Mannitol

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  • Identifiers

    CAS number
    69-65-8

    Molecular formula
    C6H14O6

    SMILES
    C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O

  • Odor profile

    Fragrance
    Odorless 69.3%
    Sweet 50.63%
    Alcoholic 23.09%
    Caramellic 21.63%
    Buttery 18.26%
    Clean 17.24%
    Cooling 15.67%
    Bitter 15.54%
    Fishy 15.34%
    Oily 14.8%

     

    Flavor
    Odorless 73.57%
    Sweet 61.86%
    Sweet-like 34.1%
    Very mild 23.89%
    Very slight 22.4%
    Bland 20.48%
    Mild 20.04%
    Cauliflower 19.33%
    Yeast 19.07%
    Soup 18.83%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.1

    pKa est.
    5.33 (weak acid)

    Molecular weight
    182.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 331 to 334 °F (NTP, 1992)
    • 168 °C
    • 166-168 °C
    • 166 °C

    Boiling point

    • 563 °F at 3.5 mmHg (NTP, 1992)
    • 290-295 °C at 3.50E+00 mm Hg
    • 290-295 °C @ 3.5 mm Hg
    • 290.00 to 295.00 °C. @ 760.00 mm Hg

    Flash point

    • 244.88 ˚C est.
    • greater than 300 °F (NTP, 1992)

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
    • 216000 mg/L (at 25 °C)
    • 1 g in about 5.5 ml water; more sol in hot water; insol in ether; sol in pyridine, aniline; sol in aq soln of alkalies; 1 g dissolves in 18 ml glycerol (density 1.24); 1 g dissolves in about 83 ml alc
    • In water, 2.16X10+5 mg/l @ 25 °C
    • 216 mg/mL at 25 °C

  • Synonyms

    • D-mannitol
    • mannitol
    • 69-65-8
    • Mannite
    • Osmitrol
    • Manna sugar
    • Cordycepic acid
    • Osmofundin
    • Resectisol
    • Diosmol
    • Mannit
    • Mannazucker
    • Mannidex
    • Mannigen
    • Mannistol
    • Invenex
    • Isotol
    • Osmosal
    • Marine Crystal
    • 87-78-5
    • Maniton-S
    • D-(-)-Mannitol
    • Bronchitol
    • Mannitol, D-
    • (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
    • (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
    • Mannogem 2080
    • DL-Mannitol
    • Mannitol 5%
    • Mannitol (VAN)
    • Aridol
    • Mannitol 10%
    • Mannitol 15%
    • Mannitol 20%
    • Osmitrol 5% In Water
    • Osmitrol 10% In Water
    • Osmitrol 15% In Water
    • Osmitrol 20% In Water
    • SDM No. 35
    • Hexahydroxyhexane
    • Resectisol In Plastic Container
    • Mannitol (USP)
    • Mannitol 5% In Plastic Container
    • NCI-C50362
    • Mannitol 10% In Plastic Container
    • Mannitol 15% In Plastic Container
    • Mannitol 20% In Plastic Container
    • CCRIS 369
    • Mannitolum
    • HSDB 714
    • Manitol
    • CHEBI:16899
    • BRN 1721898
    • Maniton s
    • Mannitol;Mannite
    • UNII-3OWL53L36A
    • MFCD00064287
    • Mannitol [USP]
    • NSC 407017
    • 3OWL53L36A
    • INS NO.421
    • OSMITROL 5% IN WATER IN PLASTIC CONTAINER
    • DTXSID1023235
    • OSMITROL 10% IN WATER IN PLASTIC CONTAINER
    • OSMITROL 15% IN WATER IN PLASTIC CONTAINER
    • OSMITROL 20% IN WATER IN PLASTIC CONTAINER
    • INS-421
    • E-421
    • NSC-407017
    • E421
    • DTXCID603235
    • 133-43-7
    • mannitol-d
    • DTXSID30858955
    • 4-01-00-02841 (Beilstein Handbook Reference)
    • Mannitol [USAN]
    • manita
    • NCGC00164246-01
    • MANNITOL (II)
    • MANNITOL [II]
    • Mannidex 16700
    • E 421
    • MANNITOL (MART.)
    • MANNITOL [MART.]
    • MANNITOL (USP-RS)
    • MANNITOL [USP-RS]
    • MTL
    • MANNITOL 25%
    • MANNITOL (EP IMPURITY)
    • MANNITOL [EP IMPURITY]
    • rel-(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
    • MANNITOL (EP MONOGRAPH)
    • MANNITOL [EP MONOGRAPH]
    • MANNITOL (USP MONOGRAPH)
    • MANNITOL [USP MONOGRAPH]
    • 1,2,3,4,5,6-Hexanehexol
    • D-Mannit
    • CAS-69-65-8
    • ISOMALT IMPURITY B (EP IMPURITY)
    • ISOMALT IMPURITY B [EP IMPURITY]
    • Osmitrol (TN)
    • SMR000857324
    • SR-01000838849
    • D-Mannitol, EP, USP grade
    • NSC 9256
    • EINECS 200-711-8
    • EINECS 201-770-2
    • Cordycepate
    • D-mitobronitol
    • MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER
    • AI3-19511
    • Mannit p
    • NSC407017
    • D-?Mannitol
    • Bronchitol (TN)
    • (D)-mannitol
    • Mannitol 25
    • Mannitol 35
    • Mannitol 60
    • D(-)Mannitol
    • Pearlitol 25 c
    • Pearlitol 50 c
    • Mannitol m300
    • Pearlitol 160 c
    • D-Mannitol - EP
    • Mannitol 200
    • Mannitol 300
    • Pearlitol 200 sd

  • Applications

    Mannitol (CAS 69-65-8) is a sugar alcohol used across multiple industries. In medicine it is administered as an osmotic diuretic and commonly employed as an excipient and bulking agent in tablet and formulation development. It also acts as a cryoprotectant and stabilizer for proteins and cells during freezing and lyophilization. In the food industry it serves as a low-calorie sweetener and a humectant to help retain moisture in products. In cosmetics and personal care it functions as a humectant and formulation stabilizer to improve texture and product stability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.35
    methanol 17.94
    isopropanol 1.41
    water 1225.55
    ethyl acetate 0.52
    n-propanol 2.24
    acetone 0.6
    n-butanol 1.28
    acetonitrile 0.5
    DMF 58.23
    toluene 0.07
    isobutanol 0.99
    1,4-dioxane 2.59
    methyl acetate 0.41
    THF 1.42
    2-butanone 0.53
    n-pentanol 0.49
    sec-butanol 1.47
    n-hexane 0.07
    ethylene glycol 107.72
    NMP 57.33
    cyclohexane 0.46
    DMSO 213.27
    n-butyl acetate 0.31
    n-octanol 0.57
    chloroform 0.14
    n-propyl acetate 0.19
    acetic acid 7.9
    dichloromethane 0.23
    cyclohexanone 1.49
    propylene glycol 32.68
    isopropyl acetate 0.3
    DMAc 29.84
    2-ethoxyethanol 6.44
    isopentanol 0.67
    n-heptane 0.4
    ethyl formate 0.57
    1,2-dichloroethane 0.35
    n-hexanol 0.85
    2-methoxyethanol 25.32
    isobutyl acetate 0.07
    tetrachloromethane 0.16
    n-pentyl acetate 0.27
    transcutol 6.04
    n-heptanol 0.86
    ethylbenzene 0.08
    MIBK 0.26
    2-propoxyethanol 4.81
    tert-butanol 1.23
    MTBE 0.32
    2-butoxyethanol 2.93
    propionic acid 4.05
    o-xylene 0.2
    formic acid 167.19
    diethyl ether 0.41
    m-xylene 0.12
    p-xylene 0.09
    chlorobenzene 0.05
    dimethyl carbonate 1.48
    n-octane 0.15
    formamide 98.0
    cyclopentanone 1.91
    2-pentanone 0.49
    anisole 0.16
    cyclopentyl methyl ether 1.01
    gamma-butyrolactone 3.17
    1-methoxy-2-propanol 11.4
    pyridine 0.58
    3-pentanone 0.65
    furfural 3.67
    n-dodecane 0.07
    diethylene glycol 21.58
    diisopropyl ether 0.17
    tert-amyl alcohol 1.42
    acetylacetone 0.83
    n-hexadecane 0.07
    acetophenone 0.35
    methyl propionate 1.28
    isopentyl acetate 0.22
    trichloroethylene 0.31
    n-nonanol 0.52
    cyclohexanol 2.25
    benzyl alcohol 0.56
    2-ethylhexanol 0.51
    isooctanol 0.58
    dipropyl ether 0.62
    1,2-dichlorobenzene 0.1
    ethyl lactate 1.52
    propylene carbonate 1.15
    n-methylformamide 21.17
    2-pentanol 0.77
    n-pentane 0.13
    1-propoxy-2-propanol 3.1
    1-methoxy-2-propyl acetate 1.16
    2-(2-methoxypropoxy) propanol 2.45
    mesitylene 0.15
    ε-caprolactone 1.94
    p-cymene 0.24
    epichlorohydrin 1.08
    1,1,1-trichloroethane 0.08
    2-aminoethanol 46.73
    morpholine-4-carbaldehyde 31.29
    sulfolane 28.71
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 0.91
    n-hexyl acetate 0.33
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 3.39
    sec-butyl acetate 0.13
    tert-butyl acetate 0.35
    decalin 0.1
    glycerin 131.55
    diglyme 5.78
    acrylic acid 7.6
    isopropyl myristate 0.14
    n-butyric acid 1.99
    acetyl acetate 0.36
    di(2-ethylhexyl) phthalate 0.34
    ethyl propionate 0.32
    nitromethane 6.18
    1,2-diethoxyethane 0.54
    benzonitrile 0.19
    trioctyl phosphate 0.37
    1-bromopropane 0.13
    gamma-valerolactone 5.64
    n-decanol 0.38
    triethyl phosphate 0.6
    4-methyl-2-pentanol 0.37
    propionitrile 0.34
    vinylene carbonate 1.11
    1,1,2-trichlorotrifluoroethane 11.29
    DMS 0.58
    cumene 0.09
    2-octanol 0.47
    2-hexanone 0.17
    octyl acetate 0.21
    limonene 0.44
    1,2-dimethoxyethane 2.88
    ethyl orthosilicate 0.53
    tributyl phosphate 0.3
    diacetone alcohol 2.09
    N,N-dimethylaniline 0.43
    acrylonitrile 0.73
    aniline 0.37
    1,3-propanediol 21.42
    bromobenzene 0.04
    dibromomethane 0.15
    1,1,2,2-tetrachloroethane 0.54
    2-methyl-cyclohexyl acetate 0.31
    tetrabutyl urea 0.7
    diisobutyl methanol 0.47
    2-phenylethanol 0.59
    styrene 0.06
    dioctyl adipate 0.28
    dimethyl sulfate 6.33
    ethyl butyrate 0.38
    methyl lactate 7.3
    butyl lactate 1.08
    diethyl carbonate 0.26
    propanediol butyl ether 4.75
    triethyl orthoformate 0.55
    p-tert-butyltoluene 0.27
    methyl 4-tert-butylbenzoate 1.14
    morpholine 5.07
    tert-butylamine 0.54
    n-dodecanol 0.3
    dimethoxymethane 5.13
    ethylene carbonate 0.9
    cyrene 7.21
    2-ethoxyethyl acetate 0.47
    2-ethylhexyl acetate 0.2
    1,2,4-trichlorobenzene 0.15
    4-methylpyridine 0.32
    dibutyl ether 0.24
    2,6-dimethyl-4-heptanol 0.47
    DEF 4.7
    dimethyl isosorbide 3.71
    tetrachloroethylene 0.68
    eugenol 1.44
    triacetin 0.77
    span 80 3.09
    1,4-butanediol 7.09
    1,1-dichloroethane 0.09
    2-methyl-1-pentanol 0.35
    methyl formate 5.88
    2-methyl-1-butanol 0.94
    n-decane 0.12
    butyronitrile 0.26
    3,7-dimethyl-1-octanol 0.35
    1-chlorooctane 0.16
    1-chlorotetradecane 0.08
    n-nonane 0.13
    undecane 0.08
    tert-butylcyclohexane 0.06
    cyclooctane 0.28
    cyclopentanol 2.74
    tetrahydropyran 0.91
    tert-amyl methyl ether 0.57
    2,5,8-trioxanonane 5.11
    1-hexene 0.08
    2-isopropoxyethanol 2.05
    2,2,2-trifluoroethanol 14.78
    methyl butyrate 0.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction