Levamisole Hydrochloride

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  • Identifiers

    CAS number
    16595-80-5

    Molecular formula
    C11H13ClN2S

    SMILES
    C1CSC2=N[C@H](CN21)C3=CC=CC=C3.Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Nutty 59.03%
    Roasted 48.51%
    Earthy 41.45%
    Popcorn 39.23%
    Meaty 37.37%
    Fishy 37.04%
    Musty 31.17%
    Cooked 30.6%
    Animal 28.52%
    Green 27.52%

     

    Flavor
    Bitter 68.6%
    Roasted 27.53%
    Animal 26.08%
    Cereal 22.17%
    Alkaline 21.7%
    Very strong 20.82%
    Shrimp 20.81%
    Indole 20.5%
    Moth ball 20.26%
    Scallion 20.04%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.46 (neutral)

    Molecular weight
    240.75 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    360°C

    Flash point

    • 175.63 ˚C est.

    Solubility expt.

    • Water 210 (mg/mL)
    • Methanol sol. (mg/mL)
    • Propylene glycol sol. (mg/mL)
    • Ethanol sl. sol. (mg/mL)
    • >36.1 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • Levamisole hydrochloride
    • 16595-80-5
    • Levamisole HCl
    • Ergamisol
    • Ascaridil
    • Tramisol
    • Decaris
    • Levasole
    • Solaskil
    • NSC-177023
    • Spartakon l
    • L-narpenol
    • R 12,564
    • L-Tetramisole hydrochloride
    • R 12564
    • DTXSID7047518
    • Tetramisole hydrochloride, (s)-
    • Levamisoli hydrochloridum
    • DL9055K809
    • Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (S)-
    • DTXCID5027518
    • R 12654
    • R-12564
    • NSC177023
    • Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (6S)-
    • Ergamisole
    • Immunol
    • Trimisol
    • LevaMed
    • Tramisol Gel
    • Ripercol L
    • PROHIBIT
    • Cloridrato de Levamizol
    • RefChem:5942
    • Hydrochloride, Levamisole
    • LevaMed Soluble Pig Wormer
    • Levasole Soluble Pig Wormer
    • Levasole Cattle Wormer Bolus
    • LevaMed Soluble Drench Powder
    • Prohibit Soluble Drench Powder
    • Ripercol L Soluble Drench Powder
    • ICI-59623
    • RP-20605
    • Ripercol L Bolus, Tramisol Cattle Wormer Bolus
    • Ripercol L, Tramisol Soluble Drench Powder for Sheep
    • Ripercol L Wormer Oblets, Tramisol Sheep Wormer Oblets
    • Levasole Sheep Wormer Bolus, Tramisole Sheep Wormer Oblets Tablets
    • (S)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole Monohydrochloride
    • 240-654-6
    • Levamisole Soluble Drench Powder, Levasole, Levasole Soluble Drench Powder, Tramisol Soluble Drench Powder
    • (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride
    • Tramisole
    • Levamisol hydrochloride
    • Niratic hydrochloride
    • Stimamizol hydrochloride
    • Niratic-puron hydrochloride
    • R-12,564
    • (-)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole monohydrochloride
    • MFCD00012675
    • Dekaris
    • Levacide
    • Levadin
    • Nemicide
    • Meglum
    • Nilverm forte
    • Worm-chek
    • (6S)-6-phenyl-2H,3H,5H,6H-imidazo[2,1-b][1,3]thiazole hydrochloride
    • Ripercol-L
    • Citarin L
    • 16595-80-5 (HCL)
    • Levomysol hydrochloride
    • Levamisole (hydrochloride)
    • (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;hydrochloride
    • KW 2LE-T
    • SMR001230807
    • KW-2-LE-T
    • Levamisole hydrochloride [USAN]
    • Levamisole Hydrochloride (1.0 mg/mL in Methanol)
    • SR-01000075969
    • EINECS 240-654-6
    • 74191-78-9
    • (-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole Hydrochloride
    • UNII-DL9055K809
    • LEV hydrochloride
    • Ergamisol (TN)
    • NCGC00094446-03
    • Prestwick_294
    • Levamisole hydrochloride [USAN:USP]
    • (7S)-7-phenyl-4-thia-1,6-diazabicyclo[3.3.0]oct-5-ene hydrochloride
    • Levamisole HCl(Ergamisol)
    • Levamisole hydrochloride RS
    • L-(-)-2,3,5,6-Tetrahydro-6-phenyl-imidazo(2,1-b)thiazole hydrochloride
    • Ergamisol (TN) (Janssen)
    • CAS-16595-80-5
    • Levamisole hydrochloride CRS
    • CHEMBL1770
    • SCHEMBL19226
    • BMK1-H6
    • Imidazo[2, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride
    • MLS002153440
    • MLS002222198
    • MLS002695941
    • orb134393
    • SPECTRUM1503245
    • CHEBI:6433
    • Levamisole hydrochloride (USP)
    • MSK5587A
    • GLXC-07877
    • HMS1568F05
    • HMS1922M11
    • MSK5587A-100M
    • Levamisole Hydrochloride (Ergamisol)
    • MSK5587A-1000M
    • Tox21_111282
    • Tox21_500690
    • CCG-40301
    • EBC-06511
    • HY-13666R
    • LEVAMISOLE HYDROCHLORIDE [MI]
    • s1939
    • Levamisole HCl - Bio-X trade mark
    • LEVAMISOLE HYDROCHLORIDE [JAN]
    • AKOS015951350
    • Levamisole (hydrochloride) (Standard)
    • Tox21_111282_1
    • FL29670
    • KW-2299
    • 16595-80-5

  • Applications

    Levamisole Hydrochloride (CAS 16595-80-5) is primarily used as an anthelmintic agent in veterinary medicine to treat and control parasitic infections in livestock and companion animals. It also serves as an active pharmaceutical ingredient (API) in medicinal products for humans and animals, and is studied for immunomodulatory properties with applications in immunology research. Additionally, it is explored as a potential intermediate in pharmaceutical synthesis. These applications reflect the compound's pharmaceutical relevance and research utility, subject to regulatory and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 41.81
    methanol 83.26
    isopropanol 19.65
    water 1.78
    ethyl acetate 96.12
    n-propanol 40.35
    acetone 138.87
    n-butanol 35.32
    acetonitrile 75.15
    DMF 527.37
    toluene 70.53
    isobutanol 28.65
    1,4-dioxane 294.75
    methyl acetate 103.39
    THF 282.59
    2-butanone 112.52
    n-pentanol 35.16
    sec-butanol 20.37
    n-hexane 0.87
    ethylene glycol 71.67
    NMP 247.6
    cyclohexane 4.76
    DMSO 374.02
    n-butyl acetate 67.32
    n-octanol 25.62
    chloroform 629.93
    n-propyl acetate 71.08
    acetic acid 165.01
    dichloromethane 587.36
    cyclohexanone 204.27
    propylene glycol 45.22
    isopropyl acetate 55.25
    DMAc 325.86
    2-ethoxyethanol 130.43
    isopentanol 34.42
    n-heptane 2.24
    ethyl formate 136.05
    1,2-dichloroethane 276.01
    n-hexanol 35.3
    2-methoxyethanol 198.78
    isobutyl acetate 56.12
    tetrachloromethane 40.26
    n-pentyl acetate 51.71
    transcutol 452.4
    n-heptanol 28.33
    ethylbenzene 26.44
    MIBK 54.88
    2-propoxyethanol 119.93
    tert-butanol 23.24
    MTBE 22.42
    2-butoxyethanol 87.81
    propionic acid 84.21
    o-xylene 36.03
    formic acid 140.4
    diethyl ether 33.13
    m-xylene 39.84
    p-xylene 37.86
    chlorobenzene 181.93
    dimethyl carbonate 97.53
    n-octane 1.43
    formamide 205.58
    cyclopentanone 279.0
    2-pentanone 81.12
    anisole 108.12
    cyclopentyl methyl ether 77.17
    gamma-butyrolactone 330.23
    1-methoxy-2-propanol 113.89
    pyridine 348.29
    3-pentanone 72.12
    furfural 536.83
    n-dodecane 2.03
    diethylene glycol 157.55
    diisopropyl ether 10.08
    tert-amyl alcohol 20.84
    acetylacetone 151.55
    n-hexadecane 2.39
    acetophenone 123.65
    methyl propionate 97.0
    isopentyl acetate 66.46
    trichloroethylene 729.91
    n-nonanol 26.26
    cyclohexanol 45.29
    benzyl alcohol 110.89
    2-ethylhexanol 29.37
    isooctanol 25.85
    dipropyl ether 27.94
    1,2-dichlorobenzene 164.84
    ethyl lactate 65.91
    propylene carbonate 194.26
    n-methylformamide 236.93
    2-pentanol 17.41
    n-pentane 1.22
    1-propoxy-2-propanol 75.85
    1-methoxy-2-propyl acetate 102.92
    2-(2-methoxypropoxy) propanol 90.68
    mesitylene 22.04
    ε-caprolactone 171.04
    p-cymene 22.02
    epichlorohydrin 405.45
    1,1,1-trichloroethane 142.94
    2-aminoethanol 66.53
    morpholine-4-carbaldehyde 379.27
    sulfolane 325.86
    2,2,4-trimethylpentane 1.54
    2-methyltetrahydrofuran 108.51
    n-hexyl acetate 59.05
    isooctane 1.2
    2-(2-butoxyethoxy)ethanol 132.66
    sec-butyl acetate 45.07
    tert-butyl acetate 52.3
    decalin 3.49
    glycerin 121.13
    diglyme 295.54
    acrylic acid 130.37
    isopropyl myristate 28.65
    n-butyric acid 111.39
    acetyl acetate 92.32
    di(2-ethylhexyl) phthalate 45.47
    ethyl propionate 60.56
    nitromethane 390.06
    1,2-diethoxyethane 97.88
    benzonitrile 157.88
    trioctyl phosphate 28.0
    1-bromopropane 57.65
    gamma-valerolactone 440.54
    n-decanol 20.55
    triethyl phosphate 44.23
    4-methyl-2-pentanol 17.65
    propionitrile 69.02
    vinylene carbonate 275.08
    1,1,2-trichlorotrifluoroethane 365.23
    DMS 85.94
    cumene 19.58
    2-octanol 16.8
    2-hexanone 61.89
    octyl acetate 37.9
    limonene 25.02
    1,2-dimethoxyethane 214.09
    ethyl orthosilicate 38.57
    tributyl phosphate 36.71
    diacetone alcohol 71.21
    N,N-dimethylaniline 62.6
    acrylonitrile 145.05
    aniline 120.74
    1,3-propanediol 80.11
    bromobenzene 181.91
    dibromomethane 246.98
    1,1,2,2-tetrachloroethane 435.09
    2-methyl-cyclohexyl acetate 58.45
    tetrabutyl urea 46.98
    diisobutyl methanol 16.86
    2-phenylethanol 81.91
    styrene 44.53
    dioctyl adipate 54.35
    dimethyl sulfate 163.12
    ethyl butyrate 61.4
    methyl lactate 91.59
    butyl lactate 58.5
    diethyl carbonate 55.77
    propanediol butyl ether 80.04
    triethyl orthoformate 53.07
    p-tert-butyltoluene 18.8
    methyl 4-tert-butylbenzoate 81.63
    morpholine 229.44
    tert-butylamine 12.73
    n-dodecanol 16.43
    dimethoxymethane 212.11
    ethylene carbonate 190.69
    cyrene 125.13
    2-ethoxyethyl acetate 102.15
    2-ethylhexyl acetate 54.95
    1,2,4-trichlorobenzene 199.66
    4-methylpyridine 217.35
    dibutyl ether 27.72
    2,6-dimethyl-4-heptanol 16.86
    DEF 121.98
    dimethyl isosorbide 158.36
    tetrachloroethylene 275.65
    eugenol 104.93
    triacetin 99.2
    span 80 72.42
    1,4-butanediol 47.48
    1,1-dichloroethane 147.4
    2-methyl-1-pentanol 35.17
    methyl formate 242.33
    2-methyl-1-butanol 29.91
    n-decane 2.83
    butyronitrile 65.42
    3,7-dimethyl-1-octanol 26.36
    1-chlorooctane 16.29
    1-chlorotetradecane 8.4
    n-nonane 2.12
    undecane 2.33
    tert-butylcyclohexane 2.59
    cyclooctane 1.99
    cyclopentanol 50.84
    tetrahydropyran 129.83
    tert-amyl methyl ether 21.44
    2,5,8-trioxanonane 191.58
    1-hexene 5.84
    2-isopropoxyethanol 77.19
    2,2,2-trifluoroethanol 104.1
    methyl butyrate 89.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction