Hexamethylene bis-hydroxystearamide

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  • Identifiers

    CAS number
    55349-01-4

    Molecular formula
    C42H84N2O4

    SMILES
    CCCCCCC(CCCCCCCCCCC(=O)NCCCCCCNC(=O)CCCCCCCCCCC(CCCCCC)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 33.34%
    Savory 33.13%
    Waxy 32.53%
    Meaty 31.82%
    Oily 31.67%
    Fatty 28.9%
    Odorless 28.4%
    Cooling 28.17%
    Fresh 27.98%
    Animal 25.91%

     

    Flavor
    Bland 33.95%
    Odorless 32.46%
    Mild 32.19%
    Fatty 29.49%
    Faint 26.08%
    Waxy 25.36%
    Slightly waxy 22.57%
    Delicate 21.45%
    Bay oil 21.38%
    Fat 20.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    13.3

    pKa est.
    10.79 (weak base)

    Molecular weight
    681.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1429°C

    Flash point

    • 306.77 ˚C est.

  • Synonyms

    • hexamethylene bis-hydroxystearamide
    • 55349-01-4
    • 2FS31BFC0F
    • SLIPACKS ZHH
    • SLIPAX ZHH
    • 12-hydroxy-N-[6-(12-hydroxyoctadecanoylamino)hexyl]octadecanamide
    • N,N'-Hexamethylenebis-12-hydroxystearamide
    • Octadecanamide, N,N'-1,6-hexanediylbis(12-hydroxy-
    • Octadecanamide, N,N'-1,6-hexanediylbis[12-hydroxy-
    • DTXSID9052214
    • HEXAMETHYLENEBIS(12-HYDROXYSTEARIC AMIDE)
    • N,N'-HEXAMETHYLENEBIS(12-HYDROXYSTEARAMIDE)
    • HEXAMETHYLENEDIAMINE 12-HYDROXYSTEARIC ACID DIAMIDE
    • 12-hydroxy-N-(6-(12-hydroxyoctadecanoylamino)hexyl)octadecanamide
    • RefChem:786208
    • DTXCID1030785
    • HEXAMETHYLENE BIS-HYDROXYSTEARAMIDE [INCI]
    • 611-260-5
    • Octadecanamide, N,N-1,6-hexanediylbis12-hydroxy-
    • UNII-2FS31BFC0F
    • SCHEMBL342717
    • CXPIOTOKMJNFSA-UHFFFAOYSA-N
    • NS00019612
    • N,N'-(Hexane-1,6-diyl)bis(12-hydroxyoctadecanamide)
    • Q27254680
    • 55349-01-4

  • Applications

    Hexamethylene bis-hydroxystearamide (CAS 55349-01-4) is a wax-like processing additive used across industries to modulate rheology and provide slip and texture. In cosmetics and personal care, it is commonly employed as a thickener/structurant and conditioning agent to improve texture, stabilize emulsions, and ease spreading in creams and lotions. In polymers and plastics, it acts as a slip/anti-block agent and processing aid, reducing interfacial friction and improving processability and surface feel. In coatings and inks, it can serve as a rheology modifier and lubricity additive to improve application, leveling, and the tactile finish of the dried film. In adhesives and other industrial formulations, it is used as a processing aid to improve handling and reduce sticking between layers during application. Use is formulation- and regulation-dependent and should comply with local rules.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.84
    methanol 1.37
    isopropanol 0.53
    water 0.02
    ethyl acetate 2.56
    n-propanol 1.16
    acetone 2.14
    n-butanol 1.18
    acetonitrile 0.46
    DMF 8.0
    toluene 2.23
    isobutanol 0.88
    1,4-dioxane 4.75
    methyl acetate 2.15
    THF 19.27
    2-butanone 4.12
    n-pentanol 1.37
    sec-butanol 1.18
    n-hexane 0.39
    ethylene glycol 0.17
    NMP 52.61
    cyclohexane 0.72
    DMSO 8.73
    n-butyl acetate 3.96
    n-octanol 2.35
    chloroform 14.01
    n-propyl acetate 3.78
    acetic acid 3.31
    dichloromethane 10.86
    cyclohexanone 16.76
    propylene glycol 0.52
    isopropyl acetate 2.76
    DMAc 29.93
    2-ethoxyethanol 3.67
    isopentanol 1.19
    n-heptane 0.38
    ethyl formate 2.22
    1,2-dichloroethane 5.39
    n-hexanol 1.16
    2-methoxyethanol 3.7
    isobutyl acetate 2.72
    tetrachloromethane 2.81
    n-pentyl acetate 8.06
    transcutol 27.61
    n-heptanol 2.0
    ethylbenzene 1.81
    MIBK 3.19
    2-propoxyethanol 4.58
    tert-butanol 0.82
    MTBE 2.12
    2-butoxyethanol 7.49
    propionic acid 2.28
    o-xylene 2.32
    formic acid 1.52
    diethyl ether 1.35
    m-xylene 1.68
    p-xylene 2.18
    chlorobenzene 3.63
    dimethyl carbonate 2.21
    n-octane 0.25
    formamide 1.98
    cyclopentanone 19.81
    2-pentanone 3.68
    anisole 3.21
    cyclopentyl methyl ether 8.85
    gamma-butyrolactone 20.97
    1-methoxy-2-propanol 3.77
    pyridine 6.97
    3-pentanone 4.25
    furfural 17.83
    n-dodecane 0.14
    diethylene glycol 1.74
    diisopropyl ether 0.74
    tert-amyl alcohol 1.96
    acetylacetone 5.58
    n-hexadecane 0.16
    acetophenone 6.17
    methyl propionate 3.38
    isopentyl acetate 4.78
    trichloroethylene 14.55
    n-nonanol 2.67
    cyclohexanol 2.91
    benzyl alcohol 2.58
    2-ethylhexanol 1.62
    isooctanol 1.97
    dipropyl ether 2.78
    1,2-dichlorobenzene 5.28
    ethyl lactate 3.34
    propylene carbonate 11.98
    n-methylformamide 2.84
    2-pentanol 0.94
    n-pentane 0.21
    1-propoxy-2-propanol 5.12
    1-methoxy-2-propyl acetate 6.71
    2-(2-methoxypropoxy) propanol 9.86
    mesitylene 1.15
    ε-caprolactone 19.02
    p-cymene 1.5
    epichlorohydrin 15.66
    1,1,1-trichloroethane 6.25
    2-aminoethanol 0.63
    morpholine-4-carbaldehyde 20.25
    sulfolane 48.97
    2,2,4-trimethylpentane 0.4
    2-methyltetrahydrofuran 11.35
    n-hexyl acetate 8.64
    isooctane 0.14
    2-(2-butoxyethoxy)ethanol 10.84
    sec-butyl acetate 3.67
    tert-butyl acetate 5.05
    decalin 0.62
    glycerin 1.31
    diglyme 23.14
    acrylic acid 2.17
    isopropyl myristate 2.51
    n-butyric acid 4.26
    acetyl acetate 2.46
    di(2-ethylhexyl) phthalate 3.58
    ethyl propionate 3.76
    nitromethane 4.93
    1,2-diethoxyethane 6.52
    benzonitrile 2.49
    trioctyl phosphate 2.34
    1-bromopropane 3.04
    gamma-valerolactone 32.76
    n-decanol 1.51
    triethyl phosphate 5.22
    4-methyl-2-pentanol 0.86
    propionitrile 0.83
    vinylene carbonate 9.11
    1,1,2-trichlorotrifluoroethane 18.05
    DMS 4.55
    cumene 1.44
    2-octanol 1.78
    2-hexanone 4.84
    octyl acetate 3.42
    limonene 2.64
    1,2-dimethoxyethane 8.56
    ethyl orthosilicate 5.31
    tributyl phosphate 3.35
    diacetone alcohol 6.21
    N,N-dimethylaniline 3.72
    acrylonitrile 1.12
    aniline 2.39
    1,3-propanediol 1.13
    bromobenzene 4.01
    dibromomethane 6.11
    1,1,2,2-tetrachloroethane 16.27
    2-methyl-cyclohexyl acetate 6.88
    tetrabutyl urea 5.74
    diisobutyl methanol 1.13
    2-phenylethanol 2.41
    styrene 1.72
    dioctyl adipate 5.43
    dimethyl sulfate 8.55
    ethyl butyrate 5.18
    methyl lactate 3.4
    butyl lactate 8.54
    diethyl carbonate 2.97
    propanediol butyl ether 6.85
    triethyl orthoformate 6.77
    p-tert-butyltoluene 1.47
    methyl 4-tert-butylbenzoate 12.24
    morpholine 7.64
    tert-butylamine 0.58
    n-dodecanol 0.89
    dimethoxymethane 4.44
    ethylene carbonate 6.7
    cyrene 13.44
    2-ethoxyethyl acetate 10.47
    2-ethylhexyl acetate 4.79
    1,2,4-trichlorobenzene 7.83
    4-methylpyridine 5.89
    dibutyl ether 3.74
    2,6-dimethyl-4-heptanol 1.13
    DEF 7.39
    dimethyl isosorbide 21.97
    tetrachloroethylene 9.96
    eugenol 8.72
    triacetin 12.45
    span 80 8.25
    1,4-butanediol 0.57
    1,1-dichloroethane 3.88
    2-methyl-1-pentanol 1.81
    methyl formate 2.37
    2-methyl-1-butanol 1.61
    n-decane 0.39
    butyronitrile 1.15
    3,7-dimethyl-1-octanol 2.18
    1-chlorooctane 2.01
    1-chlorotetradecane 0.51
    n-nonane 0.35
    undecane 0.22
    tert-butylcyclohexane 0.47
    cyclooctane 0.33
    cyclopentanol 3.39
    tetrahydropyran 6.94
    tert-amyl methyl ether 3.59
    2,5,8-trioxanonane 13.69
    1-hexene 1.16
    2-isopropoxyethanol 3.05
    2,2,2-trifluoroethanol 2.23
    methyl butyrate 5.86

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction