Honokiol

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  • Identifiers

    CAS number
    35354-74-6

    Molecular formula
    C18H18O2

    SMILES
    C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Spicy 65.37%
    Phenolic 58.72%
    Smoky 41.8%
    Medicinal 37.85%
    Woody 32.48%
    Herbal 31.9%
    Sweet 31.46%
    Burnt 31.35%
    Meaty 27.38%
    Clove 26.41%

     

    Flavor
    Phenolic 40.82%
    Bitter 38.13%
    Sweet 34.93%
    Spicy 34.86%
    Medicinal 31.66%
    Mild 30.36%
    Woody 27.47%
    Spice 25.51%
    Clove 25.24%
    Almond shell 23.2%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.0

    pKa est.
    9.41 (weak base)

    Molecular weight
    266.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    444°C

    Flash point

    • 212.74 ˚C est.

  • Synonyms

    • Honokiol
    • 35354-74-6
    • 3,5'-Diallyl-4,2'-dihydroxybiphenyl
    • Purinol
    • 4-allyl-2-(3-allyl-4-hydroxy-phenyl)phenol
    • 2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
    • DTXSID30188845
    • 11513CCO0N
    • FMLT BSASM H
    • NSC-293100
    • (1,1'-BIPHENYL)-2,4'-DIOL, 3',5-DI-2-PROPEN-1-YL-
    • RefChem:788486
    • DTXCID90111336
    • 609-119-8
    • 5,3'-Diallyl-2,4'-dihydroxybiphenyl
    • NSC 293100
    • 3',5-Di-2-propen-1-yl[1,1'-biphenyl]-2,4'-diol
    • MFCD00016674
    • 3',5-Diallylbiphenyl-2,4'-diol
    • 3',5-diallyl-[1,1'-biphenyl]-2,4'-diol
    • CPD000387107
    • CHEMBL16901
    • 2-[4-hydroxy-3-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol
    • NSC293100
    • s2310
    • [1,1'-Biphenyl]-2,4'-diol, 3',5-di-2-propenyl-
    • 2-(4-hydroxy-3-prop-2-enyl-phenyl)- 4-prop-2-enyl-phenol
    • (1P)-3',5-di(prop-2-en-1-yl)[1,1'-biphenyl]-2,4'-diol
    • SMR000387107
    • 3',5-di(prop-2-en-1-yl)biphenyl-2,4'-diol
    • 3',5-diallyl-2,4'-biphenyldiol
    • (1,1'-BIPHENYL)-2,4'-DIOL, 3',5-DI-2-PROPENYL-
    • UNII-11513CCO0N
    • Honokiol?
    • -dihydroxydiphenyl
    • Honokiol CRS
    • Honokiol, HO
    • 3',5-Di-2-propen-1-yl-[1,1'-biphenyl]-2,4'-diol; [1,1'-Biphenyl]-2,4'-diol, 3',5-di-2-propenyl- (9CI); 3',5-Diallyl-2,4'-biphenyldiol; Honokiol; NSC 293100
    • Y4T
    • Honokiol (Standard)
    • 5,3&prime
    • Honokiol - 98%
    • -Diallyl-2,4&prime
    • HONOKIOL [MI]
    • HONOKIOL [WHO-DD]
    • Honokiol, analytical standard
    • cid_72303
    • MLS000759481
    • MLS001048916
    • MLS001423980
    • MLS006011755
    • SCHEMBL133034
    • REGID_for_CID_72303
    • CHEBI:5759
    • orb1304634
    • SCHEMBL29363985
    • SCHEMBL29384099
    • SCHEMBL30008303
    • GTPL11610
    • HY-N0003R
    • MSK1624
    • 3',1'-biphenyl)-2,4'-diol
    • GLXC-06954
    • HMS2051C12
    • HMS2271J07
    • HMS3393C12
    • HMS3656G03
    • HMS5080L08
    • BB_NC-01461
    • HY-N0003
    • 5,3'-Diallyl-biphenyl-2,4'-diol
    • AC-486
    • BBL027819
    • BDBM50157304
    • EBC-11157
    • HB0328
    • STK801954
    • 3'',5-diallylbiphenyl-2,4''-diol
    • Honokiol, >=98% (HPLC), powder
    • 3,5'-diallyl-2',4-dihydroxybiphenyl
    • AKOS005622639
    • Honokiol - 98% - Bio-X trade mark
    • 3',5-Diallyl-2,4'-dihydroxybiphenyl
    • CCG-100864
    • CS-1696
    • FH09766
    • NC00114
    • 5,3''-Diallyl-biphenyl-2,4''-diol
    • SMP2_000040
    • 3',3'-Diallyl-4,6'-dihydroxybiphenyl
    • NCGC00163567-01
    • NCGC00163567-02
    • NCGC00163567-03
    • NCGC00163567-08
    • AS-15333
    • BH300084
    • 5,3''''-Diallyl-biphenyl-2,4''''-diol
    • H1309
    • NS00011726
    • SW197494-3
    • EN300-7399522
    • 3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol
    • 354H746
    • F221573
    • SR-01000758208
    • Q5896650
    • SR-01000758208-5
    • {1,1'-Biphenyl]-2,4'-diol, 3,5-di-2-propenyl-
    • 3'',5-di-2-propenyl-1,1''-biphenyl-2,4''-diol
    • BRD-K98493452-001-01-6
    • BRD-K98493452-001-14-9
    • Honokiol, European Pharmacopoeia (EP) Reference Standard
    • Z2065671480
    • [1,1'-Biphenyl]-2,4'-diol, 3',5-di-2-propen-1-yl
    • 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol
    • 3',5-Di(prop-2-en-1-yl)[1,1'-biphenyl]-2,4'-diol
    • 4-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-2-(prop-2-en-1-yl)phenol
    • 3',5-Diallyl-[1,1'-biphenyl]-2,4'-diol compound with 5,5'-diallyl-[1,1'-biphenyl]-2,2'-diol
    • InChI=1/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H
    • N-[[4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methyl]-2-fluoroaniline; N-?(2-?Fluorophenyl)?-?5-?(6-?methyl-?2-?pyridinyl)?-?4-?[1,?2,?4]?triazolo[1,?5-?a]?pyridin-?6-?yl-1H-?imidazole-?2-?methanamine
    • 35354-74-6

  • Applications

    Honokiol is a natural lignan derived from Magnolia bark (CAS 35354-74-6). In industry it is primarily considered a bioactive ingredient in cosmetics and personal care products, with potential antioxidant and anti-inflammatory activity, explored for skin and hair care formulations. It is also viewed as a natural fragrance ingredient in perfumery due to its Magnolia origin and may function as a fragrance stabilizer in fragrance systems. In cleaning and sanitation, honokiol is studied for antimicrobial activity and may be used as a bioactive additive in formulations. As a natural compound widely studied, honokiol is used in research and development as an intermediate to synthesize lignan derivatives for pharmaceutical and life-sciences applications, subject to local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 190.47
    methanol 193.05
    isopropanol 92.39
    water 0.02
    ethyl acetate 225.81
    n-propanol 201.54
    acetone 262.44
    n-butanol 113.82
    acetonitrile 72.53
    DMF 415.29
    toluene 70.2
    isobutanol 79.65
    1,4-dioxane 199.9
    methyl acetate 193.25
    THF 545.48
    2-butanone 337.91
    n-pentanol 69.21
    sec-butanol 108.04
    n-hexane 1.93
    ethylene glycol 17.62
    NMP 134.32
    cyclohexane 1.89
    DMSO 372.89
    n-butyl acetate 88.7
    n-octanol 20.15
    chloroform 122.78
    n-propyl acetate 80.95
    acetic acid 69.73
    dichloromethane 98.26
    cyclohexanone 208.78
    propylene glycol 51.08
    isopropyl acetate 115.18
    DMAc 517.73
    2-ethoxyethanol 143.78
    isopentanol 80.59
    n-heptane 1.43
    ethyl formate 50.01
    1,2-dichloroethane 161.26
    n-hexanol 68.54
    2-methoxyethanol 261.96
    isobutyl acetate 56.67
    tetrachloromethane 7.91
    n-pentyl acetate 44.55
    transcutol 461.68
    n-heptanol 30.18
    ethylbenzene 30.03
    MIBK 108.18
    2-propoxyethanol 163.77
    tert-butanol 130.18
    MTBE 190.96
    2-butoxyethanol 76.38
    propionic acid 77.12
    o-xylene 30.86
    formic acid 20.35
    diethyl ether 244.82
    m-xylene 34.18
    p-xylene 26.33
    chlorobenzene 51.09
    dimethyl carbonate 80.15
    n-octane 0.98
    formamide 76.57
    cyclopentanone 307.84
    2-pentanone 236.79
    anisole 93.97
    cyclopentyl methyl ether 145.74
    gamma-butyrolactone 221.59
    1-methoxy-2-propanol 208.97
    pyridine 189.33
    3-pentanone 188.38
    furfural 134.05
    n-dodecane 1.17
    diethylene glycol 98.3
    diisopropyl ether 35.89
    tert-amyl alcohol 122.73
    acetylacetone 189.43
    n-hexadecane 1.36
    acetophenone 71.28
    methyl propionate 211.35
    isopentyl acetate 87.95
    trichloroethylene 262.5
    n-nonanol 21.98
    cyclohexanol 58.67
    benzyl alcohol 63.69
    2-ethylhexanol 37.22
    isooctanol 27.49
    dipropyl ether 57.53
    1,2-dichlorobenzene 42.63
    ethyl lactate 40.01
    propylene carbonate 81.14
    n-methylformamide 135.66
    2-pentanol 70.69
    n-pentane 1.31
    1-propoxy-2-propanol 105.42
    1-methoxy-2-propyl acetate 125.86
    2-(2-methoxypropoxy) propanol 80.13
    mesitylene 17.23
    ε-caprolactone 135.9
    p-cymene 15.42
    epichlorohydrin 360.81
    1,1,1-trichloroethane 71.01
    2-aminoethanol 62.08
    morpholine-4-carbaldehyde 160.29
    sulfolane 203.02
    2,2,4-trimethylpentane 3.19
    2-methyltetrahydrofuran 221.08
    n-hexyl acetate 54.37
    isooctane 2.6
    2-(2-butoxyethoxy)ethanol 123.85
    sec-butyl acetate 70.38
    tert-butyl acetate 131.72
    decalin 3.03
    glycerin 65.0
    diglyme 224.05
    acrylic acid 52.3
    isopropyl myristate 23.75
    n-butyric acid 102.62
    acetyl acetate 67.83
    di(2-ethylhexyl) phthalate 24.45
    ethyl propionate 83.44
    nitromethane 178.23
    1,2-diethoxyethane 136.13
    benzonitrile 48.44
    trioctyl phosphate 17.6
    1-bromopropane 68.88
    gamma-valerolactone 282.14
    n-decanol 17.56
    triethyl phosphate 31.01
    4-methyl-2-pentanol 44.58
    propionitrile 94.23
    vinylene carbonate 62.55
    1,1,2-trichlorotrifluoroethane 155.56
    DMS 59.65
    cumene 18.86
    2-octanol 17.8
    2-hexanone 99.53
    octyl acetate 28.97
    limonene 22.0
    1,2-dimethoxyethane 235.99
    ethyl orthosilicate 32.17
    tributyl phosphate 21.68
    diacetone alcohol 154.66
    N,N-dimethylaniline 47.67
    acrylonitrile 105.73
    aniline 85.53
    1,3-propanediol 92.4
    bromobenzene 45.04
    dibromomethane 58.67
    1,1,2,2-tetrachloroethane 205.5
    2-methyl-cyclohexyl acetate 47.69
    tetrabutyl urea 29.71
    diisobutyl methanol 27.37
    2-phenylethanol 62.05
    styrene 36.7
    dioctyl adipate 35.73
    dimethyl sulfate 104.2
    ethyl butyrate 62.93
    methyl lactate 68.88
    butyl lactate 41.47
    diethyl carbonate 41.04
    propanediol butyl ether 62.88
    triethyl orthoformate 45.54
    p-tert-butyltoluene 16.32
    methyl 4-tert-butylbenzoate 56.18
    morpholine 332.2
    tert-butylamine 59.41
    n-dodecanol 13.28
    dimethoxymethane 352.3
    ethylene carbonate 51.56
    cyrene 64.85
    2-ethoxyethyl acetate 88.99
    2-ethylhexyl acetate 61.14
    1,2,4-trichlorobenzene 54.02
    4-methylpyridine 158.51
    dibutyl ether 37.22
    2,6-dimethyl-4-heptanol 27.37
    DEF 191.15
    dimethyl isosorbide 128.98
    tetrachloroethylene 91.72
    eugenol 58.5
    triacetin 54.99
    span 80 53.99
    1,4-butanediol 29.02
    1,1-dichloroethane 100.68
    2-methyl-1-pentanol 65.88
    methyl formate 74.5
    2-methyl-1-butanol 82.13
    n-decane 1.85
    butyronitrile 67.99
    3,7-dimethyl-1-octanol 29.7
    1-chlorooctane 12.46
    1-chlorotetradecane 5.31
    n-nonane 1.46
    undecane 1.43
    tert-butylcyclohexane 3.86
    cyclooctane 0.8
    cyclopentanol 58.76
    tetrahydropyran 247.94
    tert-amyl methyl ether 126.33
    2,5,8-trioxanonane 144.6
    1-hexene 21.22
    2-isopropoxyethanol 98.18
    2,2,2-trifluoroethanol 16.79
    methyl butyrate 90.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction