Kaempferitrin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    482-38-2

    Molecular formula
    C27H30O14

    SMILES
    C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=CC(=C3C(=C2)OC(=C(C3=O)O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O)O)O)C5=CC=C(C=C5)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 74.82%
    Vanilla 32.29%
    Phenolic 27.36%
    Sweet 24.5%
    Milky 22.61%
    Savory 21.98%
    Burnt 21.68%
    Smoky 19.8%
    Creamy 19.64%
    Bitter 18.58%

     

    Flavor
    Bitter 76.6%
    Bland 32.23%
    Odorless 31.88%
    Sweet-like 26.92%
    Cedarleaf 20.37%
    Parsley 19.53%
    Eugenol 19.47%
    Very mild 19.19%
    Lovage 19.12%
    Very slight 19.05%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -0.1

    pKa est.
    7.95 (neutral)

    Molecular weight
    578.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    4937°C

    Melting point expt.

    • 202 - 203 °C

    Flash point

    • 287.35 ˚C est.

  • Synonyms

    • Kaempferitrin
    • 482-38-2
    • Lespenefril
    • Kaempferol 3,7-dirhamnoside
    • lespenephril
    • Kaempferol 3,7-bisrhamnoside
    • Kaempferol-dirhamnoside
    • VPV01U3R59
    • 3,7-Bis((6-deoxy-alpha-L-mannopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
    • 4H-1-Benzopyran-4-one, 3,7-bis((6-deoxy-alpha-L-mannopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-
    • 5-hydroxy-2-(4-hydroxyphenyl)-3,7-bis[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy]chromen-4-one
    • DTXSID90197458
    • 3,7-bis-(alpha-6-deoxymannopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
    • 5-hydroxy-2-(4-hydroxyphenyl)-3,7-bis(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxy)chromen-4-one
    • RefChem:40778
    • DTXCID00119949
    • Lespedin
    • Lespenephryl
    • grosvenorine II
    • MFCD21333499
    • kaempferol-3,7-O-alpha-L-dirhamnoside
    • CHEMBL251766
    • 5-Hydroxy-2-(4-hydroxyphenyl)-3,7-bis(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
    • BRN 0073958
    • UNII-VPV01U3R59
    • Karempferitrin
    • Kaempferol 3,7-di-O-rhamnoside
    • KAEMFERITRIN
    • kaempferol dirhamnoside
    • Kaempferitrin (Standard)
    • LESPEDIN [WHO-DD]
    • kaempferol-3,7-dirhamnoside
    • kaempferol-3,7-di rhamoside
    • 4-18-00-03292 (Beilstein Handbook Reference)
    • kaempferol-3,7-di-rhamnoside
    • SCHEMBL571402
    • MEGxp0_000567
    • orb1304250
    • kaempferol-3,7-di-O-rhamnoside
    • SCHEMBL29391430
    • ACon1_000073
    • CHEBI:68883
    • GTPL13277
    • HY-N0628R
    • Kaempferitrin, >=97% (NMR)
    • WLZ4651
    • HY-N0628
    • BDBM50331856
    • s9112
    • AKOS032962036
    • kaempferol-3-O-rhamnose-7-O-rhamnose
    • CCG-270118
    • EBC-615549
    • kaempferol-3,7-O-(alpha)-dirhamnoside
    • kaempferol 3,7-di-O-alpha-L-rhamnoside
    • NCGC00168820-01
    • 5-hydroxy-2-(4-hydroxyphenyl)-3,7-bis({[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy})-4H-chromen-4-one
    • 5-hydroxy-2-(4-hydroxyphenyl)-3,7-bis[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy]chromen-4-one
    • AC-34729
    • AS-56461
    • KAEMPFEROL 3,7-DIRHAMNOSIDE [MI]
    • kaempferol-3,7-bis-O-alpha-L-rhamnoside
    • SY075828
    • XK161839
    • DB-326537
    • CS-0009620
    • kaempferol-3,7-O-alpha-L-dirhamnopyranoside
    • kaempferol-3,7-di-O-alpha-L-rhamnopyranoside
    • C16981
    • 3,4',5,7-Tetrahydroxyflavone 3,7-dirham noside
    • Q6345965
    • BRD-K45884135-001-01-5
    • kaempferol-3-O-alpha-L-rhamnopyranoside-7-O-alpha-L-rhamnopyranoside
    • 3,7-Bis[(6-Deoxy-?-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
    • 3,7-Bis[(6-deoxy-|A-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
    • 3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl 6-deoxy-alpha-L-mannopyranoside
    • 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 6-deoxy-alpha-L-mannopyranoside
    • 4H-1-BENZOPYRAN-4-ONE, 3,7-BIS((6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)OXY)-5-HYDROXY-2-(4-HYDROXYPHENYL)-
    • 482-38-2

  • Applications

    Kaempferitrin (CAS 482-38-2) is a natural flavonoid glycoside isolated from a range of plants and is primarily explored in natural product research and cosmetic applications. In cosmetics and personal care, it is considered a natural antioxidant ingredient with potential to improve oxidative stability in formulations and to act as an active component in skin care products. In pharmaceutical research, Kaempferitrin is evaluated as a bioactive compound with reported activities such as anti-inflammatory and antimicrobial effects, and is often used as a lead compound or reference standard in assay systems. In food processing and nutraceutical contexts, it can be evaluated as a plant-derived constituent contributing antioxidant activity in extracts and discussed for nutraceutical or functional food applications. In agricultural and plant science, Kaempferitrin is studied as a bioactive constituent associated with plant defense and secondary metabolism. In polymers and coatings, flavonoids like Kaempferitrin are sometimes evaluated as natural antioxidants or stabilizers for polymer materials and as additives for coatings, potentially extending material longevity.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.72
    methanol 7.17
    isopropanol 1.25
    water 0.06
    ethyl acetate 0.14
    n-propanol 3.05
    acetone 0.82
    n-butanol 1.22
    acetonitrile 0.13
    DMF 11.65
    toluene 0.05
    isobutanol 0.75
    1,4-dioxane 3.93
    methyl acetate 0.47
    THF 7.0
    2-butanone 1.2
    n-pentanol 0.64
    sec-butanol 1.32
    n-hexane 0.01
    ethylene glycol 6.93
    NMP 16.28
    cyclohexane 0.01
    DMSO 26.79
    n-butyl acetate 0.11
    n-octanol 0.4
    chloroform 0.1
    n-propyl acetate 0.12
    acetic acid 7.15
    dichloromethane 0.14
    cyclohexanone 1.53
    propylene glycol 10.08
    isopropyl acetate 0.08
    DMAc 14.68
    2-ethoxyethanol 7.21
    isopentanol 0.43
    n-heptane 0.01
    ethyl formate 0.45
    1,2-dichloroethane 0.15
    n-hexanol 0.25
    2-methoxyethanol 21.89
    isobutyl acetate 0.05
    tetrachloromethane 0.02
    n-pentyl acetate 0.32
    transcutol 9.27
    n-heptanol 0.44
    ethylbenzene 0.02
    MIBK 0.13
    2-propoxyethanol 3.58
    tert-butanol 0.44
    MTBE 0.16
    2-butoxyethanol 3.23
    propionic acid 2.25
    o-xylene 0.04
    formic acid 13.23
    diethyl ether 0.27
    m-xylene 0.02
    p-xylene 0.02
    chlorobenzene 0.02
    dimethyl carbonate 0.49
    n-octane 0.01
    formamide 10.35
    cyclopentanone 3.07
    2-pentanone 0.41
    anisole 0.09
    cyclopentyl methyl ether 0.48
    gamma-butyrolactone 3.51
    1-methoxy-2-propanol 8.78
    pyridine 1.2
    3-pentanone 0.31
    furfural 3.04
    n-dodecane 0.01
    diethylene glycol 6.1
    diisopropyl ether 0.02
    tert-amyl alcohol 0.6
    acetylacetone 0.47
    n-hexadecane 0.01
    acetophenone 0.16
    methyl propionate 0.48
    isopentyl acetate 0.09
    trichloroethylene 0.24
    n-nonanol 0.42
    cyclohexanol 0.62
    benzyl alcohol 0.38
    2-ethylhexanol 0.09
    isooctanol 0.23
    dipropyl ether 0.15
    1,2-dichlorobenzene 0.02
    ethyl lactate 0.52
    propylene carbonate 0.56
    n-methylformamide 6.06
    2-pentanol 0.36
    n-pentane 0.01
    1-propoxy-2-propanol 1.77
    1-methoxy-2-propyl acetate 0.46
    2-(2-methoxypropoxy) propanol 2.31
    mesitylene 0.01
    ε-caprolactone 1.57
    p-cymene 0.02
    epichlorohydrin 2.99
    1,1,1-trichloroethane 0.03
    2-aminoethanol 9.01
    morpholine-4-carbaldehyde 15.49
    sulfolane 10.72
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 1.33
    n-hexyl acetate 0.38
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 4.13
    sec-butyl acetate 0.06
    tert-butyl acetate 0.1
    decalin 0.0
    glycerin 22.51
    diglyme 5.86
    acrylic acid 3.46
    isopropyl myristate 0.09
    n-butyric acid 1.17
    acetyl acetate 0.08
    di(2-ethylhexyl) phthalate 0.22
    ethyl propionate 0.1
    nitromethane 4.32
    1,2-diethoxyethane 0.68
    benzonitrile 0.08
    trioctyl phosphate 0.19
    1-bromopropane 0.07
    gamma-valerolactone 13.58
    n-decanol 0.25
    triethyl phosphate 0.1
    4-methyl-2-pentanol 0.1
    propionitrile 0.18
    vinylene carbonate 0.55
    1,1,2-trichlorotrifluoroethane 7.73
    DMS 0.28
    cumene 0.01
    2-octanol 0.22
    2-hexanone 0.25
    octyl acetate 0.24
    limonene 0.03
    1,2-dimethoxyethane 3.99
    ethyl orthosilicate 0.09
    tributyl phosphate 0.14
    diacetone alcohol 1.02
    N,N-dimethylaniline 0.08
    acrylonitrile 0.35
    aniline 0.28
    1,3-propanediol 8.74
    bromobenzene 0.01
    dibromomethane 0.07
    1,1,2,2-tetrachloroethane 0.28
    2-methyl-cyclohexyl acetate 0.1
    tetrabutyl urea 0.37
    diisobutyl methanol 0.05
    2-phenylethanol 0.2
    styrene 0.02
    dioctyl adipate 0.26
    dimethyl sulfate 1.42
    ethyl butyrate 0.1
    methyl lactate 2.5
    butyl lactate 0.88
    diethyl carbonate 0.06
    propanediol butyl ether 4.41
    triethyl orthoformate 0.17
    p-tert-butyltoluene 0.02
    methyl 4-tert-butylbenzoate 0.52
    morpholine 9.53
    tert-butylamine 0.1
    n-dodecanol 0.14
    dimethoxymethane 4.02
    ethylene carbonate 0.39
    cyrene 3.14
    2-ethoxyethyl acetate 0.85
    2-ethylhexyl acetate 0.07
    1,2,4-trichlorobenzene 0.04
    4-methylpyridine 0.37
    dibutyl ether 0.15
    2,6-dimethyl-4-heptanol 0.05
    DEF 1.18
    dimethyl isosorbide 1.91
    tetrachloroethylene 0.2
    eugenol 0.73
    triacetin 0.68
    span 80 2.4
    1,4-butanediol 2.37
    1,1-dichloroethane 0.05
    2-methyl-1-pentanol 0.3
    methyl formate 3.15
    2-methyl-1-butanol 0.64
    n-decane 0.01
    butyronitrile 0.13
    3,7-dimethyl-1-octanol 0.16
    1-chlorooctane 0.05
    1-chlorotetradecane 0.02
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.0
    cyclooctane 0.01
    cyclopentanol 1.53
    tetrahydropyran 1.19
    tert-amyl methyl ether 0.2
    2,5,8-trioxanonane 4.07
    1-hexene 0.02
    2-isopropoxyethanol 1.99
    2,2,2-trifluoroethanol 2.0
    methyl butyrate 0.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction