Guanidine thiocyanate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    593-84-0

    Molecular formula
    C2H6N4S

    SMILES
    C(#N)S.C(=N)(N)N

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sulfurous 68.49%
    Garlic 46.29%
    Onion 44.51%
    Meaty 44.21%
    Alliaceous 32.55%
    Pungent 31.57%
    Roasted 29.64%
    Odorless 28.8%
    Burnt 28.51%
    Savory 27.44%

     

    Flavor
    Bitter 51.91%
    Odorless 33.6%
    Sulfur 22.18%
    Formyl 20.18%
    Rotten 19.98%
    Nitrile 18.82%
    Mousy 18.77%
    Decomposing cabbage 18.29%
    Bland 17.41%
    Penetrating 17.29%

     

    Odor impact est.
    High

  • Properties

    pKa est.
    8.58 (weak base)

    Molecular weight
    118.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    129°C

    Flash point

    • 40.1 ˚C est.

  • Synonyms

    • Guanidine thiocyanate
    • 593-84-0
    • Guanidinium thiocyanate
    • guanidine;thiocyanic acid
    • Guanidinium rhodanide
    • Guanidinium isothiocyanate
    • GCA2EU297U
    • MFCD00013027
    • Guandine thiocyanate
    • USAF EK-705
    • BUFFER AVL
    • NSC 2119
    • NSC-2119
    • EINECS 209-812-1
    • AI3-18430
    • DTXSID6060478
    • GTC
    • guanidinethiocyanate
    • GuSCN
    • UNII-GCA2EU297U
    • SCHEMBL28942
    • guanidine thiocyanate solu-tion
    • Guanidine thiocyanate, Ultrapure
    • DTXCID1042601
    • NSC2119
    • ZJYYHGLJYGJLLN-UHFFFAOYSA-N
    • Guanidine thiocyanate, >=99.5%
    • HY-D0841
    • AKOS015961014
    • Guanidine thiocyanate, >=97.0% (AT)
    • BP-13066
    • LS-12942
    • SY003172
    • Guanidine thiocyanate, >=97% (titration)
    • CS-0014812
    • G0230
    • G0360
    • Guanidine thiocyanate, Molecular Biology Grade
    • M01833
    • Q904487
    • Guanidine thiocyanate, for molecular biology, >=99%
    • Guanidine thiocyanate, Vetec(TM) reagent grade, >=97%
    • Guanidine thiocyanate, BioReagent, for molecular biology, >=99%
    • Guanidine thiocyanate, BioUltra, for molecular biology, >=99.0% (AT)
    • 209-812-1

  • Applications

    Guanidine thiocyanate is widely used as a chaotropic denaturant in molecular biology workflows, particularly for RNA isolation and purification where it helps lyse cells and inactivate nucleases to preserve nucleic acids. It is also employed to denature and solubilize proteins in biochemical and analytical procedures. It serves as a reagent intermediate in the synthesis of guanidine-containing compounds and related specialty chemicals in chemical and pharmaceutical manufacturing. Additionally, it is used to prepare chaotropic buffers and solutions for analytical and preparative workflows in research and production settings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 50.83
    methanol 93.74
    isopropanol 35.45
    water 23.81
    ethyl acetate 85.4
    n-propanol 35.13
    acetone 287.99
    n-butanol 25.57
    acetonitrile 170.9
    DMF 909.68
    toluene 24.81
    isobutanol 25.62
    1,4-dioxane 191.55
    methyl acetate 152.85
    THF 139.48
    2-butanone 116.86
    n-pentanol 23.1
    sec-butanol 25.2
    n-hexane 6.3
    ethylene glycol 81.93
    NMP 580.5
    cyclohexane 8.8
    DMSO 720.49
    n-butyl acetate 42.35
    n-octanol 26.71
    chloroform 85.91
    n-propyl acetate 52.39
    acetic acid 161.55
    dichloromethane 98.9
    cyclohexanone 116.83
    propylene glycol 46.99
    isopropyl acetate 45.67
    DMAc 689.03
    2-ethoxyethanol 83.52
    isopentanol 20.86
    n-heptane 6.5
    ethyl formate 78.77
    1,2-dichloroethane 76.61
    n-hexanol 21.38
    2-methoxyethanol 152.68
    isobutyl acetate 34.3
    tetrachloromethane 18.41
    n-pentyl acetate 36.39
    transcutol 252.74
    n-heptanol 15.83
    ethylbenzene 16.44
    MIBK 38.83
    2-propoxyethanol 71.78
    tert-butanol 41.32
    MTBE 45.15
    2-butoxyethanol 45.66
    propionic acid 81.26
    o-xylene 23.75
    formic acid 118.5
    diethyl ether 49.54
    m-xylene 18.4
    p-xylene 24.2
    chlorobenzene 50.81
    dimethyl carbonate 118.06
    n-octane 3.87
    formamide 184.42
    cyclopentanone 187.53
    2-pentanone 66.72
    anisole 64.4
    cyclopentyl methyl ether 53.17
    gamma-butyrolactone 218.75
    1-methoxy-2-propanol 94.99
    pyridine 127.34
    3-pentanone 80.27
    furfural 293.24
    n-dodecane 5.23
    diethylene glycol 112.3
    diisopropyl ether 18.12
    tert-amyl alcohol 29.1
    acetylacetone 171.01
    n-hexadecane 5.82
    acetophenone 78.4
    methyl propionate 106.11
    isopentyl acetate 34.87
    trichloroethylene 138.79
    n-nonanol 25.44
    cyclohexanol 27.0
    benzyl alcohol 47.72
    2-ethylhexanol 16.97
    isooctanol 13.47
    dipropyl ether 32.91
    1,2-dichlorobenzene 54.01
    ethyl lactate 46.56
    propylene carbonate 96.37
    n-methylformamide 246.0
    2-pentanol 17.53
    n-pentane 5.57
    1-propoxy-2-propanol 50.13
    1-methoxy-2-propyl acetate 62.37
    2-(2-methoxypropoxy) propanol 87.14
    mesitylene 14.84
    ε-caprolactone 94.0
    p-cymene 14.53
    epichlorohydrin 136.74
    1,1,1-trichloroethane 60.94
    2-aminoethanol 65.42
    morpholine-4-carbaldehyde 520.0
    sulfolane 329.28
    2,2,4-trimethylpentane 3.79
    2-methyltetrahydrofuran 72.81
    n-hexyl acetate 54.19
    isooctane 2.66
    2-(2-butoxyethoxy)ethanol 97.42
    sec-butyl acetate 32.04
    tert-butyl acetate 46.25
    decalin 6.52
    glycerin 99.61
    diglyme 196.78
    acrylic acid 126.65
    isopropyl myristate 30.45
    n-butyric acid 55.26
    acetyl acetate 102.64
    di(2-ethylhexyl) phthalate 40.0
    ethyl propionate 55.07
    nitromethane 579.92
    1,2-diethoxyethane 74.03
    benzonitrile 74.65
    trioctyl phosphate 25.64
    1-bromopropane 28.92
    gamma-valerolactone 284.62
    n-decanol 21.77
    triethyl phosphate 32.84
    4-methyl-2-pentanol 12.88
    propionitrile 63.92
    vinylene carbonate 117.57
    1,1,2-trichlorotrifluoroethane 177.46
    DMS 114.64
    cumene 14.21
    2-octanol 13.4
    2-hexanone 52.15
    octyl acetate 38.79
    limonene 20.05
    1,2-dimethoxyethane 191.3
    ethyl orthosilicate 28.04
    tributyl phosphate 33.74
    diacetone alcohol 59.69
    N,N-dimethylaniline 57.74
    acrylonitrile 119.44
    aniline 43.17
    1,3-propanediol 55.8
    bromobenzene 46.98
    dibromomethane 52.7
    1,1,2,2-tetrachloroethane 105.33
    2-methyl-cyclohexyl acetate 35.13
    tetrabutyl urea 55.42
    diisobutyl methanol 13.75
    2-phenylethanol 37.04
    styrene 26.18
    dioctyl adipate 52.11
    dimethyl sulfate 267.29
    ethyl butyrate 41.22
    methyl lactate 93.84
    butyl lactate 40.79
    diethyl carbonate 37.63
    propanediol butyl ether 67.21
    triethyl orthoformate 34.42
    p-tert-butyltoluene 14.35
    methyl 4-tert-butylbenzoate 64.95
    morpholine 149.76
    tert-butylamine 24.53
    n-dodecanol 19.71
    dimethoxymethane 218.66
    ethylene carbonate 81.79
    cyrene 94.11
    2-ethoxyethyl acetate 72.21
    2-ethylhexyl acetate 29.61
    1,2,4-trichlorobenzene 76.6
    4-methylpyridine 109.7
    dibutyl ether 35.19
    2,6-dimethyl-4-heptanol 13.75
    DEF 155.17
    dimethyl isosorbide 118.22
    tetrachloroethylene 73.83
    eugenol 75.74
    triacetin 108.76
    span 80 71.27
    1,4-butanediol 35.24
    1,1-dichloroethane 55.66
    2-methyl-1-pentanol 19.16
    methyl formate 222.87
    2-methyl-1-butanol 20.01
    n-decane 6.47
    butyronitrile 43.43
    3,7-dimethyl-1-octanol 23.96
    1-chlorooctane 18.88
    1-chlorotetradecane 12.44
    n-nonane 6.04
    undecane 5.66
    tert-butylcyclohexane 5.79
    cyclooctane 3.68
    cyclopentanol 42.22
    tetrahydropyran 71.16
    tert-amyl methyl ether 35.48
    2,5,8-trioxanonane 165.68
    1-hexene 15.29
    2-isopropoxyethanol 53.01
    2,2,2-trifluoroethanol 102.2
    methyl butyrate 68.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction