Icariside Ii

Overview IFRA Request a quote

  • Identifiers

    CAS number
    113558-15-9

    Molecular formula
    C27H30O10

    SMILES
    C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(OC3=C(C(=CC(=C3C2=O)O)O)CC=C(C)C)C4=CC=C(C=C4)OC)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 48.96%
    Phenolic 35.71%
    Spicy 33.87%
    Vanilla 32.78%
    Sweet 31.53%
    Smoky 25.33%
    Balsamic 21.98%
    Burnt 20.98%
    Milky 20.41%
    Creamy 19.84%

     

    Flavor
    Bitter 87.02%
    Bland 27.85%
    Odorless 22.83%
    Sweet-like 21.03%
    Cedarleaf 20.66%
    Parsley 20.35%
    Lovage 19.75%
    Eugenol 18.84%
    Ethyl benzoate 18.59%
    Leaves 18.45%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.5

    pKa est.
    8.98 (weak base)

    Molecular weight
    514.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    3466°C

    Flash point

    • 251.97 ˚C est.

  • Synonyms

    • Baohuoside I
    • 113558-15-9
    • Icariside II
    • ICARISID II
    • 5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one
    • CHEBI:82619
    • DTXSID40150457
    • 3,5,7-Trihydroxy-4'-methoxyl-8-prenylflavone-3-O-rhamnopyranoside
    • 4H-1-Benzopyran-4-one, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-
    • 5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-3-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxychromen-4-one
    • RefChem:923268
    • DTXCID4072948
    • 5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-3-((2S,3S,5R)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxychromen-4-one
    • BAOHUOSIDEI
    • MFCD15071140
    • CHEMBL560116
    • 4H-1-Benzopyran-4-one, 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-
    • 5,7-Dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
    • 5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}-4H-chromen-4-one
    • Baohuoside-I
    • Icarlin II
    • baohuside I
    • Baohuoside I (Standard)
    • Icaritin-3-O-alpha-rhamnoside
    • orb1304241
    • SCHEMBL4229321
    • SCHEMBL29364110
    • GTPL10686
    • HY-N0011R
    • Icarisid II - Bio-X trade mark
    • 2h44
    • GLXC-13027
    • EX-A6795
    • HY-N0011
    • BDBM50503751
    • AKOS037514560
    • CS-3673
    • EBC-615521
    • FI73956
    • AC-33977
    • AS-75062
    • BI300092
    • DA-61494
    • SY068816
    • anhydroicaritin-3-O-alpha-L-rhamnopyranoside
    • NS00014948
    • Baohuoside I; Anhydroicaritin; Icariside II
    • Q27156136
    • 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone-3-O-rhamnopyranoside
    • 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone-3-O-alpha-L-rhamnopyranoside
    • 3-[(6-Deoxy-|_-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
    • 4H-1-Benzopyran-4-one, 3-[(6-deoxy-|A-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-
    • 5,7-Dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-1-benzopyran-3-yl 6-deoxy-alpha-L-mannopyranoside
    • 5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside
    • 5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-chromen-4-one
    • 113558-15-9

  • Applications

    Icariside Ii (CAS 113558-15-9) is a natural flavonoid glycoside encountered in Epimedium species; in practice it is evaluated as a bioactive lead in pharmaceutical and natural product research, often studied for structure-function relationships and potential pharmacological activities. It is also used as an intermediate for the synthesis of flavonoid derivatives in organic synthesis workflows. In analytical and quality-control contexts, it serves as a reference material for method development and for characterizing complex plant extracts. In cosmetics and personal care development, Icariside Ii may be investigated as a candidate bioactive flavonoid with antioxidant or skin-benefit properties, though its use is subject to regulatory limits. Additionally, it is sometimes explored in nutraceutical or functional-food research as a phytochemical of interest.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.46
    methanol 4.23
    isopropanol 1.75
    water 0.02
    ethyl acetate 1.23
    n-propanol 2.71
    acetone 4.42
    n-butanol 1.41
    acetonitrile 0.95
    DMF 18.47
    toluene 0.29
    isobutanol 1.46
    1,4-dioxane 7.52
    methyl acetate 3.65
    THF 16.34
    2-butanone 5.45
    n-pentanol 1.17
    sec-butanol 2.4
    n-hexane 0.02
    ethylene glycol 3.74
    NMP 33.52
    cyclohexane 0.04
    DMSO 35.99
    n-butyl acetate 0.63
    n-octanol 0.73
    chloroform 2.36
    n-propyl acetate 0.9
    acetic acid 22.11
    dichloromethane 2.11
    cyclohexanone 6.63
    propylene glycol 7.31
    isopropyl acetate 0.77
    DMAc 36.36
    2-ethoxyethanol 8.13
    isopentanol 1.02
    n-heptane 0.03
    ethyl formate 1.43
    1,2-dichloroethane 1.53
    n-hexanol 0.62
    2-methoxyethanol 17.29
    isobutyl acetate 0.49
    tetrachloromethane 0.21
    n-pentyl acetate 1.26
    transcutol 23.09
    n-heptanol 0.85
    ethylbenzene 0.12
    MIBK 0.86
    2-propoxyethanol 6.81
    tert-butanol 1.75
    MTBE 0.87
    2-butoxyethanol 5.14
    propionic acid 7.09
    o-xylene 0.22
    formic acid 10.73
    diethyl ether 0.87
    m-xylene 0.16
    p-xylene 0.18
    chlorobenzene 0.3
    dimethyl carbonate 3.2
    n-octane 0.02
    formamide 10.0
    cyclopentanone 12.23
    2-pentanone 1.78
    anisole 0.68
    cyclopentyl methyl ether 1.82
    gamma-butyrolactone 14.76
    1-methoxy-2-propanol 11.81
    pyridine 4.75
    3-pentanone 1.96
    furfural 9.53
    n-dodecane 0.02
    diethylene glycol 8.62
    diisopropyl ether 0.15
    tert-amyl alcohol 2.06
    acetylacetone 3.88
    n-hexadecane 0.02
    acetophenone 1.31
    methyl propionate 2.96
    isopentyl acetate 0.68
    trichloroethylene 4.67
    n-nonanol 0.84
    cyclohexanol 1.55
    benzyl alcohol 1.52
    2-ethylhexanol 0.38
    isooctanol 0.65
    dipropyl ether 0.62
    1,2-dichlorobenzene 0.3
    ethyl lactate 2.02
    propylene carbonate 3.02
    n-methylformamide 7.64
    2-pentanol 0.93
    n-pentane 0.03
    1-propoxy-2-propanol 4.28
    1-methoxy-2-propyl acetate 2.4
    2-(2-methoxypropoxy) propanol 6.19
    mesitylene 0.08
    ε-caprolactone 6.18
    p-cymene 0.12
    epichlorohydrin 12.94
    1,1,1-trichloroethane 0.66
    2-aminoethanol 4.97
    morpholine-4-carbaldehyde 23.85
    sulfolane 33.77
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 4.33
    n-hexyl acetate 1.51
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 8.4
    sec-butyl acetate 0.52
    tert-butyl acetate 1.0
    decalin 0.02
    glycerin 18.45
    diglyme 13.77
    acrylic acid 10.51
    isopropyl myristate 0.49
    n-butyric acid 3.61
    acetyl acetate 1.19
    di(2-ethylhexyl) phthalate 0.97
    ethyl propionate 0.83
    nitromethane 22.38
    1,2-diethoxyethane 2.33
    benzonitrile 0.7
    trioctyl phosphate 0.69
    1-bromopropane 0.49
    gamma-valerolactone 27.72
    n-decanol 0.53
    triethyl phosphate 0.62
    4-methyl-2-pentanol 0.43
    propionitrile 1.03
    vinylene carbonate 2.97
    1,1,2-trichlorotrifluoroethane 26.84
    DMS 2.17
    cumene 0.08
    2-octanol 0.54
    2-hexanone 1.36
    octyl acetate 0.88
    limonene 0.19
    1,2-dimethoxyethane 8.03
    ethyl orthosilicate 0.56
    tributyl phosphate 0.76
    diacetone alcohol 4.35
    N,N-dimethylaniline 0.6
    acrylonitrile 2.1
    aniline 1.2
    1,3-propanediol 5.59
    bromobenzene 0.21
    dibromomethane 0.91
    1,1,2,2-tetrachloroethane 4.24
    2-methyl-cyclohexyl acetate 0.79
    tetrabutyl urea 1.38
    diisobutyl methanol 0.26
    2-phenylethanol 1.01
    styrene 0.13
    dioctyl adipate 1.24
    dimethyl sulfate 8.45
    ethyl butyrate 0.63
    methyl lactate 7.03
    butyl lactate 2.65
    diethyl carbonate 0.45
    propanediol butyl ether 6.81
    triethyl orthoformate 0.89
    p-tert-butyltoluene 0.12
    methyl 4-tert-butylbenzoate 2.67
    morpholine 11.49
    tert-butylamine 0.45
    n-dodecanol 0.34
    dimethoxymethane 9.21
    ethylene carbonate 2.1
    cyrene 8.14
    2-ethoxyethyl acetate 3.25
    2-ethylhexyl acetate 0.48
    1,2,4-trichlorobenzene 0.78
    4-methylpyridine 1.95
    dibutyl ether 0.53
    2,6-dimethyl-4-heptanol 0.26
    DEF 3.73
    dimethyl isosorbide 7.25
    tetrachloroethylene 2.39
    eugenol 3.07
    triacetin 3.45
    span 80 5.32
    1,4-butanediol 2.32
    1,1-dichloroethane 0.85
    2-methyl-1-pentanol 1.01
    methyl formate 6.22
    2-methyl-1-butanol 1.42
    n-decane 0.04
    butyronitrile 0.57
    3,7-dimethyl-1-octanol 0.6
    1-chlorooctane 0.19
    1-chlorotetradecane 0.07
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.01
    cyclooctane 0.02
    cyclopentanol 3.32
    tetrahydropyran 3.06
    tert-amyl methyl ether 0.98
    2,5,8-trioxanonane 9.94
    1-hexene 0.09
    2-isopropoxyethanol 4.13
    2,2,2-trifluoroethanol 6.76
    methyl butyrate 1.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction