Hexafluoropropene

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  • Identifiers

    CAS number
    116-15-4

    Molecular formula
    C3F6

    SMILES
    C(=C(F)F)(C(F)(F)F)F

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 54.73%
    Sweet 29.47%
    Cooling 22.43%
    Fishy 21.24%
    Savory 20.67%
    Woody 19.49%
    Balsamic 16.7%
    Clean 16.22%
    Mint 15.81%
    Dry 15.69%

     

    Flavor
    Odorless 34.86%
    Bitter 27.13%
    Bland 21.28%
    Mild 20.13%
    Nitrile 18.42%
    Sweet-like 18.07%
    Oriental 17.98%
    Bloody 17.84%
    Bouillon 17.73%
    Rotten 17.63%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    4.72 (weak acid)

    Molecular weight
    150.02 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -156.5 °C

    Boiling point

    • -29.6 °C

    Flash point

    • -37.91 ˚C est.

  • Synonyms

    • Hexafluoropropene
    • Hexafluoropropylene
    • 116-15-4
    • Perfluoropropene
    • Perfluoropropylene
    • 1,1,2,3,3,3-hexafluoroprop-1-ene
    • Propene, hexafluoro-
    • 1-Propene, 1,1,2,3,3,3-hexafluoro-
    • Perfluoro-1-propene
    • Propylene, hexafluoro-
    • Esafluoropropene
    • 1,1,2,3,3,3-HEXAFLUORO-1-PROPENE
    • propylene hexafluoride
    • HSDB 5582
    • CF3CF=CF2
    • UNII-TRW23XOS20
    • EINECS 204-127-4
    • UN1858
    • HFC 1216
    • TRW23XOS20
    • DTXSID2026949
    • R1216
    • EC 204-127-4
    • 1,1,2,3,3,3-hexafluoropropene
    • HFC-1216
    • PFC-1216
    • UN 1858
    • Hexfluoropropylene
    • F-1216
    • R-1216
    • 1,1,2,3,3,3-HEXAFLUORO-1-PROPENE [HSDB]
    • hexafluoro-1-propene
    • Hexafluoroprop-1-ene
    • 1,1,2,3,3,3-hexakis(fluoranyl)prop-1-ene
    • C3F6
    • Perfluoro1propene
    • hexafluoro-propene
    • Propene, hexafluoro
    • Fomblin?; Y
    • MFCD00000447
    • Propylene, hexafluoro
    • CF2=CFCF3
    • F 1216
    • R 1216
    • Hexafluoropropene, >=99%
    • DTXCID206949
    • CHEMBL4644489
    • REFRIGERANT GAS R-1216
    • 1,1,2,3,3,3-hexafluoropropylene
    • FD2019
    • Hexafluoropropene, purum, >=99.0%
    • 1Propene, 1,1,2,3,3,3hexafluoro
    • AKOS009157872
    • 1,1,2,3,3,3-hexafluoro-prop-1-ene
    • AS-48912
    • R1216 [UN1858] [Nonflammable gas]
    • NS00011106
    • A803566
    • Q417982
    • Hexafluoropropylene compressed or Refrigerant gas R1216
    • Hexafluoropropylene compressed or Refrigerant gas R1216 [R1216] [UN1858] [Nonflammable gas]

  • Applications

    Hexafluoropropene is primarily used as a fluorinated monomer, typically as a comonomer with tetrafluoroethylene to synthesize fluoropolymers such as fluorinated ethylene propylene (FEP) and related copolymers. These materials are widely used in plastics and materials sectors for chemical-resistant coatings and liners, as films and tubing, and as electrical insulation for wires and cables. In electronics and semiconductor manufacturing, fluoropolymer resins derived from HFP provide dielectric properties and chemical resistance. It is also used as a precursor for specialty fluorinated compounds and surface-treatment additives used in industrial material processing. Overall, applications center on polymer synthesis and processing contexts, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 345.38
    methanol 694.26
    isopropanol 280.35
    water 250.77
    ethyl acetate 60.95
    n-propanol 241.84
    acetone 207.4
    n-butanol 177.19
    acetonitrile 182.17
    DMF 799.42
    toluene 18.08
    isobutanol 171.0
    1,4-dioxane 124.48
    methyl acetate 83.95
    THF 291.77
    2-butanone 136.77
    n-pentanol 140.56
    sec-butanol 188.55
    n-hexane 24.39
    ethylene glycol 264.06
    NMP 476.07
    cyclohexane 22.82
    DMSO 1230.22
    n-butyl acetate 36.66
    n-octanol 46.5
    chloroform 32.75
    n-propyl acetate 55.99
    acetic acid 119.83
    dichloromethane 48.5
    cyclohexanone 90.82
    propylene glycol 212.26
    isopropyl acetate 48.67
    DMAc 639.19
    2-ethoxyethanol 302.85
    isopentanol 136.54
    n-heptane 24.84
    ethyl formate 70.09
    1,2-dichloroethane 57.7
    n-hexanol 78.32
    2-methoxyethanol 453.98
    isobutyl acetate 29.13
    tetrachloromethane 12.8
    n-pentyl acetate 24.98
    transcutol 196.98
    n-heptanol 43.48
    ethylbenzene 18.08
    MIBK 77.61
    2-propoxyethanol 173.58
    tert-butanol 258.14
    MTBE 121.73
    2-butoxyethanol 89.21
    propionic acid 92.45
    o-xylene 27.44
    formic acid 194.3
    diethyl ether 145.28
    m-xylene 20.23
    p-xylene 18.12
    chlorobenzene 8.41
    dimethyl carbonate 70.32
    n-octane 9.98
    formamide 340.16
    cyclopentanone 134.56
    2-pentanone 117.77
    anisole 45.58
    cyclopentyl methyl ether 129.51
    gamma-butyrolactone 132.36
    1-methoxy-2-propanol 334.61
    pyridine 68.11
    3-pentanone 100.67
    furfural 92.67
    n-dodecane 6.76
    diethylene glycol 191.9
    diisopropyl ether 47.14
    tert-amyl alcohol 189.43
    acetylacetone 71.94
    n-hexadecane 6.82
    acetophenone 52.58
    methyl propionate 96.96
    isopentyl acetate 26.89
    trichloroethylene 38.27
    n-nonanol 44.38
    cyclohexanol 102.25
    benzyl alcohol 57.23
    2-ethylhexanol 38.83
    isooctanol 33.62
    dipropyl ether 78.01
    1,2-dichlorobenzene 8.69
    ethyl lactate 69.79
    propylene carbonate 52.31
    n-methylformamide 366.11
    2-pentanol 133.83
    n-pentane 41.68
    1-propoxy-2-propanol 116.22
    1-methoxy-2-propyl acetate 53.17
    2-(2-methoxypropoxy) propanol 85.78
    mesitylene 18.02
    ε-caprolactone 73.95
    p-cymene 17.95
    epichlorohydrin 125.04
    1,1,1-trichloroethane 23.35
    2-aminoethanol 313.04
    morpholine-4-carbaldehyde 288.91
    sulfolane 220.24
    2,2,4-trimethylpentane 14.59
    2-methyltetrahydrofuran 155.07
    n-hexyl acetate 33.77
    isooctane 11.46
    2-(2-butoxyethoxy)ethanol 103.72
    sec-butyl acetate 34.79
    tert-butyl acetate 48.39
    decalin 9.29
    glycerin 238.23
    diglyme 164.11
    acrylic acid 89.19
    isopropyl myristate 19.9
    n-butyric acid 75.61
    acetyl acetate 25.54
    di(2-ethylhexyl) phthalate 17.93
    ethyl propionate 56.51
    nitromethane 205.54
    1,2-diethoxyethane 64.27
    benzonitrile 30.86
    trioctyl phosphate 17.71
    1-bromopropane 52.33
    gamma-valerolactone 150.81
    n-decanol 35.81
    triethyl phosphate 26.11
    4-methyl-2-pentanol 79.05
    propionitrile 132.39
    vinylene carbonate 40.03
    1,1,2-trichlorotrifluoroethane 106.9
    DMS 27.84
    cumene 17.75
    2-octanol 31.03
    2-hexanone 81.14
    octyl acetate 25.5
    limonene 27.01
    1,2-dimethoxyethane 295.6
    ethyl orthosilicate 26.88
    tributyl phosphate 18.03
    diacetone alcohol 109.67
    N,N-dimethylaniline 72.3
    acrylonitrile 127.52
    aniline 45.62
    1,3-propanediol 237.12
    bromobenzene 5.82
    dibromomethane 39.25
    1,1,2,2-tetrachloroethane 46.37
    2-methyl-cyclohexyl acetate 29.56
    tetrabutyl urea 41.96
    diisobutyl methanol 33.87
    2-phenylethanol 40.27
    styrene 16.37
    dioctyl adipate 26.48
    dimethyl sulfate 106.29
    ethyl butyrate 42.58
    methyl lactate 109.97
    butyl lactate 35.98
    diethyl carbonate 26.79
    propanediol butyl ether 84.5
    triethyl orthoformate 34.28
    p-tert-butyltoluene 17.9
    methyl 4-tert-butylbenzoate 46.92
    morpholine 229.44
    tert-butylamine 187.76
    n-dodecanol 28.87
    dimethoxymethane 340.85
    ethylene carbonate 40.52
    cyrene 115.57
    2-ethoxyethyl acetate 31.35
    2-ethylhexyl acetate 21.23
    1,2,4-trichlorobenzene 11.99
    4-methylpyridine 65.04
    dibutyl ether 39.32
    2,6-dimethyl-4-heptanol 33.87
    DEF 197.95
    dimethyl isosorbide 112.3
    tetrachloroethylene 30.87
    eugenol 52.91
    triacetin 34.71
    span 80 56.12
    1,4-butanediol 155.9
    1,1-dichloroethane 39.77
    2-methyl-1-pentanol 91.61
    methyl formate 184.39
    2-methyl-1-butanol 133.49
    n-decane 10.31
    butyronitrile 103.62
    3,7-dimethyl-1-octanol 34.66
    1-chlorooctane 18.37
    1-chlorotetradecane 9.78
    n-nonane 10.51
    undecane 8.12
    tert-butylcyclohexane 9.32
    cyclooctane 13.48
    cyclopentanol 136.27
    tetrahydropyran 114.26
    tert-amyl methyl ether 112.88
    2,5,8-trioxanonane 141.05
    1-hexene 43.8
    2-isopropoxyethanol 173.51
    2,2,2-trifluoroethanol 83.34
    methyl butyrate 72.62

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction