Isopropyl methoxycinnamate

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  • Identifiers

    CAS number
    53484-51-8

    Molecular formula
    C13H16O3

    SMILES
    CC(C)OC(=O)/C=C/C1=CC=C(C=C1)OC

    Safety labels

  • Odor profile

    Fragrance
    Fruity 85.36%
    Sweet 79.04%
    Balsamic 61.77%
    Floral 57.47%
    Spicy 50.55%
    Berry 45.64%
    Cherry 41.62%
    Powdery 38.48%
    Herbal 36.4%
    Tropical 34.27%

     

    Flavor
    Fruity 58.02%
    Sweet 52.28%
    Floral 48.94%
    Balsam 29.52%
    Grape 29.15%
    Powdery 28.48%
    Berry 25.7%
    Bitter 25.32%
    Strawberry 22.99%
    Wintergreen 22.67%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.0

    pKa est.
    7.23 (neutral)

    Molecular weight
    220.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    307°C

    Flash point

    • 138.21 ˚C est.

  • Synonyms

    • isopropyl methoxycinnamate
    • Isopropyl (E)-p-methoxycinnamate
    • 53484-51-8
    • 9836DH83NI
    • EINECS 258-581-3
    • NSC-406320
    • AI3-02425
    • 2-Propenoic acid, 3-(4-methoxyphenyl)-, 1-methylethyl ester, (E)-
    • AEC ISOPROPYL METHOXYCINNAMATE
    • NSC 406320
    • ISOPROPYL TRANS-4-METHOXYCINNAMATE
    • CINNAMIC ACID, P-METHOXY-, ISOPROPYL ESTER
    • 2-Propenoic acid, 3-(4-methoxyphenyl)-, 1-methylethyl ester, (2E)-
    • (2E)-3-(4-METHOXYPHENYL)-2-PROPENOIC ACID 1-METHYLETHYL ESTER
    • RefChem:792185
    • ISOPROPYL METHOXYCINNAMATE [INCI]
    • 258-581-3
    • Isopropyl p-methoxycinnamate
    • 5466-76-2
    • propan-2-yl (E)-3-(4-methoxyphenyl)prop-2-enoate
    • UNII-9836DH83NI
    • propan-2-yl 3-(4-methoxyphenyl)prop-2-enoate
    • EINECS 226-774-1
    • NSC 26464
    • SCHEMBL342878
    • propan-2-yl (2E)-3-(4-methoxyphenyl)prop-2-enoate
    • SCHEMBL8696404
    • XATKDVHSLQMHSY-RMKNXTFCSA-N
    • DTXSID501223006
    • NSC26464
    • NSC-26464
    • NSC406320
    • DB-297679
    • NS00013788
    • 1-Methylethyl (2E)-3-(4-methoxyphenyl)-2-propenoate
    • Q27272075
    • 5466-76-2

  • Applications

    Isopropyl methoxycinnamate (CAS 53484-51-8) is primarily used as a UV filter in cosmetics and personal care products, notably in sunscreens, creams, foundations, and lip products. It is also employed as a photostabilizer for polymers, coatings, and adhesives to mitigate UV-induced degradation. The ester can be used as an additive in plastic packaging materials to impart UV protection. It may serve as a synthetic intermediate for other cinnamate-based UV absorbers. In topical formulations, it can help improve the photostability of light-sensitive active ingredients.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 194.48
    methanol 223.89
    isopropanol 116.59
    water 0.4
    ethyl acetate 183.79
    n-propanol 107.08
    acetone 198.65
    n-butanol 90.7
    acetonitrile 145.89
    DMF 261.61
    toluene 63.74
    isobutanol 67.6
    1,4-dioxane 380.43
    methyl acetate 160.92
    THF 414.66
    2-butanone 122.94
    n-pentanol 73.98
    sec-butanol 82.94
    n-hexane 6.53
    ethylene glycol 49.59
    NMP 198.11
    cyclohexane 9.33
    DMSO 348.58
    n-butyl acetate 95.42
    n-octanol 29.63
    chloroform 531.06
    n-propyl acetate 80.12
    acetic acid 218.15
    dichloromethane 526.39
    cyclohexanone 171.41
    propylene glycol 79.26
    isopropyl acetate 94.01
    DMAc 357.3
    2-ethoxyethanol 202.21
    isopentanol 76.64
    n-heptane 4.35
    ethyl formate 75.8
    1,2-dichloroethane 287.64
    n-hexanol 63.51
    2-methoxyethanol 324.5
    isobutyl acetate 59.94
    tetrachloromethane 29.8
    n-pentyl acetate 42.1
    transcutol 551.89
    n-heptanol 25.88
    ethylbenzene 38.4
    MIBK 73.31
    2-propoxyethanol 171.91
    tert-butanol 175.35
    MTBE 127.12
    2-butoxyethanol 70.67
    propionic acid 103.0
    o-xylene 42.38
    formic acid 79.4
    diethyl ether 146.82
    m-xylene 46.86
    p-xylene 50.88
    chlorobenzene 105.12
    dimethyl carbonate 76.47
    n-octane 2.83
    formamide 125.94
    cyclopentanone 192.84
    2-pentanone 101.71
    anisole 113.25
    cyclopentyl methyl ether 130.54
    gamma-butyrolactone 248.6
    1-methoxy-2-propanol 202.54
    pyridine 183.56
    3-pentanone 86.56
    furfural 217.19
    n-dodecane 3.81
    diethylene glycol 176.26
    diisopropyl ether 33.67
    tert-amyl alcohol 107.92
    acetylacetone 173.98
    n-hexadecane 4.3
    acetophenone 98.58
    methyl propionate 126.11
    isopentyl acetate 93.8
    trichloroethylene 484.5
    n-nonanol 29.89
    cyclohexanol 84.15
    benzyl alcohol 91.0
    2-ethylhexanol 40.59
    isooctanol 23.43
    dipropyl ether 54.51
    1,2-dichlorobenzene 99.41
    ethyl lactate 56.31
    propylene carbonate 134.0
    n-methylformamide 101.96
    2-pentanol 56.13
    n-pentane 4.22
    1-propoxy-2-propanol 103.94
    1-methoxy-2-propyl acetate 126.41
    2-(2-methoxypropoxy) propanol 120.7
    mesitylene 28.83
    ε-caprolactone 160.12
    p-cymene 25.64
    epichlorohydrin 352.13
    1,1,1-trichloroethane 194.38
    2-aminoethanol 90.8
    morpholine-4-carbaldehyde 286.84
    sulfolane 274.0
    2,2,4-trimethylpentane 6.01
    2-methyltetrahydrofuran 221.27
    n-hexyl acetate 69.79
    isooctane 4.26
    2-(2-butoxyethoxy)ethanol 142.8
    sec-butyl acetate 63.54
    tert-butyl acetate 110.93
    decalin 10.6
    glycerin 114.93
    diglyme 263.63
    acrylic acid 91.36
    isopropyl myristate 36.14
    n-butyric acid 126.05
    acetyl acetate 134.77
    di(2-ethylhexyl) phthalate 42.11
    ethyl propionate 83.92
    nitromethane 311.66
    1,2-diethoxyethane 161.04
    benzonitrile 88.76
    trioctyl phosphate 24.66
    1-bromopropane 120.54
    gamma-valerolactone 289.41
    n-decanol 24.1
    triethyl phosphate 53.94
    4-methyl-2-pentanol 36.32
    propionitrile 90.87
    vinylene carbonate 125.41
    1,1,2-trichlorotrifluoroethane 224.11
    DMS 103.87
    cumene 29.53
    2-octanol 19.57
    2-hexanone 73.72
    octyl acetate 41.92
    limonene 35.69
    1,2-dimethoxyethane 289.26
    ethyl orthosilicate 53.23
    tributyl phosphate 39.38
    diacetone alcohol 120.18
    N,N-dimethylaniline 74.92
    acrylonitrile 113.81
    aniline 95.63
    1,3-propanediol 138.34
    bromobenzene 110.39
    dibromomethane 286.45
    1,1,2,2-tetrachloroethane 392.37
    2-methyl-cyclohexyl acetate 77.14
    tetrabutyl urea 51.14
    diisobutyl methanol 29.29
    2-phenylethanol 78.05
    styrene 50.88
    dioctyl adipate 61.9
    dimethyl sulfate 121.98
    ethyl butyrate 75.3
    methyl lactate 74.8
    butyl lactate 44.65
    diethyl carbonate 69.07
    propanediol butyl ether 67.18
    triethyl orthoformate 67.97
    p-tert-butyltoluene 26.08
    methyl 4-tert-butylbenzoate 80.69
    morpholine 385.67
    tert-butylamine 85.59
    n-dodecanol 20.34
    dimethoxymethane 239.16
    ethylene carbonate 108.75
    cyrene 111.1
    2-ethoxyethyl acetate 89.2
    2-ethylhexyl acetate 73.77
    1,2,4-trichlorobenzene 118.1
    4-methylpyridine 159.15
    dibutyl ether 53.4
    2,6-dimethyl-4-heptanol 29.29
    DEF 129.87
    dimethyl isosorbide 197.85
    tetrachloroethylene 198.75
    eugenol 84.28
    triacetin 103.79
    span 80 79.87
    1,4-butanediol 54.8
    1,1-dichloroethane 231.2
    2-methyl-1-pentanol 69.81
    methyl formate 86.27
    2-methyl-1-butanol 66.82
    n-decane 5.45
    butyronitrile 90.16
    3,7-dimethyl-1-octanol 36.86
    1-chlorooctane 23.93
    1-chlorotetradecane 12.9
    n-nonane 4.64
    undecane 4.44
    tert-butylcyclohexane 10.19
    cyclooctane 3.16
    cyclopentanol 86.6
    tetrahydropyran 229.84
    tert-amyl methyl ether 88.09
    2,5,8-trioxanonane 221.69
    1-hexene 30.99
    2-isopropoxyethanol 119.67
    2,2,2-trifluoroethanol 71.69
    methyl butyrate 99.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction