Koenidine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    24123-92-0

    Molecular formula
    C20H21NO3

    SMILES
    CC1=CC2=C(C3=C1OC(C=C3)(C)C)NC4=CC(=C(C=C42)OC)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 44.77%
    Sweet 41.66%
    Powdery 40.24%
    Floral 39.66%
    Musk 37.27%
    Phenolic 35.76%
    Spicy 33.77%
    Woody 31.27%
    Vanilla 29.68%
    Animal 26.03%

     

    Flavor
    Bitter 91.05%
    Parsley 20.38%
    Cedarleaf 19.51%
    Eugenol 19.07%
    Very strong 18.91%
    Indole 18.65%
    Ripe apricot 18.63%
    Red fruit 18.48%
    Lovage 18.36%
    Sweet-like 18.22%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.6

    pKa est.
    6.88 (neutral)

    Molecular weight
    323.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    728°C

    Melting point expt.

    • 224 - 225 °C

    Flash point

    • 219.8 ˚C est.

  • Synonyms

    • Koenigicine
    • 24123-92-0
    • Koenidine
    • 8,9-dimethoxy-3,3,5-trimethyl-11H-pyrano[3,2-a]carbazole
    • 8,9-dimethoxy-3,3,5-trimethyl-11H-pyrano(3,2-a)carbazole
    • 13,14-dimethoxy-5,5,8-trimethyl-6-oxa-17-azatetracyclo(8.7.0.0^(2,7).0^(11,16))heptadeca-1,3,7,9,11,13,15-heptaene
    • 13,14-dimethoxy-5,5,8-trimethyl-6-oxa-17-azatetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadeca-1,3,7,9,11,13,15-heptaene
    • RefChem:151358
    • Koenimbidine
    • 8,9-dimethoxy-3,3,5-trimethyl-3,11-dihydropyrano[3,2-a]carbazole
    • CHEMBL3893262
    • NSC 127151
    • Kenimbidine
    • Kenigicine
    • Kenidine
    • NSC127151
    • orb1680565
    • SCHEMBL30929796
    • DTXSID00298965
    • CHEBI:229150
    • ZAA12392
    • BDBM50207383
    • AKOS040763231
    • NSC-127151
    • 3,11-Dihydro-8,9-dimethoxy-3,3,5-trimethylpyrano[3,2-a]carbazole, 9CI
    • 24123-92-0

  • Applications

    Koenidine (CAS 24123-92-0) is primarily used as an intermediate in organic synthesis and as a building block for downstream chemical products in industrial manufacturing. It is commonly evaluated for use as a fragrance odorant or fixative in perfumery, and may appear as an ingredient in specialty coatings and inks. It can serve as a precursor or functional component in polymer/plastics chemistry and as a pharmaceutical intermediate, with use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 15.88
    methanol 12.32
    isopropanol 13.52
    water 0.02
    ethyl acetate 58.86
    n-propanol 16.7
    acetone 75.06
    n-butanol 18.0
    acetonitrile 19.8
    DMF 102.5
    toluene 11.36
    isobutanol 16.34
    1,4-dioxane 86.73
    methyl acetate 67.45
    THF 165.9
    2-butanone 67.34
    n-pentanol 22.63
    sec-butanol 14.36
    n-hexane 2.11
    ethylene glycol 6.3
    NMP 79.17
    cyclohexane 2.11
    DMSO 86.68
    n-butyl acetate 66.65
    n-octanol 24.87
    chloroform 114.84
    n-propyl acetate 75.84
    acetic acid 34.11
    dichloromethane 102.88
    cyclohexanone 82.82
    propylene glycol 6.83
    isopropyl acetate 48.24
    DMAc 148.06
    2-ethoxyethanol 66.31
    isopentanol 23.63
    n-heptane 2.53
    ethyl formate 35.03
    1,2-dichloroethane 62.94
    n-hexanol 30.97
    2-methoxyethanol 61.03
    isobutyl acetate 73.37
    tetrachloromethane 13.27
    n-pentyl acetate 70.96
    transcutol 113.68
    n-heptanol 26.0
    ethylbenzene 13.18
    MIBK 46.42
    2-propoxyethanol 91.89
    tert-butanol 20.34
    MTBE 32.56
    2-butoxyethanol 60.28
    propionic acid 24.77
    o-xylene 10.24
    formic acid 10.48
    diethyl ether 35.03
    m-xylene 11.9
    p-xylene 22.5
    chlorobenzene 28.59
    dimethyl carbonate 46.88
    n-octane 3.02
    formamide 18.02
    cyclopentanone 107.74
    2-pentanone 56.03
    anisole 35.7
    cyclopentyl methyl ether 50.15
    gamma-butyrolactone 118.58
    1-methoxy-2-propanol 49.64
    pyridine 50.36
    3-pentanone 48.81
    furfural 83.08
    n-dodecane 3.35
    diethylene glycol 64.9
    diisopropyl ether 15.34
    tert-amyl alcohol 20.68
    acetylacetone 81.74
    n-hexadecane 3.88
    acetophenone 49.59
    methyl propionate 57.83
    isopentyl acetate 68.83
    trichloroethylene 123.82
    n-nonanol 26.34
    cyclohexanol 21.51
    benzyl alcohol 34.99
    2-ethylhexanol 27.35
    isooctanol 25.52
    dipropyl ether 29.07
    1,2-dichlorobenzene 33.49
    ethyl lactate 36.07
    propylene carbonate 68.0
    n-methylformamide 30.94
    2-pentanol 14.68
    n-pentane 1.43
    1-propoxy-2-propanol 58.14
    1-methoxy-2-propyl acetate 80.39
    2-(2-methoxypropoxy) propanol 56.7
    mesitylene 8.79
    ε-caprolactone 80.25
    p-cymene 14.8
    epichlorohydrin 129.05
    1,1,1-trichloroethane 58.73
    2-aminoethanol 10.63
    morpholine-4-carbaldehyde 118.17
    sulfolane 106.24
    2,2,4-trimethylpentane 2.12
    2-methyltetrahydrofuran 76.54
    n-hexyl acetate 69.78
    isooctane 1.61
    2-(2-butoxyethoxy)ethanol 67.14
    sec-butyl acetate 55.12
    tert-butyl acetate 51.04
    decalin 3.4
    glycerin 16.16
    diglyme 114.0
    acrylic acid 24.54
    isopropyl myristate 31.55
    n-butyric acid 36.39
    acetyl acetate 46.19
    di(2-ethylhexyl) phthalate 35.16
    ethyl propionate 57.89
    nitromethane 77.62
    1,2-diethoxyethane 72.97
    benzonitrile 37.06
    trioctyl phosphate 26.6
    1-bromopropane 31.44
    gamma-valerolactone 142.54
    n-decanol 21.15
    triethyl phosphate 35.85
    4-methyl-2-pentanol 16.01
    propionitrile 24.95
    vinylene carbonate 66.79
    1,1,2-trichlorotrifluoroethane 79.43
    DMS 84.04
    cumene 13.46
    2-octanol 21.93
    2-hexanone 64.92
    octyl acetate 39.43
    limonene 16.66
    1,2-dimethoxyethane 121.33
    ethyl orthosilicate 34.52
    tributyl phosphate 31.75
    diacetone alcohol 50.23
    N,N-dimethylaniline 29.17
    acrylonitrile 30.49
    aniline 19.39
    1,3-propanediol 20.35
    bromobenzene 29.15
    dibromomethane 59.98
    1,1,2,2-tetrachloroethane 94.5
    2-methyl-cyclohexyl acetate 50.77
    tetrabutyl urea 40.92
    diisobutyl methanol 17.5
    2-phenylethanol 44.11
    styrene 13.86
    dioctyl adipate 42.89
    dimethyl sulfate 74.17
    ethyl butyrate 50.57
    methyl lactate 32.46
    butyl lactate 46.52
    diethyl carbonate 39.94
    propanediol butyl ether 41.36
    triethyl orthoformate 42.99
    p-tert-butyltoluene 13.36
    methyl 4-tert-butylbenzoate 50.9
    morpholine 77.57
    tert-butylamine 10.88
    n-dodecanol 16.96
    dimethoxymethane 101.46
    ethylene carbonate 60.22
    cyrene 65.85
    2-ethoxyethyl acetate 103.3
    2-ethylhexyl acetate 61.69
    1,2,4-trichlorobenzene 41.78
    4-methylpyridine 49.31
    dibutyl ether 31.26
    2,6-dimethyl-4-heptanol 17.5
    DEF 63.67
    dimethyl isosorbide 93.32
    tetrachloroethylene 63.4
    eugenol 56.0
    triacetin 77.21
    span 80 42.11
    1,4-butanediol 15.51
    1,1-dichloroethane 50.17
    2-methyl-1-pentanol 28.4
    methyl formate 35.73
    2-methyl-1-butanol 20.14
    n-decane 5.23
    butyronitrile 25.94
    3,7-dimethyl-1-octanol 24.22
    1-chlorooctane 18.25
    1-chlorotetradecane 9.49
    n-nonane 4.44
    undecane 4.09
    tert-butylcyclohexane 3.4
    cyclooctane 1.26
    cyclopentanol 24.0
    tetrahydropyran 54.85
    tert-amyl methyl ether 29.01
    2,5,8-trioxanonane 84.63
    1-hexene 10.07
    2-isopropoxyethanol 61.7
    2,2,2-trifluoroethanol 20.01
    methyl butyrate 69.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction