Hydromorphone Hydrochloride

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  • Identifiers

    CAS number
    71-68-1

    Molecular formula
    C17H20ClNO3

    SMILES
    CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4.Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 55.96%
    Animal 22.66%
    Spicy 22.56%
    Savory 21.34%
    Burnt 21.21%
    Phenolic 18.57%
    Roasted 18.28%
    Cooling 17.7%
    Smoky 17.34%
    Vanilla 17.16%

     

    Flavor
    Bitter 94.36%
    Sweet-like 20.55%
    Cedarleaf 20.23%
    Bland 19.29%
    Cereal 18.48%
    Alkaline 18.45%
    Lovage 17.98%
    Very strong 17.92%
    Indole 17.81%
    Nitrile 17.67%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.91 (neutral)

    Molecular weight
    321.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    676°C

    Flash point

    • 199.61 ˚C est.

  • Synonyms

    • Hydromorphone hydrochloride
    • Hydromorphone HCL
    • 71-68-1
    • Hymorphan
    • Exalgo
    • Dilaudid-hp
    • Dilaudid
    • Palladone
    • Dihydromorphinone hydrochloride
    • Dilaudid hydrochloride
    • UNII-L960UP2KRW
    • Morphinone, dihydro-, hydrochloride
    • EINECS 200-762-6
    • L960UP2KRW
    • Hydromorphone hydrochloride cii
    • NSC 117862
    • 4,5alpha-Epoxy-3-hydroxy-17-methylmorphinan-6-one hydrochloride
    • NSC-117862
    • CHEBI:5791
    • 4,5-alpha-Epoxy-3-hydroxy-17-methylmorphinan-6-one hydrochloride
    • Hydromorphone hydrochloride [USP]
    • Laudicon
    • DEA No. 9150
    • Morphinan-6-one, 4,5alpha-epoxy-3-hydroxy-17-methyl-, hydrochloride
    • Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, hydrochloride, (5alpha)-
    • Morphinan-6-one, 4,5-alpha-epoxy-3-hydroxy-17-methyl-, hydrochloride, (5'-alpha)-
    • (4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride
    • Hydromorphone hydrochloride (USP)
    • HYDROMORPHONE HYDROCHLORIDE (MART.)
    • HYDROMORPHONE HYDROCHLORIDE [MART.]
    • NSC19046
    • Hydromorphone Hydrochloride (1mg/ml in Methanol)
    • HYDROMORPHONE HYDROCHLORIDE CII (USP-RS)
    • HYDROMORPHONE HYDROCHLORIDE CII [USP-RS]
    • HYDROMORPHONE HYDROCHLORIDE (EP MONOGRAPH)
    • HYDROMORPHONE HYDROCHLORIDE (USP MONOGRAPH)
    • HYDROMORPHONE HYDROCHLORIDE [EP MONOGRAPH]
    • HYDROMORPHONE HYDROCHLORIDE [USP MONOGRAPH]
    • Novolauden
    • Hydrostat
    • Dilaudid Hp
    • Palladone (TN)
    • Dilaudid (TN)
    • Exalgo (TN)
    • 3-hydroxy-17-methyl-4,5alpha-epoxymorphinan-6-one hydrochloride
    • SCHEMBL30521
    • CHEMBL1237055
    • DTXSID90991291
    • MFCD03427563
    • Hydromorphone hydrochloride (JAN/USP)
    • HYDROMORPHONE HYDROCHLORIDE [MI]
    • HYDROMORPHONE HYDROCHLORIDE [JAN]
    • HYDROMORPHONE HYDROCHLORIDE [VANDF]
    • DB-243594
    • HYDROMORPHONE HYDROCHLORIDE [WHO-DD]
    • NS00078931
    • D00839
    • HYDROMORPHONE HYDROCHLORIDE [ORANGE BOOK]
    • Q27106892
    • (5R)-4,5-Epoxy-17-methylmorphinan-6-one monohydrochloride
    • (5alpha)-4,5-Epoxy-3-hydroxy-17-methyl-morphinan-6-one hydrochloride
    • Hydromorphone hydrochloride, European Pharmacopoeia (EP) Reference Standard
    • Hydromorphone hydrochloride, United States Pharmacopeia (USP) Reference Standard
    • Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, hydrochloride (1:1), (5.alpha.)
    • Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, hydrochloride, (5.alpha.)-
    • 200-762-6

  • Applications

    Hydromorphone Hydrochloride, CAS 71-68-1, is primarily used as an active pharmaceutical ingredient in opioid analgesics; it is also manufactured as the hydrochloride salt to improve solubility and handling for pharmaceutical production; it serves as a reference standard in analytical testing and method development (for example chromatographic assays) and is used in pharmacological research related to opioid receptors; due to its status as a controlled substance, its handling and distribution are strictly regulated; additional applications include formulation development and quality control in pharmaceutical manufacturing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.22
    methanol 4.84
    isopropanol 1.64
    water 0.45
    ethyl acetate 4.79
    n-propanol 1.31
    acetone 6.48
    n-butanol 2.05
    acetonitrile 2.86
    DMF 18.12
    toluene 3.26
    isobutanol 1.41
    1,4-dioxane 8.96
    methyl acetate 3.79
    THF 10.2
    2-butanone 4.07
    n-pentanol 1.28
    sec-butanol 0.57
    n-hexane 0.02
    ethylene glycol 4.18
    NMP 16.98
    cyclohexane 0.11
    DMSO 19.64
    n-butyl acetate 8.0
    n-octanol 2.99
    chloroform 12.26
    n-propyl acetate 4.96
    acetic acid 12.78
    dichloromethane 11.3
    cyclohexanone 19.35
    propylene glycol 1.04
    isopropyl acetate 6.64
    DMAc 17.74
    2-ethoxyethanol 7.14
    isopentanol 3.65
    n-heptane 0.08
    ethyl formate 7.27
    1,2-dichloroethane 7.06
    n-hexanol 3.12
    2-methoxyethanol 16.65
    isobutyl acetate 5.9
    tetrachloromethane 2.78
    n-pentyl acetate 11.29
    transcutol 32.62
    n-heptanol 4.8
    ethylbenzene 1.53
    MIBK 7.17
    2-propoxyethanol 18.65
    tert-butanol 2.49
    MTBE 0.55
    2-butoxyethanol 17.73
    propionic acid 3.82
    o-xylene 3.05
    formic acid 16.58
    diethyl ether 0.82
    m-xylene 3.94
    p-xylene 2.42
    chlorobenzene 7.14
    dimethyl carbonate 8.99
    n-octane 0.08
    formamide 20.35
    cyclopentanone 19.12
    2-pentanone 5.67
    anisole 3.73
    cyclopentyl methyl ether 3.64
    gamma-butyrolactone 22.8
    1-methoxy-2-propanol 12.15
    pyridine 11.09
    3-pentanone 3.44
    furfural 40.05
    n-dodecane 0.15
    diethylene glycol 31.84
    diisopropyl ether 0.73
    tert-amyl alcohol 0.9
    acetylacetone 17.58
    n-hexadecane 0.19
    acetophenone 10.46
    methyl propionate 4.67
    isopentyl acetate 10.72
    trichloroethylene 22.35
    n-nonanol 3.78
    cyclohexanol 2.81
    benzyl alcohol 8.08
    2-ethylhexanol 2.87
    isooctanol 4.84
    dipropyl ether 1.33
    1,2-dichlorobenzene 9.97
    ethyl lactate 7.95
    propylene carbonate 18.16
    n-methylformamide 10.24
    2-pentanol 1.03
    n-pentane 0.04
    1-propoxy-2-propanol 11.18
    1-methoxy-2-propyl acetate 16.2
    2-(2-methoxypropoxy) propanol 16.8
    mesitylene 2.65
    ε-caprolactone 14.97
    p-cymene 3.2
    epichlorohydrin 18.59
    1,1,1-trichloroethane 5.85
    2-aminoethanol 2.96
    morpholine-4-carbaldehyde 32.37
    sulfolane 32.89
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 2.9
    n-hexyl acetate 9.89
    isooctane 0.09
    2-(2-butoxyethoxy)ethanol 20.91
    sec-butyl acetate 3.91
    tert-butyl acetate 7.61
    decalin 0.16
    glycerin 9.39
    diglyme 36.04
    acrylic acid 7.61
    isopropyl myristate 5.22
    n-butyric acid 10.26
    acetyl acetate 11.35
    di(2-ethylhexyl) phthalate 10.34
    ethyl propionate 4.28
    nitromethane 22.79
    1,2-diethoxyethane 6.56
    benzonitrile 14.16
    trioctyl phosphate 7.67
    1-bromopropane 1.17
    gamma-valerolactone 41.43
    n-decanol 2.82
    triethyl phosphate 6.7
    4-methyl-2-pentanol 2.01
    propionitrile 2.93
    vinylene carbonate 24.91
    1,1,2-trichlorotrifluoroethane 31.48
    DMS 12.91
    cumene 1.72
    2-octanol 2.43
    2-hexanone 4.26
    octyl acetate 6.45
    limonene 2.73
    1,2-dimethoxyethane 12.58
    ethyl orthosilicate 5.98
    tributyl phosphate 7.77
    diacetone alcohol 12.55
    N,N-dimethylaniline 3.68
    acrylonitrile 7.69
    aniline 6.33
    1,3-propanediol 8.19
    bromobenzene 6.28
    dibromomethane 4.31
    1,1,2,2-tetrachloroethane 13.21
    2-methyl-cyclohexyl acetate 9.13
    tetrabutyl urea 10.59
    diisobutyl methanol 2.63
    2-phenylethanol 13.46
    styrene 1.57
    dioctyl adipate 8.86
    dimethyl sulfate 17.08
    ethyl butyrate 6.2
    methyl lactate 10.99
    butyl lactate 14.21
    diethyl carbonate 6.28
    propanediol butyl ether 12.86
    triethyl orthoformate 6.75
    p-tert-butyltoluene 2.77
    methyl 4-tert-butylbenzoate 18.23
    morpholine 7.16
    tert-butylamine 0.81
    n-dodecanol 2.11
    dimethoxymethane 14.38
    ethylene carbonate 20.09
    cyrene 21.34
    2-ethoxyethyl acetate 17.95
    2-ethylhexyl acetate 7.76
    1,2,4-trichlorobenzene 12.16
    4-methylpyridine 11.29
    dibutyl ether 1.84
    2,6-dimethyl-4-heptanol 2.63
    DEF 7.25
    dimethyl isosorbide 28.59
    tetrachloroethylene 14.04
    eugenol 21.21
    triacetin 16.45
    span 80 13.78
    1,4-butanediol 3.06
    1,1-dichloroethane 3.69
    2-methyl-1-pentanol 1.96
    methyl formate 12.86
    2-methyl-1-butanol 1.59
    n-decane 0.21
    butyronitrile 3.17
    3,7-dimethyl-1-octanol 3.64
    1-chlorooctane 1.22
    1-chlorotetradecane 0.73
    n-nonane 0.12
    undecane 0.18
    tert-butylcyclohexane 0.12
    cyclooctane 0.08
    cyclopentanol 2.39
    tetrahydropyran 2.86
    tert-amyl methyl ether 0.59
    2,5,8-trioxanonane 27.58
    1-hexene 0.12
    2-isopropoxyethanol 5.75
    2,2,2-trifluoroethanol 15.1
    methyl butyrate 6.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction