Lactoyl Phytosphingosine

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  • Identifiers

    CAS number
    173840-43-2

    Molecular formula
    C21H43NO5

    SMILES
    CCCCCCCCCCCCCC[C@H]([C@H]([C@H](C(C(=O)C(C)O)O)N)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 41.19%
    Oily 32.04%
    Waxy 30.59%
    Sweet 28.92%
    Fatty 26.35%
    Milky 26.15%
    Lactonic 24.5%
    Woody 23.65%
    Fresh 23.59%
    Savory 22.96%

     

    Flavor
    Odorless 43.06%
    Bland 37.68%
    Mild 33.09%
    Sweet-like 23.01%
    Bitter 22.19%
    Waxy 21.9%
    Faint 20.84%
    Slightly waxy 20.72%
    Bay oil 20.26%
    Delicate 20.1%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.2

    pKa est.
    6.3 (neutral)

    Molecular weight
    389.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    711°C

    Flash point

    • 215.17 ˚C est.

  • Synonyms

    • Lactoyl Phytosphingosine
    • DTXSID101021850
    • 173840-43-2
    • 173840-43-2

  • Applications

    Lactoyl Phytosphingosine (CAS 173840-43-2) is primarily used as a skin-conditioning lipid and a ceramide-like intermediate in cosmetic formulations, helping to support the skin barrier and provide moisturization. In cosmetic/personal care products, it functions as an emollient and conditioning ester that enhances texture and stability of creams, lotions, and cleansers. It can be used as a lipid-based excipient or active lipid component in topical pharmaceutical/dermocosmetic formulations to aid skin hydration and formulation integrity. As a lipid-building block and ceramide precursor, it is often evaluated for inclusion during formulation development to help restore or mimic skin lipids.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 6.61
    methanol 28.84
    isopropanol 2.77
    water 6.84
    ethyl acetate 4.85
    n-propanol 6.01
    acetone 7.0
    n-butanol 4.18
    acetonitrile 1.66
    DMF 33.12
    toluene 1.92
    isobutanol 4.32
    1,4-dioxane 12.32
    methyl acetate 4.34
    THF 31.82
    2-butanone 5.59
    n-pentanol 4.21
    sec-butanol 3.68
    n-hexane 0.37
    ethylene glycol 11.18
    NMP 132.05
    cyclohexane 1.51
    DMSO 199.87
    n-butyl acetate 4.53
    n-octanol 4.41
    chloroform 7.26
    n-propyl acetate 4.85
    acetic acid 54.49
    dichloromethane 7.35
    cyclohexanone 30.29
    propylene glycol 13.96
    isopropyl acetate 5.05
    DMAc 63.44
    2-ethoxyethanol 24.69
    isopentanol 4.74
    n-heptane 0.51
    ethyl formate 6.81
    1,2-dichloroethane 7.03
    n-hexanol 4.18
    2-methoxyethanol 39.82
    isobutyl acetate 3.59
    tetrachloromethane 3.62
    n-pentyl acetate 8.44
    transcutol 78.89
    n-heptanol 7.05
    ethylbenzene 1.85
    MIBK 5.27
    2-propoxyethanol 20.25
    tert-butanol 5.31
    MTBE 2.77
    2-butoxyethanol 26.88
    propionic acid 18.59
    o-xylene 3.39
    formic acid 69.48
    diethyl ether 1.51
    m-xylene 2.36
    p-xylene 2.49
    chlorobenzene 3.06
    dimethyl carbonate 9.56
    n-octane 0.43
    formamide 71.46
    cyclopentanone 40.37
    2-pentanone 5.41
    anisole 3.74
    cyclopentyl methyl ether 15.88
    gamma-butyrolactone 55.73
    1-methoxy-2-propanol 23.15
    pyridine 8.95
    3-pentanone 5.88
    furfural 48.16
    n-dodecane 0.23
    diethylene glycol 28.15
    diisopropyl ether 1.25
    tert-amyl alcohol 7.05
    acetylacetone 18.01
    n-hexadecane 0.25
    acetophenone 10.19
    methyl propionate 8.02
    isopentyl acetate 5.95
    trichloroethylene 15.69
    n-nonanol 4.56
    cyclohexanol 12.16
    benzyl alcohol 8.53
    2-ethylhexanol 3.65
    isooctanol 6.27
    dipropyl ether 2.69
    1,2-dichlorobenzene 4.93
    ethyl lactate 11.37
    propylene carbonate 28.34
    n-methylformamide 23.31
    2-pentanol 2.64
    n-pentane 0.28
    1-propoxy-2-propanol 14.1
    1-methoxy-2-propyl acetate 13.79
    2-(2-methoxypropoxy) propanol 19.45
    mesitylene 2.08
    ε-caprolactone 36.01
    p-cymene 2.23
    epichlorohydrin 27.36
    1,1,1-trichloroethane 5.7
    2-aminoethanol 19.01
    morpholine-4-carbaldehyde 70.17
    sulfolane 217.88
    2,2,4-trimethylpentane 0.48
    2-methyltetrahydrofuran 14.93
    n-hexyl acetate 8.68
    isooctane 0.23
    2-(2-butoxyethoxy)ethanol 30.48
    sec-butyl acetate 3.78
    tert-butyl acetate 9.07
    decalin 0.97
    glycerin 43.75
    diglyme 51.92
    acrylic acid 24.92
    isopropyl myristate 2.48
    n-butyric acid 19.94
    acetyl acetate 7.81
    di(2-ethylhexyl) phthalate 6.55
    ethyl propionate 5.03
    nitromethane 40.74
    1,2-diethoxyethane 7.38
    benzonitrile 4.95
    trioctyl phosphate 5.43
    1-bromopropane 1.77
    gamma-valerolactone 77.86
    n-decanol 2.92
    triethyl phosphate 7.37
    4-methyl-2-pentanol 2.65
    propionitrile 1.69
    vinylene carbonate 22.72
    1,1,2-trichlorotrifluoroethane 76.25
    DMS 11.06
    cumene 1.92
    2-octanol 3.85
    2-hexanone 4.23
    octyl acetate 4.21
    limonene 3.51
    1,2-dimethoxyethane 18.79
    ethyl orthosilicate 6.92
    tributyl phosphate 5.74
    diacetone alcohol 23.58
    N,N-dimethylaniline 5.57
    acrylonitrile 3.14
    aniline 5.61
    1,3-propanediol 20.75
    bromobenzene 2.54
    dibromomethane 4.4
    1,1,2,2-tetrachloroethane 18.04
    2-methyl-cyclohexyl acetate 8.84
    tetrabutyl urea 7.78
    diisobutyl methanol 2.6
    2-phenylethanol 7.59
    styrene 1.66
    dioctyl adipate 6.38
    dimethyl sulfate 40.46
    ethyl butyrate 4.98
    methyl lactate 21.15
    butyl lactate 18.72
    diethyl carbonate 4.04
    propanediol butyl ether 27.27
    triethyl orthoformate 6.86
    p-tert-butyltoluene 2.41
    methyl 4-tert-butylbenzoate 20.05
    morpholine 19.47
    tert-butylamine 2.32
    n-dodecanol 1.91
    dimethoxymethane 15.83
    ethylene carbonate 18.91
    cyrene 42.64
    2-ethoxyethyl acetate 14.47
    2-ethylhexyl acetate 4.65
    1,2,4-trichlorobenzene 7.83
    4-methylpyridine 5.98
    dibutyl ether 2.4
    2,6-dimethyl-4-heptanol 2.6
    DEF 14.81
    dimethyl isosorbide 43.66
    tetrachloroethylene 18.67
    eugenol 19.8
    triacetin 20.18
    span 80 20.73
    1,4-butanediol 10.04
    1,1-dichloroethane 3.04
    2-methyl-1-pentanol 5.26
    methyl formate 18.13
    2-methyl-1-butanol 5.23
    n-decane 0.46
    butyronitrile 1.78
    3,7-dimethyl-1-octanol 3.82
    1-chlorooctane 1.82
    1-chlorotetradecane 0.64
    n-nonane 0.43
    undecane 0.31
    tert-butylcyclohexane 0.65
    cyclooctane 0.73
    cyclopentanol 17.03
    tetrahydropyran 8.63
    tert-amyl methyl ether 4.03
    2,5,8-trioxanonane 36.74
    1-hexene 0.8
    2-isopropoxyethanol 14.67
    2,2,2-trifluoroethanol 43.2
    methyl butyrate 7.76

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction