Liriodendrin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    573-44-4

    Molecular formula
    C34H46O18

    SMILES
    COC1=CC(=CC(=C1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)OC)[C@@H]3[C@H]4CO[C@@H]([C@H]4CO3)C5=CC(=C(C(=C5)OC)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)OC

    Safety labels

  • Odor profile

    Fragrance
    Odorless 65.26%
    Vanilla 41.8%
    Sweet 29.19%
    Milky 24.21%
    Creamy 21.61%
    Balsamic 18.52%
    Alcoholic 18.25%
    Spicy 17.89%
    Phenolic 17.56%
    Smoky 17.54%

     

    Flavor
    Bitter 66.29%
    Bland 33.1%
    Odorless 29.06%
    Sweet-like 28.83%
    Fatty 24.69%
    Cedarleaf 20.76%
    Parsley 20.25%
    Cauliflower 19.89%
    Eugenol 19.82%
    Naphthalic 19.44%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.4

    pKa est.
    7.61 (neutral)

    Molecular weight
    742.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    5839°C

    Flash point

    • 260.84 ˚C est.

  • Synonyms

    • Liriodendrin
    • 573-44-4
    • (2S,3R,4S,5S,6R)-2-[4-[(3S,3aR,6S,6aR)-6-[3,5-dimethoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2,6-dimethoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
    • DTXSID80331965
    • (2S,3R,4S,5S,6R)-2-(4-((3S,3aR,6S,6aR)-6-(3,5-dimethoxy-4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro(3,4-c)furan-3-yl)-2,6-dimethoxyphenoxy)-6-(hydroxymethyl)oxane-3,4,5-triol
    • (2S,3R,4S,5S,6R)-2-(4-(6-(3,5-DIMETHOXY-4-((2S,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL)OXYPHENYL)-1,3,3A,4,6,6A-HEXAHYDROFURO(3,4-C)FURAN-3-YL)-2,6-DIMETHOXYPHENOXY)-6-(HYDROXYMETHYL)OXANE-3,4,5-TRIOL
    • RefChem:153650
    • DTXCID60283059
    • J2SJ3W6H9R
    • Syringaresinol diglucoside
    • syringaresinol di-O-glucose
    • CHEMBL445823
    • MEGxp0_000893
    • SCHEMBL5081926
    • GLXC-18087
    • syringaresinol di-O-glucopyranoside
    • HY-N3377
    • BDBM50480326
    • AKOS040760524
    • DA-65006
    • FS-10033
    • CS-0024047
    • syringaresinol-4,4'-O-bis-beta-D-glucoside
    • syringaresinol 4',4''-di-O-beta-D-glucopyranoside
    • (+)-syringaresinol-4,4'-di-O-beta-D-glucopyranoside
    • (+)-SYRINGARESINOL-DI-.BETA.-D-GLUCOPYRANOSIDE
    • (+)-SYRINGARESINOL 4,4'-DI-O-.BETA.-D-GLUCOPYRANOSIDE
    • ((1S,3AR,4S,6AR)-TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1,4-DIYL)BIS(2,6-DIMETHOXY-4,1-PHENYLENE) BIS-.BETA.-D-GLUCOPYRANOSIDE
    • .BETA.-D-GLUCOPYRANOSIDE, ((1S,3AR,4S,6AR)-TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1,4-DIYL)BIS(2,6-DIMETHOXY-4,1-PHENYLENE) BIS-
    • .BETA.-D-GLUCOPYRANOSIDE, (TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1,4-DIYL)BIS(2,6-DIMETHOXY-4,1-PHENYLENE) BIS-, (1S-(1.ALPHA.,3A.ALPHA.,4.ALPHA.,6A.ALPHA.))-
    • [(1s,3ar,4s,6ar)-tetrahydro-1h,3h-furo[3,4-c]furan-1,4-diyl]bis(2,6-dimethoxy-4,1-phenylene) bis-beta-d-glucopyranoside
    • 573-44-4

  • Applications

    Liriodendrin, CAS 573-44-4, is a lignan glycoside derived from natural sources (the tulip tree), commonly used in natural product chemistry research and phytochemical analytics. Applications include serving as an analytical reference standard for identifying and quantifying lignans in plant extracts (HPLC/LC-MS), acting as a synthetic intermediate for the development of lignan derivatives, and being evaluated for cosmetic applications as a botanical antioxidant ingredient, depending on local regulations. It is also used in plant science research to assess extract quality and as a chemical marker for Liriodendron samples, subject to regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.64
    methanol 3.03
    isopropanol 0.49
    water 0.3
    ethyl acetate 2.03
    n-propanol 0.73
    acetone 2.69
    n-butanol 0.53
    acetonitrile 1.22
    DMF 16.04
    toluene 0.52
    isobutanol 0.37
    1,4-dioxane 4.38
    methyl acetate 2.58
    THF 8.76
    2-butanone 2.22
    n-pentanol 0.4
    sec-butanol 0.44
    n-hexane 0.02
    ethylene glycol 1.99
    NMP 26.99
    cyclohexane 0.06
    DMSO 15.82
    n-butyl acetate 0.65
    n-octanol 0.75
    chloroform 4.42
    n-propyl acetate 0.83
    acetic acid 12.51
    dichloromethane 3.72
    cyclohexanone 3.82
    propylene glycol 1.54
    isopropyl acetate 1.17
    DMAc 21.18
    2-ethoxyethanol 3.57
    isopentanol 0.33
    n-heptane 0.06
    ethyl formate 2.15
    1,2-dichloroethane 1.75
    n-hexanol 0.3
    2-methoxyethanol 7.06
    isobutyl acetate 0.36
    tetrachloromethane 0.62
    n-pentyl acetate 1.57
    transcutol 8.24
    n-heptanol 0.69
    ethylbenzene 0.18
    MIBK 0.74
    2-propoxyethanol 3.22
    tert-butanol 0.49
    MTBE 0.47
    2-butoxyethanol 3.59
    propionic acid 3.03
    o-xylene 0.38
    formic acid 13.71
    diethyl ether 0.71
    m-xylene 0.3
    p-xylene 0.23
    chlorobenzene 0.71
    dimethyl carbonate 5.53
    n-octane 0.04
    formamide 12.07
    cyclopentanone 8.15
    2-pentanone 1.58
    anisole 0.74
    cyclopentyl methyl ether 2.09
    gamma-butyrolactone 13.38
    1-methoxy-2-propanol 4.36
    pyridine 3.33
    3-pentanone 1.57
    furfural 12.1
    n-dodecane 0.04
    diethylene glycol 4.23
    diisopropyl ether 0.16
    tert-amyl alcohol 0.46
    acetylacetone 4.74
    n-hexadecane 0.04
    acetophenone 1.39
    methyl propionate 3.22
    isopentyl acetate 0.53
    trichloroethylene 5.85
    n-nonanol 0.81
    cyclohexanol 0.65
    benzyl alcohol 1.1
    2-ethylhexanol 0.24
    isooctanol 0.47
    dipropyl ether 0.57
    1,2-dichlorobenzene 0.85
    ethyl lactate 1.62
    propylene carbonate 5.08
    n-methylformamide 7.73
    2-pentanol 0.31
    n-pentane 0.03
    1-propoxy-2-propanol 2.11
    1-methoxy-2-propyl acetate 2.28
    2-(2-methoxypropoxy) propanol 2.85
    mesitylene 0.17
    ε-caprolactone 4.54
    p-cymene 0.18
    epichlorohydrin 8.61
    1,1,1-trichloroethane 1.26
    2-aminoethanol 1.92
    morpholine-4-carbaldehyde 18.91
    sulfolane 23.77
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 2.36
    n-hexyl acetate 1.51
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 4.03
    sec-butyl acetate 0.49
    tert-butyl acetate 1.02
    decalin 0.03
    glycerin 5.51
    diglyme 7.83
    acrylic acid 6.23
    isopropyl myristate 0.46
    n-butyric acid 2.79
    acetyl acetate 3.02
    di(2-ethylhexyl) phthalate 0.71
    ethyl propionate 0.99
    nitromethane 21.49
    1,2-diethoxyethane 1.59
    benzonitrile 0.96
    trioctyl phosphate 0.62
    1-bromopropane 0.48
    gamma-valerolactone 17.65
    n-decanol 0.5
    triethyl phosphate 0.72
    4-methyl-2-pentanol 0.19
    propionitrile 0.83
    vinylene carbonate 5.74
    1,1,2-trichlorotrifluoroethane 18.68
    DMS 2.26
    cumene 0.11
    2-octanol 0.45
    2-hexanone 0.79
    octyl acetate 0.87
    limonene 0.25
    1,2-dimethoxyethane 3.96
    ethyl orthosilicate 0.64
    tributyl phosphate 0.58
    diacetone alcohol 2.29
    N,N-dimethylaniline 0.63
    acrylonitrile 1.98
    aniline 1.07
    1,3-propanediol 2.16
    bromobenzene 0.62
    dibromomethane 1.56
    1,1,2,2-tetrachloroethane 4.39
    2-methyl-cyclohexyl acetate 0.62
    tetrabutyl urea 1.01
    diisobutyl methanol 0.16
    2-phenylethanol 0.84
    styrene 0.21
    dioctyl adipate 0.95
    dimethyl sulfate 12.89
    ethyl butyrate 0.76
    methyl lactate 5.69
    butyl lactate 2.17
    diethyl carbonate 0.64
    propanediol butyl ether 3.72
    triethyl orthoformate 0.9
    p-tert-butyltoluene 0.18
    methyl 4-tert-butylbenzoate 2.4
    morpholine 4.99
    tert-butylamine 0.18
    n-dodecanol 0.31
    dimethoxymethane 7.84
    ethylene carbonate 3.84
    cyrene 5.15
    2-ethoxyethyl acetate 3.41
    2-ethylhexyl acetate 0.43
    1,2,4-trichlorobenzene 1.29
    4-methylpyridine 2.11
    dibutyl ether 0.5
    2,6-dimethyl-4-heptanol 0.16
    DEF 3.67
    dimethyl isosorbide 5.01
    tetrachloroethylene 3.08
    eugenol 2.3
    triacetin 3.37
    span 80 2.9
    1,4-butanediol 0.95
    1,1-dichloroethane 1.15
    2-methyl-1-pentanol 0.27
    methyl formate 8.05
    2-methyl-1-butanol 0.36
    n-decane 0.07
    butyronitrile 0.59
    3,7-dimethyl-1-octanol 0.38
    1-chlorooctane 0.29
    1-chlorotetradecane 0.1
    n-nonane 0.06
    undecane 0.05
    tert-butylcyclohexane 0.02
    cyclooctane 0.04
    cyclopentanol 1.23
    tetrahydropyran 1.68
    tert-amyl methyl ether 0.55
    2,5,8-trioxanonane 5.29
    1-hexene 0.07
    2-isopropoxyethanol 1.79
    2,2,2-trifluoroethanol 10.09
    methyl butyrate 1.3

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction