L-Glutamic acid monosodium salt monohydrate

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  • Identifiers

    CAS number
    6106-04-3

    Molecular formula
    C5H10NNaO5

    SMILES
    C(CC(=O)[O-])[C@@H](C(=O)O)N.O.[Na+]

  • Odor profile

    Fragrance
    Odorless 73.65%
    Sweet 37.64%
    Savory 32.15%
    Meaty 21.46%
    Milky 18.84%
    Buttery 17.17%
    Cooked 16.62%
    Sour 16.39%
    Caramellic 15.17%
    Cocoa 15.11%

     

    Flavor
    Odorless 71.23%
    Mild 35.03%
    Very mild 30.11%
    Bland 26.23%
    Yeast 24.4%
    Faint 23.38%
    Sour 23.22%
    Sweet-like 22.5%
    Mousy 19.43%
    Urine 19.41%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.71 (weak acid)

    Molecular weight
    187.13 g/mol

    Melting point expt.

    • 450 °F (Decomposes) (NTP, 1992)

    Boiling point

    • 225 °C (decomposes)

    Flash point

    • 152.08 ˚C est.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
    • Freely soluble in water; practically insoluble in ethanol or ether
    • SPARINGLY SOL IN ALCOHOL
    • 73.9 G PER 100 ML WATER @ 25 °C; IT IS PRACTICALLY INSOL IN OIL OR ORGANIC SOLVENTS
    • In water, 385,000 ppm at 25 °C

  • Synonyms

    • L-Glutamic acid monosodium salt monohydrate
    • 6106-04-3
    • MONOSODIUM GLUTAMATE
    • Sodium glutamate
    • MFCD00150138
    • monosodium l-glutamate monohydrate
    • Monosodium glutamate monohydrate
    • SodiuM L-GlutaMate Monohydrate
    • L-Glutamic acid, monosodium salt, monohydrate
    • MSG monohydrate
    • Sodium glutamate monohydrate
    • MSG
    • Monosodium glutamate (NF)
    • Monosodium glutamate [NF]
    • L-Glutamic acid monosodium salt hydrate
    • UNII-W81N5U6R6U
    • W81N5U6R6U
    • L-Glutamic acid Monosodium salt
    • Sodium L-glutamate hydrate (JAN)
    • Ancoma (TN)
    • H-Glu-OH.Na monohydrate
    • Glutamic acid, monosodium salt, monohydrate, L-
    • Sodium L-glutamatemonohydrate
    • MLS001335935
    • 142-47-2 (anhydrous)
    • Monosodium L-glutamate hydrate
    • CHEBI:232425
    • L-Glutamic acid sodium salt hydrate
    • AKOS015950651
    • SMR000875341
    • D02280

  • Applications

    L-Glutamic acid monosodium salt monohydrate (CAS 6106-04-3) is the sodium salt of glutamic acid and is predominantly used as a flavor enhancer in foods (MSG). It is also employed as a nutritional supplement in animal feeds to supply amino acids and support palatability. In biotechnology and fermentation, it serves as a glutamate source for microbial growth and can function as a buffering component in fermentation media. It is used as a chemical synthesis intermediate for the production of glutamate derivatives and related pharmaceutical intermediates. Additionally, it may be used as a pH adjuster or formulation aid in certain chemical formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.13
    methanol 8.54
    isopropanol 1.53
    water 33.85
    ethyl acetate 1.25
    n-propanol 1.28
    acetone 4.64
    n-butanol 1.15
    acetonitrile 1.19
    DMF 98.02
    toluene 0.36
    isobutanol 0.92
    1,4-dioxane 7.24
    methyl acetate 1.26
    THF 6.75
    2-butanone 1.7
    n-pentanol 0.77
    sec-butanol 0.97
    n-hexane 0.21
    ethylene glycol 17.16
    NMP 133.62
    cyclohexane 0.27
    DMSO 133.87
    n-butyl acetate 1.28
    n-octanol 1.1
    chloroform 0.09
    n-propyl acetate 0.72
    acetic acid 15.93
    dichloromethane 0.31
    cyclohexanone 4.84
    propylene glycol 8.58
    isopropyl acetate 1.01
    DMAc 71.11
    2-ethoxyethanol 10.19
    isopentanol 1.34
    n-heptane 0.32
    ethyl formate 2.58
    1,2-dichloroethane 0.54
    n-hexanol 1.2
    2-methoxyethanol 26.04
    isobutyl acetate 0.33
    tetrachloromethane 0.07
    n-pentyl acetate 1.15
    transcutol 33.4
    n-heptanol 1.33
    ethylbenzene 0.33
    MIBK 1.38
    2-propoxyethanol 9.34
    tert-butanol 3.06
    MTBE 1.11
    2-butoxyethanol 7.29
    propionic acid 4.04
    o-xylene 0.84
    formic acid 65.48
    diethyl ether 0.86
    m-xylene 0.51
    p-xylene 0.47
    chlorobenzene 0.21
    dimethyl carbonate 3.51
    n-octane 0.15
    formamide 61.96
    cyclopentanone 7.67
    2-pentanone 1.92
    anisole 1.13
    cyclopentyl methyl ether 2.89
    gamma-butyrolactone 13.94
    1-methoxy-2-propanol 13.64
    pyridine 2.39
    3-pentanone 1.56
    furfural 22.14
    n-dodecane 0.09
    diethylene glycol 23.92
    diisopropyl ether 0.48
    tert-amyl alcohol 2.31
    acetylacetone 6.06
    n-hexadecane 0.1
    acetophenone 2.27
    methyl propionate 2.14
    isopentyl acetate 1.18
    trichloroethylene 0.55
    n-nonanol 1.17
    cyclohexanol 1.64
    benzyl alcohol 1.77
    2-ethylhexanol 0.88
    isooctanol 1.04
    dipropyl ether 1.23
    1,2-dichlorobenzene 0.35
    ethyl lactate 2.59
    propylene carbonate 5.81
    n-methylformamide 21.87
    2-pentanol 0.85
    n-pentane 0.16
    1-propoxy-2-propanol 5.64
    1-methoxy-2-propyl acetate 3.8
    2-(2-methoxypropoxy) propanol 12.48
    mesitylene 0.54
    ε-caprolactone 6.64
    p-cymene 0.55
    epichlorohydrin 4.6
    1,1,1-trichloroethane 0.12
    2-aminoethanol 12.84
    morpholine-4-carbaldehyde 76.3
    sulfolane 52.63
    2,2,4-trimethylpentane 0.11
    2-methyltetrahydrofuran 3.19
    n-hexyl acetate 1.59
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 17.59
    sec-butyl acetate 0.47
    tert-butyl acetate 1.85
    decalin 0.15
    glycerin 36.14
    diglyme 25.33
    acrylic acid 8.81
    isopropyl myristate 0.8
    n-butyric acid 3.32
    acetyl acetate 1.57
    di(2-ethylhexyl) phthalate 2.08
    ethyl propionate 0.97
    nitromethane 21.84
    1,2-diethoxyethane 2.74
    benzonitrile 0.85
    trioctyl phosphate 1.42
    1-bromopropane 0.16
    gamma-valerolactone 29.2
    n-decanol 0.95
    triethyl phosphate 1.51
    4-methyl-2-pentanol 0.69
    propionitrile 0.51
    vinylene carbonate 4.93
    1,1,2-trichlorotrifluoroethane 10.54
    DMS 2.78
    cumene 0.35
    2-octanol 0.73
    2-hexanone 0.91
    octyl acetate 1.3
    limonene 0.81
    1,2-dimethoxyethane 11.33
    ethyl orthosilicate 1.23
    tributyl phosphate 1.43
    diacetone alcohol 7.28
    N,N-dimethylaniline 2.0
    acrylonitrile 1.35
    aniline 1.08
    1,3-propanediol 10.7
    bromobenzene 0.15
    dibromomethane 0.16
    1,1,2,2-tetrachloroethane 0.59
    2-methyl-cyclohexyl acetate 1.43
    tetrabutyl urea 3.69
    diisobutyl methanol 0.77
    2-phenylethanol 1.7
    styrene 0.28
    dioctyl adipate 1.91
    dimethyl sulfate 14.65
    ethyl butyrate 1.25
    methyl lactate 8.37
    butyl lactate 3.01
    diethyl carbonate 0.95
    propanediol butyl ether 10.41
    triethyl orthoformate 1.48
    p-tert-butyltoluene 0.54
    methyl 4-tert-butylbenzoate 5.63
    morpholine 8.58
    tert-butylamine 1.09
    n-dodecanol 0.76
    dimethoxymethane 14.27
    ethylene carbonate 3.13
    cyrene 18.68
    2-ethoxyethyl acetate 3.14
    2-ethylhexyl acetate 0.86
    1,2,4-trichlorobenzene 0.55
    4-methylpyridine 2.23
    dibutyl ether 0.8
    2,6-dimethyl-4-heptanol 0.77
    DEF 10.13
    dimethyl isosorbide 16.99
    tetrachloroethylene 0.58
    eugenol 6.51
    triacetin 4.66
    span 80 9.83
    1,4-butanediol 4.23
    1,1-dichloroethane 0.13
    2-methyl-1-pentanol 0.87
    methyl formate 14.39
    2-methyl-1-butanol 1.17
    n-decane 0.15
    butyronitrile 0.57
    3,7-dimethyl-1-octanol 0.83
    1-chlorooctane 0.28
    1-chlorotetradecane 0.18
    n-nonane 0.15
    undecane 0.12
    tert-butylcyclohexane 0.11
    cyclooctane 0.2
    cyclopentanol 2.29
    tetrahydropyran 1.46
    tert-amyl methyl ether 1.48
    2,5,8-trioxanonane 24.95
    1-hexene 0.27
    2-isopropoxyethanol 4.47
    2,2,2-trifluoroethanol 9.19
    methyl butyrate 1.48

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction