Methanedisulfonic acid

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  • Identifiers

    CAS number
    503-40-2

    Molecular formula
    CH4O6S2

    SMILES
    C(S(=O)(=O)O)S(=O)(=O)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 83.84%
    Sulfurous 22.83%
    Pungent 19.27%
    Cooked 18.63%
    Savory 17.37%
    Roasted 15.04%
    Burnt 14.77%
    Garlic 14.21%
    Onion 13.98%
    Alliaceous 12.78%

     

    Flavor
    Bitter 78.9%
    Odorless 31.22%
    Bland 25.71%
    Nitrile 19.36%
    Formyl 19.22%
    Rotten 18.58%
    Bread crust 17.84%
    Taco 17.77%
    Mousy 17.44%
    Urine 17.41%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    -1.9

    pKa est.
    4.39 (weak acid)

    Molecular weight
    176.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    500°C

    Flash point

    • 261.82 ˚C est.

  • Synonyms

    • METHANEDISULFONIC ACID
    • 503-40-2
    • Methionic acid
    • UNII-55N1VUX48W
    • 55N1VUX48W
    • methylenedisulfonic acid
    • EINECS 207-966-4
    • METHIONIC ACID [MI]
    • DTXSID3060118
    • RefChem:156914
    • DTXCID2040814
    • 207-966-4
    • Methane disulfonic acid
    • Methanedisulphonic acid
    • METHANEDISULFONICACID
    • MFCD00041888
    • NSC8541
    • CH4O6S2
    • Methionsaure
    • UNII-93NQD5PEW6
    • SCHEMBL34406
    • SCHEMBL9474675
    • BBL103928
    • STL557738
    • AKOS005259705
    • AS-17428
    • Methionic Acid; Methylenedisulfonic Acid;
    • SY157937
    • DB-001041
    • NS00020520
    • EN300-180243
    • F16475
    • 503M402
    • F533031
    • Q27261323
    • 503-40-2

  • Applications

    Methanedisulfonic acid is a strong, highly water-soluble Brønsted acid used mainly as a catalyst and reactive intermediate in various chemical processes. In industrial manufacturing, it serves as an acid catalyst for organic synthesis, including esterification, acetal/ketal formation, alkylation, and condensation reactions. In polymers and plastics, it is used as a building block for sulfonated polymers and specialty resins, or as an acid component in polymer preparations. In coatings and inks, it can act as a catalyst or acidity modifier to promote curing and improve performance. In cleaning formulations, it provides high acidity and water solubility for metal surface cleaning and descaling. In pharmaceutical and agrochemical synthesis, it is evaluated or used as a reagent to introduce sulfonic acid functionality into target molecules, subject to formulation limits and regulatory controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 57.38
    methanol 115.56
    isopropanol 39.82
    water 137.13
    ethyl acetate 13.43
    n-propanol 34.29
    acetone 81.39
    n-butanol 23.02
    acetonitrile 30.37
    DMF 399.03
    toluene 4.8
    isobutanol 20.23
    1,4-dioxane 27.7
    methyl acetate 20.13
    THF 86.27
    2-butanone 37.42
    n-pentanol 14.15
    sec-butanol 21.77
    n-hexane 1.44
    ethylene glycol 73.3
    NMP 260.14
    cyclohexane 1.9
    DMSO 381.25
    n-butyl acetate 10.63
    n-octanol 8.37
    chloroform 3.23
    n-propyl acetate 12.73
    acetic acid 44.72
    dichloromethane 5.79
    cyclohexanone 33.34
    propylene glycol 63.75
    isopropyl acetate 11.52
    DMAc 232.93
    2-ethoxyethanol 65.82
    isopentanol 14.48
    n-heptane 2.12
    ethyl formate 24.86
    1,2-dichloroethane 8.39
    n-hexanol 11.87
    2-methoxyethanol 147.43
    isobutyl acetate 6.53
    tetrachloromethane 1.1
    n-pentyl acetate 8.44
    transcutol 69.83
    n-heptanol 7.97
    ethylbenzene 2.32
    MIBK 18.58
    2-propoxyethanol 60.21
    tert-butanol 33.63
    MTBE 9.7
    2-butoxyethanol 28.83
    propionic acid 30.38
    o-xylene 4.78
    formic acid 85.19
    diethyl ether 14.5
    m-xylene 4.83
    p-xylene 2.88
    chlorobenzene 2.4
    dimethyl carbonate 25.59
    n-octane 0.87
    formamide 144.89
    cyclopentanone 68.87
    2-pentanone 33.04
    anisole 8.59
    cyclopentyl methyl ether 27.85
    gamma-butyrolactone 72.84
    1-methoxy-2-propanol 119.99
    pyridine 20.72
    3-pentanone 24.01
    furfural 66.29
    n-dodecane 0.65
    diethylene glycol 79.04
    diisopropyl ether 4.79
    tert-amyl alcohol 19.19
    acetylacetone 33.68
    n-hexadecane 0.7
    acetophenone 15.08
    methyl propionate 27.0
    isopentyl acetate 6.69
    trichloroethylene 7.6
    n-nonanol 8.03
    cyclohexanol 15.34
    benzyl alcohol 13.53
    2-ethylhexanol 5.55
    isooctanol 5.23
    dipropyl ether 12.96
    1,2-dichlorobenzene 2.27
    ethyl lactate 22.9
    propylene carbonate 27.6
    n-methylformamide 152.89
    2-pentanol 15.74
    n-pentane 2.29
    1-propoxy-2-propanol 41.71
    1-methoxy-2-propyl acetate 22.03
    2-(2-methoxypropoxy) propanol 30.67
    mesitylene 3.74
    ε-caprolactone 26.03
    p-cymene 2.89
    epichlorohydrin 37.65
    1,1,1-trichloroethane 3.04
    2-aminoethanol 80.24
    morpholine-4-carbaldehyde 150.15
    sulfolane 129.91
    2,2,4-trimethylpentane 0.72
    2-methyltetrahydrofuran 29.36
    n-hexyl acetate 9.77
    isooctane 0.66
    2-(2-butoxyethoxy)ethanol 38.38
    sec-butyl acetate 6.92
    tert-butyl acetate 12.63
    decalin 0.78
    glycerin 114.63
    diglyme 59.83
    acrylic acid 36.29
    isopropyl myristate 5.32
    n-butyric acid 24.87
    acetyl acetate 7.16
    di(2-ethylhexyl) phthalate 6.23
    ethyl propionate 12.98
    nitromethane 89.66
    1,2-diethoxyethane 14.58
    benzonitrile 8.12
    trioctyl phosphate 5.76
    1-bromopropane 4.39
    gamma-valerolactone 96.88
    n-decanol 6.28
    triethyl phosphate 7.1
    4-methyl-2-pentanol 8.14
    propionitrile 18.7
    vinylene carbonate 22.67
    1,1,2-trichlorotrifluoroethane 43.97
    DMS 9.67
    cumene 2.07
    2-octanol 5.55
    2-hexanone 17.4
    octyl acetate 7.38
    limonene 4.51
    1,2-dimethoxyethane 69.66
    ethyl orthosilicate 6.18
    tributyl phosphate 6.57
    diacetone alcohol 36.4
    N,N-dimethylaniline 11.82
    acrylonitrile 29.36
    aniline 13.39
    1,3-propanediol 60.93
    bromobenzene 1.42
    dibromomethane 3.86
    1,1,2,2-tetrachloroethane 7.87
    2-methyl-cyclohexyl acetate 8.2
    tetrabutyl urea 15.56
    diisobutyl methanol 4.76
    2-phenylethanol 11.33
    styrene 2.38
    dioctyl adipate 9.05
    dimethyl sulfate 57.4
    ethyl butyrate 11.0
    methyl lactate 52.25
    butyl lactate 15.86
    diethyl carbonate 6.5
    propanediol butyl ether 32.53
    triethyl orthoformate 9.31
    p-tert-butyltoluene 3.21
    methyl 4-tert-butylbenzoate 17.86
    morpholine 52.8
    tert-butylamine 16.19
    n-dodecanol 4.85
    dimethoxymethane 117.14
    ethylene carbonate 18.11
    cyrene 47.64
    2-ethoxyethyl acetate 12.13
    2-ethylhexyl acetate 5.32
    1,2,4-trichlorobenzene 2.97
    4-methylpyridine 19.55
    dibutyl ether 6.09
    2,6-dimethyl-4-heptanol 4.76
    DEF 55.9
    dimethyl isosorbide 48.13
    tetrachloroethylene 4.9
    eugenol 25.48
    triacetin 14.31
    span 80 23.7
    1,4-butanediol 29.64
    1,1-dichloroethane 4.92
    2-methyl-1-pentanol 7.92
    methyl formate 89.57
    2-methyl-1-butanol 14.21
    n-decane 0.98
    butyronitrile 16.18
    3,7-dimethyl-1-octanol 5.89
    1-chlorooctane 2.46
    1-chlorotetradecane 1.34
    n-nonane 0.95
    undecane 0.78
    tert-butylcyclohexane 0.69
    cyclooctane 1.09
    cyclopentanol 29.84
    tetrahydropyran 18.52
    tert-amyl methyl ether 10.24
    2,5,8-trioxanonane 51.06
    1-hexene 3.19
    2-isopropoxyethanol 33.63
    2,2,2-trifluoroethanol 37.37
    methyl butyrate 18.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction