L-Ascorbic acid 2-glucoside

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  • Identifiers

    CAS number
    129499-78-1

    Molecular formula
    C12H18O11

    SMILES
    C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)OC2=C([C@H](OC2=O)[C@H](CO)O)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 75.72%
    Sweet 34.72%
    Caramellic 27.86%
    Savory 18.92%
    Clean 18.24%
    Milky 17.44%
    Alcoholic 16.41%
    Burnt 16.25%
    Buttery 15.25%
    Cooling 14.22%

     

    Flavor
    Bitter 50.17%
    Odorless 49.59%
    Sweet 37.94%
    Sweet-like 31.87%
    Very mild 30.32%
    Bland 27.22%
    Very slight 21.11%
    Cauliflower 20.89%
    Fenugreek 20.58%
    Cotton candy 20.01%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.1

    pKa est.
    3.94 (weak acid)

    Molecular weight
    338.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    3138°C

    Flash point

    • 290.01 ˚C est.

  • Synonyms

    • ascorbyl glucoside
    • 129499-78-1
    • L-Ascorbic acid 2-glucoside
    • AA2G
    • 2V52R0NHXW
    • DTXSID50926423
    • Brightening
    • skin whitening
    • RefChem:58140
    • GlyTouCan:G32886OM
    • OJW Hydrating Brightening spray
    • DTXCID801765786
    • G32886OM
    • Sandawha Vitamin C Brightening Essence
    • L-Ascorbic acid, 2-O-alpha-D-glucopyranosyl-
    • 603-337-7
    • 2-O-alpha-D-Glucopyranosyl-L-ascorbic acid
    • AA-2G
    • Ascorbic acid 2-O-glucoside
    • MFCD23701380
    • 2-o-a-d-glucopyranosyl-l-ascorbic acid
    • Ascorbic acid 2-glucoside
    • L-Ascorbic acid 2-O-alpha-glucoside
    • L-Ascorbic acid-2-glucoside
    • (R)-5-((S)-1,2-DIHYDROXYETHYL)-4-HYDROXY-3-(((2R,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YL)OXY)FURAN-2(5H)-ONE
    • (2R)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-4-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2h-furan-5-one
    • 2-O-|A-D-Glucopyranosyl-L-ascorbic Acid
    • C12H18O11
    • Ascofresh
    • L-Ascorbicacid2-glucoside
    • UNII-2V52R0NHXW
    • 2-o--d-glucopyranosyl-l-ascorbic acid
    • SCHEMBL37903
    • orb1299155
    • orb3026044
    • SCHEMBL2388533
    • CHEMBL2011961
    • CHEBI:81685
    • HY-N6821R
    • MSK1604
    • L-ascorbic acid 2-O-|A-glucoside
    • EX-A2888
    • HY-N6821
    • s3215
    • AKOS015999708
    • DB11335
    • MG12858
    • DS-17832
    • SY056213
    • DB-365211
    • CS-0100234
    • NS00077720
    • ASCORBIC ACID 2-O-GLUCOSIDE [WHO-DD]
    • C18339
    • F20404
    • 2-O-|A-D-Glucopyranosyl-L-ascorbic Acid (Standard)
    • Q27155554
    • L-ASCORBIC ACID, 2-O-,.ALPHA.-D-GLUCOPYRANOSYL-
    • 2-O-a-D-Glucopyranosyl-L-ascorbic Acid, >=98% (HPLC)
    • Ascorbyl Glucoside, Pharmaceutical Secondary Standard; Certified Reference Material
    • (2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2H-furan-5-one
    • (5R)-5-[(1S)-1,2-Dihydroxyethyl]-4-hydroxy-3-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}furan-2(5H)-one
    • 154160-11-9
    • Pyrido(1,2-a)indol-6(7H)-one, 8,9-dihydro-7-(hydroxy(5-methyl-1H-imidazol-4-yl)methyl)-10-propyl-, (R*,S*)-
    • 129499-78-1

  • Applications

    L-Ascorbic acid 2-glucoside (CAS 129499-78-1) is used as a stabilized vitamin C derivative across several industries. In cosmetics and personal care, it serves as an antioxidant and as a reservoir that releases ascorbic acid under formulation and skin conditions, supporting serums and creams. In food processing and nutraceutical applications, it may function as a stabilized source of ascorbic acid to enhance shelf life and provide vitamin C. In pharmaceuticals, it can be employed as an antioxidant and vitamin C source in topical or oral dosage forms. In polymers and plastics as well as coatings and inks, it can act as an antioxidant stabilizer to reduce oxidative degradation and color fading in formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.07
    methanol 20.64
    isopropanol 2.1
    water 211.76
    ethyl acetate 0.65
    n-propanol 2.2
    acetone 1.72
    n-butanol 1.8
    acetonitrile 1.01
    DMF 118.39
    toluene 0.43
    isobutanol 0.8
    1,4-dioxane 3.84
    methyl acetate 0.74
    THF 3.63
    2-butanone 0.84
    n-pentanol 0.75
    sec-butanol 1.21
    n-hexane 0.08
    ethylene glycol 96.42
    NMP 108.11
    cyclohexane 0.54
    DMSO 403.69
    n-butyl acetate 0.44
    n-octanol 0.89
    chloroform 0.14
    n-propyl acetate 0.33
    acetic acid 28.79
    dichloromethane 0.22
    cyclohexanone 2.65
    propylene glycol 39.2
    isopropyl acetate 0.49
    DMAc 68.08
    2-ethoxyethanol 15.7
    isopentanol 0.96
    n-heptane 0.36
    ethyl formate 1.08
    1,2-dichloroethane 0.37
    n-hexanol 0.99
    2-methoxyethanol 57.19
    isobutyl acetate 0.13
    tetrachloromethane 0.1
    n-pentyl acetate 0.51
    transcutol 21.43
    n-heptanol 1.19
    ethylbenzene 0.18
    MIBK 0.59
    2-propoxyethanol 9.44
    tert-butanol 2.11
    MTBE 0.38
    2-butoxyethanol 6.0
    propionic acid 4.42
    o-xylene 0.61
    formic acid 342.14
    diethyl ether 0.62
    m-xylene 0.43
    p-xylene 0.17
    chlorobenzene 0.1
    dimethyl carbonate 4.63
    n-octane 0.19
    formamide 263.65
    cyclopentanone 3.85
    2-pentanone 1.0
    anisole 0.43
    cyclopentyl methyl ether 2.04
    gamma-butyrolactone 6.45
    1-methoxy-2-propanol 27.69
    pyridine 2.11
    3-pentanone 1.0
    furfural 8.61
    n-dodecane 0.1
    diethylene glycol 40.77
    diisopropyl ether 0.26
    tert-amyl alcohol 1.46
    acetylacetone 2.73
    n-hexadecane 0.11
    acetophenone 0.92
    methyl propionate 1.86
    isopentyl acetate 0.32
    trichloroethylene 0.45
    n-nonanol 0.9
    cyclohexanol 3.09
    benzyl alcohol 1.4
    2-ethylhexanol 0.51
    isooctanol 0.68
    dipropyl ether 0.98
    1,2-dichlorobenzene 0.14
    ethyl lactate 2.88
    propylene carbonate 2.24
    n-methylformamide 38.41
    2-pentanol 1.06
    n-pentane 0.18
    1-propoxy-2-propanol 5.12
    1-methoxy-2-propyl acetate 2.24
    2-(2-methoxypropoxy) propanol 6.59
    mesitylene 0.35
    ε-caprolactone 2.98
    p-cymene 0.29
    epichlorohydrin 2.26
    1,1,1-trichloroethane 0.09
    2-aminoethanol 47.82
    morpholine-4-carbaldehyde 59.58
    sulfolane 45.18
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 1.42
    n-hexyl acetate 0.58
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 9.46
    sec-butyl acetate 0.2
    tert-butyl acetate 0.68
    decalin 0.1
    glycerin 180.35
    diglyme 14.95
    acrylic acid 11.67
    isopropyl myristate 0.31
    n-butyric acid 2.9
    acetyl acetate 0.72
    di(2-ethylhexyl) phthalate 0.59
    ethyl propionate 0.46
    nitromethane 23.39
    1,2-diethoxyethane 1.38
    benzonitrile 0.43
    trioctyl phosphate 0.63
    1-bromopropane 0.16
    gamma-valerolactone 14.3
    n-decanol 0.72
    triethyl phosphate 0.81
    4-methyl-2-pentanol 0.5
    propionitrile 0.52
    vinylene carbonate 2.26
    1,1,2-trichlorotrifluoroethane 18.78
    DMS 1.22
    cumene 0.13
    2-octanol 0.65
    2-hexanone 0.33
    octyl acetate 0.52
    limonene 0.5
    1,2-dimethoxyethane 6.41
    ethyl orthosilicate 0.68
    tributyl phosphate 0.49
    diacetone alcohol 5.03
    N,N-dimethylaniline 0.82
    acrylonitrile 1.44
    aniline 1.42
    1,3-propanediol 29.61
    bromobenzene 0.07
    dibromomethane 0.14
    1,1,2,2-tetrachloroethane 0.59
    2-methyl-cyclohexyl acetate 0.51
    tetrabutyl urea 1.47
    diisobutyl methanol 0.44
    2-phenylethanol 1.29
    styrene 0.15
    dioctyl adipate 0.66
    dimethyl sulfate 19.02
    ethyl butyrate 0.54
    methyl lactate 16.12
    butyl lactate 1.78
    diethyl carbonate 0.43
    propanediol butyl ether 8.87
    triethyl orthoformate 0.87
    p-tert-butyltoluene 0.32
    methyl 4-tert-butylbenzoate 2.4
    morpholine 8.07
    tert-butylamine 0.74
    n-dodecanol 0.57
    dimethoxymethane 17.35
    ethylene carbonate 1.63
    cyrene 13.02
    2-ethoxyethyl acetate 1.19
    2-ethylhexyl acetate 0.25
    1,2,4-trichlorobenzene 0.24
    4-methylpyridine 1.06
    dibutyl ether 0.44
    2,6-dimethyl-4-heptanol 0.44
    DEF 7.08
    dimethyl isosorbide 7.86
    tetrachloroethylene 0.61
    eugenol 3.02
    triacetin 1.89
    span 80 5.73
    1,4-butanediol 9.52
    1,1-dichloroethane 0.1
    2-methyl-1-pentanol 0.43
    methyl formate 15.25
    2-methyl-1-butanol 0.9
    n-decane 0.17
    butyronitrile 0.41
    3,7-dimethyl-1-octanol 0.48
    1-chlorooctane 0.23
    1-chlorotetradecane 0.12
    n-nonane 0.18
    undecane 0.13
    tert-butylcyclohexane 0.04
    cyclooctane 0.34
    cyclopentanol 3.07
    tetrahydropyran 1.49
    tert-amyl methyl ether 0.66
    2,5,8-trioxanonane 13.47
    1-hexene 0.11
    2-isopropoxyethanol 4.54
    2,2,2-trifluoroethanol 24.34
    methyl butyrate 0.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction