L-Serine, methyl ester, hydrochloride (1:1)

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  • Identifiers

    CAS number
    5680-80-8

    Molecular formula
    C4H10ClNO3

    SMILES
    COC(=O)[C@H](CO)N.Cl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 46.32%
    Odorless 43.46%
    Sweet 36.23%
    Ethereal 26.01%
    Caramellic 25.2%
    Buttery 24.29%
    Grape 22.25%
    Winey 21.73%
    Milky 19.06%
    Fresh 18.22%

     

    Flavor
    Odorless 49.8%
    Fruity 35.38%
    Mild 26.83%
    Very mild 25.33%
    Sweet-like 23.29%
    Bland 22.29%
    Yeast 22.1%
    Roquefort cheese 20.42%
    Very slight 20.28%
    Marshmallow 19.96%

     

    Odor impact est.
    Medium

  • Properties

    pKa est.
    5.99 (weak acid)

    Molecular weight
    155.58 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    215°C

    Flash point

    • 109.76 ˚C est.

  • Synonyms

    • 5680-80-8
    • DTXSID801323780
    • L-Serine, methyl ester, hydrochloride (1:1)
    • RefChem:924441
    • DTXCID101753190
    • 227-140-7
    • L-serine methyl ester
    • Serine methyl ester
    • L-Serine methyl ester hydrochloride
    • H-Ser-OMe.HCl
    • Methyl L-serinate hydrochloride
    • (S)-Methyl 2-amino-3-hydroxypropanoate hydrochloride
    • methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride
    • MFCD00063680
    • H-Ser-OMe . HCl
    • (2-methoxy-2-oxoethyl)azanium;chloride
    • methyl (2S)-2-amino-3-hydroxypropanoate;hydrochloride
    • Serine methyl ester hydrochloride
    • L-Serine methyl ester (hydrochloride)
    • M03012
    • L-Ser-OMe HCl
    • L-SERINE METHYL ESTER HCL
    • EINECS 227-140-7
    • H-Ser-OMe HCl
    • H-Ser-OMe-HCl
    • L-Ser-OMe.HCl
    • serine methyl ester HCl
    • L-serine methyl ester-HCl
    • methyl serinate hydrochloride
    • L-METHYL SERINATE HCL
    • SCHEMBL159222
    • serine methylester hydrochloride
    • l-serine methylate hydrochloride
    • serine methyl ester hydrochoride
    • CHEMBL1222334
    • L-serine methylester hydrochloride
    • L-serine-methylester hydrochloride
    • L-serine-methyl ester hydrochloride
    • BB_NC-02218
    • CS-B1301
    • STR01147
    • L-serine methyl ester, hydrochloride
    • L-serine, methyl ester hydrochloride
    • HY-32687A
    • NSC 84252
    • (S)-serine methyl ester hydrochloride
    • (5)-serine methyl ester hydrochloride
    • AKOS015846051
    • AKOS015892710
    • FS11275
    • L-Serine Methyl Ester Monohydrochloride
    • L-(+)-serine methyl ester hydrochloride
    • PD195973
    • SY005340
    • L-Serine methyl ester hydrochloride, 98%
    • B0267
    • L-serine methyl ester hydrochloric acid salt
    • Methyl L-serinate--hydrogen chloride (1/1)
    • NS00082596
    • ST50824528
    • EN300-71341
    • 80S808
    • doi:10.14272/NDBQJIBNNUJNHA-DFWYDOINSA-N.2
    • methyl (2S)-2-amino-3-hydroxypropanoate, chloride
    • methyl (2S)-2-amino-3-hydroxy-propanoate hydrochloride
    • methyl (2S)-2-amino-3-hydroxy-propanoate;hydrochloride
    • (2S)-2-amino-3-hydroxy-propionic acid methyl ester hydrochloride
    • (S)-Serine Methyl Ester Hydrochloride; Methyl L-serinate hydrochloride; L-Serine Methyl Ester Monohydrochloride;
    • 5680-80-8

  • Applications

    L-Serine, methyl ester, hydrochloride (1:1) is a protected amino acid derivative used primarily as a building block in peptide and peptidomimetic synthesis, where the methyl ester protects the carboxyl group and the amine is provided as a hydrochloride salt for convenient handling. It serves as a chiral starting material and intermediate in organic synthesis, enabling subsequent transformations to serine-containing compounds and derivatives. In pharmaceutical research and development, it is commonly evaluated as a precursor for serine-containing APIs and for the preparation of peptide-based motifs. The salt form improves aqueous solubility and handling, supporting laboratory-scale reactions, purification, and integration into scalable synthesis workflows, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 10.82
    methanol 46.05
    isopropanol 3.91
    water 452.27
    ethyl acetate 1.43
    n-propanol 6.19
    acetone 3.63
    n-butanol 4.22
    acetonitrile 4.1
    DMF 62.08
    toluene 0.42
    isobutanol 4.25
    1,4-dioxane 6.5
    methyl acetate 2.07
    THF 6.99
    2-butanone 2.87
    n-pentanol 2.59
    sec-butanol 3.9
    n-hexane 0.14
    ethylene glycol 71.23
    NMP 88.51
    cyclohexane 0.29
    DMSO 166.63
    n-butyl acetate 0.96
    n-octanol 1.64
    chloroform 1.25
    n-propyl acetate 0.96
    acetic acid 55.16
    dichloromethane 2.05
    cyclohexanone 7.51
    propylene glycol 30.6
    isopropyl acetate 0.91
    DMAc 52.18
    2-ethoxyethanol 19.28
    isopentanol 3.51
    n-heptane 0.3
    ethyl formate 5.12
    1,2-dichloroethane 1.71
    n-hexanol 2.19
    2-methoxyethanol 44.63
    isobutyl acetate 0.59
    tetrachloromethane 0.85
    n-pentyl acetate 1.14
    transcutol 17.86
    n-heptanol 2.07
    ethylbenzene 0.36
    MIBK 1.76
    2-propoxyethanol 10.62
    tert-butanol 5.79
    MTBE 1.64
    2-butoxyethanol 7.47
    propionic acid 12.07
    o-xylene 0.98
    formic acid 307.97
    diethyl ether 0.86
    m-xylene 0.7
    p-xylene 0.55
    chlorobenzene 0.67
    dimethyl carbonate 1.9
    n-octane 0.16
    formamide 153.5
    cyclopentanone 9.97
    2-pentanone 2.11
    anisole 1.36
    cyclopentyl methyl ether 2.45
    gamma-butyrolactone 15.18
    1-methoxy-2-propanol 16.88
    pyridine 3.3
    3-pentanone 1.84
    furfural 30.81
    n-dodecane 0.11
    diethylene glycol 30.08
    diisopropyl ether 0.46
    tert-amyl alcohol 6.41
    acetylacetone 3.58
    n-hexadecane 0.12
    acetophenone 2.91
    methyl propionate 2.38
    isopentyl acetate 1.15
    trichloroethylene 2.96
    n-nonanol 1.5
    cyclohexanol 4.21
    benzyl alcohol 3.69
    2-ethylhexanol 1.52
    isooctanol 1.87
    dipropyl ether 0.95
    1,2-dichlorobenzene 1.15
    ethyl lactate 3.75
    propylene carbonate 6.1
    n-methylformamide 38.71
    2-pentanol 1.96
    n-pentane 0.18
    1-propoxy-2-propanol 5.7
    1-methoxy-2-propyl acetate 2.5
    2-(2-methoxypropoxy) propanol 8.88
    mesitylene 0.72
    ε-caprolactone 7.45
    p-cymene 0.77
    epichlorohydrin 8.37
    1,1,1-trichloroethane 0.86
    2-aminoethanol 48.75
    morpholine-4-carbaldehyde 52.77
    sulfolane 63.93
    2,2,4-trimethylpentane 0.25
    2-methyltetrahydrofuran 4.19
    n-hexyl acetate 1.66
    isooctane 0.14
    2-(2-butoxyethoxy)ethanol 9.91
    sec-butyl acetate 0.63
    tert-butyl acetate 1.47
    decalin 0.2
    glycerin 91.74
    diglyme 18.44
    acrylic acid 22.06
    isopropyl myristate 0.75
    n-butyric acid 8.44
    acetyl acetate 1.37
    di(2-ethylhexyl) phthalate 2.65
    ethyl propionate 1.12
    nitromethane 40.0
    1,2-diethoxyethane 1.62
    benzonitrile 2.37
    trioctyl phosphate 1.79
    1-bromopropane 0.59
    gamma-valerolactone 27.63
    n-decanol 1.13
    triethyl phosphate 1.79
    4-methyl-2-pentanol 1.48
    propionitrile 2.11
    vinylene carbonate 7.12
    1,1,2-trichlorotrifluoroethane 30.36
    DMS 1.8
    cumene 0.49
    2-octanol 1.18
    2-hexanone 1.4
    octyl acetate 1.18
    limonene 1.21
    1,2-dimethoxyethane 13.34
    ethyl orthosilicate 1.57
    tributyl phosphate 1.66
    diacetone alcohol 6.66
    N,N-dimethylaniline 2.12
    acrylonitrile 4.47
    aniline 2.16
    1,3-propanediol 32.76
    bromobenzene 0.46
    dibromomethane 1.12
    1,1,2,2-tetrachloroethane 3.05
    2-methyl-cyclohexyl acetate 1.76
    tetrabutyl urea 3.03
    diisobutyl methanol 1.25
    2-phenylethanol 2.7
    styrene 0.35
    dioctyl adipate 1.73
    dimethyl sulfate 11.15
    ethyl butyrate 1.27
    methyl lactate 8.98
    butyl lactate 3.37
    diethyl carbonate 0.94
    propanediol butyl ether 10.21
    triethyl orthoformate 1.5
    p-tert-butyltoluene 0.77
    methyl 4-tert-butylbenzoate 5.45
    morpholine 10.17
    tert-butylamine 2.21
    n-dodecanol 0.85
    dimethoxymethane 8.26
    ethylene carbonate 4.26
    cyrene 20.45
    2-ethoxyethyl acetate 2.12
    2-ethylhexyl acetate 0.88
    1,2,4-trichlorobenzene 1.61
    4-methylpyridine 2.81
    dibutyl ether 0.7
    2,6-dimethyl-4-heptanol 1.25
    DEF 8.0
    dimethyl isosorbide 13.07
    tetrachloroethylene 2.98
    eugenol 7.19
    triacetin 3.41
    span 80 7.71
    1,4-butanediol 16.42
    1,1-dichloroethane 0.7
    2-methyl-1-pentanol 2.64
    methyl formate 22.18
    2-methyl-1-butanol 4.08
    n-decane 0.17
    butyronitrile 2.09
    3,7-dimethyl-1-octanol 1.7
    1-chlorooctane 0.48
    1-chlorotetradecane 0.25
    n-nonane 0.16
    undecane 0.13
    tert-butylcyclohexane 0.18
    cyclooctane 0.19
    cyclopentanol 6.01
    tetrahydropyran 2.06
    tert-amyl methyl ether 2.17
    2,5,8-trioxanonane 15.48
    1-hexene 0.3
    2-isopropoxyethanol 7.47
    2,2,2-trifluoroethanol 35.38
    methyl butyrate 2.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction