Methamphetamine

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  • Identifiers

    CAS number
    537-46-2

    Molecular formula
    C10H15N

    SMILES
    C[C@@H](CC1=CC=CC=C1)NC

    Safety labels

    Acute Toxic
    Acute Toxic

  • Odor profile

    Fragrance
    Fishy 55.47%
    Cheesy 40.92%
    Ripe 34.07%
    Animal 31.39%
    Meaty 28.41%
    Savory 25.04%
    Grapefruit 23.83%
    Citrus 23.8%
    Burnt 21.62%
    Cooling 21.24%

     

    Flavor
    Mild 27.5%
    Green 24.7%
    Fishy 23.44%
    Ammoniacal 22.46%
    Meaty 21.03%
    Floral 20.35%
    Fresh 19.94%
    Skunky 19.82%
    Cyclamen 19.65%
    Yeasty 19.58%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    6.86 (neutral)

    Molecular weight
    149.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Melting point expt.

    • 170-2 °C

    Boiling point

    • 212 °C

    Flash point

    • 75.39 ˚C est.
    • 9.7 °C (49.5 °F) - closed cup

    Solubility expt.

    • In water, 0.5 g/mL
    • Soluble in ethanol, diethyl ether
    • Miscible with chloroform
    • 9.28e-01 g/L

  • Synonyms

    • METHAMPHETAMINE
    • Metamfetamine
    • d-Deoxyephedrine
    • d-Desoxyephedrine
    • d-Methamphetamine
    • Methylamphetamine
    • d-N-Methylamphetamine
    • Metamphetamine
    • d-Methylamphetamine
    • N-Methylamphetamine
    • d-Phenylisopropylmethylamine
    • (S)-Methamphetamine
    • D-1-Phenyl-2-methylaminopropane
    • Norodin
    • (S)-Methylamphetamine
    • (+)-Methylamphetamine
    • d-(S)-Methamphetamine
    • Metamfetamina
    • Metamfetaminum
    • Metanfetamina
    • Methyl-beta-phenylisopropylamine
    • (+)-N-Methylamphetamine
    • 537-46-2
    • (+)-(S)-Deoxyephedrine
    • (S)-(+)-Deoxyephedrine
    • (2S)-N-methyl-1-phenylpropan-2-amine
    • 1-Phenyl-2-methylaminopropane
    • Desyphed
    • S-(+)-Methamphetamine
    • (+)-methamphetamine
    • (S)-N,alpha-Dimethylbenzeneethanamine
    • D-N,alpha-dimethylphenethylamine
    • Crank
    • Methamphetaminum
    • Meth
    • Crystal Meth
    • Metamfetamine [INN]
    • (+)-2-(N-Methylamino)-1-phenylpropane
    • Metamfetaminum [INN-Latin]
    • Metamfetamina [INN-Spanish]
    • Metanfetamina [INN-Spanish]
    • Methamphetaminum [INN-Latin]
    • (+)-N,alpha-Dimethylphenethylamine
    • dextromethamphetamine
    • D-1-Phenyl-2-methylaminopropan
    • (+)-N,alpha-Dimethyl-beta-phenylethylamine
    • Meth (Street Name)
    • N-Methyl-beta-phenylisopropylamine
    • 1-Phenyl-2-methylamino-propan [German]
    • (+)-(S)-N-alpha-Dimethylphenethylamine
    • Metamfetaminum [Latin]
    • d-1-Phenyl-2-methylaminopropan [German]
    • 2S-(+)-Methamphetamine
    • (S)-(+)-Methamphetamine
    • (alphaS)-N,alpha-dimethylbenzeneethanamine
    • ICE [Street Name]
    • N-Methyl-beta-phenylisopropylamin [German]
    • Crank [Street Name]
    • Speed [Street Name]
    • NSC 25115
    • CHEBI:6809
    • HSDB 3359
    • (s)-phenylmethylaminopropane
    • EINECS 208-668-7
    • Crystal Meth [Street Name]
    • NSC-25115
    • (S)-N,alpha-Dimethylbenzeneethanoamine
    • UNII-44RAL3456C
    • (S)-(+)-N,alpha,dimethylphenethylamine
    • Metamfetamine (INN)
    • Phenethylamine, N,alpha-dimethyl-, (+)-
    • 44RAL3456C
    • Benzeneethanamine, N,alpha-dimethyl-, (S)-
    • Methyl-.beta.-phenylisopropylamine
    • d-N,.alpha.-Dimethylphenethylamine
    • Stimulex
    • Speed
    • Benzeneethanamine, N,alpha-dimethyl-, (alphaS)-
    • J6.362B
    • DTXSID8037128
    • Desoxyephedrine hydrochloride
    • 1-Phenyl-2-methylamino-propan
    • Crank (Street Name)
    • ICE (Street Name)
    • Speed (Street Name)
    • N-Methyl-beta-phenylisopropylamin
    • Metamfetaminum (Latin)
    • Methamphetaminum [JP]
    • Metanfetamina [Spanish]
    • Metamfetaminum (INN-Latin)
    • Crystal Meth (Street Name)
    • Metamfetamina (INN-Spanish)
    • Metanfetamina (INN-Spanish)
    • Methamphetaminum (INN-Latin)
    • N Methylamphetamine
    • N-Methyl-1-phenyl-2-propanamine
    • (+ )-Methylamphetamine
    • Benzeneethanamine, N,alpha-dimethyl-, (+)-
    • DEA No. 1105
    • B40
    • metamfetamine racemate
    • Methamphetamine (MA)
    • Benzeneethanamine, N,.alpha.-dimethyl-, (S)-
    • Phenethylamine, N,.alpha.-dimethyl-, (S)-(+)-
    • Epitope ID:178090
    • intra-venous methamphetamine
    • Phenethylamine, N,alpha-dimethyl-, (S)-(+)-
    • Benzeneethanamine,.alpha.-dimethyl-, (S)-
    • d-N,a-dimethylphenethylamine
    • METHAMPHETAMINE [MI]
    • SCHEMBL42615
    • Phenethylamine,.alpha.-dimethyl-, (S)-(+)-
    • METHAMPHETAMINE [HSDB]
    • METAMFETAMINE [WHO-DD]
    • METHAMPHETAMINE [VANDF]
    • CHEMBL1201201
    • DTXCID6017128
    • WLN: 1MY1&1R -D
    • N06BA03
    • N,I+/--Dimethyl-phenethyl amine
    • Desyphed hydrochloride (Salt/Mix)
    • NSC25115
    • N-Methyl-1-phenyl-2-propanamine #
    • BDBM50359499
    • PDSP1_001404
    • PDSP1_001405
    • PDSP2_001388
    • PDSP2_001389

  • Applications

    Methamphetamine (CAS 537-46-2) is primarily used as a tightly regulated pharmaceutical active ingredient in prescription medicines for attention-deficit/hyperactivity disorder (ADHD) and, in certain jurisdictions, for obesity under strict regulatory controls. Beyond its medicinal use, it may serve as a synthetic intermediate or precursor in the development of related phenethylamine compounds under licensed, controlled conditions. In analytical chemistry and forensic contexts, it is employed as a target analyte and reference material within regulated testing workflows. In research settings, methamphetamine is studied under strict controls to understand its pharmacology and neurobiological effects.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 653.0
    methanol 484.79
    isopropanol 394.61
    water 1.2
    ethyl acetate 442.8
    n-propanol 513.57
    acetone 575.59
    n-butanol 490.86
    acetonitrile 391.73
    DMF 596.93
    toluene 190.09
    isobutanol 347.52
    1,4-dioxane 799.67
    methyl acetate 373.3
    THF 846.07
    2-butanone 397.27
    n-pentanol 269.18
    sec-butanol 288.89
    n-hexane 55.13
    ethylene glycol 180.14
    NMP 409.91
    cyclohexane 127.57
    DMSO 830.27
    n-butyl acetate 441.99
    n-octanol 129.92
    chloroform 1174.65
    n-propyl acetate 210.76
    acetic acid 496.16
    dichloromethane 933.67
    cyclohexanone 565.2
    propylene glycol 267.54
    isopropyl acetate 189.35
    DMAc 395.52
    2-ethoxyethanol 314.67
    isopentanol 296.91
    n-heptane 101.2
    ethyl formate 314.2
    1,2-dichloroethane 562.99
    n-hexanol 570.26
    2-methoxyethanol 577.81
    isobutyl acetate 138.35
    tetrachloromethane 214.09
    n-pentyl acetate 125.76
    transcutol 713.85
    n-heptanol 152.6
    ethylbenzene 68.97
    MIBK 153.23
    2-propoxyethanol 599.95
    tert-butanol 411.89
    MTBE 281.87
    2-butoxyethanol 216.14
    propionic acid 425.31
    o-xylene 110.59
    formic acid 132.01
    diethyl ether 406.61
    m-xylene 109.49
    p-xylene 89.51
    chlorobenzene 283.28
    dimethyl carbonate 131.6
    n-octane 25.94
    formamide 145.06
    cyclopentanone 657.79
    2-pentanone 323.91
    anisole 153.83
    cyclopentyl methyl ether 390.04
    gamma-butyrolactone 692.22
    1-methoxy-2-propanol 385.82
    pyridine 557.16
    3-pentanone 266.15
    furfural 492.46
    n-dodecane 19.6
    diethylene glycol 402.22
    diisopropyl ether 92.75
    tert-amyl alcohol 258.18
    acetylacetone 285.87
    n-hexadecane 21.52
    acetophenone 134.29
    methyl propionate 332.35
    isopentyl acetate 280.0
    trichloroethylene 868.8
    n-nonanol 111.01
    cyclohexanol 332.91
    benzyl alcohol 149.88
    2-ethylhexanol 281.89
    isooctanol 104.75
    dipropyl ether 395.58
    1,2-dichlorobenzene 212.07
    ethyl lactate 111.38
    propylene carbonate 392.2
    n-methylformamide 305.91
    2-pentanol 242.7
    n-pentane 63.26
    1-propoxy-2-propanol 438.96
    1-methoxy-2-propyl acetate 303.59
    2-(2-methoxypropoxy) propanol 153.1
    mesitylene 67.89
    ε-caprolactone 421.0
    p-cymene 80.38
    epichlorohydrin 583.83
    1,1,1-trichloroethane 483.33
    2-aminoethanol 319.96
    morpholine-4-carbaldehyde 463.47
    sulfolane 633.44
    2,2,4-trimethylpentane 30.69
    2-methyltetrahydrofuran 579.36
    n-hexyl acetate 169.22
    isooctane 23.06
    2-(2-butoxyethoxy)ethanol 234.15
    sec-butyl acetate 115.31
    tert-butyl acetate 176.69
    decalin 39.88
    glycerin 273.36
    diglyme 452.91
    acrylic acid 332.81
    isopropyl myristate 70.0
    n-butyric acid 588.25
    acetyl acetate 248.24
    di(2-ethylhexyl) phthalate 76.23
    ethyl propionate 173.11
    nitromethane 613.31
    1,2-diethoxyethane 306.81
    benzonitrile 199.76
    trioctyl phosphate 63.31
    1-bromopropane 371.46
    gamma-valerolactone 622.45
    n-decanol 89.47
    triethyl phosphate 99.58
    4-methyl-2-pentanol 119.45
    propionitrile 359.14
    vinylene carbonate 342.82
    1,1,2-trichlorotrifluoroethane 503.07
    DMS 134.34
    cumene 50.95
    2-octanol 80.35
    2-hexanone 197.83
    octyl acetate 93.71
    limonene 151.45
    1,2-dimethoxyethane 451.41
    ethyl orthosilicate 106.24
    tributyl phosphate 74.17
    diacetone alcohol 200.81
    N,N-dimethylaniline 96.81
    acrylonitrile 363.6
    aniline 264.73
    1,3-propanediol 351.4
    bromobenzene 282.85
    dibromomethane 635.85
    1,1,2,2-tetrachloroethane 716.33
    2-methyl-cyclohexyl acetate 157.77
    tetrabutyl urea 96.21
    diisobutyl methanol 125.43
    2-phenylethanol 199.68
    styrene 105.0
    dioctyl adipate 95.64
    dimethyl sulfate 184.12
    ethyl butyrate 272.95
    methyl lactate 162.65
    butyl lactate 114.76
    diethyl carbonate 157.33
    propanediol butyl ether 174.67
    triethyl orthoformate 179.85
    p-tert-butyltoluene 79.56
    methyl 4-tert-butylbenzoate 119.75
    morpholine 859.3
    tert-butylamine 265.28
    n-dodecanol 74.17
    dimethoxymethane 373.49
    ethylene carbonate 325.78
    cyrene 146.77
    2-ethoxyethyl acetate 174.82
    2-ethylhexyl acetate 223.42
    1,2,4-trichlorobenzene 237.22
    4-methylpyridine 405.87
    dibutyl ether 173.9
    2,6-dimethyl-4-heptanol 125.43
    DEF 343.74
    dimethyl isosorbide 248.91
    tetrachloroethylene 532.17
    eugenol 123.0
    triacetin 150.26
    span 80 168.56
    1,4-butanediol 152.8
    1,1-dichloroethane 534.13
    2-methyl-1-pentanol 175.22
    methyl formate 252.75
    2-methyl-1-butanol 276.56
    n-decane 32.37
    butyronitrile 371.12
    3,7-dimethyl-1-octanol 124.87
    1-chlorooctane 100.12
    1-chlorotetradecane 42.5
    n-nonane 33.15
    undecane 24.11
    tert-butylcyclohexane 34.87
    cyclooctane 41.68
    cyclopentanol 368.27
    tetrahydropyran 749.32
    tert-amyl methyl ether 180.86
    2,5,8-trioxanonane 279.34
    1-hexene 165.58
    2-isopropoxyethanol 196.57
    2,2,2-trifluoroethanol 136.27
    methyl butyrate 244.93

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction