Mefenamic Acid

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  • Identifiers

    CAS number
    61-68-7

    Molecular formula
    C15H15NO2

    SMILES
    CC1=C(C(=CC=C1)NC2=CC=CC=C2C(=O)O)C

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Floral 65.12%
    Grape 62.68%
    Fruity 51.79%
    Neroli 48.99%
    Sweet 44.82%
    Orange 44.59%
    Animal 38.48%
    Honey 35.64%
    Citrus 33.3%
    Powdery 30.23%

     

    Flavor
    Bitter 41.57%
    Mild 37.74%
    Odorless 35.02%
    Phenolic 31.34%
    Fruity 30.66%
    Powdery 24.75%
    Orange flower 22.91%
    Orange blossom 22.19%
    Animal 22.15%
    Very strong 21.33%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.1

    pKa est.
    6.9 (neutral)

    Molecular weight
    241.28 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    412°C

    Melting point expt.

    • 230-231 °C
    • DECARBOXYLATES @ TEMP ABOVE ITS MELTING POINT (@ 300 °C, 100% IS DECARBOXYLATED IN 3 MIN)
    • 230 - 231 °C

    Flash point

    • 196.35 ˚C est.

    Solubility expt.

    • 20 mg/L (at 30 °C)
    • WHITE POWDER; SOLUBILITY IN WATER: GREATER THAN 5 G/100 ML /SODIUM SALT/
    • IN WATER @ PH 7.1: 0.0041 G/100 ML @ 25 °C, 0.008 G/100 ML @ 37 °C; SOL IN SOLN OF ALKALI HYDROXIDES; SPARINGLY SOL IN ETHER, CHLOROFORM; SLIGHTLY SOL IN ETHANOL
    • 1 G SOL IN 26 ML DIMETHYLFORMAMIDE & 220 ML ALCOHOL
    • 1.37e-02 g/L
    • >36.2 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • mefenamic acid
    • 61-68-7
    • Ponstel
    • 2-[(2,3-dimethylphenyl)amino]benzoic acid
    • Mephenamic acid
    • 2-((2,3-Dimethylphenyl)amino)benzoic acid
    • Mephenaminic acid
    • Ponstan
    • Methenamic acid
    • Vialidon
    • Lysalgo
    • Tanston
    • Acide mefenamique
    • Mefenaminsaeure
    • CN-35355
    • N-2,3-Xylylanthranilic acid
    • Acido mefenamico
    • Mefenaminic Acid
    • INF-3355
    • CI-473
    • Acidum mefenamicum
    • INF 3355
    • N-(2,3-Xylyl)-2-aminobenzoic acid
    • N-(2,3-Dimethylphenyl)anthranilic acid
    • Gardan
    • Anthranilic acid, N-2,3-xylyl-
    • 2-(2,3-dimethylphenylamino)benzoic acid
    • Benzoic acid, 2-[(2,3-dimethylphenyl)amino]-
    • CN 35355
    • DTXSID5023243
    • NSC-94437
    • Benzoic acid, 2-((2,3-dimethylphenyl)amino)-
    • J2.344B
    • 2-Diphenylaminecarboxylic acid, 2',3'-dimethyl-
    • M01AG01
    • Benzoic acid, 2-(2,3-dimethylphenyl)amino-
    • NSC94437
    • 367589PJ2C
    • CHEBI:6717
    • DTXCID103243
    • Mefenamicacid
    • Mendys
    • Ponstan fte
    • Opustan 250
    • Opustan 500
    • Dysman-250
    • Dysman-500
    • Meflam 250
    • Meflam 500
    • RefChem:5988
    • 200-513-1
    • Acid, Mefenamic
    • Apo Mefenamic
    • Nu Mefenamic
    • PMS Mefenamic Acid
    • Mefacit
    • Parkemed
    • Coslan
    • Ponalar
    • Bonabol
    • Bafameritin-M
    • Tamany Bonsan
    • Mefenamate
    • Pontal
    • Ponstan forte
    • Bafhameritin-M
    • 2-(2,3-Dimethylanilino)benzoic acid
    • Mefenacid
    • Namphen
    • Mefanamic acid
    • Ponstil
    • Ponstyl
    • HL 1
    • N-(2,3-Xylyl)anthranilic acid
    • AGN-1255
    • CL 473
    • MFCD00051721
    • NSC 94437
    • CI 473
    • CHEMBL686
    • MLS000069709
    • CAS-61-68-7
    • NCGC00016278-07
    • SMR000058188
    • Mefenaminsaeure [German]
    • Ac. mefenamico [Italian]
    • in-M
    • Acide mefenamique [French]
    • Acide mefenamique [INN-French]
    • Acido mefenamico [INN-Spanish]
    • Acidum mefenamicum [INN-Latin]
    • 2-(2,3-Xylidino)benzoic Acid
    • HSDB 3115
    • SR-01000000216
    • EINECS 200-513-1
    • BRN 2216243
    • mefenamic-acid
    • UNII-367589PJ2C
    • Mefenamic acid CRS
    • Prestwick_506
    • Anthranilic acid, N-(2,3-xylyl)-
    • Spectrum_000174
    • CPD000058188
    • Opera_ID_542
    • Mefenamic acid [USAN:USP:INN:BAN:JAN]
    • Prestwick0_000054
    • Prestwick1_000054
    • Prestwick2_000054
    • Prestwick3_000054
    • Spectrum2_001941
    • Spectrum3_001082
    • Spectrum4_001235
    • Spectrum5_001341
    • M1782
    • Mefenamic acid (Standard)
    • Anthranilic acid,3-xylyl-
    • cid_4044
    • SCHEMBL3544
    • MEFENAMIC ACID [MI]
    • Oprea1_193889
    • BSPBio_000207
    • BSPBio_002724
    • KBioGR_001730
    • KBioSS_000654
    • MEFENAMIC ACID [INN]
    • MEFENAMIC ACID [JAN]
    • MLS001074162
    • 61-68-7

  • Applications

    Mefenamic Acid is primarily used as an active pharmaceutical ingredient in analgesic/anti-inflammatory drug products, typically formulated for oral administration (tablets or capsules) and, in some markets, topical dosage forms; it also serves as a key intermediate in the synthesis of related fenamate NSAIDs in pharmaceutical manufacturing; in analytical and quality-control environments it is used as a reference standard for assay, impurity profiling and method development; in research and development it is evaluated for new formulations and pharmacokinetic studies; usage is subject to local regulations and formulation limits, and the CAS number is 61-68-7.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 9.38
    methanol 20.22
    isopropanol 6.73
    water 0.09
    ethyl acetate 16.19
    n-propanol 18.99
    acetone 16.22
    n-butanol 17.68
    acetonitrile 4.66
    DMF 85.08
    toluene 15.51
    isobutanol 12.86
    1,4-dioxane 55.61
    methyl acetate 25.03
    THF 92.76
    2-butanone 49.37
    n-pentanol 18.32
    sec-butanol 17.61
    n-hexane 2.31
    ethylene glycol 4.15
    NMP 157.45
    cyclohexane 1.43
    DMSO 109.07
    n-butyl acetate 33.66
    n-octanol 5.9
    chloroform 42.48
    n-propyl acetate 19.1
    acetic acid 17.67
    dichloromethane 22.72
    cyclohexanone 61.53
    propylene glycol 10.79
    isopropyl acetate 20.43
    DMAc 375.13
    2-ethoxyethanol 42.38
    isopentanol 21.84
    n-heptane 1.75
    ethyl formate 7.1
    1,2-dichloroethane 43.02
    n-hexanol 30.82
    2-methoxyethanol 59.97
    isobutyl acetate 14.92
    tetrachloromethane 4.86
    n-pentyl acetate 15.97
    transcutol 222.84
    n-heptanol 15.56
    ethylbenzene 10.41
    MIBK 31.26
    2-propoxyethanol 72.36
    tert-butanol 27.1
    MTBE 43.03
    2-butoxyethanol 43.37
    propionic acid 24.63
    o-xylene 14.99
    formic acid 14.48
    diethyl ether 34.84
    m-xylene 13.69
    p-xylene 11.49
    chlorobenzene 15.52
    dimethyl carbonate 28.4
    n-octane 0.49
    formamide 41.04
    cyclopentanone 81.25
    2-pentanone 29.53
    anisole 34.53
    cyclopentyl methyl ether 52.88
    gamma-butyrolactone 72.94
    1-methoxy-2-propanol 58.3
    pyridine 38.43
    3-pentanone 51.61
    furfural 55.88
    n-dodecane 0.3
    diethylene glycol 44.84
    diisopropyl ether 11.87
    tert-amyl alcohol 37.28
    acetylacetone 33.98
    n-hexadecane 0.37
    acetophenone 33.12
    methyl propionate 35.59
    isopentyl acetate 37.14
    trichloroethylene 77.08
    n-nonanol 7.23
    cyclohexanol 19.66
    benzyl alcohol 22.16
    2-ethylhexanol 18.72
    isooctanol 13.59
    dipropyl ether 25.8
    1,2-dichlorobenzene 18.28
    ethyl lactate 18.85
    propylene carbonate 31.54
    n-methylformamide 30.43
    2-pentanol 15.36
    n-pentane 1.15
    1-propoxy-2-propanol 53.44
    1-methoxy-2-propyl acetate 60.84
    2-(2-methoxypropoxy) propanol 52.76
    mesitylene 8.75
    ε-caprolactone 49.26
    p-cymene 8.49
    epichlorohydrin 90.9
    1,1,1-trichloroethane 23.22
    2-aminoethanol 15.85
    morpholine-4-carbaldehyde 109.29
    sulfolane 164.83
    2,2,4-trimethylpentane 1.6
    2-methyltetrahydrofuran 59.86
    n-hexyl acetate 18.42
    isooctane 1.2
    2-(2-butoxyethoxy)ethanol 67.93
    sec-butyl acetate 21.49
    tert-butyl acetate 47.49
    decalin 1.67
    glycerin 26.16
    diglyme 135.21
    acrylic acid 22.47
    isopropyl myristate 9.7
    n-butyric acid 27.14
    acetyl acetate 12.31
    di(2-ethylhexyl) phthalate 13.27
    ethyl propionate 24.26
    nitromethane 38.32
    1,2-diethoxyethane 52.2
    benzonitrile 11.55
    trioctyl phosphate 8.49
    1-bromopropane 17.68
    gamma-valerolactone 99.24
    n-decanol 5.66
    triethyl phosphate 19.96
    4-methyl-2-pentanol 15.81
    propionitrile 11.23
    vinylene carbonate 24.35
    1,1,2-trichlorotrifluoroethane 82.26
    DMS 30.44
    cumene 8.77
    2-octanol 7.39
    2-hexanone 27.16
    octyl acetate 11.89
    limonene 12.55
    1,2-dimethoxyethane 73.64
    ethyl orthosilicate 20.07
    tributyl phosphate 10.54
    diacetone alcohol 62.41
    N,N-dimethylaniline 29.38
    acrylonitrile 14.44
    aniline 29.7
    1,3-propanediol 21.69
    bromobenzene 13.62
    dibromomethane 17.04
    1,1,2,2-tetrachloroethane 93.17
    2-methyl-cyclohexyl acetate 29.12
    tetrabutyl urea 16.31
    diisobutyl methanol 12.38
    2-phenylethanol 29.35
    styrene 9.75
    dioctyl adipate 17.32
    dimethyl sulfate 68.33
    ethyl butyrate 26.37
    methyl lactate 32.25
    butyl lactate 21.14
    diethyl carbonate 18.18
    propanediol butyl ether 28.19
    triethyl orthoformate 25.2
    p-tert-butyltoluene 8.9
    methyl 4-tert-butylbenzoate 36.83
    morpholine 72.53
    tert-butylamine 15.08
    n-dodecanol 4.28
    dimethoxymethane 78.94
    ethylene carbonate 19.68
    cyrene 47.93
    2-ethoxyethyl acetate 35.01
    2-ethylhexyl acetate 30.06
    1,2,4-trichlorobenzene 26.51
    4-methylpyridine 33.0
    dibutyl ether 10.43
    2,6-dimethyl-4-heptanol 12.38
    DEF 60.82
    dimethyl isosorbide 96.2
    tetrachloroethylene 46.2
    eugenol 37.49
    triacetin 27.11
    span 80 33.68
    1,4-butanediol 8.27
    1,1-dichloroethane 19.8
    2-methyl-1-pentanol 25.46
    methyl formate 15.49
    2-methyl-1-butanol 23.56
    n-decane 0.53
    butyronitrile 7.73
    3,7-dimethyl-1-octanol 9.82
    1-chlorooctane 3.62
    1-chlorotetradecane 1.58
    n-nonane 0.45
    undecane 0.39
    tert-butylcyclohexane 2.06
    cyclooctane 0.59
    cyclopentanol 19.98
    tetrahydropyran 46.27
    tert-amyl methyl ether 46.0
    2,5,8-trioxanonane 94.47
    1-hexene 11.0
    2-isopropoxyethanol 35.34
    2,2,2-trifluoroethanol 11.61
    methyl butyrate 26.28

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction