Iodoquinol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    83-73-8

    Molecular formula
    C9H5I2NO

    SMILES
    C1=CC2=C(C(=C(C=C2I)I)O)N=C1

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 45.54%
    Burnt 38.24%
    Phenolic 37.28%
    Smoky 25.06%
    Meaty 23.79%
    Animal 22.72%
    Savory 21.59%
    Bitter 20.19%
    Roasted 19.81%
    Fruity 19.45%

     

    Flavor
    Bitter 87.78%
    Odorless 31.19%
    Mild 23.33%
    Very strong 21.64%
    Sweet-like 21.12%
    Indole 21.01%
    Nitrile 20.27%
    Scallion 19.87%
    Rotten 19.86%
    Bread crust 19.8%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.1

    pKa est.
    4.86 (weak acid)

    Molecular weight
    396.95 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    516°C

    Melting point expt.

    • MP 200-215 °C WITH EXTENSIVE DECOMP

    Flash point

    • 183.08 ˚C est.

    Solubility expt.

    • ALMOST INSOL IN WATER; SPARINGLY SOL IN ALCOHOL, ETHER, ACETONE; SOL IN HOT PYRIDINE & HOT DIOXANE

  • Synonyms

    • iodoquinol
    • 83-73-8
    • Diiodohydroxyquinoline
    • 5,7-diiodoquinolin-8-ol
    • 5,7-Diiodo-8-hydroxyquinoline
    • 5,7-Diiodo-8-quinolinol
    • Diiodoquin
    • Diodoquin
    • Yodoxin
    • Lanodoxin
    • Searlequin
    • Ioquin
    • Zoaquin
    • DIIODOHYDROXYQUIN
    • Quinadome
    • 8-Quinolinol, 5,7-diiodo-
    • Diamoebin
    • Diodoquine
    • Diodoxylin
    • Direxiode
    • Embequin
    • Enterosept
    • Floraquin
    • Fluoraquin
    • Moebiquin
    • Sebaquin
    • Dyodin
    • Diodohydroxyquin
    • Dijodoxichinoline
    • Enterodiamoebin
    • Dinoleine
    • Disoquin
    • Rafamebin
    • Di-quinol
    • Stanquinate
    • 8-Hydroxy-5,7-diiodoquinoline
    • 5,7-Diiodo-oxine
    • Ioquin suspension
    • Diiodohidroxiquinoleina
    • Diiodohydroxyquinoleine
    • Dijodoxichinolinum
    • 5,7-Diodo-8-quinolinol
    • Diiodohydroxyquinolinum
    • Diodoxyquinoleine
    • Diiodoidrossichinolina
    • Iodoquinol [USAN]
    • Panaquin
    • Enterodiamoebine
    • SS 578
    • NSC 8704
    • NSC-8704
    • Diiodohydroxyquinoline [INN]
    • Yodoxin (TN)
    • CHEBI:5950
    • DTXSID6023155
    • 63W7IE88K8
    • IODOQUINOL [MI]
    • 5,7-Diiod-8-chinolinol [IUPAC]
    • IODOQUINOL [HSDB]
    • SS-578
    • IODOQUINOL [USP-RS]
    • Diiodohydroxyquinoline (INN)
    • MLS000069404
    • DI-IODOHYDROXY QUINOLINE
    • DTXCID003155
    • UXZFQZANDVDGMM-UHFFFAOYSA-
    • IODOQUINOL [USP IMPURITY]
    • NSC8704
    • IODOQUINOL [USP MONOGRAPH]
    • MMV002817
    • DIIODOHYDROXYQUINOLINE [MART.]
    • DIIODOHYDROXYQUINOLINE [WHO-DD]
    • NCGC00018098-04
    • SMR000059090
    • C9H5I2NO
    • Diodoxyquinoline
    • IODOQUINOL (USP-RS)
    • Caswell No. 354
    • diiodoquinol
    • IODOQUINOL (USP IMPURITY)
    • IODOQUINOL (USP MONOGRAPH)
    • Iodoquinol;5,7-Diiodo-8-hydroxyquinoline;5,7-Diiodo-8-quinolinol
    • DIIODOHYDROXYQUINOLINE (MART.)
    • CAS-83-73-8
    • Diiodoidrossichinolina [DCIT]
    • HSDB 3224
    • SR-01000002969
    • Diiodohydroxyquinolinum [INN-Latin]
    • Iodoquinol [USAN:USP]
    • Diiodohydroxyquinoleine [INN-French]
    • EINECS 201-497-9
    • MFCD00006789
    • 5,7-Diiod-8-chinolinol
    • Diiodohidroxiquinoleina [INN-Spanish]
    • EPA Pesticide Chemical Code 024003
    • BRN 0153639
    • Searlewuin
    • Meobiquin
    • UNII-63W7IE88K8
    • AI3-16443
    • 5,7-Diiodooxine
    • component of Vytone
    • Iodoquinol (USP)
    • di-iodohyroxyquinoline
    • di-iodohydroxyquinoline
    • diyodohidroxiquinoleAna
    • Spectrum_000943
    • 8-Quinolinol,7-diiodo-
    • Spectrum2_001041
    • Spectrum3_000470
    • Spectrum4_000020
    • Spectrum5_000872
    • 4,7-Diiodo-8-quinolinol
    • bmse000836
    • EC 201-497-9
    • cid_3728
    • SCHEMBL3460
    • BSPBio_002180
    • CBDivE_011080
    • KBioGR_000399
    • KBioSS_001423
    • ksc-8-193
    • CHEMBL86754
    • DivK1c_000119
    • SPECTRUM1500353
    • SPBio_000962
    • 5,7-bis(iodanyl)quinolin-8-ol
    • BDBM66035

  • Applications

    Iodoquinol (CAS 83-73-8) is primarily used as a pharmaceutical agent, specifically as a luminal antiprotozoal active pharmaceutical ingredient. In pharmaceutical practice it serves as an active ingredient in oral formulations intended for luminal antiprotozoal activity and is commonly used in combination regimens with other antiprotozoals such as metronidazole. Beyond formulation development, it is encountered in research and analytical contexts as a reference compound for the study of iodinated heterocycles and related analytical methods for iodinated phenolics. Its use is subject to pharmaceutical regulations and formulation specifications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.82
    methanol 0.49
    isopropanol 0.59
    water 0.0
    ethyl acetate 3.11
    n-propanol 0.91
    acetone 2.41
    n-butanol 0.87
    acetonitrile 1.13
    DMF 14.72
    toluene 3.76
    isobutanol 0.95
    1,4-dioxane 12.49
    methyl acetate 3.1
    THF 23.82
    2-butanone 3.15
    n-pentanol 2.42
    sec-butanol 0.96
    n-hexane 0.64
    ethylene glycol 0.45
    NMP 20.56
    cyclohexane 0.44
    DMSO 3.96
    n-butyl acetate 11.12
    n-octanol 7.09
    chloroform 5.67
    n-propyl acetate 7.7
    acetic acid 1.97
    dichloromethane 5.86
    cyclohexanone 7.7
    propylene glycol 0.44
    isopropyl acetate 4.06
    DMAc 14.65
    2-ethoxyethanol 7.49
    isopentanol 1.56
    n-heptane 2.43
    ethyl formate 2.4
    1,2-dichloroethane 4.63
    n-hexanol 6.0
    2-methoxyethanol 5.01
    isobutyl acetate 7.58
    tetrachloromethane 1.19
    n-pentyl acetate 14.68
    transcutol 30.27
    n-heptanol 7.62
    ethylbenzene 4.55
    MIBK 5.19
    2-propoxyethanol 15.24
    tert-butanol 1.68
    MTBE 3.39
    2-butoxyethanol 14.74
    propionic acid 1.19
    o-xylene 3.79
    formic acid 0.89
    diethyl ether 2.75
    m-xylene 4.32
    p-xylene 5.39
    chlorobenzene 4.33
    dimethyl carbonate 3.87
    n-octane 1.63
    formamide 2.0
    cyclopentanone 12.23
    2-pentanone 3.45
    anisole 10.8
    cyclopentyl methyl ether 11.49
    gamma-butyrolactone 13.27
    1-methoxy-2-propanol 4.75
    pyridine 11.65
    3-pentanone 3.01
    furfural 18.24
    n-dodecane 1.5
    diethylene glycol 7.92
    diisopropyl ether 2.38
    tert-amyl alcohol 2.25
    acetylacetone 6.66
    n-hexadecane 1.73
    acetophenone 12.36
    methyl propionate 3.71
    isopentyl acetate 12.46
    trichloroethylene 11.13
    n-nonanol 8.32
    cyclohexanol 1.93
    benzyl alcohol 6.48
    2-ethylhexanol 8.27
    isooctanol 7.86
    dipropyl ether 11.12
    1,2-dichlorobenzene 5.59
    ethyl lactate 4.92
    propylene carbonate 7.49
    n-methylformamide 3.41
    2-pentanol 1.12
    n-pentane 0.31
    1-propoxy-2-propanol 13.33
    1-methoxy-2-propyl acetate 15.86
    2-(2-methoxypropoxy) propanol 17.99
    mesitylene 3.26
    ε-caprolactone 10.01
    p-cymene 8.01
    epichlorohydrin 18.56
    1,1,1-trichloroethane 3.61
    2-aminoethanol 0.94
    morpholine-4-carbaldehyde 26.5
    sulfolane 15.53
    2,2,4-trimethylpentane 0.63
    2-methyltetrahydrofuran 11.89
    n-hexyl acetate 14.62
    isooctane 0.61
    2-(2-butoxyethoxy)ethanol 20.93
    sec-butyl acetate 6.39
    tert-butyl acetate 7.24
    decalin 1.19
    glycerin 1.31
    diglyme 36.27
    acrylic acid 1.82
    isopropyl myristate 9.63
    n-butyric acid 1.94
    acetyl acetate 3.01
    di(2-ethylhexyl) phthalate 10.14
    ethyl propionate 5.99
    nitromethane 4.52
    1,2-diethoxyethane 18.82
    benzonitrile 7.58
    trioctyl phosphate 7.71
    1-bromopropane 2.63
    gamma-valerolactone 20.63
    n-decanol 7.05
    triethyl phosphate 7.06
    4-methyl-2-pentanol 1.93
    propionitrile 1.56
    vinylene carbonate 7.14
    1,1,2-trichlorotrifluoroethane 15.35
    DMS 10.26
    cumene 4.76
    2-octanol 6.4
    2-hexanone 8.88
    octyl acetate 11.2
    limonene 9.71
    1,2-dimethoxyethane 20.25
    ethyl orthosilicate 7.9
    tributyl phosphate 7.6
    diacetone alcohol 7.97
    N,N-dimethylaniline 12.83
    acrylonitrile 2.75
    aniline 4.43
    1,3-propanediol 1.15
    bromobenzene 4.58
    dibromomethane 3.6
    1,1,2,2-tetrachloroethane 9.14
    2-methyl-cyclohexyl acetate 14.82
    tetrabutyl urea 13.8
    diisobutyl methanol 5.9
    2-phenylethanol 12.87
    styrene 4.5
    dioctyl adipate 12.58
    dimethyl sulfate 6.42
    ethyl butyrate 9.84
    methyl lactate 3.3
    butyl lactate 10.31
    diethyl carbonate 6.27
    propanediol butyl ether 9.57
    triethyl orthoformate 10.48
    p-tert-butyltoluene 8.01
    methyl 4-tert-butylbenzoate 20.51
    morpholine 12.53
    tert-butylamine 1.52
    n-dodecanol 5.87
    dimethoxymethane 11.3
    ethylene carbonate 4.88
    cyrene 17.87
    2-ethoxyethyl acetate 17.97
    2-ethylhexyl acetate 12.69
    1,2,4-trichlorobenzene 7.76
    4-methylpyridine 9.4
    dibutyl ether 10.58
    2,6-dimethyl-4-heptanol 5.9
    DEF 9.04
    dimethyl isosorbide 40.63
    tetrachloroethylene 6.28
    eugenol 22.6
    triacetin 13.88
    span 80 15.78
    1,4-butanediol 1.16
    1,1-dichloroethane 2.31
    2-methyl-1-pentanol 3.7
    methyl formate 3.36
    2-methyl-1-butanol 1.39
    n-decane 2.43
    butyronitrile 1.85
    3,7-dimethyl-1-octanol 7.86
    1-chlorooctane 7.05
    1-chlorotetradecane 3.72
    n-nonane 2.04
    undecane 1.89
    tert-butylcyclohexane 1.47
    cyclooctane 0.46
    cyclopentanol 2.78
    tetrahydropyran 7.02
    tert-amyl methyl ether 4.82
    2,5,8-trioxanonane 30.14
    1-hexene 2.39
    2-isopropoxyethanol 7.61
    2,2,2-trifluoroethanol 1.77
    methyl butyrate 7.52

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction