L-Asparagine, monohydrate

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  • Identifiers

    CAS number
    5794-13-8

    Molecular formula
    C4H10N2O4

    SMILES
    C([C@@H](C(=O)O)N)C(=O)N.O

  • Odor profile

    Fragrance
    Odorless 77.07%
    Savory 34.18%
    Sweet 30.21%
    Meaty 21.96%
    Fishy 18.56%
    Cooked 18.04%
    Cocoa 17.12%
    Milky 16.94%
    Bitter 15.82%
    Cooling 15.36%

     

    Flavor
    Odorless 66.69%
    Mild 32.31%
    Bland 26.42%
    Very mild 25.26%
    Yeast 23.23%
    Bitter 22.4%
    Faint 21.33%
    Sweet-like 21.33%
    Sour 20.15%
    Cooked 20.07%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.58 (weak acid)

    Molecular weight
    150.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    372°C

    Flash point

    • 185.71 ˚C est.

  • Synonyms

    • l-Asparagine monohydrate
    • 5794-13-8
    • L(+)-Asparagine monohydrate
    • L-Asparagine, monohydrate
    • Asparagine monohydrate
    • H-Asn-OH.H2O
    • l-asparagine hydrate
    • (S)-2,4-diamino-4-oxobutanoic acid hydrate
    • L-Aspartic acid 4-amide
    • Asparagine [NF]
    • MFCD00151038
    • Aminoplasmal
    • Normofundin
    • Nutrifundin
    • Thomaeamin
    • (S)-(+)-2-Aminosuccinamic acid
    • L-Asparagine (monohydrate)
    • L-Asparagin-1-wasser
    • (S)-2-Aminosuccinic acid 4-amide
    • (2S)-2,4-diamino-4-oxobutanoic acid;hydrate
    • Asparagine (NF)
    • 2PD79VF521
    • UNII-2PD79VF521
    • L-Asparagine-13C4,15N2 monohydrate
    • Asparagine Monohydrate (L-Asparagine Monohydrate)
    • 53844-04-5
    • L-(+)-Asparagine Monohydrate
    • (2S)-2-amino-3-carbamoylpropanoic acid hydrate
    • NSC 760099
    • Asparagine, monohydrate, L-
    • Asparagine monohydrate; (2S)-2,4-Diamino-4-oxobutanoic acid monohydrate; Aspartic Acid Impurity G as Monohydrate; Magnesium Aspartate Dihydrate Impurity H as Monohydrate; Magnesium Aspartate Impurity H as Monohydrate
    • starbld0001284
    • (S)-2,4-DIAMINO-4-OXOBUTANOIC ACID H2O
    • SCHEMBL50255
    • SCHEMBL6659104
    • DTXSID90973512
    • 4-Iminohomoserine--water (1/1)
    • DL-2-Aminosuccinamic Acid Hydrate
    • ASPARAGINE, L-, MONOHYDRATE
    • HY-W017443R
    • s4950
    • AKOS015855256
    • ASPARAGINE MONOHYDRATE [USP-RS]
    • ASPARAGINE MONOHYDRATE [WHO-DD]
    • CS-W018159
    • FA30557
    • FD20027
    • HY-W017443
    • L-Asparagine (monohydrate) (Standard)
    • AS-11745
    • L-Asparagine monohydrate, p.a., 98.5%
    • L-Asparagine monohydrate, >=99% (TLC)
    • ASPARAGINE MONOHYDRATE [EP IMPURITY]
    • DB-230564
    • ASPARAGINE MONOHYDRATE [EP MONOGRAPH]
    • NS00082127
    • D09738
    • F83117
    • Q27255389
    • L-Asparagine monohydrate, suitable for cell culture, BioReagent
    • Asparagine monohydrate, European Pharmacopoeia (EP) Reference Standard
    • Asparagine monohydrate, United States Pharmacopeia (USP) Reference Standard
    • L-Asparagine monohydrate, from non-animal source, BioReagent, suitable for cell culture, >=98.0%

  • Applications

    L-Asparagine, monohydrate (CAS 5794-13-8) is primarily used as a nutrient source in cell culture and industrial fermentation media, providing an amino-nitrogen source to support microbial and mammalian cell growth; it also serves as a building block or intermediate in peptide synthesis and pharmaceutical manufacturing. In analytical workflows, it can function as a reference standard for amino acid quantification (e.g., HPLC/GC methods). In food processing research, it is commonly evaluated in acrylamide formation studies to understand and mitigate potential hazards. Additionally, it is employed as a laboratory reagent for research, development, and quality control activities involving amino acid formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.09
    methanol 0.14
    isopropanol 0.05
    water 4.96
    ethyl acetate 0.12
    n-propanol 0.05
    acetone 0.45
    n-butanol 0.04
    acetonitrile 0.12
    DMF 3.56
    toluene 0.06
    isobutanol 0.04
    1,4-dioxane 0.78
    methyl acetate 0.12
    THF 0.65
    2-butanone 0.14
    n-pentanol 0.05
    sec-butanol 0.05
    n-hexane 0.04
    ethylene glycol 1.47
    NMP 7.07
    cyclohexane 0.03
    DMSO 5.36
    n-butyl acetate 0.11
    n-octanol 0.07
    chloroform 0.06
    n-propyl acetate 0.07
    acetic acid 1.07
    dichloromethane 0.08
    cyclohexanone 0.44
    propylene glycol 0.62
    isopropyl acetate 0.1
    DMAc 4.52
    2-ethoxyethanol 0.66
    isopentanol 0.06
    n-heptane 0.06
    ethyl formate 0.42
    1,2-dichloroethane 0.07
    n-hexanol 0.11
    2-methoxyethanol 1.39
    isobutyl acetate 0.04
    tetrachloromethane 0.09
    n-pentyl acetate 0.08
    transcutol 0.67
    n-heptanol 0.12
    ethylbenzene 0.07
    MIBK 0.14
    2-propoxyethanol 0.83
    tert-butanol 0.16
    MTBE 0.08
    2-butoxyethanol 0.56
    propionic acid 0.22
    o-xylene 0.13
    formic acid 8.19
    diethyl ether 0.06
    m-xylene 0.09
    p-xylene 0.1
    chlorobenzene 0.03
    dimethyl carbonate 0.32
    n-octane 0.03
    formamide 3.44
    cyclopentanone 0.72
    2-pentanone 0.14
    anisole 0.14
    cyclopentyl methyl ether 0.26
    gamma-butyrolactone 1.2
    1-methoxy-2-propanol 0.68
    pyridine 0.21
    3-pentanone 0.14
    furfural 3.06
    n-dodecane 0.01
    diethylene glycol 2.65
    diisopropyl ether 0.04
    tert-amyl alcohol 0.16
    acetylacetone 0.64
    n-hexadecane 0.01
    acetophenone 0.26
    methyl propionate 0.17
    isopentyl acetate 0.11
    trichloroethylene 0.12
    n-nonanol 0.07
    cyclohexanol 0.11
    benzyl alcohol 0.16
    2-ethylhexanol 0.11
    isooctanol 0.11
    dipropyl ether 0.14
    1,2-dichlorobenzene 0.06
    ethyl lactate 0.32
    propylene carbonate 0.7
    n-methylformamide 1.1
    2-pentanol 0.04
    n-pentane 0.02
    1-propoxy-2-propanol 0.48
    1-methoxy-2-propyl acetate 0.35
    2-(2-methoxypropoxy) propanol 0.86
    mesitylene 0.1
    ε-caprolactone 0.48
    p-cymene 0.1
    epichlorohydrin 0.39
    1,1,1-trichloroethane 0.06
    2-aminoethanol 0.68
    morpholine-4-carbaldehyde 5.22
    sulfolane 4.57
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.25
    n-hexyl acetate 0.09
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 0.76
    sec-butyl acetate 0.05
    tert-butyl acetate 0.18
    decalin 0.03
    glycerin 4.61
    diglyme 1.59
    acrylic acid 0.48
    isopropyl myristate 0.05
    n-butyric acid 0.21
    acetyl acetate 0.19
    di(2-ethylhexyl) phthalate 0.17
    ethyl propionate 0.11
    nitromethane 1.68
    1,2-diethoxyethane 0.13
    benzonitrile 0.12
    trioctyl phosphate 0.12
    1-bromopropane 0.02
    gamma-valerolactone 2.46
    n-decanol 0.06
    triethyl phosphate 0.26
    4-methyl-2-pentanol 0.06
    propionitrile 0.06
    vinylene carbonate 0.56
    1,1,2-trichlorotrifluoroethane 2.15
    DMS 0.16
    cumene 0.08
    2-octanol 0.07
    2-hexanone 0.1
    octyl acetate 0.07
    limonene 0.11
    1,2-dimethoxyethane 1.36
    ethyl orthosilicate 0.23
    tributyl phosphate 0.12
    diacetone alcohol 0.72
    N,N-dimethylaniline 0.29
    acrylonitrile 0.13
    aniline 0.1
    1,3-propanediol 0.47
    bromobenzene 0.03
    dibromomethane 0.05
    1,1,2,2-tetrachloroethane 0.14
    2-methyl-cyclohexyl acetate 0.17
    tetrabutyl urea 0.3
    diisobutyl methanol 0.12
    2-phenylethanol 0.2
    styrene 0.05
    dioctyl adipate 0.1
    dimethyl sulfate 1.53
    ethyl butyrate 0.15
    methyl lactate 0.76
    butyl lactate 0.26
    diethyl carbonate 0.12
    propanediol butyl ether 0.55
    triethyl orthoformate 0.21
    p-tert-butyltoluene 0.1
    methyl 4-tert-butylbenzoate 0.56
    morpholine 0.52
    tert-butylamine 0.07
    n-dodecanol 0.06
    dimethoxymethane 0.96
    ethylene carbonate 0.37
    cyrene 2.19
    2-ethoxyethyl acetate 0.14
    2-ethylhexyl acetate 0.09
    1,2,4-trichlorobenzene 0.08
    4-methylpyridine 0.23
    dibutyl ether 0.06
    2,6-dimethyl-4-heptanol 0.12
    DEF 0.62
    dimethyl isosorbide 1.86
    tetrachloroethylene 0.18
    eugenol 0.74
    triacetin 0.23
    span 80 0.57
    1,4-butanediol 0.28
    1,1-dichloroethane 0.03
    2-methyl-1-pentanol 0.07
    methyl formate 1.52
    2-methyl-1-butanol 0.06
    n-decane 0.02
    butyronitrile 0.06
    3,7-dimethyl-1-octanol 0.07
    1-chlorooctane 0.03
    1-chlorotetradecane 0.02
    n-nonane 0.02
    undecane 0.02
    tert-butylcyclohexane 0.03
    cyclooctane 0.03
    cyclopentanol 0.17
    tetrahydropyran 0.12
    tert-amyl methyl ether 0.12
    2,5,8-trioxanonane 1.67
    1-hexene 0.04
    2-isopropoxyethanol 0.33
    2,2,2-trifluoroethanol 1.71
    methyl butyrate 0.18

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction