Lactitol

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  • Identifiers

    CAS number
    585-86-4

    Molecular formula
    C12H24O11

    SMILES
    C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@H]([C@@H](CO)O)[C@@H]([C@H](CO)O)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 73.32%
    Sweet 49.59%
    Alcoholic 24.54%
    Caramellic 18.77%
    Cooling 17.29%
    Clean 16.63%
    Bitter 15.83%
    Savory 15.41%
    Milky 15.29%
    Buttery 15.02%

     

    Flavor
    Sweet 69.02%
    Odorless 66.8%
    Sweet-like 35.25%
    Bitter 33.83%
    Very mild 23.19%
    Bland 22.57%
    Very slight 22.37%
    Cauliflower 20.89%
    Soup 19.78%
    Alkaline 19.62%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -5.2

    pKa est.
    4.15 (weak acid)

    Molecular weight
    344.31 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2987°C

    Melting point expt.

    • 146 °C
    • White, sweet, odorless, crystalline powder. Data for food grade: mp: 752 °C; specific optical rotation: -13.5 to +15.0 deg at 25 °C/D. pH of 10% solution 4.5 to 8.5; 140 g will dissolves in 100 mL water at 25 °C /Lactitol dihydrate/
    • 95 - 98 °C

    Flash point

    • 305.31 ˚C est.

    Solubility expt.

    • Very soluble in water
    • Soluble in dimethyl sulfoxide, N,N-dimethylformamide; slightly soluble in ether
    • In ethanol, 0.75 g/100 g solution of the monohydrate at 20 °C
    • In water, 57.2 g/100 g at 20 °C. ... With increasing temperature the solubility rises considerably
    • 667 mg/mL at 25 °C

  • Synonyms

    • lactitol
    • 585-86-4
    • 4-O-beta-D-Galactopyranosyl-D-glucitol
    • Importal
    • D-lactitol
    • lactositol
    • Lactosit
    • Miruhen
    • lactitolum
    • lactobiosit
    • LACTITOL ANHYDROUS
    • Milchen
    • Lactit
    • Finlac dc
    • Lactitol acm 50
    • Lacty (saccharide)
    • L2B0WJF7ZY
    • pizensy
    • INS NO.966
    • DTXSID9044247
    • INS-966
    • NSC-231323
    • E-966
    • CHEBI:75323
    • BLI-400
    • NSC-759131
    • Neda Lactiv Importal
    • NSC231323
    • (2S,3R,4R,5R)-4-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl)oxyhexane-1,2,3,5,6-pentol
    • (2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxyhexane-1,2,3,5,6-pentol
    • RefChem:57073
    • GlyTouCan:G26039ES
    • DTXCID7024247
    • G26039ES
    • 209-566-5
    • (2S,3R,4S,5R,6R)-2-((2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl)oxy-6-(hydroxymethyl)oxane-3,4,5-triol
    • Lacitol
    • MFCD00079407
    • D-Glucitol, 4-O-beta-D-galactopyranosyl-
    • DSSTox_CID_24247
    • DSSTox_RID_80133
    • DSSTox_GSID_44247
    • (2S,3R,4R,5R)-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,5,6-pentaol
    • (2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol
    • Emportal
    • Oponaf
    • CAS-585-86-4
    • Lactitolum [INN-Latin]
    • UNII-L2B0WJF7ZY
    • Lactitol [INN:BAN:NF]
    • Floralac
    • Portolac
    • CCRIS 7077
    • HSDB 7970
    • VQHSOMBJVWLPSR-JVCRWLNRSA-N
    • NCGC00166295-01
    • Importal (TN)
    • EINECS 209-566-5
    • Pizensy (TN)
    • NSC 231323
    • Lactitol (NF/INN)
    • LACTITOL [INN]
    • LACTITOL [MI]
    • (2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxyhexane-1,2,3,5,6-pentol
    • LACTITOL [USP-RS]
    • LACTITOL [WHO-DD]
    • SCHEMBL3849
    • CHEMBL1661
    • Lactitol, analytical standard
    • LACTITOL [ORANGE BOOK]
    • orb1306606
    • MSK3109
    • GLXC-23694
    • HMS3264E13
    • Pharmakon1600-01301027
    • HY-N7104
    • Tox21_112397
    • EBC-26671
    • NSC760415
    • s5368
    • 4-beta-D-galactopyranosyl-D-glucito1
    • 4-O-?-D-Galactopyranosyl-D-glucitol
    • AKOS030228540
    • Tox21_112397_1
    • CCG-213712
    • DB12942
    • NSC-760415
    • OL09821
    • NCGC00263893-02
    • (2S,3R,4R,5R)-4-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexane-1,2,3,5,6-pentol
    • DA-74867
    • TS-08107
    • 4-O-b-D-Galactopyranosyl-D-glucitol, 9CI
    • beta-D-galactopyranosyl-(1->4)-D-glucitol
    • CS-0069039
    • A11574
    • D08266
    • AB00698230_06
    • 4-O-.BETA.-D-GALACTOPYRANOSYL-D-GLUCITOL
    • EN300-19737008
    • Q415020
    • BRD-K40787673-001-01-3
    • BRD-K40787673-001-02-1
    • 262A7827-24F7-47EE-B528-3AF52CA860CE
    • 585-86-4

  • Applications

    In the food industry, lactitol is used as a low-calorie sweetener and bulking agent for sugar-free products such as candies, chocolates, and baked goods, helping to maintain texture and mouthfeel. In cosmetics and personal care, it serves as a humectant and skin-conditioning agent, improving moisture retention and texture in various formulations. In pharmaceuticals, lactitol acts as an excipient and filler/binder in tablets and syrups, and it is sometimes used as an osmotic laxative in bowel-related products. In household and cleaning products, lactitol can be used as a humectant and stabilizer to protect moisture and stabilize formulation components in cleaners and surface-care products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.3
    methanol 2.58
    isopropanol 0.1
    water 688.6
    ethyl acetate 0.07
    n-propanol 0.2
    acetone 0.12
    n-butanol 0.12
    acetonitrile 0.1
    DMF 32.88
    toluene 0.07
    isobutanol 0.1
    1,4-dioxane 0.65
    methyl acetate 0.09
    THF 0.36
    2-butanone 0.09
    n-pentanol 0.08
    sec-butanol 0.13
    n-hexane 0.02
    ethylene glycol 32.1
    NMP 34.11
    cyclohexane 0.16
    DMSO 110.11
    n-butyl acetate 0.1
    n-octanol 0.22
    chloroform 0.03
    n-propyl acetate 0.05
    acetic acid 4.89
    dichloromethane 0.04
    cyclohexanone 0.49
    propylene glycol 8.16
    isopropyl acetate 0.06
    DMAc 16.45
    2-ethoxyethanol 2.08
    isopentanol 0.09
    n-heptane 0.13
    ethyl formate 0.13
    1,2-dichloroethane 0.06
    n-hexanol 0.22
    2-methoxyethanol 7.14
    isobutyl acetate 0.03
    tetrachloromethane 0.03
    n-pentyl acetate 0.12
    transcutol 5.07
    n-heptanol 0.34
    ethylbenzene 0.04
    MIBK 0.07
    2-propoxyethanol 2.14
    tert-butanol 0.16
    MTBE 0.05
    2-butoxyethanol 1.62
    propionic acid 0.96
    o-xylene 0.15
    formic acid 126.52
    diethyl ether 0.06
    m-xylene 0.09
    p-xylene 0.04
    chlorobenzene 0.02
    dimethyl carbonate 0.97
    n-octane 0.06
    formamide 64.71
    cyclopentanone 0.62
    2-pentanone 0.09
    anisole 0.09
    cyclopentyl methyl ether 0.38
    gamma-butyrolactone 1.2
    1-methoxy-2-propanol 3.71
    pyridine 0.36
    3-pentanone 0.16
    furfural 2.13
    n-dodecane 0.03
    diethylene glycol 11.79
    diisopropyl ether 0.04
    tert-amyl alcohol 0.2
    acetylacetone 0.34
    n-hexadecane 0.03
    acetophenone 0.22
    methyl propionate 0.32
    isopentyl acetate 0.08
    trichloroethylene 0.08
    n-nonanol 0.23
    cyclohexanol 0.52
    benzyl alcohol 0.29
    2-ethylhexanol 0.14
    isooctanol 0.2
    dipropyl ether 0.22
    1,2-dichlorobenzene 0.04
    ethyl lactate 0.73
    propylene carbonate 0.46
    n-methylformamide 7.21
    2-pentanol 0.09
    n-pentane 0.04
    1-propoxy-2-propanol 1.42
    1-methoxy-2-propyl acetate 0.63
    2-(2-methoxypropoxy) propanol 1.81
    mesitylene 0.09
    ε-caprolactone 0.64
    p-cymene 0.1
    epichlorohydrin 0.31
    1,1,1-trichloroethane 0.02
    2-aminoethanol 10.63
    morpholine-4-carbaldehyde 17.85
    sulfolane 14.27
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.18
    n-hexyl acetate 0.14
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 2.53
    sec-butyl acetate 0.04
    tert-butyl acetate 0.11
    decalin 0.04
    glycerin 71.18
    diglyme 3.77
    acrylic acid 3.11
    isopropyl myristate 0.07
    n-butyric acid 0.39
    acetyl acetate 0.12
    di(2-ethylhexyl) phthalate 0.18
    ethyl propionate 0.09
    nitromethane 3.11
    1,2-diethoxyethane 0.29
    benzonitrile 0.09
    trioctyl phosphate 0.18
    1-bromopropane 0.02
    gamma-valerolactone 2.9
    n-decanol 0.17
    triethyl phosphate 0.26
    4-methyl-2-pentanol 0.07
    propionitrile 0.07
    vinylene carbonate 0.53
    1,1,2-trichlorotrifluoroethane 6.24
    DMS 0.36
    cumene 0.04
    2-octanol 0.17
    2-hexanone 0.05
    octyl acetate 0.12
    limonene 0.17
    1,2-dimethoxyethane 0.94
    ethyl orthosilicate 0.22
    tributyl phosphate 0.13
    diacetone alcohol 0.84
    N,N-dimethylaniline 0.23
    acrylonitrile 0.22
    aniline 0.25
    1,3-propanediol 3.58
    bromobenzene 0.02
    dibromomethane 0.03
    1,1,2,2-tetrachloroethane 0.14
    2-methyl-cyclohexyl acetate 0.14
    tetrabutyl urea 0.38
    diisobutyl methanol 0.12
    2-phenylethanol 0.31
    styrene 0.03
    dioctyl adipate 0.15
    dimethyl sulfate 5.35
    ethyl butyrate 0.13
    methyl lactate 4.29
    butyl lactate 0.58
    diethyl carbonate 0.11
    propanediol butyl ether 2.96
    triethyl orthoformate 0.25
    p-tert-butyltoluene 0.12
    methyl 4-tert-butylbenzoate 0.78
    morpholine 1.21
    tert-butylamine 0.08
    n-dodecanol 0.14
    dimethoxymethane 2.58
    ethylene carbonate 0.35
    cyrene 4.95
    2-ethoxyethyl acetate 0.26
    2-ethylhexyl acetate 0.07
    1,2,4-trichlorobenzene 0.06
    4-methylpyridine 0.15
    dibutyl ether 0.09
    2,6-dimethyl-4-heptanol 0.12
    DEF 1.31
    dimethyl isosorbide 2.49
    tetrachloroethylene 0.18
    eugenol 0.94
    triacetin 0.55
    span 80 2.09
    1,4-butanediol 1.66
    1,1-dichloroethane 0.01
    2-methyl-1-pentanol 0.06
    methyl formate 2.52
    2-methyl-1-butanol 0.12
    n-decane 0.05
    butyronitrile 0.04
    3,7-dimethyl-1-octanol 0.11
    1-chlorooctane 0.06
    1-chlorotetradecane 0.03
    n-nonane 0.05
    undecane 0.04
    tert-butylcyclohexane 0.01
    cyclooctane 0.12
    cyclopentanol 0.51
    tetrahydropyran 0.19
    tert-amyl methyl ether 0.12
    2,5,8-trioxanonane 3.83
    1-hexene 0.02
    2-isopropoxyethanol 0.73
    2,2,2-trifluoroethanol 7.62
    methyl butyrate 0.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction