Hydroquinone diacetate

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  • Identifiers

    CAS number
    1205-91-0

    Molecular formula
    C10H10O4

    SMILES
    CC(=O)OC1=CC=C(C=C1)OC(=O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 62.06%
    Odorless 38.45%
    Floral 37.89%
    Animal 37.14%
    Burnt 34.9%
    Balsamic 33.25%
    Woody 32.81%
    Aromatic 30.3%
    Spicy 29.49%
    Medicinal 29.1%

     

    Flavor
    Sweet 77.63%
    Woody 40.37%
    Floral 38.75%
    Powdery 36.26%
    Creamy 30.75%
    Phenolic 29.18%
    Dry 28.62%
    Balsam 27.09%
    Mild 26.95%
    Tobacco 24.95%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    7.83 (neutral)

    Molecular weight
    194.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    276°C

    Flash point

    • 136.23 ˚C est.

  • Synonyms

    • 1,4-Diacetoxybenzene
    • 1205-91-0
    • Hydroquinone diacetate
    • 1,4-Benzenediol, diacetate
    • Hydroquinone, diacetate
    • 1,4-BENZENEDIOL DIACETATE
    • 1,4-Benzenediol, 1,4-diacetate
    • NSC 9277
    • p-Phenylene di(acetate)
    • NSC-9277
    • EINECS 214-887-9
    • 18I4277Z6G
    • AI3-11162
    • DTXSID30875905
    • RefChem:789398
    • DTXCID601014022
    • 1,4-phenylene diacetate
    • p-Phenylene diacetate
    • 4-(Acetyloxy)phenyl acetate
    • MFCD00011643
    • (4-acetyloxyphenyl) acetate
    • benzene-1,4-diyl diacetate
    • p-Diacetoxybenzene
    • 4-acetyloxyphenyl acetate
    • UNII-18I4277Z6G
    • 1,4-diacetoxy-benzene
    • 1,4-phenylenediacetate
    • 1 pound not4-Diacetoxybenzene
    • SCHEMBL269329
    • 4-(Acetyloxy)phenyl acetate #
    • F1037-0015
    • orb1306679
    • SCHEMBL6198568
    • NSC9277
    • HMS1786A06
    • STR03107
    • SBB008048
    • STK033177
    • AKOS000120579
    • PS-4026
    • AC-17036
    • SY049032
    • DB-041569
    • HY-118292
    • CS-0065623
    • D1803
    • EU-0066892
    • NS00044767
    • ST50825364
    • EN300-17071
    • A24734
    • D83403
    • 1,4-Benzenediol diacetate; Hydroquinone diacetate
    • F341925
    • Q27252007
    • Z56871713
    • 1,4-Benzenediacetic acid;4-Phenylenediacetic acid;1,4-Phenylenebis(acetic acid)
    • 1205-91-0

  • Applications

    Hydroquinone diacetate (CAS 1205-91-0) is primarily used as a protected form of hydroquinone in organic synthesis, with the phenolic OH groups acetylated to enable selective transformations, improve handling and storage, and facilitate compatibility in pharmaceutical and fine-chemical workflows; upon deacetylation it can regenerate hydroquinone for subsequent steps, making it a convenient intermediate. It also serves as a building block for the synthesis of quinone and phenolic derivatives and can function as a precursor to stabilizers and antioxidants used in polymers, coatings, and inks. Additionally, it has been explored in fragrance chemistry as a masked hydroquinone precursor for scent formulations under controlled processing conditions, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.29
    methanol 7.14
    isopropanol 2.97
    water 0.16
    ethyl acetate 16.08
    n-propanol 2.67
    acetone 36.68
    n-butanol 2.32
    acetonitrile 22.9
    DMF 112.08
    toluene 2.51
    isobutanol 2.18
    1,4-dioxane 17.4
    methyl acetate 31.15
    THF 34.93
    2-butanone 25.44
    n-pentanol 2.22
    sec-butanol 2.91
    n-hexane 0.94
    ethylene glycol 3.13
    NMP 141.54
    cyclohexane 0.36
    DMSO 189.89
    n-butyl acetate 15.82
    n-octanol 2.77
    chloroform 28.15
    n-propyl acetate 11.87
    acetic acid 15.8
    dichloromethane 42.71
    cyclohexanone 20.85
    propylene glycol 2.73
    isopropyl acetate 10.28
    DMAc 188.69
    2-ethoxyethanol 14.51
    isopentanol 2.65
    n-heptane 0.49
    ethyl formate 14.6
    1,2-dichloroethane 25.3
    n-hexanol 2.39
    2-methoxyethanol 24.54
    isobutyl acetate 6.63
    tetrachloromethane 2.61
    n-pentyl acetate 6.27
    transcutol 51.59
    n-heptanol 1.42
    ethylbenzene 3.78
    MIBK 9.4
    2-propoxyethanol 15.94
    tert-butanol 5.7
    MTBE 9.89
    2-butoxyethanol 6.85
    propionic acid 9.93
    o-xylene 3.91
    formic acid 10.66
    diethyl ether 7.66
    m-xylene 2.38
    p-xylene 5.57
    chlorobenzene 8.46
    dimethyl carbonate 17.73
    n-octane 0.26
    formamide 23.22
    cyclopentanone 41.76
    2-pentanone 13.88
    anisole 20.27
    cyclopentyl methyl ether 10.96
    gamma-butyrolactone 59.15
    1-methoxy-2-propanol 16.33
    pyridine 17.94
    3-pentanone 15.95
    furfural 72.23
    n-dodecane 0.33
    diethylene glycol 16.87
    diisopropyl ether 2.71
    tert-amyl alcohol 5.75
    acetylacetone 38.33
    n-hexadecane 0.38
    acetophenone 25.3
    methyl propionate 19.35
    isopentyl acetate 15.14
    trichloroethylene 52.53
    n-nonanol 2.75
    cyclohexanol 2.28
    benzyl alcohol 8.16
    2-ethylhexanol 2.9
    isooctanol 1.56
    dipropyl ether 6.75
    1,2-dichlorobenzene 14.12
    ethyl lactate 10.62
    propylene carbonate 29.43
    n-methylformamide 29.47
    2-pentanol 1.86
    n-pentane 0.33
    1-propoxy-2-propanol 12.65
    1-methoxy-2-propyl acetate 27.06
    2-(2-methoxypropoxy) propanol 26.37
    mesitylene 1.91
    ε-caprolactone 22.57
    p-cymene 3.53
    epichlorohydrin 60.31
    1,1,1-trichloroethane 16.83
    2-aminoethanol 3.91
    morpholine-4-carbaldehyde 86.24
    sulfolane 129.02
    2,2,4-trimethylpentane 0.5
    2-methyltetrahydrofuran 19.83
    n-hexyl acetate 11.16
    isooctane 0.25
    2-(2-butoxyethoxy)ethanol 18.53
    sec-butyl acetate 8.4
    tert-butyl acetate 15.94
    decalin 1.02
    glycerin 8.7
    diglyme 45.81
    acrylic acid 12.87
    isopropyl myristate 5.97
    n-butyric acid 8.52
    acetyl acetate 16.16
    di(2-ethylhexyl) phthalate 8.25
    ethyl propionate 15.17
    nitromethane 89.61
    1,2-diethoxyethane 15.06
    benzonitrile 12.41
    trioctyl phosphate 4.38
    1-bromopropane 8.93
    gamma-valerolactone 64.21
    n-decanol 2.16
    triethyl phosphate 16.51
    4-methyl-2-pentanol 1.62
    propionitrile 8.78
    vinylene carbonate 27.51
    1,1,2-trichlorotrifluoroethane 49.48
    DMS 25.5
    cumene 3.71
    2-octanol 1.35
    2-hexanone 13.56
    octyl acetate 6.87
    limonene 4.48
    1,2-dimethoxyethane 49.09
    ethyl orthosilicate 12.9
    tributyl phosphate 8.69
    diacetone alcohol 18.14
    N,N-dimethylaniline 18.69
    acrylonitrile 17.27
    aniline 5.35
    1,3-propanediol 5.27
    bromobenzene 8.69
    dibromomethane 21.08
    1,1,2,2-tetrachloroethane 38.07
    2-methyl-cyclohexyl acetate 15.11
    tetrabutyl urea 13.69
    diisobutyl methanol 2.75
    2-phenylethanol 7.48
    styrene 4.36
    dioctyl adipate 12.65
    dimethyl sulfate 75.94
    ethyl butyrate 14.92
    methyl lactate 16.42
    butyl lactate 7.74
    diethyl carbonate 14.9
    propanediol butyl ether 8.11
    triethyl orthoformate 12.87
    p-tert-butyltoluene 3.65
    methyl 4-tert-butylbenzoate 21.97
    morpholine 18.76
    tert-butylamine 2.93
    n-dodecanol 1.76
    dimethoxymethane 35.41
    ethylene carbonate 16.67
    cyrene 28.78
    2-ethoxyethyl acetate 14.59
    2-ethylhexyl acetate 12.31
    1,2,4-trichlorobenzene 20.15
    4-methylpyridine 20.93
    dibutyl ether 6.36
    2,6-dimethyl-4-heptanol 2.75
    DEF 30.87
    dimethyl isosorbide 60.26
    tetrachloroethylene 18.18
    eugenol 18.8
    triacetin 25.82
    span 80 12.0
    1,4-butanediol 2.5
    1,1-dichloroethane 14.35
    2-methyl-1-pentanol 3.06
    methyl formate 28.46
    2-methyl-1-butanol 2.63
    n-decane 0.51
    butyronitrile 6.84
    3,7-dimethyl-1-octanol 4.08
    1-chlorooctane 2.61
    1-chlorotetradecane 1.4
    n-nonane 0.45
    undecane 0.4
    tert-butylcyclohexane 1.08
    cyclooctane 0.18
    cyclopentanol 3.89
    tetrahydropyran 7.88
    tert-amyl methyl ether 10.32
    2,5,8-trioxanonane 41.52
    1-hexene 2.75
    2-isopropoxyethanol 9.57
    2,2,2-trifluoroethanol 12.31
    methyl butyrate 19.69

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction