Lysergide

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  • Identifiers

    CAS number
    50-37-3

    Molecular formula
    C20H25N3O

    SMILES
    CCN(CC)C(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 45.34%
    Roasted 32.56%
    Savory 29.15%
    Meaty 27.79%
    Cooling 27.41%
    Animal 25.99%
    Burnt 23.82%
    Cooked 23.34%
    Fishy 22.6%
    Nutty 22.2%

     

    Flavor
    Bitter 92.42%
    Odorless 28.46%
    Bland 24.48%
    Sweet-like 19.76%
    Cedarleaf 19.55%
    Nitrile 18.49%
    Very strong 18.12%
    Indole 17.94%
    Cereal 17.9%
    Lovage 17.77%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.0

    pKa est.
    7.03 (neutral)

    Molecular weight
    323.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    760°C

    Melting point expt.

    • 176 to 185 °F (NTP, 1992)
    • 82.5 °C
    • 82 °C
    • Crystals (with 1-2 molecules of water) in plates from water. MP: 240 °C (decomposes). Amphoteric; moderately soluble in pyridine; slightly soluble in water and neutral organic sovents; soluble in alkaline and acid solutions /Lysergic acid/

    Flash point

    • 260.76 ˚C est.

    Solubility expt.

    • Water soluble

  • Synonyms

    • Lysergide
    • LYSERGIC ACID DIETHYLAMIDE
    • N,N-Diethyllysergamide
    • D-Lysergic acid diethylamide
    • D-Lsd
    • Delysid
    • LSD
    • Lysergamid
    • 50-37-3
    • Lysergsaeurediaethylamid
    • Cubes
    • Pearly gates
    • Heavenly Blue
    • Royal blue
    • Lysergaure diethylamid
    • LSD-25
    • N,N-Diethyl-D-lysergamide
    • LSD (alkaloid)
    • LSD 25
    • Lysergsauerediaethylamid
    • Lysergic acid diethylamide-25
    • Lisergide
    • Lisergido
    • Lysergidum
    • Lysergamide, N,N-diethyl-
    • N,N-Diethyl-(+)-Lysergamide
    • Dextrolysergic Acid diethylamide
    • HSDB 3920
    • Lysergsaeurediethylamid
    • lisergida
    • (+)-Lysergic acid diethylamide
    • UNII-8NA5SWF92O
    • EINECS 200-033-2
    • 8NA5SWF92O
    • (+)-Lysergide
    • Diethylamid kyseliny lysergove
    • BRN 0094179
    • CHEBI:6605
    • Acid [Street Name]
    • Cubes [Street Name]
    • DTXSID1023231
    • (+)-LSD
    • Royal Blue [Street Name]
    • Pearly gates [Street Name]
    • Wedding bells [Street Name]
    • Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8beta)-
    • Heavenly Blue [Street Name]
    • Lysergic acid diethylamide tartrate
    • [3H]-LSD
    • CHEMBL263881
    • DTXCID003231
    • Wedding bells
    • 9,10-Didehydro-N,N-diethyl-6-methyl-ergoline-8-beta-carboxamide
    • Ergoline-8beta-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-
    • 4-25-00-00939 (Beilstein Handbook Reference)
    • Acid (Street Name)
    • Cubes (Street Name)
    • NCGC00168265-01
    • NCGC00168265-02
    • (8R)-9,10-didehydro-N,N-diethyl-6-methylergoline-8-carboxamide
    • Ergoline-8-beta-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-
    • Royal Blue (Street Name)
    • Lysergidum [INN-Latin]
    • Pearly gates (Street Name)
    • Heavenly Blue (Street Name)
    • Wedding bells (Street Name)
    • Lisergide [DCIT]
    • Clearlight
    • Ubergluben
    • Barrels
    • Bartman
    • Cupcakes
    • Greenies
    • Microdots
    • Spoonies
    • Sunshine
    • Trippers
    • Yellows
    • Beast
    • CHEMBL463207
    • Chief
    • Domes
    • Fifty
    • Flats
    • Owsley
    • Scapes
    • Wedges
    • Chocolate Chips
    • Orange Mushroom
    • Orange Sunshine
    • Purple Microdot
    • Gelatin Chips
    • Mellow Yellow
    • Orange Wedges
    • Bart Simpson
    • Blotter Acid
    • Contact Lens
    • (8alpha)-N,N-Diethyl-6-Methyl-9,10-Didehydroergoline-8-Carboxamide
    • Purple Haze
    • White Light
    • Window Pane
    • Blue Cheer
    • Brown Dots
    • Cherry Top
    • Lisergido [INN-Spanish]
    • Mean Green
    • Paper Acid
    • Sugar Lump
    • Blue Acid
    • Blue Mist
    • Strawberry Fields
    • The Hawk
    • CAS-50-37-3
    • California Sunshine
    • LSD (d-Lysergic acid N,N-diethylamide)
    • Lysergide [INN:BAN:DCF]
    • (4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide
    • Diethylamid kyseliny lysergove [Czech]
    • Big F
    • (+)-Lysergide (1.0 mg/mL in Acetonitrile)
    • (+)-Lysergide (100 microg/mL in Methanol)
    • Acid Diethylamide, Lysergic
    • Diethylamide, Lysergic Acid
    • Hawk
    • Haze
    • Lucy in the Sky with Diamonds
    • Instant Zen
    • DEA No. 7315

  • Applications

    Lysergide (LSD), CAS 50-37-3, is primarily used in controlled research settings to investigate serotonergic pharmacology and CNS effects, serving as a tool compound for neuroscience and psychopharmacology studies. It also functions as a reference material and enables analytical method development for detecting and quantifying LSD in forensic toxicology samples. In academia, it is used to illustrate cognitive and perceptual phenomena related to the nervous system under strict regulatory oversight. These applications are focused on basic research and preclinical/early translational studies, with adherence to relevant laws and handling restrictions.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.49
    methanol 11.65
    isopropanol 6.76
    water 0.06
    ethyl acetate 11.78
    n-propanol 9.09
    acetone 15.09
    n-butanol 11.23
    acetonitrile 3.18
    DMF 47.42
    toluene 4.52
    isobutanol 10.14
    1,4-dioxane 21.03
    methyl acetate 15.13
    THF 19.61
    2-butanone 20.75
    n-pentanol 11.06
    sec-butanol 6.21
    n-hexane 0.17
    ethylene glycol 3.45
    NMP 41.53
    cyclohexane 0.36
    DMSO 15.56
    n-butyl acetate 19.61
    n-octanol 2.41
    chloroform 51.11
    n-propyl acetate 17.03
    acetic acid 26.46
    dichloromethane 39.32
    cyclohexanone 38.42
    propylene glycol 2.78
    isopropyl acetate 11.66
    DMAc 86.84
    2-ethoxyethanol 28.4
    isopentanol 14.64
    n-heptane 0.15
    ethyl formate 13.51
    1,2-dichloroethane 20.71
    n-hexanol 8.13
    2-methoxyethanol 30.49
    isobutyl acetate 18.41
    tetrachloromethane 5.57
    n-pentyl acetate 18.72
    transcutol 52.27
    n-heptanol 5.85
    ethylbenzene 2.96
    MIBK 13.56
    2-propoxyethanol 36.41
    tert-butanol 6.66
    MTBE 4.47
    2-butoxyethanol 27.76
    propionic acid 12.58
    o-xylene 3.62
    formic acid 13.85
    diethyl ether 4.39
    m-xylene 4.04
    p-xylene 5.39
    chlorobenzene 11.93
    dimethyl carbonate 11.86
    n-octane 0.13
    formamide 17.19
    cyclopentanone 31.3
    2-pentanone 15.44
    anisole 7.07
    cyclopentyl methyl ether 8.04
    gamma-butyrolactone 35.06
    1-methoxy-2-propanol 19.62
    pyridine 24.06
    3-pentanone 13.4
    furfural 49.31
    n-dodecane 0.16
    diethylene glycol 32.86
    diisopropyl ether 1.66
    tert-amyl alcohol 6.92
    acetylacetone 21.56
    n-hexadecane 0.19
    acetophenone 16.06
    methyl propionate 13.42
    isopentyl acetate 24.32
    trichloroethylene 55.98
    n-nonanol 3.35
    cyclohexanol 9.5
    benzyl alcohol 16.3
    2-ethylhexanol 5.81
    isooctanol 6.41
    dipropyl ether 3.04
    1,2-dichlorobenzene 14.15
    ethyl lactate 12.24
    propylene carbonate 25.6
    n-methylformamide 17.22
    2-pentanol 5.66
    n-pentane 0.2
    1-propoxy-2-propanol 17.91
    1-methoxy-2-propyl acetate 25.89
    2-(2-methoxypropoxy) propanol 23.12
    mesitylene 2.47
    ε-caprolactone 34.06
    p-cymene 3.33
    epichlorohydrin 42.17
    1,1,1-trichloroethane 17.43
    2-aminoethanol 6.61
    morpholine-4-carbaldehyde 56.25
    sulfolane 34.49
    2,2,4-trimethylpentane 0.31
    2-methyltetrahydrofuran 11.93
    n-hexyl acetate 12.69
    isooctane 0.21
    2-(2-butoxyethoxy)ethanol 28.36
    sec-butyl acetate 12.83
    tert-butyl acetate 11.61
    decalin 0.39
    glycerin 8.72
    diglyme 47.3
    acrylic acid 14.75
    isopropyl myristate 5.56
    n-butyric acid 23.79
    acetyl acetate 12.84
    di(2-ethylhexyl) phthalate 14.04
    ethyl propionate 11.66
    nitromethane 28.7
    1,2-diethoxyethane 15.85
    benzonitrile 16.22
    trioctyl phosphate 7.81
    1-bromopropane 7.13
    gamma-valerolactone 69.09
    n-decanol 2.6
    triethyl phosphate 11.81
    4-methyl-2-pentanol 5.59
    propionitrile 7.03
    vinylene carbonate 31.36
    1,1,2-trichlorotrifluoroethane 48.83
    DMS 20.31
    cumene 2.88
    2-octanol 3.14
    2-hexanone 15.93
    octyl acetate 7.44
    limonene 3.47
    1,2-dimethoxyethane 32.08
    ethyl orthosilicate 10.92
    tributyl phosphate 9.99
    diacetone alcohol 17.27
    N,N-dimethylaniline 6.42
    acrylonitrile 10.1
    aniline 10.39
    1,3-propanediol 16.2
    bromobenzene 9.97
    dibromomethane 18.63
    1,1,2,2-tetrachloroethane 38.91
    2-methyl-cyclohexyl acetate 15.7
    tetrabutyl urea 13.86
    diisobutyl methanol 3.59
    2-phenylethanol 18.52
    styrene 3.25
    dioctyl adipate 11.41
    dimethyl sulfate 19.66
    ethyl butyrate 12.76
    methyl lactate 12.22
    butyl lactate 19.08
    diethyl carbonate 11.94
    propanediol butyl ether 14.16
    triethyl orthoformate 12.62
    p-tert-butyltoluene 2.79
    methyl 4-tert-butylbenzoate 19.01
    morpholine 23.33
    tert-butylamine 2.99
    n-dodecanol 2.04
    dimethoxymethane 23.56
    ethylene carbonate 26.5
    cyrene 30.28
    2-ethoxyethyl acetate 34.49
    2-ethylhexyl acetate 18.3
    1,2,4-trichlorobenzene 19.75
    4-methylpyridine 22.73
    dibutyl ether 2.97
    2,6-dimethyl-4-heptanol 3.59
    DEF 22.32
    dimethyl isosorbide 35.27
    tetrachloroethylene 29.58
    eugenol 27.68
    triacetin 20.42
    span 80 16.02
    1,4-butanediol 8.98
    1,1-dichloroethane 15.53
    2-methyl-1-pentanol 14.69
    methyl formate 15.44
    2-methyl-1-butanol 12.88
    n-decane 0.22
    butyronitrile 8.2
    3,7-dimethyl-1-octanol 4.17
    1-chlorooctane 1.31
    1-chlorotetradecane 0.74
    n-nonane 0.15
    undecane 0.18
    tert-butylcyclohexane 0.36
    cyclooctane 0.14
    cyclopentanol 8.13
    tetrahydropyran 11.53
    tert-amyl methyl ether 4.38
    2,5,8-trioxanonane 34.28
    1-hexene 1.12
    2-isopropoxyethanol 23.15
    2,2,2-trifluoroethanol 17.57
    methyl butyrate 17.13

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction