Iodoethane

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  • Identifiers

    CAS number
    75-03-6

    Molecular formula
    C2H5I

    SMILES
    CCI

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Ethereal 55.78%
    Alcoholic 52.72%
    Solvent 51.3%
    Sweet 50.91%
    Fermented 47.57%
    Musty 39.24%
    Fishy 37.02%
    Gassy 34.87%
    Oily 34.67%
    Cheesy 34.38%

     

    Flavor
    Fishy 46.62%
    Onion 31.05%
    Fruity 30.94%
    Sulfurous 28.95%
    Meaty 27.99%
    Ammoniacal 27.34%
    Ammonia 26.41%
    Gassy 24.2%
    Egg 23.96%
    Garlic 23.77%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    3.96 (weak acid)

    Molecular weight
    155.97 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -108 °C

    Boiling point

    • 72 °C

    Flash point

    • 10.63 ˚C est.
    • 61 °C c.c.

    Solubility expt.

    • Solubility in water, g/100ml at 20 °C: 0.4

  • Synonyms

    • Iodoethane
    • 75-03-6
    • ETHYL IODIDE
    • Ethane, iodo-
    • Monoiodoethane
    • Hydriodic ether
    • ethyliodide
    • iodo-ethane
    • 1-Iodoethane
    • Ethyljodid
    • Jodethan
    • C2H5I
    • NSC 8825
    • EINECS 200-833-1
    • UNII-59PO05D39L
    • AI3-28593
    • 59PO05D39L
    • 1-IODO-ETHANE
    • NSC-8825
    • MFCD00001091
    • ETHYL IODIDE [MI]
    • IODOETHANE-2-D1
    • DTXSID9058783
    • CHEBI:42487
    • Jodethan [Czech]
    • Ethyljodid [Czech]
    • IODOETHANE (2,2,2-D3)
    • MFCD00001092
    • 57460-45-4
    • ethyliodid
    • ethyliodine
    • iodanylethane
    • iodethane
    • iodoethan
    • ethyl iodine
    • iodo ethane
    • 2-iodoethane
    • ethane, iodo
    • 1-iodethane
    • 1-Iodoethane; Ethyl Iodide; Hydriodic Ether; NSC 8825; Monoiodoethane
    • 1-iodo ethane
    • 1-iodo ethan
    • Iodoethane over Cu
    • Et-I
    • CH3CH2I
    • SCHEMBL5055
    • DTXCID1047730
    • NSC8825
    • BCP26938
    • BBL034620
    • STL185613
    • AKOS000119806
    • FI44407
    • Iodoethane - stabilized with Copper chip
    • BP-21421
    • SY076665
    • I0058
    • NS00022755
    • EN300-18902
    • G77207
    • A838307
    • Q417320
    • F2190-0171
    • Iodoethane, contains copper as stabilizer, ReagentPlus(R), 99%

  • Applications

    Iodoethane (CAS 75-03-6) is mainly used as an alkylating reagent in organic synthesis, enabling introduction of the ethyl group into amines, phenols, and alcohols, and it can participate in reactions to form ethyl ethers. It serves as a key precursor for pharmaceutical and agrochemical intermediates in N-ethylated or other ethylated derivatives. It is employed to prepare quaternary ammonium salts and related phase-transfer catalysts, by carrying out exhaustive ethylation of tertiary amines, generating ethyl-substituted ammonium salts. In polymer and coatings chemistry, it can be used to functionalize or end-cap polymer chains with ethyl groups to modify material properties. In R&D contexts, iodoethane is commonly used as an alkylating reagent to generate ethylated derivatives from diverse substrates.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 153.13
    methanol 103.96
    isopropanol 133.76
    water 0.66
    ethyl acetate 233.73
    n-propanol 148.29
    acetone 322.28
    n-butanol 173.4
    acetonitrile 168.31
    DMF 268.98
    toluene 322.99
    isobutanol 119.1
    1,4-dioxane 490.71
    methyl acetate 192.95
    THF 795.28
    2-butanone 278.94
    n-pentanol 145.07
    sec-butanol 143.95
    n-hexane 89.14
    ethylene glycol 35.61
    NMP 377.44
    cyclohexane 223.96
    DMSO 366.58
    n-butyl acetate 386.73
    n-octanol 165.12
    chloroform 698.48
    n-propyl acetate 229.19
    acetic acid 221.87
    dichloromethane 536.59
    cyclohexanone 559.2
    propylene glycol 50.5
    isopropyl acetate 184.08
    DMAc 223.59
    2-ethoxyethanol 193.81
    isopentanol 154.33
    n-heptane 206.73
    ethyl formate 146.52
    1,2-dichloroethane 344.89
    n-hexanol 237.42
    2-methoxyethanol 232.79
    isobutyl acetate 184.16
    tetrachloromethane 216.2
    n-pentyl acetate 255.08
    transcutol 680.42
    n-heptanol 160.27
    ethylbenzene 161.1
    MIBK 213.69
    2-propoxyethanol 297.3
    tert-butanol 188.64
    MTBE 218.79
    2-butoxyethanol 223.11
    propionic acid 140.25
    o-xylene 208.75
    formic acid 46.31
    diethyl ether 266.41
    m-xylene 221.96
    p-xylene 202.89
    chlorobenzene 324.08
    dimethyl carbonate 89.0
    n-octane 76.3
    formamide 68.25
    cyclopentanone 567.4
    2-pentanone 303.27
    anisole 259.86
    cyclopentyl methyl ether 424.17
    gamma-butyrolactone 459.32
    1-methoxy-2-propanol 199.06
    pyridine 522.12
    3-pentanone 239.69
    furfural 436.44
    n-dodecane 51.82
    diethylene glycol 184.75
    diisopropyl ether 142.72
    tert-amyl alcohol 164.23
    acetylacetone 308.42
    n-hexadecane 58.67
    acetophenone 259.03
    methyl propionate 170.43
    isopentyl acetate 319.38
    trichloroethylene 624.26
    n-nonanol 149.05
    cyclohexanol 267.41
    benzyl alcohol 185.44
    2-ethylhexanol 217.49
    isooctanol 141.14
    dipropyl ether 367.65
    1,2-dichlorobenzene 274.39
    ethyl lactate 97.97
    propylene carbonate 277.31
    n-methylformamide 117.89
    2-pentanol 149.35
    n-pentane 104.15
    1-propoxy-2-propanol 319.72
    1-methoxy-2-propyl acetate 289.32
    2-(2-methoxypropoxy) propanol 211.57
    mesitylene 171.73
    ε-caprolactone 425.17
    p-cymene 198.05
    epichlorohydrin 462.91
    1,1,1-trichloroethane 448.65
    2-aminoethanol 64.79
    morpholine-4-carbaldehyde 391.75
    sulfolane 499.38
    2,2,4-trimethylpentane 57.97
    2-methyltetrahydrofuran 541.67
    n-hexyl acetate 274.57
    isooctane 56.27
    2-(2-butoxyethoxy)ethanol 287.87
    sec-butyl acetate 178.58
    tert-butyl acetate 239.76
    decalin 89.26
    glycerin 76.64
    diglyme 537.12
    acrylic acid 133.99
    isopropyl myristate 149.75
    n-butyric acid 226.41
    acetyl acetate 180.7
    di(2-ethylhexyl) phthalate 123.59
    ethyl propionate 175.38
    nitromethane 249.65
    1,2-diethoxyethane 402.4
    benzonitrile 266.59
    trioctyl phosphate 101.36
    1-bromopropane 322.33
    gamma-valerolactone 549.78
    n-decanol 119.88
    triethyl phosphate 142.45
    4-methyl-2-pentanol 111.0
    propionitrile 159.88
    vinylene carbonate 239.82
    1,1,2-trichlorotrifluoroethane 298.3
    DMS 174.81
    cumene 121.86
    2-octanol 132.99
    2-hexanone 267.03
    octyl acetate 168.64
    limonene 285.18
    1,2-dimethoxyethane 369.04
    ethyl orthosilicate 156.52
    tributyl phosphate 121.46
    diacetone alcohol 235.33
    N,N-dimethylaniline 198.18
    acrylonitrile 172.5
    aniline 244.04
    1,3-propanediol 112.04
    bromobenzene 370.12
    dibromomethane 469.11
    1,1,2,2-tetrachloroethane 502.42
    2-methyl-cyclohexyl acetate 237.57
    tetrabutyl urea 169.01
    diisobutyl methanol 186.01
    2-phenylethanol 232.47
    styrene 201.89
    dioctyl adipate 189.52
    dimethyl sulfate 140.51
    ethyl butyrate 292.68
    methyl lactate 91.67
    butyl lactate 163.38
    diethyl carbonate 172.78
    propanediol butyl ether 186.51
    triethyl orthoformate 230.72
    p-tert-butyltoluene 201.68
    methyl 4-tert-butylbenzoate 234.39
    morpholine 476.62
    tert-butylamine 144.05
    n-dodecanol 105.65
    dimethoxymethane 223.02
    ethylene carbonate 204.45
    cyrene 219.26
    2-ethoxyethyl acetate 271.92
    2-ethylhexyl acetate 308.4
    1,2,4-trichlorobenzene 328.88
    4-methylpyridine 428.51
    dibutyl ether 272.67
    2,6-dimethyl-4-heptanol 186.01
    DEF 258.09
    dimethyl isosorbide 396.1
    tetrachloroethylene 364.17
    eugenol 212.03
    triacetin 251.98
    span 80 245.58
    1,4-butanediol 62.27
    1,1-dichloroethane 371.46
    2-methyl-1-pentanol 138.05
    methyl formate 104.27
    2-methyl-1-butanol 136.3
    n-decane 80.15
    butyronitrile 210.6
    3,7-dimethyl-1-octanol 171.97
    1-chlorooctane 172.86
    1-chlorotetradecane 90.87
    n-nonane 86.72
    undecane 61.3
    tert-butylcyclohexane 81.07
    cyclooctane 109.74
    cyclopentanol 260.62
    tetrahydropyran 577.89
    tert-amyl methyl ether 198.34
    2,5,8-trioxanonane 389.19
    1-hexene 174.15
    2-isopropoxyethanol 181.27
    2,2,2-trifluoroethanol 85.9
    methyl butyrate 229.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction