Hydroxyurea

Overview IFRA Request a quote

  • Identifiers

    CAS number
    127-07-1

    Molecular formula
    CH4N2O2

    SMILES
    C(=O)(N)NO

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 71.81%
    Fishy 24.22%
    Savory 21.7%
    Sweet 20.35%
    Meaty 16.91%
    Pungent 16.2%
    Cooked 14.62%
    Sulfurous 14.1%
    Cheesy 13.97%
    Bitter 13.76%

     

    Flavor
    Odorless 69.27%
    Sour 25.78%
    Mild 24.06%
    Very mild 23.13%
    Bland 21.39%
    Yeast 21.19%
    Sweet-like 20.98%
    Acidic 20.45%
    Formyl 20.44%
    Mousy 20.3%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -1.8

    pKa est.
    9.23 (weak base)

    Molecular weight
    76.055 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 291 to 295 °F (decomposes) (NTP, 1992)
    • 133-136
    • 141 °C
    • MP: 133-136 °C. Somewhat hygroscopic
    • 142 - 146 °C

    Boiling point

    • Decomposes (NTP, 1992)
    • Decomposes

    Flash point

    • 159.08 ˚C est.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 70 °F (NTP, 1992)
    • 1000000 mg/L (at 25 °C)
    • Freely soluble in water /1.0X10+6 mg/L at 25 °C/
    • Freely soluble in hot alcohol
    • Very soluble in water... insoluble in ethanol and benzene
    • 2.69e+02 g/L

  • Synonyms

    • hydroxyurea
    • 127-07-1
    • Hydroxycarbamide
    • Hydrea
    • N-Hydroxyurea
    • 1-HYDROXYUREA
    • Oxyurea
    • Carbamoyl oxime
    • Urea, hydroxy-
    • Biosupressin
    • Droxia
    • Carbamohydroxamic acid
    • Carbamohydroximic acid
    • Litalir
    • Hydroxycarbamine
    • Onco-carbide
    • Carbamyl hydroxamate
    • Hydurea
    • N-Carbamoylhydroxylamine
    • Hidrix
    • Hydura
    • Siklos
    • Hydroxicarbamidum
    • Hydroxylurea
    • Hydreia
    • Litaler
    • urea, N-hydroxy-
    • Hidroxicarbamida
    • Idrossicarbamide [DCIT]
    • Carbamohydroxyamic acid
    • Hydroxycarbamid
    • Oncocarbide
    • hydroxy urea
    • Hydroxyharnstoff
    • Xromi
    • SQ 1089
    • Hydroxycarbamidum
    • N-Hydroxymocovina
    • Hydroxylamine, N-carbamoyl-
    • Hydroxycarbamidum [INN-Latin]
    • Hydroxyharnstoff [German]
    • Hidroxicarbamida [INN-Spanish]
    • N-Hydroxymocovina [Czech]
    • carbamide oxide
    • HYDROXY-UREA
    • Hydroxylamine, N-(aminocarbonyl)-
    • CCRIS 958
    • SK 22591
    • Droxia (TN)
    • NCI-C04831
    • HU
    • MFCD00007943
    • N-(Aminocarbonyl)hydroxylamine
    • NSC 32065
    • NSC-32065
    • Ammonium ichthosulfonate
    • Hydroxycarbamide [INN]
    • SQ-1089
    • HSDB 6887
    • HYDREA (TN)
    • Hydroxyurea [USAN:USP]
    • UNII-X6Q56QN5QC
    • NSC32065
    • 8029-68-3
    • EINECS 204-821-7
    • BRN 1741548
    • DTXSID6025438
    • CHEBI:44423
    • AI3-51139
    • Hydroxyurea (Cytodrox)
    • HYDROXYUREA [MI]
    • HYDROXYUREA [HSDB]
    • HYDROXYUREA [IARC]
    • HYDROXYUREA [USAN]
    • CHEMBL467
    • HYDROXYUREA [VANDF]
    • X6Q56QN5QC
    • HYDROXYUREA [USP-RS]
    • HYDROXYCARBAMIDE [JAN]
    • DTXCID405438
    • HYDROXYCARBAMIDE [MART.]
    • HYDROXYCARBAMIDE [WHO-DD]
    • HYDROXYUREA [ORANGE BOOK]
    • HYDROXYCARBAMIDE [EMA EPAR]
    • HYDROXYUREA [USP MONOGRAPH]
    • HYDROXYCARBAMIDE [EP MONOGRAPH]
    • NCGC00015520-03
    • Idrossicarbamide
    • Hydroxyurea (USAN:USP)
    • HYDROXYUREA (IARC)
    • HYDROXYUREA (USP-RS)
    • NHY
    • Hydroxyurea (D4)
    • Hydroxycarbamidum (INN-Latin)
    • Hidroxicarbamida (INN-Spanish)
    • HYDROXYCARBAMIDE (MART.)
    • N-HYDROXY UREA
    • Mylocel
    • HYDROXYUREA (USP MONOGRAPH)
    • HYDROXYCARBAMIDE (EP MONOGRAPH)
    • CAS-127-07-1
    • SMR000059149
    • Hydroxyurea (USP)
    • Droxia (TM)
    • Hydrea (TM)
    • hydroxyaminomethanamide
    • SR-01000075919
    • DRG-0253
    • idroxicarbamide
    • Hydroxycarbamide (JAN/INN)
    • hydroxyl urea
    • Oxeron
    • Syrea
    • n-hydroxy-urea
    • S-phase/G-1 interface inhibitor
    • aminohydroxamic acid
    • carbamic acid oxime
    • Siklos (TN)
    • BIOSUPPRESSIN
    • Spectrum_000909
    • WLN: ZVMQ
    • Hydrea (Bristol Meyers)
    • Spectrum2_000064
    • Spectrum3_000462
    • Spectrum4_000012
    • Spectrum5_000836
    • Hydroxycarbamidum (Latin)
    • Lopac-H-8627

  • Applications

    Hydroxyurea (CAS 127-07-1) is used primarily in pharmaceuticals as an active pharmaceutical ingredient (API) and as a precursor in drug synthesis; it is also regarded as an important intermediate in organic synthesis for nitrogen-containing compounds. In research and industrial production, hydroxyurea may be used as a laboratory reagent and as a building block for specialty polymers and materials, depending on processing conditions and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.68
    methanol 11.37
    isopropanol 1.59
    water 264.64
    ethyl acetate 0.4
    n-propanol 2.05
    acetone 1.91
    n-butanol 1.51
    acetonitrile 1.61
    DMF 59.12
    toluene 0.26
    isobutanol 1.27
    1,4-dioxane 2.06
    methyl acetate 0.85
    THF 2.2
    2-butanone 0.91
    n-pentanol 0.78
    sec-butanol 1.27
    n-hexane 0.22
    ethylene glycol 10.82
    NMP 28.73
    cyclohexane 0.33
    DMSO 28.78
    n-butyl acetate 0.27
    n-octanol 0.31
    chloroform 0.36
    n-propyl acetate 0.28
    acetic acid 11.74
    dichloromethane 0.6
    cyclohexanone 1.54
    propylene glycol 7.03
    isopropyl acetate 0.26
    DMAc 24.3
    2-ethoxyethanol 3.67
    isopentanol 1.13
    n-heptane 0.23
    ethyl formate 2.65
    1,2-dichloroethane 0.47
    n-hexanol 0.48
    2-methoxyethanol 11.75
    isobutyl acetate 0.14
    tetrachloromethane 0.29
    n-pentyl acetate 0.32
    transcutol 2.88
    n-heptanol 0.54
    ethylbenzene 0.15
    MIBK 0.36
    2-propoxyethanol 2.08
    tert-butanol 1.78
    MTBE 0.61
    2-butoxyethanol 2.24
    propionic acid 2.92
    o-xylene 0.39
    formic acid 59.69
    diethyl ether 0.54
    m-xylene 0.22
    p-xylene 0.23
    chlorobenzene 0.14
    dimethyl carbonate 1.39
    n-octane 0.1
    formamide 45.04
    cyclopentanone 2.3
    2-pentanone 0.61
    anisole 0.31
    cyclopentyl methyl ether 0.89
    gamma-butyrolactone 3.24
    1-methoxy-2-propanol 4.8
    pyridine 1.42
    3-pentanone 0.61
    furfural 7.22
    n-dodecane 0.04
    diethylene glycol 4.96
    diisopropyl ether 0.16
    tert-amyl alcohol 1.55
    acetylacetone 0.85
    n-hexadecane 0.04
    acetophenone 0.46
    methyl propionate 0.8
    isopentyl acetate 0.24
    trichloroethylene 0.58
    n-nonanol 0.31
    cyclohexanol 1.11
    benzyl alcohol 0.67
    2-ethylhexanol 0.3
    isooctanol 0.4
    dipropyl ether 0.39
    1,2-dichlorobenzene 0.14
    ethyl lactate 0.83
    propylene carbonate 1.69
    n-methylformamide 22.31
    2-pentanol 0.66
    n-pentane 0.24
    1-propoxy-2-propanol 1.28
    1-methoxy-2-propyl acetate 0.5
    2-(2-methoxypropoxy) propanol 1.76
    mesitylene 0.2
    ε-caprolactone 1.46
    p-cymene 0.16
    epichlorohydrin 1.49
    1,1,1-trichloroethane 0.22
    2-aminoethanol 10.7
    morpholine-4-carbaldehyde 16.56
    sulfolane 9.89
    2,2,4-trimethylpentane 0.11
    2-methyltetrahydrofuran 1.07
    n-hexyl acetate 0.29
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 2.07
    sec-butyl acetate 0.14
    tert-butyl acetate 0.3
    decalin 0.09
    glycerin 20.84
    diglyme 4.55
    acrylic acid 5.19
    isopropyl myristate 0.12
    n-butyric acid 2.12
    acetyl acetate 0.37
    di(2-ethylhexyl) phthalate 0.37
    ethyl propionate 0.3
    nitromethane 11.52
    1,2-diethoxyethane 0.45
    benzonitrile 0.46
    trioctyl phosphate 0.27
    1-bromopropane 0.28
    gamma-valerolactone 6.12
    n-decanol 0.23
    triethyl phosphate 0.37
    4-methyl-2-pentanol 0.39
    propionitrile 0.87
    vinylene carbonate 2.0
    1,1,2-trichlorotrifluoroethane 4.71
    DMS 0.37
    cumene 0.13
    2-octanol 0.31
    2-hexanone 0.34
    octyl acetate 0.2
    limonene 0.24
    1,2-dimethoxyethane 4.78
    ethyl orthosilicate 0.37
    tributyl phosphate 0.29
    diacetone alcohol 1.24
    N,N-dimethylaniline 0.66
    acrylonitrile 1.7
    aniline 0.74
    1,3-propanediol 7.12
    bromobenzene 0.1
    dibromomethane 0.35
    1,1,2,2-tetrachloroethane 0.54
    2-methyl-cyclohexyl acetate 0.26
    tetrabutyl urea 0.7
    diisobutyl methanol 0.23
    2-phenylethanol 0.43
    styrene 0.15
    dioctyl adipate 0.25
    dimethyl sulfate 4.07
    ethyl butyrate 0.3
    methyl lactate 2.84
    butyl lactate 0.92
    diethyl carbonate 0.25
    propanediol butyl ether 2.58
    triethyl orthoformate 0.43
    p-tert-butyltoluene 0.17
    methyl 4-tert-butylbenzoate 0.98
    morpholine 3.34
    tert-butylamine 0.95
    n-dodecanol 0.18
    dimethoxymethane 5.14
    ethylene carbonate 1.37
    cyrene 2.81
    2-ethoxyethyl acetate 0.46
    2-ethylhexyl acetate 0.19
    1,2,4-trichlorobenzene 0.19
    4-methylpyridine 1.31
    dibutyl ether 0.22
    2,6-dimethyl-4-heptanol 0.23
    DEF 3.56
    dimethyl isosorbide 1.88
    tetrachloroethylene 0.62
    eugenol 1.48
    triacetin 0.5
    span 80 1.31
    1,4-butanediol 2.86
    1,1-dichloroethane 0.25
    2-methyl-1-pentanol 0.62
    methyl formate 13.24
    2-methyl-1-butanol 1.24
    n-decane 0.07
    butyronitrile 0.86
    3,7-dimethyl-1-octanol 0.23
    1-chlorooctane 0.09
    1-chlorotetradecane 0.05
    n-nonane 0.08
    undecane 0.05
    tert-butylcyclohexane 0.06
    cyclooctane 0.16
    cyclopentanol 1.71
    tetrahydropyran 0.88
    tert-amyl methyl ether 0.63
    2,5,8-trioxanonane 3.38
    1-hexene 0.27
    2-isopropoxyethanol 1.39
    2,2,2-trifluoroethanol 9.08
    methyl butyrate 0.64

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction