Halothane

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  • Identifiers

    CAS number
    151-67-7

    Molecular formula
    C2HBrClF3

    SMILES
    C(C(F)(F)F)(Cl)Br

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 57.49%
    Fishy 31.23%
    Cooling 21.75%
    Sweet 20.11%
    Savory 18.49%
    Woody 17.54%
    Ripe 16.73%
    Animal 16.63%
    Oily 15.53%
    Mint 15.09%

     

    Flavor
    Odorless 33.6%
    Sulfurous 24.92%
    Sulfury 20.6%
    Bland 19.61%
    Mild 19.41%
    Meaty 19.04%
    Bloody 18.49%
    Glue 18.38%
    Bouillon 17.99%
    Skunky 17.83%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    4.71 (weak acid)

    Molecular weight
    197.38 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -180 °F (NIOSH, 2024)
    • 50-50.5
    • -118 °C
    • -180 °F

    Boiling point

    • 122.4 °F at 760 mmHg (NTP, 1992)
    • 50.2 °C
    • 50 °C
    • 122.4 °F
    • 122 °F

    Flash point

    • -16.74 ˚C est.

    Solubility expt.

    • 0.1 to 1.0 mg/mL at 64 °F (NTP, 1992)
    • 4070 mg/L (at 25 °C)
    • Miscible with petroleum ether, other fat solvents
    • In water, 4,070 mg/L at 25 °C
    • 3.81e+00 g/L
    • Solubility in water, g/100ml: 0.45
    • 0.3%

  • Synonyms

    • halothane
    • 151-67-7
    • 2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE
    • Fluothane
    • Narcotane
    • Rhodialothan
    • Bromochlorotrifluoroethane
    • Phthorothanum
    • Ftuorotan
    • Halothan
    • Narcotan
    • Anestan
    • Fluorotane
    • Fluktan
    • Ftorotan
    • Halotano
    • Narkotan
    • Freon 123B1
    • Halotan
    • Halsan
    • Halan
    • Chalothane
    • Halothanum
    • Alotano
    • Bromchlortrifluoraethanum
    • Ftorotan [Russian]
    • Alotano [DCIT]
    • 1,1,1-Trifluoro-2-chloro-2-bromoethane
    • 1-Bromo-1-chloro-2,2,2-trifluoroethane
    • Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-
    • 1,1,1-Trifluoro-2-bromo-2-chloroethane
    • 2,2,2-Trifluoro-1-chloro-1-bromoethane
    • Halotano [INN-Spanish]
    • Halothanum [INN-Latin]
    • Narcotann ne-spofa
    • Narcotann NE-spofa [Russian]
    • CF3CHClBr
    • CCRIS 6244
    • CHEBI:5615
    • 2-Brom-2-chlor-1,1,1-trifluorethan
    • NSC 143490
    • HSDB 6753
    • UNII-UQT9G45D1P
    • EINECS 205-796-5
    • UQT9G45D1P
    • MFCD00009602
    • NSC-143490
    • BRN 1736947
    • DTXSID4025371
    • Ethane, 1-bromo-1-chloro-2,2,2-trifluoro-
    • CHEMBL931
    • DTXCID605371
    • Halothane [USP:INN:BAN:JAN]
    • NSC143490
    • NCGC00090868-01
    • Halotano (INN-Spanish)
    • Halothanum (INN-Latin)
    • HALOTHANE (MART.)
    • HALOTHANE [MART.]
    • HALOTHANE (EP IMPURITY)
    • HALOTHANE [EP IMPURITY]
    • Ethane, bromochlorotrifluoro-
    • HALOTHANE (EP MONOGRAPH)
    • HALOTHANE [EP MONOGRAPH]
    • (+/-)-2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE
    • HALOTHANE (USP MONOGRAPH)
    • Halothane (USP:INN:BAN:JAN)
    • HALOTHANE [USP MONOGRAPH]
    • ETHANE, 2-BROMO-2-CHLORO-1,1,1-TRIFLUORO-,(+/-)-
    • Fluothane (TN)
    • CAS-151-67-7
    • Halothane [Anaesthetics, volatile]
    • Fluotane
    • (+-)-2-Bromo-2-chloro-1,1,1-trifluoroethane
    • Halothanum (Latin)
    • 2,2,2-trifluoro-1-bromo-1-chloroethane
    • WLN: GYEXFFF
    • HALOTHANE [INN]
    • HALOTHANE [JAN]
    • HALOTHANE [MI]
    • Ethane,1,1-trifluoro-
    • Halon 2311
    • HALOTHANE [HSDB]
    • HALOTHANE [VANDF]
    • Epitope ID:150925
    • (.+/-.))-Halothane
    • Fluothane, Halothane, USP
    • HALOTHANE [WHO-DD]
    • HALOTHANE [WHO-IP]
    • SCHEMBL25588
    • Halothane (JP18/USP/INN)
    • HALOTHANE [GREEN BOOK]
    • GTPL2401
    • HALOTHANE [ORANGE BOOK]
    • Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-, (+-)-
    • BCQZXOMGPXTTIC-UHFFFAOYSA-
    • N01AB01
    • HALOTHANUM [WHO-IP LATIN]
    • HMS2094K17
    • HMS3885H08
    • Pharmakon1600-01505434
    • 51230-18-3
    • HY-B1010
    • Tox21_111033
    • Tox21_200850
    • BDBM50112212
    • NSC760138
    • s4570
    • AKOS006227959
    • Tox21_111033_1
    • 1,1-Trifluoro-2-bromo-2-chloroethane
    • 1,1-Trifluoro-2-chloro-2-bromoethane
    • 2,2-Trifluoro-1-chloro-1-bromoethane
    • 2-Bromo-2-chloro-1,1-trifluoroethane
    • CCG-213438
    • CS-4523
    • DB01159
    • NSC-760138
    • R 123B1
    • 1,1,1-trifluoro-2,2-chlorobromoethane
    • 1-bromo-1-chloro-2,2,2-trifluorethane
    • NCGC00090868-02
    • NCGC00090868-03
    • NCGC00090868-05
    • NCGC00090868-06
    • NCGC00258404-01
    • FB165735
    • TS-07651

  • Applications

    Halothane (CAS 151-67-7) is a volatile inhalational anesthetic agent primarily used in clinical medicine to induce general anesthesia for surgery, administered via anesthesia machines and patient breathing circuits. In addition to human medicine, it is used in veterinary medicine for anesthesia in animals during medical procedures or surgery. Because of its volatility and potent anesthetic effect, halothane is now less favored in many health systems due to hepatotoxic risk and side effects, so usage is governed by local regulations and guidelines. In education and research, halothane is referenced as a classic example of inhalation anesthetics and pharmacology, but its clinical use remains restricted by safety and environmental considerations associated with halogenated compounds.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 462.91
    methanol 688.47
    isopropanol 356.89
    water 207.79
    ethyl acetate 267.9
    n-propanol 314.6
    acetone 729.58
    n-butanol 267.39
    acetonitrile 475.26
    DMF 1494.3
    toluene 184.27
    isobutanol 236.09
    1,4-dioxane 570.71
    methyl acetate 303.56
    THF 836.11
    2-butanone 388.86
    n-pentanol 238.24
    sec-butanol 278.02
    n-hexane 129.83
    ethylene glycol 276.98
    NMP 941.94
    cyclohexane 130.96
    DMSO 1546.74
    n-butyl acetate 160.45
    n-octanol 178.41
    chloroform 254.93
    n-propyl acetate 245.95
    acetic acid 286.98
    dichloromethane 359.42
    cyclohexanone 362.56
    propylene glycol 179.94
    isopropyl acetate 211.6
    DMAc 1009.9
    2-ethoxyethanol 523.4
    isopentanol 228.84
    n-heptane 100.4
    ethyl formate 247.29
    1,2-dichloroethane 333.36
    n-hexanol 176.38
    2-methoxyethanol 765.11
    isobutyl acetate 143.06
    tetrachloromethane 88.73
    n-pentyl acetate 151.23
    transcutol 583.89
    n-heptanol 129.82
    ethylbenzene 142.54
    MIBK 280.85
    2-propoxyethanol 420.34
    tert-butanol 384.06
    MTBE 300.12
    2-butoxyethanol 234.4
    propionic acid 179.22
    o-xylene 187.79
    formic acid 315.8
    diethyl ether 487.4
    m-xylene 185.01
    p-xylene 153.67
    chlorobenzene 96.49
    dimethyl carbonate 261.31
    n-octane 54.42
    formamide 564.35
    cyclopentanone 475.82
    2-pentanone 390.49
    anisole 295.44
    cyclopentyl methyl ether 454.82
    gamma-butyrolactone 431.93
    1-methoxy-2-propanol 591.36
    pyridine 332.42
    3-pentanone 342.93
    furfural 423.42
    n-dodecane 41.4
    diethylene glycol 413.48
    diisopropyl ether 197.53
    tert-amyl alcohol 288.75
    acetylacetone 430.9
    n-hexadecane 42.73
    acetophenone 269.11
    methyl propionate 309.6
    isopentyl acetate 121.88
    trichloroethylene 293.12
    n-nonanol 164.47
    cyclohexanol 242.56
    benzyl alcohol 205.63
    2-ethylhexanol 130.98
    isooctanol 108.34
    dipropyl ether 284.91
    1,2-dichlorobenzene 99.17
    ethyl lactate 179.96
    propylene carbonate 199.64
    n-methylformamide 637.03
    2-pentanol 248.04
    n-pentane 172.35
    1-propoxy-2-propanol 301.38
    1-methoxy-2-propyl acetate 208.89
    2-(2-methoxypropoxy) propanol 264.15
    mesitylene 151.83
    ε-caprolactone 281.64
    p-cymene 101.0
    epichlorohydrin 458.6
    1,1,1-trichloroethane 182.35
    2-aminoethanol 311.53
    morpholine-4-carbaldehyde 918.0
    sulfolane 572.29
    2,2,4-trimethylpentane 57.2
    2-methyltetrahydrofuran 441.43
    n-hexyl acetate 186.23
    isooctane 50.19
    2-(2-butoxyethoxy)ethanol 299.57
    sec-butyl acetate 163.77
    tert-butyl acetate 227.42
    decalin 58.99
    glycerin 260.51
    diglyme 575.05
    acrylic acid 179.72
    isopropyl myristate 121.55
    n-butyric acid 188.39
    acetyl acetate 167.28
    di(2-ethylhexyl) phthalate 93.34
    ethyl propionate 252.51
    nitromethane 665.85
    1,2-diethoxyethane 311.34
    benzonitrile 166.21
    trioctyl phosphate 87.89
    1-bromopropane 267.85
    gamma-valerolactone 597.13
    n-decanol 136.47
    triethyl phosphate 113.02
    4-methyl-2-pentanol 173.45
    propionitrile 289.53
    vinylene carbonate 183.57
    1,1,2-trichlorotrifluoroethane 297.15
    DMS 165.93
    cumene 120.14
    2-octanol 124.54
    2-hexanone 294.18
    octyl acetate 138.44
    limonene 136.48
    1,2-dimethoxyethane 915.59
    ethyl orthosilicate 114.57
    tributyl phosphate 93.25
    diacetone alcohol 311.34
    N,N-dimethylaniline 345.46
    acrylonitrile 324.12
    aniline 202.71
    1,3-propanediol 318.42
    bromobenzene 86.25
    dibromomethane 300.67
    1,1,2,2-tetrachloroethane 268.03
    2-methyl-cyclohexyl acetate 137.8
    tetrabutyl urea 178.44
    diisobutyl methanol 114.38
    2-phenylethanol 155.03
    styrene 148.6
    dioctyl adipate 144.25
    dimethyl sulfate 380.4
    ethyl butyrate 186.17
    methyl lactate 242.75
    butyl lactate 132.35
    diethyl carbonate 126.2
    propanediol butyl ether 207.78
    triethyl orthoformate 147.82
    p-tert-butyltoluene 104.42
    methyl 4-tert-butylbenzoate 213.58
    morpholine 610.44
    tert-butylamine 322.84
    n-dodecanol 118.35
    dimethoxymethane 1022.67
    ethylene carbonate 170.86
    cyrene 289.13
    2-ethoxyethyl acetate 184.46
    2-ethylhexyl acetate 106.07
    1,2,4-trichlorobenzene 113.29
    4-methylpyridine 330.95
    dibutyl ether 199.45
    2,6-dimethyl-4-heptanol 114.38
    DEF 552.54
    dimethyl isosorbide 386.44
    tetrachloroethylene 203.31
    eugenol 221.58
    triacetin 187.09
    span 80 186.02
    1,4-butanediol 198.64
    1,1-dichloroethane 241.8
    2-methyl-1-pentanol 190.09
    methyl formate 492.42
    2-methyl-1-butanol 220.13
    n-decane 62.16
    butyronitrile 261.29
    3,7-dimethyl-1-octanol 149.66
    1-chlorooctane 118.5
    1-chlorotetradecane 66.09
    n-nonane 63.81
    undecane 48.84
    tert-butylcyclohexane 53.0
    cyclooctane 72.29
    cyclopentanol 285.34
    tetrahydropyran 408.2
    tert-amyl methyl ether 295.67
    2,5,8-trioxanonane 453.72
    1-hexene 214.86
    2-isopropoxyethanol 356.59
    2,2,2-trifluoroethanol 213.67
    methyl butyrate 292.87

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction