Gossypetin

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  • Identifiers

    CAS number
    489-35-0

    Molecular formula
    C15H10O8

    SMILES
    C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C(=C(C=C3O)O)O)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 65.2%
    Phenolic 53.26%
    Burnt 40.01%
    Smoky 25.68%
    Medicinal 22.14%
    Spicy 18.81%
    Savory 17.84%
    Balsamic 17.21%
    Dry 15.03%
    Bitter 14.72%

     

    Flavor
    Bitter 90.57%
    Odorless 27.34%
    Mild 22.65%
    Sweet-like 22.53%
    Bland 21.67%
    Eugenol 20.62%
    Rotten 20.19%
    Very strong 20.0%
    Cedarleaf 19.85%
    Indole 19.77%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    10.38 (weak base)

    Molecular weight
    318.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1180°C

    Flash point

    • 267.07 ˚C est.

  • Synonyms

    • Gossypetin
    • 489-35-0
    • Articulatidin
    • Equisporol
    • 3,5,7,8,3',4'-Hexahydroxyflavone
    • 3,3',4',5,7,8-Hexahydroxyflavone
    • 2-(3,4-Dihydroxyphenyl)-3,5,7,8-tetrahydroxychromen-4-one
    • 8-hydroxyquercetin
    • SET4M23ZTM
    • 2-(3,4-Dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-chromen-4-one
    • 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy-
    • CHEBI:16400
    • DTXSID50197631
    • RefChem:37676
    • DTXCID10120122
    • UNII-SET4M23ZTM
    • MFCD00017680
    • CHEMBL253570
    • 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy-chromen-4-one
    • BSPBio_002552
    • SCHEMBL157033
    • SPECTRUM1505143
    • orb1684559
    • SCHEMBL29419067
    • SCHEMBL29929428
    • BDBM26655
    • GLXC-06243
    • LMPK12113231
    • AKOS024283047
    • AT33743
    • CCG-231029
    • FH46598
    • NCGC00096031-01
    • NCGC00096031-02
    • NCGC00178604-01
    • BP-10444
    • MS-24692
    • ST059622
    • DB-051591
    • HY-119917
    • C.I.-75750
    • CS-0078364
    • C04109
    • Gossypetin,3,3',4',5,7,8-Hexahydroxyflavone
    • FLAVONE, 3,3',4',5,7,8-HEXAHYDROXY-
    • SR-05000002577
    • Q3036428
    • SR-05000002577-1
    • BRD-K06692906-001-01-6
    • 2-(3,4-Dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-chromen-4-one #
    • 2-(3,4-Dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-1-benzopyran-4-one
    • 489-35-0

  • Applications

    Gossypetin is a plant flavonol that is primarily studied for antioxidant activity and bioactive properties. In industry, it is commonly evaluated as a research chemical and used as an intermediate in the synthesis of flavonoid derivatives. It may be used as a cosmetic ingredient, where its antioxidant activity can support formulation stability in skin-care products. It is also investigated for polymer and materials applications as a radical scavenger to help stabilize polymers and coatings against oxidation. Additionally, gossypetin has been explored for nutraceutical or health-related research contexts and may be considered as a natural pigment or colorant in specialty coatings or inks. All uses are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.26
    methanol 0.46
    isopropanol 0.38
    water 0.01
    ethyl acetate 0.19
    n-propanol 0.75
    acetone 0.0
    n-butanol 0.62
    acetonitrile 0.01
    DMF 2.96
    toluene 0.01
    isobutanol 0.29
    1,4-dioxane 0.39
    methyl acetate 0.12
    THF 1.76
    2-butanone 0.12
    n-pentanol 0.22
    sec-butanol 1.28
    n-hexane 0.0
    ethylene glycol 2.0
    NMP 6.91
    cyclohexane 0.0
    DMSO 5.31
    n-butyl acetate 0.26
    n-octanol 1.22
    chloroform 0.0
    n-propyl acetate 0.12
    acetic acid 0.15
    dichloromethane 0.0
    cyclohexanone 0.15
    propylene glycol 2.97
    isopropyl acetate 0.2
    DMAc 9.8
    2-ethoxyethanol 6.65
    isopentanol 0.57
    n-heptane 0.01
    ethyl formate 0.07
    1,2-dichloroethane 0.0
    n-hexanol 0.37
    2-methoxyethanol 20.2
    isobutyl acetate 0.03
    tetrachloromethane 0.0
    n-pentyl acetate 0.51
    transcutol 10.97
    n-heptanol 1.08
    ethylbenzene 0.01
    MIBK 0.1
    2-propoxyethanol 8.38
    tert-butanol 0.9
    MTBE 0.3
    2-butoxyethanol 6.19
    propionic acid 0.57
    o-xylene 0.03
    formic acid 0.9
    diethyl ether 0.08
    m-xylene 0.01
    p-xylene 0.01
    chlorobenzene 0.0
    dimethyl carbonate 0.36
    n-octane 0.01
    formamide 1.76
    cyclopentanone 0.33
    2-pentanone 0.08
    anisole 0.12
    cyclopentyl methyl ether 0.54
    gamma-butyrolactone 1.08
    1-methoxy-2-propanol 19.5
    pyridine 0.13
    3-pentanone 0.08
    furfural 0.77
    n-dodecane 0.01
    diethylene glycol 9.46
    diisopropyl ether 0.04
    tert-amyl alcohol 2.16
    acetylacetone 0.12
    n-hexadecane 0.01
    acetophenone 0.15
    methyl propionate 0.56
    isopentyl acetate 0.27
    trichloroethylene 0.0
    n-nonanol 1.36
    cyclohexanol 0.44
    benzyl alcohol 0.2
    2-ethylhexanol 0.3
    isooctanol 0.76
    dipropyl ether 0.41
    1,2-dichlorobenzene 0.0
    ethyl lactate 0.93
    propylene carbonate 0.23
    n-methylformamide 1.18
    2-pentanol 0.63
    n-pentane 0.0
    1-propoxy-2-propanol 6.95
    1-methoxy-2-propyl acetate 1.99
    2-(2-methoxypropoxy) propanol 5.16
    mesitylene 0.01
    ε-caprolactone 0.95
    p-cymene 0.05
    epichlorohydrin 0.3
    1,1,1-trichloroethane 0.0
    2-aminoethanol 4.02
    morpholine-4-carbaldehyde 7.25
    sulfolane 4.68
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.9
    n-hexyl acetate 0.87
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 7.91
    sec-butyl acetate 0.13
    tert-butyl acetate 0.52
    decalin 0.0
    glycerin 14.05
    diglyme 9.49
    acrylic acid 0.54
    isopropyl myristate 0.39
    n-butyric acid 0.55
    acetyl acetate 0.03
    di(2-ethylhexyl) phthalate 0.33
    ethyl propionate 0.26
    nitromethane 0.19
    1,2-diethoxyethane 1.09
    benzonitrile 0.03
    trioctyl phosphate 0.42
    1-bromopropane 0.0
    gamma-valerolactone 3.1
    n-decanol 0.84
    triethyl phosphate 0.34
    4-methyl-2-pentanol 0.31
    propionitrile 0.05
    vinylene carbonate 0.11
    1,1,2-trichlorotrifluoroethane 1.49
    DMS 0.41
    cumene 0.01
    2-octanol 0.84
    2-hexanone 0.07
    octyl acetate 0.62
    limonene 0.07
    1,2-dimethoxyethane 3.9
    ethyl orthosilicate 0.35
    tributyl phosphate 0.29
    diacetone alcohol 4.01
    N,N-dimethylaniline 0.17
    acrylonitrile 0.09
    aniline 0.12
    1,3-propanediol 5.35
    bromobenzene 0.0
    dibromomethane 0.0
    1,1,2,2-tetrachloroethane 0.0
    2-methyl-cyclohexyl acetate 0.25
    tetrabutyl urea 0.82
    diisobutyl methanol 0.26
    2-phenylethanol 0.33
    styrene 0.0
    dioctyl adipate 0.55
    dimethyl sulfate 1.05
    ethyl butyrate 0.37
    methyl lactate 3.86
    butyl lactate 1.51
    diethyl carbonate 0.18
    propanediol butyl ether 5.74
    triethyl orthoformate 0.66
    p-tert-butyltoluene 0.06
    methyl 4-tert-butylbenzoate 1.46
    morpholine 2.68
    tert-butylamine 0.19
    n-dodecanol 0.47
    dimethoxymethane 2.36
    ethylene carbonate 0.09
    cyrene 3.04
    2-ethoxyethyl acetate 1.06
    2-ethylhexyl acetate 0.18
    1,2,4-trichlorobenzene 0.0
    4-methylpyridine 0.08
    dibutyl ether 0.39
    2,6-dimethyl-4-heptanol 0.26
    DEF 1.37
    dimethyl isosorbide 4.63
    tetrachloroethylene 0.0
    eugenol 1.62
    triacetin 0.91
    span 80 3.34
    1,4-butanediol 0.85
    1,1-dichloroethane 0.0
    2-methyl-1-pentanol 0.3
    methyl formate 0.21
    2-methyl-1-butanol 0.83
    n-decane 0.01
    butyronitrile 0.04
    3,7-dimethyl-1-octanol 0.63
    1-chlorooctane 0.05
    1-chlorotetradecane 0.02
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.63
    tetrahydropyran 0.16
    tert-amyl methyl ether 0.86
    2,5,8-trioxanonane 7.27
    1-hexene 0.0
    2-isopropoxyethanol 2.58
    2,2,2-trifluoroethanol 0.14
    methyl butyrate 0.26

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction