Hexafluoroethane

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  • Identifiers

    CAS number
    76-16-4

    Molecular formula
    C2F6

    SMILES
    C(C(F)(F)F)(F)(F)F

    Safety labels

    Compressed Gas
    Compressed Gas

  • Odor profile

    Fragrance
    Odorless 58.51%
    Fishy 25.83%
    Sweet 23.6%
    Cooling 18.73%
    Woody 17.8%
    Balsamic 16.31%
    Savory 16.26%
    Clean 15.24%
    Animal 15.12%
    Dry 14.43%

     

    Flavor
    Odorless 33.62%
    Sulfurous 21.84%
    Bland 20.65%
    Mild 19.08%
    Sulfury 18.53%
    Bloody 17.9%
    Glue 17.87%
    Sweet-like 17.79%
    Bouillon 17.68%
    Skunky 17.42%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    4.4 (weak acid)

    Molecular weight
    138.01 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -100.015 °C

    Boiling point

    • -78.1 °C

    Flash point

    • -8.13 ˚C est.

    Solubility expt.

    • In water, 7.78 mg/L at 25 °C
    • Insoluble in water; slightly soluble in ethanol, ethyl ether

  • Synonyms

    • HEXAFLUOROETHANE
    • Perfluoroethane
    • 76-16-4
    • 1,1,1,2,2,2-Hexafluoroethane
    • Ethane, hexafluoro-
    • Freon 116
    • UNII-7VL5Z0IY3A
    • EINECS 200-939-8
    • UN2193
    • Fluorocarbon 116
    • BRN 1740328
    • CHEBI:32905
    • HSDB 7870
    • F 116
    • R 116
    • 7VL5Z0IY3A
    • DTXSID2041915
    • HFC 116
    • EC 200-939-8
    • 1,1,1,2,2,2-hexafluoro-ethane
    • Ethane, 1,1,1,2,2,2-hexafluoro-
    • UN 2193
    • R-116
    • C2F6
    • Ethane, hexafluoro
    • MFCD00000428
    • Hexafluoroethane 99%
    • ETHYL HEXAFLUORIDE
    • Hexafluoroethane, >=98%
    • Perfluoroethane (FC-116)
    • CHEMBL116574
    • DTXCID0021915
    • CFC-116
    • (Trifluoromethyl) trifluoromethane
    • HEXAFLUOROETHANE, COMPRESSED
    • Ethane, 1,1,1,2,2,2hexafluoro
    • AKOS015915973
    • 1,1,1,2,2,2-hexakis(fluoranyl)ethane
    • REFRIGERANT GAS R-116, COMPRESSED
    • NS00002995
    • A838625
    • Q417035
    • Hexafluoroethane, compressed or Refrigerant gas R116
    • Hexafluoroethane, compressed or Refrigerant gas R116 [UN2193] [Nonflammable gas]

  • Applications

    Hexafluoroethane (CAS 76-16-4) is used as a processing gas in semiconductor manufacturing, particularly for plasma etching and surface cleaning; it serves as a purge or carrier gas for electronics fabrication processes such as Chemical Vapor Deposition (CVD) and surface treatment; it is employed as a specialty refrigerant or heat-transfer fluid in niche cooling applications, with use governed by local regulations; and it can act as an inert background gas in certain chemical processing steps depending on the process.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 43.68
    methanol 88.96
    isopropanol 24.53
    water 30.64
    ethyl acetate 12.78
    n-propanol 25.94
    acetone 33.43
    n-butanol 16.91
    acetonitrile 20.91
    DMF 144.06
    toluene 3.63
    isobutanol 13.94
    1,4-dioxane 26.72
    methyl acetate 18.97
    THF 40.09
    2-butanone 20.89
    n-pentanol 11.05
    sec-butanol 18.83
    n-hexane 2.17
    ethylene glycol 48.96
    NMP 132.97
    cyclohexane 6.58
    DMSO 428.19
    n-butyl acetate 9.35
    n-octanol 9.41
    chloroform 13.13
    n-propyl acetate 7.74
    acetic acid 41.66
    dichloromethane 21.63
    cyclohexanone 21.84
    propylene glycol 25.35
    isopropyl acetate 7.72
    DMAc 120.49
    2-ethoxyethanol 37.98
    isopentanol 11.36
    n-heptane 5.62
    ethyl formate 16.94
    1,2-dichloroethane 20.25
    n-hexanol 10.46
    2-methoxyethanol 73.5
    isobutyl acetate 2.8
    tetrachloromethane 3.97
    n-pentyl acetate 8.14
    transcutol 55.9
    n-heptanol 8.89
    ethylbenzene 2.5
    MIBK 6.95
    2-propoxyethanol 26.84
    tert-butanol 22.86
    MTBE 11.88
    2-butoxyethanol 19.42
    propionic acid 26.37
    o-xylene 5.34
    formic acid 79.67
    diethyl ether 16.87
    m-xylene 3.08
    p-xylene 2.68
    chlorobenzene 3.27
    dimethyl carbonate 13.3
    n-octane 2.45
    formamide 129.4
    cyclopentanone 29.23
    2-pentanone 13.55
    anisole 5.92
    cyclopentyl methyl ether 14.78
    gamma-butyrolactone 36.62
    1-methoxy-2-propanol 43.44
    pyridine 22.39
    3-pentanone 14.29
    furfural 35.97
    n-dodecane 1.57
    diethylene glycol 38.7
    diisopropyl ether 4.77
    tert-amyl alcohol 18.46
    acetylacetone 16.04
    n-hexadecane 1.67
    acetophenone 9.56
    methyl propionate 18.41
    isopentyl acetate 6.23
    trichloroethylene 17.8
    n-nonanol 8.7
    cyclohexanol 17.04
    benzyl alcohol 10.81
    2-ethylhexanol 6.63
    isooctanol 6.47
    dipropyl ether 11.65
    1,2-dichlorobenzene 3.91
    ethyl lactate 12.05
    propylene carbonate 14.59
    n-methylformamide 74.97
    2-pentanol 11.65
    n-pentane 4.88
    1-propoxy-2-propanol 20.34
    1-methoxy-2-propyl acetate 13.68
    2-(2-methoxypropoxy) propanol 20.89
    mesitylene 2.86
    ε-caprolactone 20.52
    p-cymene 4.82
    epichlorohydrin 27.91
    1,1,1-trichloroethane 5.5
    2-aminoethanol 46.24
    morpholine-4-carbaldehyde 78.16
    sulfolane 85.53
    2,2,4-trimethylpentane 1.71
    2-methyltetrahydrofuran 21.23
    n-hexyl acetate 9.23
    isooctane 1.04
    2-(2-butoxyethoxy)ethanol 26.03
    sec-butyl acetate 4.46
    tert-butyl acetate 7.33
    decalin 1.5
    glycerin 45.51
    diglyme 46.68
    acrylic acid 30.62
    isopropyl myristate 4.77
    n-butyric acid 18.36
    acetyl acetate 8.05
    di(2-ethylhexyl) phthalate 5.55
    ethyl propionate 8.18
    nitromethane 68.0
    1,2-diethoxyethane 14.84
    benzonitrile 7.37
    trioctyl phosphate 5.51
    1-bromopropane 10.51
    gamma-valerolactone 39.49
    n-decanol 6.97
    triethyl phosphate 7.92
    4-methyl-2-pentanol 5.97
    propionitrile 14.94
    vinylene carbonate 13.24
    1,1,2-trichlorotrifluoroethane 39.74
    DMS 10.36
    cumene 2.34
    2-octanol 6.17
    2-hexanone 7.24
    octyl acetate 6.57
    limonene 7.26
    1,2-dimethoxyethane 41.48
    ethyl orthosilicate 7.13
    tributyl phosphate 5.65
    diacetone alcohol 16.37
    N,N-dimethylaniline 9.41
    acrylonitrile 22.51
    aniline 10.09
    1,3-propanediol 36.55
    bromobenzene 2.53
    dibromomethane 15.24
    1,1,2,2-tetrachloroethane 20.22
    2-methyl-cyclohexyl acetate 6.58
    tetrabutyl urea 12.14
    diisobutyl methanol 6.04
    2-phenylethanol 9.28
    styrene 2.92
    dioctyl adipate 7.83
    dimethyl sulfate 32.04
    ethyl butyrate 8.89
    methyl lactate 24.66
    butyl lactate 11.05
    diethyl carbonate 7.21
    propanediol butyl ether 19.88
    triethyl orthoformate 8.97
    p-tert-butyltoluene 4.64
    methyl 4-tert-butylbenzoate 14.95
    morpholine 41.27
    tert-butylamine 14.86
    n-dodecanol 5.68
    dimethoxymethane 46.79
    ethylene carbonate 11.62
    cyrene 22.87
    2-ethoxyethyl acetate 10.83
    2-ethylhexyl acetate 5.21
    1,2,4-trichlorobenzene 5.06
    4-methylpyridine 13.79
    dibutyl ether 7.08
    2,6-dimethyl-4-heptanol 6.04
    DEF 37.06
    dimethyl isosorbide 27.09
    tetrachloroethylene 17.39
    eugenol 14.6
    triacetin 12.75
    span 80 16.05
    1,4-butanediol 19.24
    1,1-dichloroethane 8.68
    2-methyl-1-pentanol 7.41
    methyl formate 43.16
    2-methyl-1-butanol 12.03
    n-decane 2.51
    butyronitrile 11.0
    3,7-dimethyl-1-octanol 7.04
    1-chlorooctane 4.69
    1-chlorotetradecane 2.39
    n-nonane 2.51
    undecane 1.93
    tert-butylcyclohexane 1.11
    cyclooctane 2.89
    cyclopentanol 21.58
    tetrahydropyran 18.63
    tert-amyl methyl ether 12.12
    2,5,8-trioxanonane 37.17
    1-hexene 3.66
    2-isopropoxyethanol 19.24
    2,2,2-trifluoroethanol 26.64
    methyl butyrate 10.96

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction