Lufenuron

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  • Identifiers

    CAS number
    103055-07-8

    Molecular formula
    C17H8Cl2F8N2O3

    SMILES
    C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=CC(=C(C=C2Cl)OC(C(C(F)(F)F)F)(F)F)Cl)F

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 60.33%
    Cooling 27.83%
    Savory 26.63%
    Milky 19.24%
    Animal 19.17%
    Meaty 18.45%
    Bitter 17.82%
    Grape 17.81%
    Fruity 17.75%
    Cooked 17.75%

     

    Flavor
    Bitter 65.95%
    Odorless 49.07%
    Bland 29.65%
    Mild 24.61%
    Sweet-like 20.62%
    Nitrile 18.92%
    Scallion 18.09%
    Yeast 18.01%
    Cedarleaf 17.74%
    Very strong 17.64%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    6.4

    pKa est.
    5.31 (weak acid)

    Molecular weight
    511.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    400°C

    Flash point

    • 151.24 ˚C est.

  • Synonyms

    • Lufenuron
    • 103055-07-8
    • Fluphenacur
    • Lufenurone
    • Lufenuronum
    • Program flavor tabs
    • PROGRAM
    • CGA-184699
    • DTXSID5034357
    • 1-(2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)-3-(2,6-difluorobenzoyl)urea
    • NSC-759097
    • N-((2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)carbamoyl)-2,6-difluorobenzamide
    • N-[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl]-2,6-difluorobenzamide
    • 1R754M4918
    • DTXCID3014357
    • CHEBI:39384
    • N-{[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl}-2,6-difluorobenzamide
    • N-({[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]amino}carbonyl)-2,6-difluorobenzamide
    • N-(((2,5-DICHLORO-4-(1,1,2,3,3,3-HEXAFLUOROPROPOXY)PHENYL)AMINO)CARBONYL)-2,6-DIFLUOROBENZAMIDE
    • Program Suspension
    • RefChem:55522
    • Program Cat Flavor Tabs
    • Program 6 Month Injectable for Cats
    • N-(2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenylaminocarbonyl)-2,6-difluorobenzamide
    • 410-690-9
    • Lufenuron, (-)-
    • Lufenuron, (+)-
    • MFCD00867616
    • 130841-26-8
    • 130841-22-4
    • 9CR45YMS74
    • Benzamide, N-(((2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)amino)carbonyl)-2,6-difluoro-, (+)-
    • Benzamide, N-(((2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)amino)carbonyl)-2,6-difluoro-, (-)-
    • NCGC00095978-02
    • 4629851K7Q
    • N-[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl]-2,6-difluoro-benzamide
    • 3-[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-1-[(2,6-difluorophenyl)carbonyl]urea
    • Benzamide, N-[[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]amino]carbonyl]-2,6-difluoro-
    • Benzamide,N-[[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]amino]carbonyl]-2,6-difluoro-
    • C17H8Cl2F8N2O3
    • Cigna
    • Match (pesticide)
    • Lufenuron;(RS)-1-[2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy) phenyl]-3-(2,6-difluorobenzoyl) urea
    • CAS-103055-07-8
    • Lufenuron [INN:BAN]
    • Lufenurone [INN-French]
    • Lufenuronum [INN-Latin]
    • Lufenuron CRS
    • UNII-1R754M4918
    • Lufenuron anhydrous; 1-[2,5-Dichloro-4-[(2RS)-1,1,2,3,3,3-hexafluoropropoxy]phenyl]-3-(2,6-difluorobenzoyl)urea
    • Lufenuron (Standard)
    • CGA 184699
    • Lufenuron (USP/INN)
    • LUFENURON [INN]
    • LUFENURON [MI]
    • LUFENURON [MART.]
    • EC 410-690-9
    • LUFENURON [USP-RS]
    • Program [veterinary] (TN)
    • UNII-9CR45YMS74
    • SCHEMBL27105
    • BSPBio_002424
    • MLS004712069
    • SPECTRUM1505355
    • LUFENURON [GREEN BOOK]
    • orb1301629
    • orb3025388
    • CHEMBL1364906
    • SCHEMBL29350147
    • LUFENURON [USP MONOGRAPH]
    • HMS3264N09
    • Pharmakon1600-01505355
    • UNII-4629851K7Q
    • SENTINEL COMPONENT LUFENURON
    • MSK20342
    • Tox21_111542
    • Tox21_300907
    • NSC759097
    • Lufenuron for peak identification CRS
    • AKOS022185021
    • Tox21_111542_1
    • CCG-213976
    • DB11424
    • FL31878
    • HY-115584B
    • HY-115584R
    • NSC 759097
    • Lufenuron 100 microg/mL in Acetonitrile
    • NCGC00095978-01
    • NCGC00095978-03
    • NCGC00095978-04
    • NCGC00095978-06
    • NCGC00254811-01
    • AS-13363
    • N-(2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)-phenyl-aminocarbonyl)-2,6-difluorobenzamide
    • SMR001563631
    • SY464620
    • SBI-0207025.P001
    • DB-040412
    • HY-115584
    • CS-0088780
    • L0358
    • NS00001576
    • Lufenuron, PESTANAL(R), analytical standard
    • C18434
    • D08150
    • E78989
    • AB01563233_01
    • LUFENURON (ANHYDROUS) FOR VETERINARY USE
    • 055L078
    • Q412933
    • SR-01000872762
    • SR-01000872762-1
    • BRD-A71774530-001-01-8
    • BRD-A71774530-001-02-6
    • BRD-A71774530-001-05-9
    • Lufenuron, European Pharmacopoeia (EP) Reference Standard
    • LUFENURON (ANHYDROUS) FOR VETERINARY USE [EP IMPURITY]
    • Lufenuron, United States Pharmacopeia (USP) Reference Standard
    • Lufenuron for peak identification, European Pharmacopoeia (EP) Reference Standard
    • (+)-N-(((2,5-DICHLORO-4-(1,1,2,3,3,3-HEXAFLUOROPROPOXY)PHENYL)AMINO)CARBONYL)-2,6-DIFLUOROBENZAMIDE
    • (+)-N-((2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)carbamoyl)-2,6-difluorobenzamide
    • (-)-N-(((2,5-DICHLORO-4-(1,1,2,3,3,3-HEXAFLUOROPROPOXY)PHENYL)AMINO)CARBONYL)-2,6-DIFLUOROBENZAMIDE
    • (-)-N-((2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)carbamoyl)-2,6-difluorobenzamide
    • (rs)-1-(2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)-3-(2,6-difluorobenzoyl)urea
    • 1-(2,5-DICHLORO-4-(1,1,2,3,3,3-HEXAFLUOROPROPOXY)PHENYL)-3-(2,6-DIFLUOROBENZOYL)-UREA
    • 1-[2,5-Dichloro-4-[(2RS)-1,1,2,3,3,3-hexafluoropropoxy]- phenyl]-3-(2,6-difluorobenzoyl)urea
    • 103055-07-8

  • Applications

    Lufenuron is an insect growth regulator (IGR) that inhibits chitin synthesis in developing insects. It is widely used in veterinary medicine as a flea-control agent for companion animals such as dogs and cats, typically formulated as oral tablets or topical formulations to prevent flea development. In agriculture, it is used as a chitin-synthesis inhibitor to manage certain lepidopteran and coleopteran crop pests, typically applied as part of crop protection programs in field or greenhouse settings. In stored-product protection, it is employed to suppress larval development of pest insects in grains and other stored commodities as part of integrated pest management. It may also appear as a component in IPM formulations, often used in combination with other insecticides to broaden spectrum and delay resistance.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 643.63
    methanol 1504.25
    isopropanol 206.3
    water 0.23
    ethyl acetate 252.5
    n-propanol 377.32
    acetone 878.8
    n-butanol 226.89
    acetonitrile 234.49
    DMF 2726.03
    toluene 24.7
    isobutanol 145.38
    1,4-dioxane 300.58
    methyl acetate 296.0
    THF 1735.34
    2-butanone 613.78
    n-pentanol 97.68
    sec-butanol 163.02
    n-hexane 1.12
    ethylene glycol 154.65
    NMP 1653.29
    cyclohexane 1.62
    DMSO 3145.09
    n-butyl acetate 92.63
    n-octanol 15.65
    chloroform 76.79
    n-propyl acetate 133.29
    acetic acid 374.97
    dichloromethane 161.33
    cyclohexanone 387.9
    propylene glycol 211.35
    isopropyl acetate 105.8
    DMAc 1545.87
    2-ethoxyethanol 507.68
    isopentanol 93.99
    n-heptane 1.62
    ethyl formate 334.44
    1,2-dichloroethane 135.73
    n-hexanol 45.73
    2-methoxyethanol 1524.67
    isobutyl acetate 34.44
    tetrachloromethane 3.21
    n-pentyl acetate 50.46
    transcutol 347.59
    n-heptanol 20.02
    ethylbenzene 8.44
    MIBK 113.61
    2-propoxyethanol 422.89
    tert-butanol 87.31
    MTBE 69.54
    2-butoxyethanol 138.95
    propionic acid 185.43
    o-xylene 12.55
    formic acid 409.82
    diethyl ether 184.91
    m-xylene 9.93
    p-xylene 6.98
    chlorobenzene 13.87
    dimethyl carbonate 215.92
    n-octane 0.53
    formamide 853.08
    cyclopentanone 931.16
    2-pentanone 414.05
    anisole 70.26
    cyclopentyl methyl ether 212.7
    gamma-butyrolactone 929.21
    1-methoxy-2-propanol 846.45
    pyridine 298.58
    3-pentanone 234.98
    furfural 581.98
    n-dodecane 0.48
    diethylene glycol 296.31
    diisopropyl ether 11.81
    tert-amyl alcohol 88.27
    acetylacetone 364.76
    n-hexadecane 0.53
    acetophenone 93.34
    methyl propionate 361.91
    isopentyl acetate 48.21
    trichloroethylene 181.5
    n-nonanol 16.14
    cyclohexanol 61.62
    benzyl alcohol 75.51
    2-ethylhexanol 19.01
    isooctanol 12.3
    dipropyl ether 70.94
    1,2-dichlorobenzene 10.52
    ethyl lactate 116.98
    propylene carbonate 236.75
    n-methylformamide 1499.62
    2-pentanol 76.34
    n-pentane 3.04
    1-propoxy-2-propanol 203.11
    1-methoxy-2-propyl acetate 187.13
    2-(2-methoxypropoxy) propanol 113.59
    mesitylene 3.63
    ε-caprolactone 317.84
    p-cymene 6.04
    epichlorohydrin 920.7
    1,1,1-trichloroethane 25.82
    2-aminoethanol 322.26
    morpholine-4-carbaldehyde 1032.75
    sulfolane 1289.72
    2,2,4-trimethylpentane 0.66
    2-methyltetrahydrofuran 390.82
    n-hexyl acetate 48.33
    isooctane 0.27
    2-(2-butoxyethoxy)ethanol 159.38
    sec-butyl acetate 51.03
    tert-butyl acetate 77.06
    decalin 0.5
    glycerin 270.02
    diglyme 341.89
    acrylic acid 187.63
    isopropyl myristate 17.05
    n-butyric acid 233.97
    acetyl acetate 81.03
    di(2-ethylhexyl) phthalate 20.31
    ethyl propionate 141.08
    nitromethane 1278.17
    1,2-diethoxyethane 125.23
    benzonitrile 48.88
    trioctyl phosphate 14.35
    1-bromopropane 69.45
    gamma-valerolactone 1257.96
    n-decanol 12.34
    triethyl phosphate 27.98
    4-methyl-2-pentanol 20.99
    propionitrile 170.2
    vinylene carbonate 187.9
    1,1,2-trichlorotrifluoroethane 378.84
    DMS 63.41
    cumene 3.89
    2-octanol 10.71
    2-hexanone 156.32
    octyl acetate 29.76
    limonene 11.68
    1,2-dimethoxyethane 742.42
    ethyl orthosilicate 22.04
    tributyl phosphate 19.46
    diacetone alcohol 185.9
    N,N-dimethylaniline 43.0
    acrylonitrile 260.75
    aniline 65.22
    1,3-propanediol 392.7
    bromobenzene 9.39
    dibromomethane 77.86
    1,1,2,2-tetrachloroethane 117.26
    2-methyl-cyclohexyl acetate 43.29
    tetrabutyl urea 53.3
    diisobutyl methanol 7.49
    2-phenylethanol 54.48
    styrene 10.93
    dioctyl adipate 39.97
    dimethyl sulfate 338.42
    ethyl butyrate 96.07
    methyl lactate 352.48
    butyl lactate 72.27
    diethyl carbonate 45.95
    propanediol butyl ether 95.75
    triethyl orthoformate 49.27
    p-tert-butyltoluene 5.23
    methyl 4-tert-butylbenzoate 62.09
    morpholine 695.78
    tert-butylamine 24.87
    n-dodecanol 8.34
    dimethoxymethane 1372.16
    ethylene carbonate 144.59
    cyrene 205.03
    2-ethoxyethyl acetate 111.94
    2-ethylhexyl acetate 34.19
    1,2,4-trichlorobenzene 17.07
    4-methylpyridine 211.54
    dibutyl ether 27.6
    2,6-dimethyl-4-heptanol 7.49
    DEF 574.76
    dimethyl isosorbide 232.65
    tetrachloroethylene 55.52
    eugenol 69.01
    triacetin 70.76
    span 80 73.41
    1,4-butanediol 90.92
    1,1-dichloroethane 65.31
    2-methyl-1-pentanol 46.63
    methyl formate 953.38
    2-methyl-1-butanol 115.44
    n-decane 0.82
    butyronitrile 163.43
    3,7-dimethyl-1-octanol 11.31
    1-chlorooctane 5.06
    1-chlorotetradecane 1.87
    n-nonane 0.7
    undecane 0.63
    tert-butylcyclohexane 0.33
    cyclooctane 0.5
    cyclopentanol 146.48
    tetrahydropyran 241.8
    tert-amyl methyl ether 72.75
    2,5,8-trioxanonane 223.75
    1-hexene 10.22
    2-isopropoxyethanol 166.31
    2,2,2-trifluoroethanol 82.54
    methyl butyrate 218.85

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction