.37
    tetrahydropyran 241.96
    tert-amyl methyl ether 77.27
    2,5,8-trioxanonane 133.77
    1-hexene 80.19
    2-isopropoxyethanol 67.66
    2,2,2-trifluoroethanol 163.26
    methyl butyrate 89.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction