Homodihydrocapsaicin

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  • Identifiers

    CAS number
    20279-06-5

    Molecular formula
    C19H31NO3

    SMILES
    CC(C)CCCCCCCC(=O)NCC1=CC(=C(C=C1)O)OC

    Safety labels

  • Odor profile

    Fragrance
    Cooling 39.31%
    Odorless 38.29%
    Savory 37.93%
    Spicy 32.36%
    Meaty 31.15%
    Herbal 28.77%
    Mint 28.45%
    Animal 26.68%
    Burnt 21.15%
    Warm 20.84%

     

    Flavor
    Herbal 44.25%
    Bland 35.82%
    Odorless 34.61%
    Mild 32.75%
    Woody 25.33%
    Warm 23.4%
    Spicy 21.07%
    Parsley 20.38%
    Lovage 20.34%
    Faint 20.28%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.0

    pKa est.
    9.99 (weak base)

    Molecular weight
    321.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    473°C

    Melting point expt.

    • 70 - 71 °C

    Flash point

    • 182.41 ˚C est.

  • Synonyms

    • Homodihydrocapsaicin I
    • homodihydrocapsaicin
    • 20279-06-5
    • n-(4-hydroxy-3-methoxybenzyl)-9-methyldecanamide
    • UNII-QE35S0T20Z
    • QE35S0T20Z
    • DECANAMIDE, 9-METHYL-N-VANILLYL-
    • RefChem:39049
    • N-[(4-hydroxy-3-methoxyphenyl)methyl]-9-methyldecanamide
    • Decanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-9-methyl-
    • Dihydro Homocapsaicin I
    • Decanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-9-methyl-
    • orb1297339
    • SCHEMBL1870592
    • C19H31NO3
    • N-(vanillyl)-9-methyldecanamide
    • DTXSID30174127
    • AKDLSISGGARWFP-UHFFFAOYSA-N
    • CHEBI:174344
    • HY-N5082
    • MFCD30533883
    • MSK158333
    • AKOS028111714
    • EBC-617271
    • DA-74256
    • MS-24760
    • CS-0032400
    • NS00094666
    • E80599
    • Q5891091
    • N-((4-Hydroxy-3-methoxyphenyl)methyl)-9-methyl-Decanamide
    • N-[(4-hydroxy-3-methoxy-phenyl)methyl]-9-methyl-decanamide
    • N-[(4-Hydroxy-3-methoxyphenyl)methyl]-9-methyldecanamide, 9CI
    • 9-Methyl-N-vanillyl-decanamide; N-[(4-Hydroxy-3-methoxyphenyl)methyl]-9-methyldecanamide; Homodihydrocapsaicin; Homodihydrocapsaicin I; N-(4-Hydroxy-3-methoxybenzyl)-9-methyldecanamide
    • 20279-06-5

  • Applications

    Homodihydrocapsaicin (CAS 20279-06-5) is a capsaicinoid with several practical applications across industry and research: it provides heat and flavor in food and food-processing formulations; it may be considered for cosmetic/personal-care formulations to impart a warming or mild irritant sensation; it is studied and used in agriculture and crop protection as a natural irritant and deterrent against pests; it features in public-safety and self-defense product formulations such as pepper-spray variants where capsaicinoids deliver rapid irritant effects; and in research and development as a model compound for studying TRPV1 receptor activation and structure-activity relationships. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1036.99
    methanol 1603.07
    isopropanol 420.04
    water 0.18
    ethyl acetate 869.69
    n-propanol 451.63
    acetone 1408.83
    n-butanol 280.3
    acetonitrile 259.27
    DMF 535.52
    toluene 41.75
    isobutanol 215.71
    1,4-dioxane 516.03
    methyl acetate 445.38
    THF 995.49
    2-butanone 529.74
    n-pentanol 143.77
    sec-butanol 205.56
    n-hexane 0.51
    ethylene glycol 43.88
    NMP 233.57
    cyclohexane 3.14
    DMSO 1538.43
    n-butyl acetate 165.79
    n-octanol 39.96
    chloroform 430.63
    n-propyl acetate 237.67
    acetic acid 643.69
    dichloromethane 474.44
    cyclohexanone 546.52
    propylene glycol 133.99
    isopropyl acetate 343.66
    DMAc 565.42
    2-ethoxyethanol 474.38
    isopentanol 195.45
    n-heptane 0.75
    ethyl formate 286.2
    1,2-dichloroethane 385.62
    n-hexanol 85.61
    2-methoxyethanol 1024.59
    isobutyl acetate 135.58
    tetrachloromethane 37.19
    n-pentyl acetate 122.14
    transcutol 939.1
    n-heptanol 48.06
    ethylbenzene 21.51
    MIBK 203.2
    2-propoxyethanol 308.55
    tert-butanol 395.91
    MTBE 249.45
    2-butoxyethanol 166.32
    propionic acid 271.64
    o-xylene 31.66
    formic acid 177.24
    diethyl ether 135.71
    m-xylene 33.28
    p-xylene 32.88
    chlorobenzene 95.88
    dimethyl carbonate 102.23
    n-octane 1.02
    formamide 363.74
    cyclopentanone 677.91
    2-pentanone 461.53
    anisole 90.48
    cyclopentyl methyl ether 178.04
    gamma-butyrolactone 648.32
    1-methoxy-2-propanol 544.35
    pyridine 232.51
    3-pentanone 187.09
    furfural 375.31
    n-dodecane 1.47
    diethylene glycol 235.33
    diisopropyl ether 25.88
    tert-amyl alcohol 222.86
    acetylacetone 622.95
    n-hexadecane 1.67
    acetophenone 117.19
    methyl propionate 342.66
    isopentyl acetate 155.71
    trichloroethylene 597.19
    n-nonanol 38.31
    cyclohexanol 164.32
    benzyl alcohol 110.47
    2-ethylhexanol 38.77
    isooctanol 44.32
    dipropyl ether 30.61
    1,2-dichlorobenzene 91.44
    ethyl lactate 98.18
    propylene carbonate 285.86
    n-methylformamide 375.62
    2-pentanol 103.42
    n-pentane 0.43
    1-propoxy-2-propanol 173.01
    1-methoxy-2-propyl acetate 225.68
    2-(2-methoxypropoxy) propanol 130.09
    mesitylene 20.72
    ε-caprolactone 418.06
    p-cymene 17.42
    epichlorohydrin 763.67
    1,1,1-trichloroethane 239.33
    2-aminoethanol 189.73
    morpholine-4-carbaldehyde 353.89
    sulfolane 601.48
    2,2,4-trimethylpentane 2.34
    2-methyltetrahydrofuran 365.75
    n-hexyl acetate 126.07
    isooctane 1.65
    2-(2-butoxyethoxy)ethanol 219.95
    sec-butyl acetate 143.32
    tert-butyl acetate 291.73
    decalin 2.9
    glycerin 159.74
    diglyme 463.64
    acrylic acid 174.25
    isopropyl myristate 37.74
    n-butyric acid 605.26
    acetyl acetate 294.75
    di(2-ethylhexyl) phthalate 49.26
    ethyl propionate 160.51
    nitromethane 1162.0
    1,2-diethoxyethane 203.24
    benzonitrile 111.28
    trioctyl phosphate 33.87
    1-bromopropane 86.66
    gamma-valerolactone 887.33
    n-decanol 26.8
    triethyl phosphate 50.52
    4-methyl-2-pentanol 58.9
    propionitrile 142.38
    vinylene carbonate 211.91
    1,1,2-trichlorotrifluoroethane 405.65
    DMS 115.08
    cumene 17.25
    2-octanol 32.42
    2-hexanone 174.63
    octyl acetate 52.64
    limonene 23.59
    1,2-dimethoxyethane 547.09
    ethyl orthosilicate 48.23
    tributyl phosphate 42.49
    diacetone alcohol 330.67
    N,N-dimethylaniline 49.23
    acrylonitrile 181.52
    aniline 99.78
    1,3-propanediol 440.17
    bromobenzene 83.38
    dibromomethane 225.83
    1,1,2,2-tetrachloroethane 479.68
    2-methyl-cyclohexyl acetate 82.77
    tetrabutyl urea 54.91
    diisobutyl methanol 27.28
    2-phenylethanol 94.69
    styrene 28.49
    dioctyl adipate 69.88
    dimethyl sulfate 172.11
    ethyl butyrate 106.2
    methyl lactate 143.83
    butyl lactate 114.64
    diethyl carbonate 71.72
    propanediol butyl ether 156.63
    triethyl orthoformate 70.32
    p-tert-butyltoluene 17.36
    methyl 4-tert-butylbenzoate 111.42
    morpholine 740.54
    tert-butylamine 90.48
    n-dodecanol 19.32
    dimethoxymethane 475.75
    ethylene carbonate 220.97
    cyrene 131.66
    2-ethoxyethyl acetate 234.65
    2-ethylhexyl acetate 98.39
    1,2,4-trichlorobenzene 111.54
    4-methylpyridine 190.01
    dibutyl ether 43.06
    2,6-dimethyl-4-heptanol 27.28
    DEF 285.51
    dimethyl isosorbide 219.38
    tetrachloroethylene 264.36
    eugenol 114.87
    triacetin 162.74
    span 80 107.94
    1,4-butanediol 117.61
    1,1-dichloroethane 314.79
    2-methyl-1-pentanol 117.47
    methyl formate 268.48
    2-methyl-1-butanol 152.82
    n-decane 2.34
    butyronitrile 183.1
    3,7-dimethyl-1-octanol 45.56
    1-chlorooctane 18.97
    1-chlorotetradecane 6.89
    n-nonane 1.85
    undecane 1.78
    tert-butylcyclohexane 2.84
    cyclooctane 0.85
    cyclopentanol 177.23
    tetrahydropyran 415.03
    tert-amyl methyl ether 114.77
    2,5,8-trioxanonane 254.25
    1-hexene 6.19
    2-isopropoxyethanol 243.8
    2,2,2-trifluoroethanol 156.09
    methyl butyrate 249.27

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction