Guanosine

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  • Identifiers

    CAS number
    118-00-3

    Molecular formula
    C10H13N5O5

    SMILES
    C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N=C(NC2=O)N

    Safety labels

    Acute Toxic
    Acute Toxic

  • Odor profile

    Fragrance
    Odorless 87.25%
    Bitter 19.6%
    Savory 19.35%
    Cooked 14.86%
    Burnt 14.43%
    Milky 14.14%
    Meaty 12.68%
    Cooling 12.64%
    Sweet 12.23%
    Popcorn 11.47%

     

    Flavor
    Bitter 84.64%
    Odorless 42.61%
    Bland 27.8%
    Sweet-like 24.58%
    Very mild 19.35%
    Cedarleaf 19.2%
    Bread crust 18.79%
    Nitrile 18.65%
    Alkaline 18.28%
    Scallion 18.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.9

    pKa est.
    5.64 (weak acid)

    Molecular weight
    283.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2577°C

    Melting point expt.

    • 239 dec °C
    • 239 °C

    Flash point

    • 367.87 ˚C est.

    Solubility expt.

    • 700 mg/L (at 18 °C)
    • 0.7 mg/mL at 18 °C

  • Synonyms

    • guanosine
    • 118-00-3
    • guanine riboside
    • vernine
    • Guanosin
    • 2-Amino-1,9-dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one
    • Guanine-9-beta-D-ribofuranoside
    • 2(3H)-Imino-9-beta-D-ribofuranosyl-9H-purin-6(1H)-one
    • 9-beta-D-ribofuranosyl-guanine
    • CHEBI:16750
    • DTXSID00893055
    • 12133JR80S
    • NSC-19994
    • 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
    • 2-AMINO-9-[(2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-6,9-DIHYDRO-1H-PURIN-6-ONE
    • 2-amino-9-beta-D-ribofuranosyl-1,9-dihydro-6H-purin-6-one
    • 2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-1H-purin-6-one
    • 2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6,9-dihydro-1H-purin-6-one
    • RefChem:5875
    • 2-Amino-9-beta-D-ribofuranosyl-9H-purine-6(1H)-one
    • DTXCID601322998
    • 2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-3H-purin-6-one
    • 204-227-8
    • Guanozin
    • USAF CB-11
    • Inosine, 2-amino-
    • Vernine (VAN)
    • MFCD00010182
    • 9-beta-D-Ribofuranosylguanine
    • beta-D-Ribofuranoside, guanine-9
    • Guanine, 9-beta-D-ribofuranosyl-
    • Guo
    • Inosine, 2-amino- (VAN)
    • Ribofuranoside, guanine-9, beta-D-
    • GUANINE-9:BETA-D-RIBOFURANOSIDE
    • DL-Guanosine
    • AI3-52065
    • NSC 19994
    • 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one
    • Guanine, 9-beta-D-ribofuranosyl- (VAN)
    • 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
    • 6H-Purin-6-one, 2-amino-1,9-dihydro-9-beta-D-ribofuranosyl-
    • 9-(beta-D-Ribofuranosyl)guanine
    • ST057098
    • 2-Amino-9-beta-D-ribofuranosyl-1,9-dihydro-6H-purin-6-one (Guanosine)
    • 9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-aminohydropurin -6-one
    • 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one
    • 9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-imino-2,3-dihydro-1H-purin-6(9H)-one
    • 85-30-3
    • EINECS 204-227-8
    • 9-.beta.-D-ribofuranosylguanine
    • Ribonucleoside
    • Guanine, 9.beta.-d-ribofuranosyl-
    • .beta.-D-Ribofuranoside, guanine-9
    • 3h-guanosine
    • UNII-12133JR80S
    • 2-amino-Inosine
    • 1odj
    • 2fqx
    • 9-B-D-RIBOFURANOSYLGUANINE
    • [3H]-guanosine
    • Inosine, 2-amino
    • Guanosine, >=98%
    • GUANOSINE [MI]
    • bmse000091
    • bmse001018
    • Epitope ID:141493
    • GUANOSINE [MART.]
    • GUANOSINE [WHO-DD]
    • 9-b-D-ribofuranosyl-Guanine
    • SCHEMBL21217
    • 2(3H)-Imino-9-.beta.-D-ribofuranosyl-9H-purin-6(1H)-one
    • b-D-Ribofuranoside guanine-9
    • 9-beta-D-ribofuranosyl guanine
    • CHEMBL375655
    • GTPL4567
    • orb1300694
    • orb3025491
    • SCHEMBL2774083
    • SCHEMBL3370382
    • SGCUT00093
    • Guanine-9-ss--D-ribofuranoside
    • GUANOSINE [USP IMPURITY]
    • SCHEMBL12212184
    • SCHEMBL27349775
    • 9-(ss--D-Ribofuranosyl)guanine
    • MSK6804
    • 9-beta-delta-ribofuranosyl-Guanine
    • Guanine-9-.beta.-D-ribofuranoside
    • 89618-09-7
    • BB_NC-01240
    • beta-delta-Ribofuranoside guanine-9
    • Guanosine, >=97.0% (HPLC)
    • HY-N0097
    • STR04471
    • to_000053
    • BBL033925
    • BDBM50366814
    • EBC-12148
    • EBC-44144
    • s2439
    • SBB003009
    • STK801927
    • AKOS005622500
    • AKOS007930368
    • AKOS015896931
    • AKOS032949764
    • CCG-267277
    • CS-W020018
    • DB02857
    • Ribofuranoside, guanine-9, .beta.-D-
    • NCGC00142496-01
    • NCGC00142496-02
    • 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one
    • BP-58656
    • Guanosine(Discontinued,See C4X-23916)
    • ADENOSINE IMPURITY H [EP IMPURITY]
    • DB-029875
    • G0171
    • NS00009027
    • Guanosine, Vetec(TM) reagent grade, >=98%
    • C00387
    • EN300-204342
    • Guanosine, suitable for cell culture, BioReagent
    • F212784
    • Q422462
    • Z1741979723
    • 118-00-3

  • Applications

    Guanosine is a purine nucleoside used primarily as a building block and intermediate in pharmaceutical nucleotide synthesis and in biochemical research. It serves as a substrate in nucleotide salvage pathways and as a precursor for GMP/GTP in in vitro systems, and is commonly employed as a reagent and reference standard in analytical workflows (HPLC/LC-MS) for nucleosides. In biotechnology and molecular biology, it is used in nucleoside/nucleotide metabolism studies and as a component in specialized cell culture media to provide nucleosides for certain applications. It can also function as a research reagent in diagnostics and assay development related to purine metabolism.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.43
    methanol 0.89
    isopropanol 0.28
    water 2.07
    ethyl acetate 0.01
    n-propanol 0.58
    acetone 0.01
    n-butanol 0.46
    acetonitrile 0.09
    DMF 6.9
    toluene 0.0
    isobutanol 0.25
    1,4-dioxane 0.07
    methyl acetate 0.04
    THF 0.33
    2-butanone 0.11
    n-pentanol 0.21
    sec-butanol 0.39
    n-hexane 0.01
    ethylene glycol 3.49
    NMP 32.72
    cyclohexane 0.01
    DMSO 8.24
    n-butyl acetate 0.06
    n-octanol 0.06
    chloroform 0.01
    n-propyl acetate 0.03
    acetic acid 1.33
    dichloromethane 0.01
    cyclohexanone 0.3
    propylene glycol 5.94
    isopropyl acetate 0.01
    DMAc 8.52
    2-ethoxyethanol 1.9
    isopentanol 0.22
    n-heptane 0.02
    ethyl formate 0.09
    1,2-dichloroethane 0.01
    n-hexanol 0.2
    2-methoxyethanol 5.53
    isobutyl acetate 0.01
    tetrachloromethane 0.01
    n-pentyl acetate 0.04
    transcutol 0.97
    n-heptanol 0.16
    ethylbenzene 0.01
    MIBK 0.03
    2-propoxyethanol 1.74
    tert-butanol 0.13
    MTBE 0.01
    2-butoxyethanol 1.11
    propionic acid 0.72
    o-xylene 0.01
    formic acid 23.73
    diethyl ether 0.02
    m-xylene 0.0
    p-xylene 0.01
    chlorobenzene 0.0
    dimethyl carbonate 0.08
    n-octane 0.01
    formamide 16.0
    cyclopentanone 0.58
    2-pentanone 0.04
    anisole 0.01
    cyclopentyl methyl ether 0.07
    gamma-butyrolactone 1.0
    1-methoxy-2-propanol 2.45
    pyridine 0.15
    3-pentanone 0.05
    furfural 1.48
    n-dodecane 0.0
    diethylene glycol 4.84
    diisopropyl ether 0.0
    tert-amyl alcohol 0.21
    acetylacetone 0.02
    n-hexadecane 0.0
    acetophenone 0.05
    methyl propionate 0.06
    isopentyl acetate 0.06
    trichloroethylene 0.02
    n-nonanol 0.07
    cyclohexanol 0.24
    benzyl alcohol 0.09
    2-ethylhexanol 0.1
    isooctanol 0.1
    dipropyl ether 0.09
    1,2-dichlorobenzene 0.01
    ethyl lactate 0.45
    propylene carbonate 0.26
    n-methylformamide 3.87
    2-pentanol 0.15
    n-pentane 0.01
    1-propoxy-2-propanol 1.02
    1-methoxy-2-propyl acetate 0.11
    2-(2-methoxypropoxy) propanol 0.76
    mesitylene 0.0
    ε-caprolactone 0.42
    p-cymene 0.02
    epichlorohydrin 0.24
    1,1,1-trichloroethane 0.0
    2-aminoethanol 4.23
    morpholine-4-carbaldehyde 5.85
    sulfolane 7.69
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.15
    n-hexyl acetate 0.04
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.99
    sec-butyl acetate 0.01
    tert-butyl acetate 0.01
    decalin 0.0
    glycerin 24.72
    diglyme 1.36
    acrylic acid 1.58
    isopropyl myristate 0.02
    n-butyric acid 0.34
    acetyl acetate 0.0
    di(2-ethylhexyl) phthalate 0.07
    ethyl propionate 0.03
    nitromethane 0.92
    1,2-diethoxyethane 0.06
    benzonitrile 0.06
    trioctyl phosphate 0.08
    1-bromopropane 0.01
    gamma-valerolactone 2.17
    n-decanol 0.05
    triethyl phosphate 0.14
    4-methyl-2-pentanol 0.05
    propionitrile 0.13
    vinylene carbonate 0.22
    1,1,2-trichlorotrifluoroethane 3.35
    DMS 0.04
    cumene 0.01
    2-octanol 0.07
    2-hexanone 0.06
    octyl acetate 0.03
    limonene 0.02
    1,2-dimethoxyethane 0.75
    ethyl orthosilicate 0.11
    tributyl phosphate 0.08
    diacetone alcohol 0.24
    N,N-dimethylaniline 0.04
    acrylonitrile 0.27
    aniline 0.04
    1,3-propanediol 3.58
    bromobenzene 0.0
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.03
    2-methyl-cyclohexyl acetate 0.09
    tetrabutyl urea 0.23
    diisobutyl methanol 0.04
    2-phenylethanol 0.1
    styrene 0.0
    dioctyl adipate 0.05
    dimethyl sulfate 0.53
    ethyl butyrate 0.07
    methyl lactate 1.14
    butyl lactate 0.42
    diethyl carbonate 0.06
    propanediol butyl ether 1.34
    triethyl orthoformate 0.13
    p-tert-butyltoluene 0.01
    methyl 4-tert-butylbenzoate 0.16
    morpholine 0.46
    tert-butylamine 0.04
    n-dodecanol 0.04
    dimethoxymethane 0.36
    ethylene carbonate 0.13
    cyrene 2.6
    2-ethoxyethyl acetate 0.06
    2-ethylhexyl acetate 0.06
    1,2,4-trichlorobenzene 0.01
    4-methylpyridine 0.06
    dibutyl ether 0.04
    2,6-dimethyl-4-heptanol 0.04
    DEF 0.37
    dimethyl isosorbide 1.05
    tetrachloroethylene 0.04
    eugenol 0.41
    triacetin 0.08
    span 80 0.57
    1,4-butanediol 1.42
    1,1-dichloroethane 0.0
    2-methyl-1-pentanol 0.12
    methyl formate 0.75
    2-methyl-1-butanol 0.32
    n-decane 0.01
    butyronitrile 0.1
    3,7-dimethyl-1-octanol 0.04
    1-chlorooctane 0.01
    1-chlorotetradecane 0.01
    n-nonane 0.01
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.6
    tetrahydropyran 0.08
    tert-amyl methyl ether 0.03
    2,5,8-trioxanonane 1.12
    1-hexene 0.02
    2-isopropoxyethanol 0.46
    2,2,2-trifluoroethanol 1.69
    methyl butyrate 0.08

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction