Indoxacarb

Overview IFRA Request a quote

  • Identifiers

    CAS number
    173584-44-6

    Molecular formula
    C22H17ClF3N3O7

    SMILES
    COC(=O)[C@]12CC3=C(C1=NN(CO2)C(=O)N(C4=CC=C(C=C4)OC(F)(F)F)C(=O)OC)C=CC(=C3)Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 58.04%
    Grape 33.17%
    Fruity 24.94%
    Citrus 21.36%
    Fresh 21.16%
    Fatty 20.25%
    Milky 19.93%
    Floral 19.75%
    Savory 19.13%
    Neroli 18.99%

     

    Flavor
    Bitter 85.56%
    Odorless 40.31%
    Bland 29.11%
    Sweet-like 20.31%
    Very mild 19.85%
    Mild 18.66%
    Nitrile 18.4%
    Cedarleaf 18.4%
    Orange flower 17.98%
    Taco 17.88%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    4.8

    pKa est.
    4.2 (weak acid)

    Molecular weight
    527.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    576°C

    Melting point expt.

    • 88.1 °C

    Flash point

    • 252.64 ˚C est.

    Solubility expt.

    • Solubility in n-octanol 14.5 g/L, methanol 103 g/L, acetonitrile 139 g/L, acetone >250 g/kg (all at 25 °C)
    • In water, 0.20 mg/L at 20 °C

  • Synonyms

    • Indoxacarb
    • 173584-44-6
    • Steward
    • Provaunt
    • Advion
    • Avaunt
    • Avatar
    • Avent
    • DPX-KN 128
    • DPX-KN128
    • ACTIVYL
    • 52H0D26MWR
    • DTXSID1032690
    • Indeno(1,2-e)(1,3,4)oxadiazine-4a(3H)-carboxylic acid, 7-chloro-2,5-dihydro-2-(((methoxycarbonyl)(4-(trifluoromethoxy)phenyl)amino)carbonyl)-, methyl ester, (4aS)-
    • DTXCID9012690
    • CHEBI:38630
    • methyl (4aS)-7-chloro-2-{(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]carbamoyl}-2,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate
    • methyl (4aS)-7-chloro-2-((methoxycarbonyl)(4-(trifluoromethoxy)phenyl)carbamoyl)-2,5-dihydroindeno(1,2-e)(1,3,4)oxadiazine-4a(3H)-carboxylate
    • RefChem:148240
    • 605-683-4
    • methyl (4aS)-7-chloro-2-(((methoxycarbonyl)(4-(trifluoromethoxy)phenyl)amino)carbonyl)-2H,3H,4aH,5H-indeno(1,2-e)(1,3,4)oxadiazine-4a-carboxylate
    • (S)-Indoxacarb
    • Insecticide
    • Indoxacarb [ISO]
    • 174060-41-4
    • methyl (4aS)-7-chloro-2-[methoxycarbonyl-[4-(trifluoromethoxy)phenyl]carbamoyl]-3,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a-carboxylate
    • Indoxacarb (JAN)
    • C22H17ClF3N3O7
    • MFCD03792834
    • INDOXACARB (EMA EPAR: VETERINARY)
    • INDOXACARB [JAN]
    • Indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylic acid,7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino]carbonyl]-, methyl ester, (4aS)-
    • HSDB 7280
    • DPX-MP 062-381
    • UNII-52H0D26MWR
    • DPX-MP062
    • (+/-)-Indoxacarb;DPX-JW 062; DPX-MP 062; Tornado; Tornado 10FL
    • Indoxacarb 10 microg/mL in Cyclohexane
    • (4aS)-indoxacarb
    • Methyl 7-chloro-2,5-dihydro-2-[N-(methoxycarbonyl)-4-(trifluoromethoxy)anilinocarbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)carboxylate
    • INDOXACARB [MI]
    • INDOXACARB [HSDB]
    • (+)-INDOXACARB
    • INDOXACARB, (+)-
    • SCHEMBL22073
    • Methyl (S)-7chloro-2,5-dihydro-2-(((methoxycarbonyl)(4-(trifluoromethoxy)phenyl)amino)carbonylindeno(1,2-e)(1,3,4)oxadiazine-4a(3H)-carboxylate
    • CHEMBL197676
    • orb2281138
    • orb3026132
    • SCHEMBL29370513
    • MSK20287
    • Tox21_300723
    • AKOS037643748
    • NCGC00164264-02
    • NCGC00164264-03
    • NCGC00254629-01
    • AS-35129
    • ACTIVYL TICK PLUS COMPONENT INDOXACARB
    • CAS-173584-44-6
    • CS-0064002
    • NS00098526
    • Indoxacarb, PESTANAL(R), analytical standard
    • (S)-Indoxacarb 100 microg/mL in Acetonitrile
    • C18569
    • D06316
    • Q421469
    • ()-Indoxacarb;DPX-JW 062; DPX-MP 062; Tornado; Tornado 10FL
    • Indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylicacid,7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino]carbonyl]-,methyl ester
    • Indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylicacid,7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino]carbonyl]-,methyl ester, (4aS)-
    • METHYL (4AS)-7-CHLORO-2,5-DIHYDRO-2-(((METHOXYCARBONYL)(4-(TRIFLUOROMETHOXY)PHENYL)AMINO)CARBONYL)INDENO(1,2-E)(1,3,4)OXADIAZINE-4A(3H)-CARBOXYLATE
    • 173584-44-6

  • Applications

    Indoxacarb (CAS 173584-44-6) is a crop-protection insecticide used in agriculture to control lepidopteran and other susceptible pests by blocking insect sodium channels. Real-world applications include field crop protection on crops such as corn and cotton; protection of vegetables and fruits in open-field and protected-environment production; use in greenhouse and nursery settings to manage caterpillars and related pests; protection of ornamental and landscape plants; and formulations such as emulsifiable concentrates, suspension concentrates, and granules prepared for foliar or soil applications within integrated pest management programs. Applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.56
    methanol 3.16
    isopropanol 1.73
    water 0.0
    ethyl acetate 7.54
    n-propanol 2.45
    acetone 13.71
    n-butanol 2.37
    acetonitrile 5.59
    DMF 14.45
    toluene 2.04
    isobutanol 1.65
    1,4-dioxane 11.27
    methyl acetate 8.99
    THF 19.69
    2-butanone 15.29
    n-pentanol 1.77
    sec-butanol 2.15
    n-hexane 0.03
    ethylene glycol 0.69
    NMP 23.24
    cyclohexane 0.1
    DMSO 27.99
    n-butyl acetate 5.17
    n-octanol 1.28
    chloroform 8.16
    n-propyl acetate 5.04
    acetic acid 6.14
    dichloromethane 9.66
    cyclohexanone 22.06
    propylene glycol 0.69
    isopropyl acetate 4.05
    DMAc 24.43
    2-ethoxyethanol 5.98
    isopentanol 1.94
    n-heptane 0.04
    ethyl formate 6.75
    1,2-dichloroethane 6.35
    n-hexanol 1.49
    2-methoxyethanol 9.5
    isobutyl acetate 1.87
    tetrachloromethane 0.56
    n-pentyl acetate 4.69
    transcutol 7.45
    n-heptanol 1.51
    ethylbenzene 0.71
    MIBK 3.69
    2-propoxyethanol 8.06
    tert-butanol 1.57
    MTBE 1.54
    2-butoxyethanol 5.92
    propionic acid 3.72
    o-xylene 1.15
    formic acid 3.92
    diethyl ether 3.11
    m-xylene 0.8
    p-xylene 0.91
    chlorobenzene 2.3
    dimethyl carbonate 4.84
    n-octane 0.04
    formamide 6.92
    cyclopentanone 22.83
    2-pentanone 9.03
    anisole 2.33
    cyclopentyl methyl ether 3.11
    gamma-butyrolactone 19.71
    1-methoxy-2-propanol 5.52
    pyridine 13.1
    3-pentanone 8.04
    furfural 17.13
    n-dodecane 0.06
    diethylene glycol 5.39
    diisopropyl ether 0.42
    tert-amyl alcohol 2.06
    acetylacetone 12.3
    n-hexadecane 0.07
    acetophenone 4.7
    methyl propionate 7.49
    isopentyl acetate 3.28
    trichloroethylene 12.17
    n-nonanol 1.45
    cyclohexanol 2.2
    benzyl alcohol 3.32
    2-ethylhexanol 0.95
    isooctanol 1.12
    dipropyl ether 1.47
    1,2-dichlorobenzene 1.87
    ethyl lactate 3.28
    propylene carbonate 7.4
    n-methylformamide 8.29
    2-pentanol 1.14
    n-pentane 0.06
    1-propoxy-2-propanol 4.5
    1-methoxy-2-propyl acetate 5.87
    2-(2-methoxypropoxy) propanol 5.89
    mesitylene 0.35
    ε-caprolactone 15.42
    p-cymene 0.54
    epichlorohydrin 19.21
    1,1,1-trichloroethane 2.89
    2-aminoethanol 1.42
    morpholine-4-carbaldehyde 17.28
    sulfolane 23.76
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 7.83
    n-hexyl acetate 4.21
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 6.79
    sec-butyl acetate 2.53
    tert-butyl acetate 2.88
    decalin 0.04
    glycerin 1.66
    diglyme 11.56
    acrylic acid 4.04
    isopropyl myristate 1.71
    n-butyric acid 5.38
    acetyl acetate 5.14
    di(2-ethylhexyl) phthalate 3.01
    ethyl propionate 4.88
    nitromethane 18.54
    1,2-diethoxyethane 4.4
    benzonitrile 4.56
    trioctyl phosphate 1.95
    1-bromopropane 2.75
    gamma-valerolactone 32.56
    n-decanol 1.1
    triethyl phosphate 2.34
    4-methyl-2-pentanol 0.63
    propionitrile 5.18
    vinylene carbonate 7.85
    1,1,2-trichlorotrifluoroethane 11.7
    DMS 4.89
    cumene 0.37
    2-octanol 1.04
    2-hexanone 6.47
    octyl acetate 2.81
    limonene 0.69
    1,2-dimethoxyethane 12.17
    ethyl orthosilicate 1.8
    tributyl phosphate 2.13
    diacetone alcohol 4.69
    N,N-dimethylaniline 1.28
    acrylonitrile 7.72
    aniline 3.1
    1,3-propanediol 3.25
    bromobenzene 1.83
    dibromomethane 5.18
    1,1,2,2-tetrachloroethane 8.26
    2-methyl-cyclohexyl acetate 2.64
    tetrabutyl urea 4.39
    diisobutyl methanol 0.46
    2-phenylethanol 3.46
    styrene 0.9
    dioctyl adipate 3.18
    dimethyl sulfate 7.04
    ethyl butyrate 4.16
    methyl lactate 4.39
    butyl lactate 3.76
    diethyl carbonate 3.17
    propanediol butyl ether 3.14
    triethyl orthoformate 2.9
    p-tert-butyltoluene 0.42
    methyl 4-tert-butylbenzoate 4.27
    morpholine 11.45
    tert-butylamine 0.59
    n-dodecanol 0.81
    dimethoxymethane 10.06
    ethylene carbonate 7.28
    cyrene 6.78
    2-ethoxyethyl acetate 7.85
    2-ethylhexyl acetate 2.74
    1,2,4-trichlorobenzene 2.93
    4-methylpyridine 8.93
    dibutyl ether 1.35
    2,6-dimethyl-4-heptanol 0.46
    DEF 9.94
    dimethyl isosorbide 8.16
    tetrachloroethylene 4.95
    eugenol 5.11
    triacetin 4.98
    span 80 4.33
    1,4-butanediol 1.25
    1,1-dichloroethane 3.79
    2-methyl-1-pentanol 1.67
    methyl formate 7.61
    2-methyl-1-butanol 2.09
    n-decane 0.08
    butyronitrile 4.68
    3,7-dimethyl-1-octanol 0.97
    1-chlorooctane 0.59
    1-chlorotetradecane 0.29
    n-nonane 0.06
    undecane 0.07
    tert-butylcyclohexane 0.03
    cyclooctane 0.03
    cyclopentanol 2.82
    tetrahydropyran 6.78
    tert-amyl methyl ether 1.72
    2,5,8-trioxanonane 9.49
    1-hexene 0.32
    2-isopropoxyethanol 3.62
    2,2,2-trifluoroethanol 2.98
    methyl butyrate 6.43

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction