L-Cysteic acid

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  • Identifiers

    CAS number
    498-40-8

    Molecular formula
    C3H7NO5S

    SMILES
    C([C@@H](C(=O)O)N)S(=O)(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 90.02%
    Savory 23.44%
    Sulfurous 19.27%
    Cooked 17.93%
    Meaty 14.03%
    Roasted 13.39%
    Pungent 12.9%
    Clean 12.16%
    Burnt 11.66%
    Sour 10.54%

     

    Flavor
    Bitter 70.05%
    Odorless 48.16%
    Bland 31.23%
    Mild 23.52%
    Very mild 21.04%
    Nitrile 20.33%
    Yeast 20.23%
    Sweet-like 20.1%
    Formyl 19.44%
    Taco 19.01%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -4.5

    pKa est.
    6.75 (neutral)

    Molecular weight
    169.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    453°C

    Flash point

    • 200.43 ˚C est.

  • Synonyms

    • L-Cysteic acid
    • 498-40-8
    • Cysteinesulfonic acid
    • (R)-2-Amino-3-sulfopropanoic acid
    • Cysteic acid, L-
    • 3-sulfo-L-alanine
    • L-Alanine, 3-sulfo-
    • (2R)-2-amino-3-sulfopropanoic acid
    • Cysteric acid
    • MFCD00007524
    • Alanine, 3-sulfo-, L-
    • C3H7NO5S
    • Cysteic acid (VAN)
    • Cysteinic acid
    • Cepteic acid
    • Cipteic acid
    • sulfo-D-alanine
    • 2-Amino-3-sulfopropionic acid
    • (2R)-2-amino-3-sulfo-propanoic acid
    • M6W2DJ6N5K
    • L-Cysteate
    • alpha-amino-beta-sulfopropionic acid
    • (R)-cysteate
    • Cysteinesulfonate
    • Cysteic acid; L-3-sulfo-alanine
    • H-Cys(O)2-OH.H2O
    • NSC 254030
    • OCS
    • UNII-M6W2DJ6N5K
    • NSC-254030
    • EINECS 207-861-3
    • bmse000380
    • L-Cysteic acid (Standard)
    • SCHEMBL44031
    • L-CYSTEIC ACID [MI]
    • CYSTEIC ACID, (+)-
    • orb1703564
    • DTXSID7075424
    • L-Alanine, 3-sulfo- (9CI)
    • CHEBI:17285
    • MSK1478
    • Alanine, 3-sulfo-, L- (8CI)
    • AKOS006281833
    • AKOS015854116
    • (2R)-2-amino-3-sulfo-propionic acid
    • DB03661
    • HY-124009R
    • (2R)-2-azanyl-3-sulfo-propanoic acid
    • DS-12037
    • FC167998
    • ST079666
    • SY113770
    • DB-294486
    • CS-0083859
    • NS00014864
    • C00506
    • D81957
    • EN300-302681
    • F517654
    • Q29743881
    • 498-40-8

  • Applications

    L-Cysteic acid (CAS 498-40-8) is employed as a versatile building block in organic synthesis, providing a sulfonic-acid-bearing cysteine-derived scaffold for pharmaceutical and agrochemical intermediates. It also serves as a hydrophilic precursor for sulfonated polymers and surface-modification chemistries used in coatings and adhesives. In industrial settings, it can function as a chelating/ion-binding precursor for metal ions in cleaning, electroplating, and water-treatment formulations. Additionally, it is used as an analytical reagent or standard in amino-acid analysis and related enzymatic assays due to its stable sulfonic acid functionality.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.58
    methanol 8.64
    isopropanol 2.5
    water 41.69
    ethyl acetate 1.23
    n-propanol 2.1
    acetone 21.19
    n-butanol 1.39
    acetonitrile 3.51
    DMF 101.35
    toluene 0.73
    isobutanol 1.07
    1,4-dioxane 13.76
    methyl acetate 2.0
    THF 13.58
    2-butanone 3.68
    n-pentanol 0.86
    sec-butanol 1.27
    n-hexane 0.22
    ethylene glycol 21.52
    NMP 49.41
    cyclohexane 0.53
    DMSO 133.39
    n-butyl acetate 1.0
    n-octanol 0.81
    chloroform 0.35
    n-propyl acetate 0.85
    acetic acid 8.09
    dichloromethane 0.85
    cyclohexanone 6.21
    propylene glycol 6.72
    isopropyl acetate 0.96
    DMAc 52.36
    2-ethoxyethanol 14.61
    isopentanol 1.06
    n-heptane 0.47
    ethyl formate 5.26
    1,2-dichloroethane 1.38
    n-hexanol 1.35
    2-methoxyethanol 44.04
    isobutyl acetate 0.25
    tetrachloromethane 0.39
    n-pentyl acetate 0.67
    transcutol 5.61
    n-heptanol 1.13
    ethylbenzene 0.46
    MIBK 1.75
    2-propoxyethanol 9.13
    tert-butanol 3.74
    MTBE 1.12
    2-butoxyethanol 4.83
    propionic acid 1.91
    o-xylene 1.14
    formic acid 43.08
    diethyl ether 1.67
    m-xylene 0.74
    p-xylene 0.58
    chlorobenzene 0.32
    dimethyl carbonate 3.19
    n-octane 0.2
    formamide 56.93
    cyclopentanone 12.33
    2-pentanone 3.38
    anisole 1.55
    cyclopentyl methyl ether 3.28
    gamma-butyrolactone 11.05
    1-methoxy-2-propanol 16.09
    pyridine 3.27
    3-pentanone 2.42
    furfural 19.71
    n-dodecane 0.11
    diethylene glycol 23.2
    diisopropyl ether 0.5
    tert-amyl alcohol 2.09
    acetylacetone 9.37
    n-hexadecane 0.12
    acetophenone 2.3
    methyl propionate 2.25
    isopentyl acetate 0.72
    trichloroethylene 1.09
    n-nonanol 0.79
    cyclohexanol 1.56
    benzyl alcohol 1.79
    2-ethylhexanol 0.77
    isooctanol 0.68
    dipropyl ether 1.49
    1,2-dichlorobenzene 0.41
    ethyl lactate 1.96
    propylene carbonate 3.21
    n-methylformamide 32.14
    2-pentanol 0.8
    n-pentane 0.23
    1-propoxy-2-propanol 4.37
    1-methoxy-2-propyl acetate 2.42
    2-(2-methoxypropoxy) propanol 3.87
    mesitylene 0.74
    ε-caprolactone 3.69
    p-cymene 0.6
    epichlorohydrin 6.51
    1,1,1-trichloroethane 0.44
    2-aminoethanol 13.14
    morpholine-4-carbaldehyde 44.46
    sulfolane 30.67
    2,2,4-trimethylpentane 0.08
    2-methyltetrahydrofuran 3.23
    n-hexyl acetate 0.72
    isooctane 0.06
    2-(2-butoxyethoxy)ethanol 4.99
    sec-butyl acetate 0.4
    tert-butyl acetate 1.52
    decalin 0.17
    glycerin 28.44
    diglyme 13.75
    acrylic acid 3.33
    isopropyl myristate 0.4
    n-butyric acid 1.94
    acetyl acetate 1.33
    di(2-ethylhexyl) phthalate 0.7
    ethyl propionate 0.97
    nitromethane 24.74
    1,2-diethoxyethane 1.57
    benzonitrile 0.99
    trioctyl phosphate 0.65
    1-bromopropane 0.36
    gamma-valerolactone 27.03
    n-decanol 0.67
    triethyl phosphate 1.04
    4-methyl-2-pentanol 0.55
    propionitrile 1.05
    vinylene carbonate 2.85
    1,1,2-trichlorotrifluoroethane 10.98
    DMS 0.92
    cumene 0.38
    2-octanol 0.57
    2-hexanone 1.27
    octyl acetate 0.59
    limonene 0.79
    1,2-dimethoxyethane 23.34
    ethyl orthosilicate 0.93
    tributyl phosphate 0.57
    diacetone alcohol 5.82
    N,N-dimethylaniline 2.24
    acrylonitrile 2.27
    aniline 1.48
    1,3-propanediol 12.23
    bromobenzene 0.25
    dibromomethane 0.51
    1,1,2,2-tetrachloroethane 1.28
    2-methyl-cyclohexyl acetate 0.93
    tetrabutyl urea 1.93
    diisobutyl methanol 0.67
    2-phenylethanol 1.66
    styrene 0.45
    dioctyl adipate 0.61
    dimethyl sulfate 11.39
    ethyl butyrate 1.13
    methyl lactate 6.13
    butyl lactate 1.36
    diethyl carbonate 0.74
    propanediol butyl ether 3.52
    triethyl orthoformate 1.1
    p-tert-butyltoluene 0.58
    methyl 4-tert-butylbenzoate 2.59
    morpholine 11.39
    tert-butylamine 1.43
    n-dodecanol 0.56
    dimethoxymethane 25.91
    ethylene carbonate 2.19
    cyrene 8.35
    2-ethoxyethyl acetate 1.2
    2-ethylhexyl acetate 0.57
    1,2,4-trichlorobenzene 0.5
    4-methylpyridine 2.91
    dibutyl ether 0.56
    2,6-dimethyl-4-heptanol 0.67
    DEF 9.44
    dimethyl isosorbide 7.48
    tetrachloroethylene 1.38
    eugenol 3.62
    triacetin 1.17
    span 80 2.47
    1,4-butanediol 4.63
    1,1-dichloroethane 0.41
    2-methyl-1-pentanol 0.57
    methyl formate 28.95
    2-methyl-1-butanol 0.93
    n-decane 0.18
    butyronitrile 1.0
    3,7-dimethyl-1-octanol 0.52
    1-chlorooctane 0.32
    1-chlorotetradecane 0.18
    n-nonane 0.19
    undecane 0.14
    tert-butylcyclohexane 0.1
    cyclooctane 0.31
    cyclopentanol 2.72
    tetrahydropyran 2.51
    tert-amyl methyl ether 1.18
    2,5,8-trioxanonane 10.33
    1-hexene 0.3
    2-isopropoxyethanol 4.67
    2,2,2-trifluoroethanol 8.78
    methyl butyrate 1.69

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction