Mandipropamid

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  • Identifiers

    CAS number
    374726-62-2

    Molecular formula
    C23H22ClNO4

    SMILES
    COC1=C(C=CC(=C1)CCNC(=O)C(C2=CC=C(C=C2)Cl)OCC#C)OCC#C

    Safety labels

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sweet 37.59%
    Floral 33.94%
    Spicy 27.89%
    Savory 27.32%
    Odorless 25.0%
    Citrus 24.07%
    Meaty 23.98%
    Vanilla 23.8%
    Milky 22.23%
    Bitter 21.43%

     

    Flavor
    Bitter 67.09%
    Odorless 42.94%
    Bland 29.88%
    Mild 26.35%
    Sweet-like 21.06%
    Nitrile 18.98%
    Orange flower 18.71%
    Taco 18.33%
    Parsley 18.2%
    Scallion 18.13%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.9

    pKa est.
    6.5 (neutral)

    Molecular weight
    411.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    543°C

    Melting point expt.

    • 96.4-97.3 °C

    Flash point

    • 191.37 ˚C est.

    Solubility expt.

    • Solubilities (g/L, 25 °C): n-hexane 0.042, n-octanol 4.8, toluene 29, methanol 66, ethyl acetate 120, acetone 300, dichloromethane 400
    • In water, 4.2 mg/L at 25 °C

  • Synonyms

    • Mandipropamid
    • 374726-62-2
    • Revus
    • MPD fungicide
    • PERGADO
    • 11GP4ELK0U
    • DTXSID4058075
    • 2-(4-chlorophenyl)-N-(2-(3-methoxy-4-(2-propyn-1-yloxy)phenyl)ethyl)-2-(2-propyn-1-yloxy)acetamide
    • RefChem:809769
    • DTXCID0031843
    • CHEBI:81802
    • 609-434-0
    • Mandipropamid [ISO]
    • Mandipropamide
    • 2-(4-chlorophenyl)-N-[2-(3-methoxy-4-prop-2-ynoxyphenyl)ethyl]-2-prop-2-ynoxyacetamide
    • UNII-11GP4ELK0U
    • Mandipropamid?
    • HSDB 7878
    • BENZENEACETAMIDE, 4-CHLORO-N-(2-(3-METHOXY-4-(2-PROPYN-1-YLOXY)PHENYL)ETHYL)-.ALPHA.-(2-PROPYN-1-YLOXY)-
    • Benzeneacetamide, 4-chloro-N-[2-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]ethyl]-.alpha.-(2-propyn-1-yloxy)-
    • Mandipropamid 10 microg/mL in Cyclohexane
    • Mandipropamid 100 microg/mL in Acetonitrile
    • MANDIPROPAMID [MI]
    • 2-(4-chlorophenyl)-N-[2-(3-methoxy-4-prop-2-ynoxy-phenyl)ethyl]-2-prop-2-ynoxy-acetamide
    • MANDIPROPAMID [HSDB]
    • SCHEMBL22338
    • CHEMBL271907
    • orb2283339
    • orb3025374
    • SCHEMBL29379242
    • CHEBI:83617
    • MSK21244
    • MFCD09751510
    • AKOS025295244
    • AT33985
    • HY-W744966
    • 2-(4-chlorophenyl)-N-{2-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]ethyl}-2-(prop-2-yn-1-yloxy)acetamide
    • CS-0790685
    • NS00000495
    • C18522
    • 726M622
    • Q2057167
    • 2-(4-Chlorophenyl)-N-(3-methoxy-4-(prop-2-ynyloxy)phenethyl)-2-(prop-2-ynyloxy)acetamide
    • 2-(4-Chlorophenyl)-N-[3-methoxy-4-(2-propynyloxy)phenethyl]-2-(2-propynyloxy)acetamide
    • (+/-)-CHLOROPHENYL)-N-(2-(3-METHOXY-4-(PROP-2-YNYLOXY)PHENYL)ETHYL)-2-(PROP-2-YNYLOXY)ACETAMIDE
    • 2-(4-Chloro-phenyl)-N-[2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl]-2-(prop-2-ynyloxy)-acetamide
    • 2-(4-chloro-phenyl)-N-[2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl]-2-prop-2-ynyloxy-acetamide
    • 2-(4-Chloro-phenyl)-N-[2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl]-2-prop-2-ynyloxyacetamide
    • 2-(4-CHLOROPHENYL)-N-(2-(3-METHOXY-4-(PROP-2-YNYLOXY)PHENYL)ETHYL)-2-(PROP-2-YNYLOXY)ACETAMIDE
    • 2-(4-Chlorophenyl)-N-(2-{3-methoxy-4-[(prop-2-yn-1-yl)oxy]phenyl}ethyl)-2-[(prop-2-yn-1-yl)oxy]acetamide
    • BENZENEACETAMIDE, 4-CHLORO-N-(2-(3-METHOXY-4-(2-PROPYNYLOXY)PHENYL)ETHYL)-.ALPHA.-(2-PROPYNYLOXY)-
    • 374726-62-2

  • Applications

    Chemical name: Mandipropamid; CAS number: 374726-62-2 is used as a fungicide to control oomycete diseases in agriculture. Typical applications include protecting crops such as grapes, tomatoes, potatoes and cucurbits from Phytophthora, Pythium and Peronospora pathogens; applying as a foliar spray in field or greenhouse settings to prevent late blight and downy mildew; using it in commercial farming and nursery production within integrated pest management programs to manage disease pressure; and formulating it as an approved crop protection product, with use subject to local regulations and label instructions.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 13.85
    methanol 28.8
    isopropanol 6.13
    water 0.73
    ethyl acetate 12.57
    n-propanol 11.21
    acetone 27.48
    n-butanol 7.73
    acetonitrile 16.57
    DMF 59.53
    toluene 4.35
    isobutanol 6.48
    1,4-dioxane 19.87
    methyl acetate 14.65
    THF 45.54
    2-butanone 19.01
    n-pentanol 9.79
    sec-butanol 7.35
    n-hexane 0.32
    ethylene glycol 18.15
    NMP 50.61
    cyclohexane 1.01
    DMSO 131.56
    n-butyl acetate 6.18
    n-octanol 6.73
    chloroform 36.75
    n-propyl acetate 9.91
    acetic acid 47.47
    dichloromethane 47.96
    cyclohexanone 33.32
    propylene glycol 12.77
    isopropyl acetate 7.2
    DMAc 94.56
    2-ethoxyethanol 36.57
    isopentanol 5.87
    n-heptane 0.82
    ethyl formate 16.19
    1,2-dichloroethane 21.66
    n-hexanol 6.07
    2-methoxyethanol 43.42
    isobutyl acetate 6.3
    tetrachloromethane 3.6
    n-pentyl acetate 9.8
    transcutol 56.6
    n-heptanol 7.68
    ethylbenzene 2.64
    MIBK 8.02
    2-propoxyethanol 23.45
    tert-butanol 6.13
    MTBE 3.97
    2-butoxyethanol 21.28
    propionic acid 18.04
    o-xylene 3.29
    formic acid 59.14
    diethyl ether 5.92
    m-xylene 2.69
    p-xylene 2.92
    chlorobenzene 6.76
    dimethyl carbonate 19.29
    n-octane 0.55
    formamide 72.3
    cyclopentanone 41.62
    2-pentanone 13.33
    anisole 8.46
    cyclopentyl methyl ether 10.99
    gamma-butyrolactone 42.69
    1-methoxy-2-propanol 26.11
    pyridine 22.07
    3-pentanone 12.69
    furfural 49.99
    n-dodecane 0.5
    diethylene glycol 31.49
    diisopropyl ether 1.47
    tert-amyl alcohol 6.52
    acetylacetone 25.92
    n-hexadecane 0.55
    acetophenone 14.58
    methyl propionate 16.27
    isopentyl acetate 6.41
    trichloroethylene 50.07
    n-nonanol 7.1
    cyclohexanol 9.54
    benzyl alcohol 13.23
    2-ethylhexanol 4.46
    isooctanol 6.24
    dipropyl ether 5.99
    1,2-dichlorobenzene 8.17
    ethyl lactate 14.45
    propylene carbonate 21.95
    n-methylformamide 36.14
    2-pentanol 4.36
    n-pentane 0.38
    1-propoxy-2-propanol 15.39
    1-methoxy-2-propyl acetate 14.11
    2-(2-methoxypropoxy) propanol 20.54
    mesitylene 1.58
    ε-caprolactone 24.79
    p-cymene 2.32
    epichlorohydrin 46.88
    1,1,1-trichloroethane 9.96
    2-aminoethanol 20.08
    morpholine-4-carbaldehyde 49.02
    sulfolane 69.7
    2,2,4-trimethylpentane 0.3
    2-methyltetrahydrofuran 14.13
    n-hexyl acetate 10.07
    isooctane 0.16
    2-(2-butoxyethoxy)ethanol 25.34
    sec-butyl acetate 5.85
    tert-butyl acetate 7.51
    decalin 0.48
    glycerin 31.16
    diglyme 51.35
    acrylic acid 26.12
    isopropyl myristate 4.8
    n-butyric acid 16.87
    acetyl acetate 13.22
    di(2-ethylhexyl) phthalate 8.27
    ethyl propionate 10.08
    nitromethane 79.23
    1,2-diethoxyethane 13.88
    benzonitrile 12.09
    trioctyl phosphate 6.0
    1-bromopropane 6.73
    gamma-valerolactone 55.02
    n-decanol 5.26
    triethyl phosphate 7.4
    4-methyl-2-pentanol 2.86
    propionitrile 11.8
    vinylene carbonate 25.45
    1,1,2-trichlorotrifluoroethane 64.36
    DMS 13.49
    cumene 1.9
    2-octanol 4.71
    2-hexanone 12.41
    octyl acetate 6.84
    limonene 3.4
    1,2-dimethoxyethane 37.03
    ethyl orthosilicate 6.66
    tributyl phosphate 6.63
    diacetone alcohol 15.82
    N,N-dimethylaniline 7.42
    acrylonitrile 20.74
    aniline 9.17
    1,3-propanediol 18.59
    bromobenzene 5.74
    dibromomethane 21.82
    1,1,2,2-tetrachloroethane 34.66
    2-methyl-cyclohexyl acetate 9.16
    tetrabutyl urea 10.55
    diisobutyl methanol 2.91
    2-phenylethanol 9.97
    styrene 3.15
    dioctyl adipate 10.8
    dimethyl sulfate 37.03
    ethyl butyrate 8.43
    methyl lactate 23.91
    butyl lactate 13.88
    diethyl carbonate 7.62
    propanediol butyl ether 19.69
    triethyl orthoformate 8.32
    p-tert-butyltoluene 2.11
    methyl 4-tert-butylbenzoate 16.89
    morpholine 26.29
    tert-butylamine 2.83
    n-dodecanol 3.87
    dimethoxymethane 38.37
    ethylene carbonate 18.48
    cyrene 32.65
    2-ethoxyethyl acetate 17.64
    2-ethylhexyl acetate 5.18
    1,2,4-trichlorobenzene 10.48
    4-methylpyridine 13.92
    dibutyl ether 5.61
    2,6-dimethyl-4-heptanol 2.91
    DEF 22.59
    dimethyl isosorbide 29.98
    tetrachloroethylene 24.27
    eugenol 19.68
    triacetin 21.04
    span 80 16.86
    1,4-butanediol 14.33
    1,1-dichloroethane 11.51
    2-methyl-1-pentanol 7.6
    methyl formate 33.23
    2-methyl-1-butanol 6.63
    n-decane 0.88
    butyronitrile 9.96
    3,7-dimethyl-1-octanol 5.06
    1-chlorooctane 3.4
    1-chlorotetradecane 1.48
    n-nonane 0.77
    undecane 0.65
    tert-butylcyclohexane 0.35
    cyclooctane 0.42
    cyclopentanol 11.21
    tetrahydropyran 14.12
    tert-amyl methyl ether 4.86
    2,5,8-trioxanonane 36.92
    1-hexene 1.64
    2-isopropoxyethanol 20.37
    2,2,2-trifluoroethanol 29.48
    methyl butyrate 13.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction