Khusiol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    66512-56-9

    Molecular formula
    C15H26O

    SMILES
    C[C@H]1CC[C@H]2[C@]13CC[C@@](C2(C)C)([C@@H](C3)O)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 85.85%
    Amber 51.3%
    Dry 49.74%
    Earthy 47.29%
    Cedar 45.85%
    Balsamic 45.28%
    Camphoreous 43.24%
    Spicy 42.78%
    Sandalwood 40.54%
    Vetiver 35.5%

     

    Flavor
    Woody 67.76%
    Camphor 58.36%
    Earthy 53.09%
    Pine 49.73%
    Herbal 48.49%
    Sweet 48.12%
    Balsam 43.92%
    Earth 41.39%
    Dry 38.55%
    Spicy 35.72%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    4.3

    pKa est.
    8.17 (weak base)

    Molecular weight
    222.37 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    317°C

    Flash point

    • 138.51 ˚C est.

  • Synonyms

    • Khusiol
    • SCHEMBL5066801
    • DTXSID801377749
    • (1S,2S,5S,7S,8R)-2,6,6,7-tetramethyltricyclo[5.2.2.01,5]undecan-8-ol
    • 66512-56-9
    • 66512-56-9

  • Applications

    Khusiol (CAS 66512-56-9) is used primarily as a fragrance ingredient in perfumery and cosmetics, functioning as an odorant and, in some formulations, as a fixative to help retain fragrance. It may also appear in household products and cleaning formulations as a fragrance component. In industrial manufacturing, it can serve as a processing aid or specialty additive in coatings and inks, and as an intermediate in organic synthesis under appropriate regulatory controls. Its use is formulation- and regulation-dependent and must comply with local guidelines.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 159.61
    methanol 179.99
    isopropanol 155.92
    water 3.64
    ethyl acetate 139.52
    n-propanol 152.29
    acetone 222.06
    n-butanol 139.49
    acetonitrile 184.99
    DMF 316.9
    toluene 164.38
    isobutanol 97.48
    1,4-dioxane 427.36
    methyl acetate 137.35
    THF 823.72
    2-butanone 154.18
    n-pentanol 57.72
    sec-butanol 71.58
    n-hexane 9.12
    ethylene glycol 37.85
    NMP 157.61
    cyclohexane 26.23
    DMSO 155.99
    n-butyl acetate 131.94
    n-octanol 62.68
    chloroform 380.49
    n-propyl acetate 78.5
    acetic acid 73.02
    dichloromethane 283.75
    cyclohexanone 243.26
    propylene glycol 42.77
    isopropyl acetate 118.03
    DMAc 133.69
    2-ethoxyethanol 100.24
    isopentanol 93.6
    n-heptane 16.55
    ethyl formate 116.8
    1,2-dichloroethane 175.51
    n-hexanol 124.14
    2-methoxyethanol 241.22
    isobutyl acetate 66.74
    tetrachloromethane 102.59
    n-pentyl acetate 93.82
    transcutol 196.69
    n-heptanol 82.5
    ethylbenzene 69.7
    MIBK 115.12
    2-propoxyethanol 240.0
    tert-butanol 146.83
    MTBE 114.55
    2-butoxyethanol 134.5
    propionic acid 71.53
    o-xylene 94.33
    formic acid 40.86
    diethyl ether 154.33
    m-xylene 130.62
    p-xylene 95.02
    chlorobenzene 141.85
    dimethyl carbonate 84.2
    n-octane 8.54
    formamide 84.6
    cyclopentanone 384.81
    2-pentanone 151.41
    anisole 113.64
    cyclopentyl methyl ether 208.7
    gamma-butyrolactone 362.77
    1-methoxy-2-propanol 211.85
    pyridine 271.63
    3-pentanone 107.03
    furfural 244.04
    n-dodecane 6.15
    diethylene glycol 158.24
    diisopropyl ether 58.94
    tert-amyl alcohol 66.66
    acetylacetone 174.84
    n-hexadecane 7.4
    acetophenone 99.64
    methyl propionate 122.49
    isopentyl acetate 121.45
    trichloroethylene 281.27
    n-nonanol 59.82
    cyclohexanol 95.88
    benzyl alcohol 83.15
    2-ethylhexanol 66.65
    isooctanol 60.29
    dipropyl ether 102.28
    1,2-dichlorobenzene 127.1
    ethyl lactate 51.78
    propylene carbonate 153.79
    n-methylformamide 183.56
    2-pentanol 75.1
    n-pentane 15.83
    1-propoxy-2-propanol 173.18
    1-methoxy-2-propyl acetate 167.35
    2-(2-methoxypropoxy) propanol 92.34
    mesitylene 88.82
    ε-caprolactone 182.17
    p-cymene 62.25
    epichlorohydrin 337.71
    1,1,1-trichloroethane 189.08
    2-aminoethanol 78.44
    morpholine-4-carbaldehyde 239.24
    sulfolane 253.47
    2,2,4-trimethylpentane 8.9
    2-methyltetrahydrofuran 268.6
    n-hexyl acetate 107.18
    isooctane 11.84
    2-(2-butoxyethoxy)ethanol 124.45
    sec-butyl acetate 61.66
    tert-butyl acetate 127.2
    decalin 14.6
    glycerin 69.39
    diglyme 247.57
    acrylic acid 62.49
    isopropyl myristate 51.67
    n-butyric acid 124.85
    acetyl acetate 103.92
    di(2-ethylhexyl) phthalate 48.92
    ethyl propionate 81.81
    nitromethane 205.63
    1,2-diethoxyethane 120.01
    benzonitrile 142.67
    trioctyl phosphate 43.59
    1-bromopropane 112.11
    gamma-valerolactone 402.57
    n-decanol 44.29
    triethyl phosphate 49.01
    4-methyl-2-pentanol 60.6
    propionitrile 180.43
    vinylene carbonate 168.28
    1,1,2-trichlorotrifluoroethane 146.7
    DMS 97.08
    cumene 54.67
    2-octanol 50.93
    2-hexanone 79.49
    octyl acetate 59.28
    limonene 66.39
    1,2-dimethoxyethane 205.93
    ethyl orthosilicate 50.62
    tributyl phosphate 43.41
    diacetone alcohol 123.27
    N,N-dimethylaniline 79.0
    acrylonitrile 204.67
    aniline 132.27
    1,3-propanediol 133.66
    bromobenzene 155.61
    dibromomethane 184.8
    1,1,2,2-tetrachloroethane 207.66
    2-methyl-cyclohexyl acetate 80.27
    tetrabutyl urea 54.36
    diisobutyl methanol 54.77
    2-phenylethanol 126.91
    styrene 72.32
    dioctyl adipate 57.76
    dimethyl sulfate 105.27
    ethyl butyrate 89.34
    methyl lactate 72.29
    butyl lactate 76.49
    diethyl carbonate 60.14
    propanediol butyl ether 90.95
    triethyl orthoformate 75.3
    p-tert-butyltoluene 66.26
    methyl 4-tert-butylbenzoate 115.31
    morpholine 368.93
    tert-butylamine 100.06
    n-dodecanol 32.25
    dimethoxymethane 309.44
    ethylene carbonate 148.54
    cyrene 86.47
    2-ethoxyethyl acetate 127.01
    2-ethylhexyl acetate 94.16
    1,2,4-trichlorobenzene 130.94
    4-methylpyridine 226.49
    dibutyl ether 62.9
    2,6-dimethyl-4-heptanol 54.77
    DEF 114.41
    dimethyl isosorbide 173.79
    tetrachloroethylene 166.65
    eugenol 104.21
    triacetin 90.51
    span 80 83.44
    1,4-butanediol 38.26
    1,1-dichloroethane 182.63
    2-methyl-1-pentanol 42.71
    methyl formate 151.27
    2-methyl-1-butanol 68.91
    n-decane 12.06
    butyronitrile 178.27
    3,7-dimethyl-1-octanol 55.76
    1-chlorooctane 42.03
    1-chlorotetradecane 16.48
    n-nonane 10.23
    undecane 8.36
    tert-butylcyclohexane 14.68
    cyclooctane 12.51
    cyclopentanol 127.19
    tetrahydropyran 311.23
    tert-amyl methyl ether 68.39
    2,5,8-trioxanonane 144.24
    1-hexene 31.14
    2-isopropoxyethanol 75.85
    2,2,2-trifluoroethanol 58.74
    methyl butyrate 90.63

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction