Methyl 2-hydroxy-5-methoxybenzoate

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  • Identifiers

    CAS number
    2905-82-0

    Molecular formula
    C9H10O4

    SMILES
    COC1=CC(=C(C=C1)O)C(=O)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 79.91%
    Floral 62.39%
    Phenolic 49.61%
    Vanilla 48.63%
    Green 48.22%
    Fruity 44.12%
    Herbal 42.85%
    Spicy 41.45%
    Anisic 41.43%
    Aromatic 38.09%

     

    Flavor
    Bitter 53.16%
    Wintergreen 27.22%
    Herbal 26.52%
    Odorless 25.6%
    Woody 24.78%
    Powdery 23.49%
    Faint 23.19%
    Balsam 22.82%
    Bland 22.47%
    Sweet 22.23%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    7.64 (neutral)

    Molecular weight
    182.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    268°C

    Flash point

    • 130.04 ˚C est.

  • Synonyms

    • Methyl 2-hydroxy-5-methoxybenzoate
    • 2905-82-0
    • Methyl 5-methoxysalicylate
    • Benzoic acid, 2-hydroxy-5-methoxy-, methyl ester
    • 5-Methoxysalicylic Acid Methyl Ester
    • MFCD00017185
    • DTXSID00399022
    • 2-hydroxy-5-methoxy-benzoic acid methyl ester
    • 2-Hydroxy-5-methoxybenzoic Acid Methyl Ester
    • Benzoicacid, 2-hydroxy-5-methoxy-, methyl ester
    • SCHEMBL643758
    • CHEMBL2252247
    • DTXCID60349881
    • Methyl 5-methoxysalicylate, 98%
    • ALBB-030153
    • methyl 2-hydroxy-5-methoxy-benzoate
    • AKOS008909270
    • CS-W002115
    • DS-1152
    • FM71188
    • SY003498
    • M2127
    • 2-hydroxy-5-methoxybenzoic acid, methyl ester
    • EN300-53985
    • Z24427281
    • InChI=1/C9H10O4/c1-12-6-3-4-8(10)7(5-6)9(11)13-2/h3-5,10H,1-2H
    • 5-Methoxysalicylic Acid Methyl Ester;Methyl 5-methoxysalicylate;2-Hydroxy-5-methoxybenzoic acid methyl ester
    • 628-236-5

  • Applications

    Methyl 2-hydroxy-5-methoxybenzoate (CAS 2905-82-0) is used primarily as an aromatic building block and synthesis intermediate across several industries: it can serve as a fragrance ingredient or fragrance intermediate in perfumery and cosmetic formulations; it is commonly evaluated as an intermediate in pharmaceutical synthesis; it provides a functionalized aromatic building block for polymer and coatings/inks chemistries; and it can act as a versatile precursor for derivatization in specialty chemical applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 37.97
    methanol 54.71
    isopropanol 35.27
    water 1.02
    ethyl acetate 58.76
    n-propanol 29.43
    acetone 90.41
    n-butanol 23.73
    acetonitrile 67.04
    DMF 184.22
    toluene 19.04
    isobutanol 22.59
    1,4-dioxane 157.28
    methyl acetate 104.66
    THF 205.3
    2-butanone 67.35
    n-pentanol 19.85
    sec-butanol 25.68
    n-hexane 0.71
    ethylene glycol 37.39
    NMP 174.03
    cyclohexane 2.15
    DMSO 243.91
    n-butyl acetate 24.96
    n-octanol 14.42
    chloroform 75.07
    n-propyl acetate 33.65
    acetic acid 69.56
    dichloromethane 109.78
    cyclohexanone 80.85
    propylene glycol 19.66
    isopropyl acetate 31.14
    DMAc 221.45
    2-ethoxyethanol 70.79
    isopentanol 27.99
    n-heptane 1.47
    ethyl formate 52.3
    1,2-dichloroethane 79.32
    n-hexanol 20.45
    2-methoxyethanol 137.55
    isobutyl acetate 21.35
    tetrachloromethane 12.63
    n-pentyl acetate 15.5
    transcutol 75.82
    n-heptanol 14.11
    ethylbenzene 15.9
    MIBK 31.25
    2-propoxyethanol 57.51
    tert-butanol 106.44
    MTBE 47.14
    2-butoxyethanol 34.22
    propionic acid 42.32
    o-xylene 22.48
    formic acid 59.21
    diethyl ether 29.73
    m-xylene 17.92
    p-xylene 21.88
    chlorobenzene 29.04
    dimethyl carbonate 54.23
    n-octane 1.01
    formamide 137.64
    cyclopentanone 130.76
    2-pentanone 39.43
    anisole 55.76
    cyclopentyl methyl ether 53.3
    gamma-butyrolactone 169.08
    1-methoxy-2-propanol 69.07
    pyridine 79.44
    3-pentanone 37.73
    furfural 141.92
    n-dodecane 1.36
    diethylene glycol 71.64
    diisopropyl ether 9.75
    tert-amyl alcohol 61.01
    acetylacetone 71.35
    n-hexadecane 1.57
    acetophenone 56.17
    methyl propionate 61.06
    isopentyl acetate 27.74
    trichloroethylene 134.92
    n-nonanol 14.13
    cyclohexanol 32.03
    benzyl alcohol 42.0
    2-ethylhexanol 16.43
    isooctanol 13.89
    dipropyl ether 15.77
    1,2-dichlorobenzene 35.09
    ethyl lactate 24.09
    propylene carbonate 71.02
    n-methylformamide 93.81
    2-pentanol 16.74
    n-pentane 0.74
    1-propoxy-2-propanol 32.19
    1-methoxy-2-propyl acetate 39.47
    2-(2-methoxypropoxy) propanol 40.24
    mesitylene 11.76
    ε-caprolactone 73.4
    p-cymene 12.06
    epichlorohydrin 189.88
    1,1,1-trichloroethane 59.22
    2-aminoethanol 42.65
    morpholine-4-carbaldehyde 161.94
    sulfolane 182.01
    2,2,4-trimethylpentane 1.59
    2-methyltetrahydrofuran 103.62
    n-hexyl acetate 24.37
    isooctane 1.01
    2-(2-butoxyethoxy)ethanol 44.38
    sec-butyl acetate 23.79
    tert-butyl acetate 46.58
    decalin 2.85
    glycerin 52.42
    diglyme 95.93
    acrylic acid 44.74
    isopropyl myristate 13.38
    n-butyric acid 39.64
    acetyl acetate 49.55
    di(2-ethylhexyl) phthalate 16.9
    ethyl propionate 34.27
    nitromethane 184.6
    1,2-diethoxyethane 27.17
    benzonitrile 41.1
    trioctyl phosphate 12.12
    1-bromopropane 21.96
    gamma-valerolactone 151.11
    n-decanol 11.45
    triethyl phosphate 26.06
    4-methyl-2-pentanol 14.33
    propionitrile 44.61
    vinylene carbonate 71.01
    1,1,2-trichlorotrifluoroethane 116.95
    DMS 37.4
    cumene 13.26
    2-octanol 10.07
    2-hexanone 30.92
    octyl acetate 15.99
    limonene 15.29
    1,2-dimethoxyethane 122.92
    ethyl orthosilicate 22.64
    tributyl phosphate 13.72
    diacetone alcohol 64.02
    N,N-dimethylaniline 39.96
    acrylonitrile 68.61
    aniline 41.86
    1,3-propanediol 54.92
    bromobenzene 26.26
    dibromomethane 48.25
    1,1,2,2-tetrachloroethane 93.84
    2-methyl-cyclohexyl acetate 30.92
    tetrabutyl urea 20.76
    diisobutyl methanol 12.58
    2-phenylethanol 36.23
    styrene 17.16
    dioctyl adipate 22.32
    dimethyl sulfate 97.52
    ethyl butyrate 26.87
    methyl lactate 39.71
    butyl lactate 15.21
    diethyl carbonate 26.26
    propanediol butyl ether 24.14
    triethyl orthoformate 23.03
    p-tert-butyltoluene 12.16
    methyl 4-tert-butylbenzoate 41.45
    morpholine 149.98
    tert-butylamine 39.64
    n-dodecanol 9.43
    dimethoxymethane 118.57
    ethylene carbonate 57.77
    cyrene 64.4
    2-ethoxyethyl acetate 28.69
    2-ethylhexyl acetate 21.54
    1,2,4-trichlorobenzene 46.54
    4-methylpyridine 73.08
    dibutyl ether 12.69
    2,6-dimethyl-4-heptanol 12.58
    DEF 64.66
    dimethyl isosorbide 81.56
    tetrachloroethylene 60.85
    eugenol 40.78
    triacetin 35.29
    span 80 26.57
    1,4-butanediol 19.49
    1,1-dichloroethane 51.59
    2-methyl-1-pentanol 23.15
    methyl formate 97.21
    2-methyl-1-butanol 23.92
    n-decane 1.9
    butyronitrile 32.47
    3,7-dimethyl-1-octanol 15.27
    1-chlorooctane 8.34
    1-chlorotetradecane 4.45
    n-nonane 1.56
    undecane 1.58
    tert-butylcyclohexane 2.71
    cyclooctane 0.94
    cyclopentanol 43.19
    tetrahydropyran 68.89
    tert-amyl methyl ether 35.83
    2,5,8-trioxanonane 74.52
    1-hexene 4.05
    2-isopropoxyethanol 44.5
    2,2,2-trifluoroethanol 52.18
    methyl butyrate 45.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction