Lauramidobutyl guanidine hydrochloride

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  • Identifiers

    CAS number
    499222-90-1

    Molecular formula
    C17H37ClN4O

    SMILES
    CCCCCCCCCCCC(=O)NCCCCN=C(N)N.Cl

    Safety labels

  • Odor profile

    Fragrance
    Fishy 46.99%
    Meaty 41.08%
    Savory 36.84%
    Cooling 32.77%
    Odorless 32.14%
    Cheesy 31.87%
    Animal 28.08%
    Ripe 23.81%
    Fresh 21.93%
    Mint 20.5%

     

    Flavor
    Odorless 31.85%
    Bland 29.67%
    Mild 28.15%
    Herbal 24.74%
    Faint 22.92%
    Slightly waxy 20.77%
    Bay oil 19.91%
    Delicate 19.89%
    Skunky 19.5%
    Glue 19.45%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    8.18 (weak base)

    Molecular weight
    349.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    466°C

    Flash point

    • 193.85 ˚C est.

  • Synonyms

    • LAG hydrochloride
    • Lauramidobutyl guanidine hydrochloride
    • Lauramidobutyl guanidine HCl
    • Lauramidobutyl guanidineHcl
    • UNII-35NC02CW5M
    • 35NC02CW5M
    • 499222-90-1
    • Dodecanamide, N-(4-((aminoiminomethyl)amino)butyl)-, monohydrochloride
    • Dodecanamide, N-(4-((aminoiminomethyl)amino)butyl)-, hydrochloride (1:1)
    • DTXSID20198155
    • RefChem:152480
    • DTXCID50120646
    • LAURAMIDOBUTYL GUANIDINE HCL [INCI]
    • SCHEMBL6138673
    • OIRJSOTXADYFGE-UHFFFAOYSA-N
    • Q27256477
    • N-{4-[(Diaminomethylidene)amino]butyl}dodecanamide--hydrogen chloride (1/1)
    • 499222-90-1

  • Applications

    Lauramidobutyl guanidine hydrochloride (CAS 499222-90-1) is a cationic surfactant derived from a lauryl chain with a guanidine moiety, and in formulations it is commonly used as a surfactant and conditioning agent in cosmetics and personal care products. It can function as a dispersant and wetting agent in coatings and inks, improving pigment dispersion and substrate wetting. In industrial manufacturing, it may be employed as a specialty surfactant or processing aid in polymer blends and emulsions. In household cleaning products, it may contribute antimicrobial functionality and cleaning performance as part of cationic formulations. It is also used as an intermediate in the synthesis of other surfactants and specialty additives.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 13.98
    methanol 40.47
    isopropanol 5.69
    water 0.49
    ethyl acetate 4.66
    n-propanol 9.6
    acetone 9.14
    n-butanol 8.39
    acetonitrile 2.56
    DMF 40.93
    toluene 3.28
    isobutanol 6.55
    1,4-dioxane 6.8
    methyl acetate 4.27
    THF 32.89
    2-butanone 8.16
    n-pentanol 9.39
    sec-butanol 5.54
    n-hexane 0.47
    ethylene glycol 4.94
    NMP 74.99
    cyclohexane 0.64
    DMSO 113.68
    n-butyl acetate 7.51
    n-octanol 3.87
    chloroform 31.58
    n-propyl acetate 9.0
    acetic acid 42.46
    dichloromethane 27.03
    cyclohexanone 30.26
    propylene glycol 10.45
    isopropyl acetate 4.98
    DMAc 70.75
    2-ethoxyethanol 28.4
    isopentanol 7.92
    n-heptane 0.3
    ethyl formate 9.43
    1,2-dichloroethane 13.71
    n-hexanol 5.66
    2-methoxyethanol 36.66
    isobutyl acetate 7.11
    tetrachloromethane 5.44
    n-pentyl acetate 8.26
    transcutol 70.2
    n-heptanol 5.34
    ethylbenzene 2.46
    MIBK 6.77
    2-propoxyethanol 22.41
    tert-butanol 5.63
    MTBE 2.69
    2-butoxyethanol 22.18
    propionic acid 16.07
    o-xylene 3.36
    formic acid 35.65
    diethyl ether 1.62
    m-xylene 2.92
    p-xylene 3.96
    chlorobenzene 7.06
    dimethyl carbonate 4.52
    n-octane 0.19
    formamide 35.15
    cyclopentanone 39.95
    2-pentanone 7.02
    anisole 5.56
    cyclopentyl methyl ether 10.43
    gamma-butyrolactone 42.92
    1-methoxy-2-propanol 25.35
    pyridine 16.21
    3-pentanone 5.77
    furfural 53.03
    n-dodecane 0.14
    diethylene glycol 19.24
    diisopropyl ether 0.84
    tert-amyl alcohol 6.74
    acetylacetone 13.9
    n-hexadecane 0.16
    acetophenone 12.6
    methyl propionate 5.93
    isopentyl acetate 8.46
    trichloroethylene 35.82
    n-nonanol 4.09
    cyclohexanol 9.7
    benzyl alcohol 11.68
    2-ethylhexanol 3.87
    isooctanol 4.65
    dipropyl ether 2.79
    1,2-dichlorobenzene 8.86
    ethyl lactate 10.46
    propylene carbonate 25.47
    n-methylformamide 22.76
    2-pentanol 3.64
    n-pentane 0.26
    1-propoxy-2-propanol 15.28
    1-methoxy-2-propyl acetate 13.36
    2-(2-methoxypropoxy) propanol 19.45
    mesitylene 2.02
    ε-caprolactone 27.4
    p-cymene 2.18
    epichlorohydrin 33.85
    1,1,1-trichloroethane 10.54
    2-aminoethanol 14.05
    morpholine-4-carbaldehyde 44.5
    sulfolane 99.67
    2,2,4-trimethylpentane 0.33
    2-methyltetrahydrofuran 12.73
    n-hexyl acetate 8.85
    isooctane 0.17
    2-(2-butoxyethoxy)ethanol 25.91
    sec-butyl acetate 5.72
    tert-butyl acetate 6.91
    decalin 0.57
    glycerin 24.76
    diglyme 48.13
    acrylic acid 18.19
    isopropyl myristate 2.81
    n-butyric acid 24.77
    acetyl acetate 6.64
    di(2-ethylhexyl) phthalate 7.59
    ethyl propionate 5.92
    nitromethane 35.38
    1,2-diethoxyethane 8.0
    benzonitrile 8.74
    trioctyl phosphate 4.73
    1-bromopropane 4.29
    gamma-valerolactone 64.52
    n-decanol 2.66
    triethyl phosphate 6.91
    4-methyl-2-pentanol 3.28
    propionitrile 3.14
    vinylene carbonate 20.65
    1,1,2-trichlorotrifluoroethane 72.04
    DMS 7.34
    cumene 2.38
    2-octanol 2.75
    2-hexanone 9.26
    octyl acetate 4.36
    limonene 2.68
    1,2-dimethoxyethane 29.57
    ethyl orthosilicate 6.87
    tributyl phosphate 6.18
    diacetone alcohol 16.7
    N,N-dimethylaniline 6.18
    acrylonitrile 5.35
    aniline 8.73
    1,3-propanediol 18.76
    bromobenzene 6.14
    dibromomethane 13.58
    1,1,2,2-tetrachloroethane 34.56
    2-methyl-cyclohexyl acetate 10.12
    tetrabutyl urea 8.54
    diisobutyl methanol 2.19
    2-phenylethanol 9.5
    styrene 3.0
    dioctyl adipate 7.2
    dimethyl sulfate 16.85
    ethyl butyrate 7.14
    methyl lactate 13.29
    butyl lactate 14.63
    diethyl carbonate 5.23
    propanediol butyl ether 22.33
    triethyl orthoformate 7.91
    p-tert-butyltoluene 1.99
    methyl 4-tert-butylbenzoate 16.31
    morpholine 15.99
    tert-butylamine 2.42
    n-dodecanol 1.7
    dimethoxymethane 13.94
    ethylene carbonate 15.51
    cyrene 29.86
    2-ethoxyethyl acetate 12.83
    2-ethylhexyl acetate 6.68
    1,2,4-trichlorobenzene 13.13
    4-methylpyridine 13.04
    dibutyl ether 2.72
    2,6-dimethyl-4-heptanol 2.19
    DEF 15.25
    dimethyl isosorbide 34.24
    tetrachloroethylene 26.38
    eugenol 18.4
    triacetin 16.52
    span 80 16.53
    1,4-butanediol 9.29
    1,1-dichloroethane 8.01
    2-methyl-1-pentanol 8.67
    methyl formate 14.46
    2-methyl-1-butanol 7.54
    n-decane 0.27
    butyronitrile 4.44
    3,7-dimethyl-1-octanol 3.61
    1-chlorooctane 1.62
    1-chlorotetradecane 0.55
    n-nonane 0.23
    undecane 0.18
    tert-butylcyclohexane 0.44
    cyclooctane 0.27
    cyclopentanol 13.54
    tetrahydropyran 8.03
    tert-amyl methyl ether 3.45
    2,5,8-trioxanonane 31.6
    1-hexene 1.84
    2-isopropoxyethanol 16.56
    2,2,2-trifluoroethanol 21.31
    methyl butyrate 10.85

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction