Glycyrrhiza flavonol A

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  • Identifiers

    CAS number
    197304-01-1

    Molecular formula
    C20H18O7

    SMILES
    CC1(C(CC2=C(O1)C=CC(=C2)C3=C(C(=O)C4=C(C=C(C=C4O3)O)O)O)O)C

    Safety labels

  • Odor profile

    Fragrance
    Odorless 49.83%
    Phenolic 47.81%
    Vanilla 30.16%
    Burnt 30.04%
    Sweet 24.27%
    Smoky 23.42%
    Creamy 22.62%
    Spicy 21.6%
    Fruity 21.49%
    Powdery 20.79%

     

    Flavor
    Bitter 92.84%
    Bland 22.53%
    Odorless 21.71%
    Sweet-like 21.31%
    Cedarleaf 20.4%
    Parsley 20.34%
    Eugenol 20.01%
    Lovage 19.61%
    Ripe apricot 19.18%
    Red fruit 19.08%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    10.11 (weak base)

    Molecular weight
    370.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1655°C

    Melting point expt.

    • 163 °C

    Flash point

    • 268.6 ˚C est.

  • Synonyms

    • Glycyrrhiza flavonol A
    • 3,5,7-trihydroxy-2-(3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-6-yl)chromen-4-one
    • RefChem:1086104
    • 197304-01-1
    • Glycyrrhizaflavonol A
    • Glycyrrhiza-flavonol A
    • [2,6'-Bi-4H-1-benzopyran]-4-one, 2',3'-dihydro-3,3',5,7-tetrahydroxy-2',2'-dimethyl-
    • orb1984193
    • CHEMBL5430013
    • CHEBI:175752
    • DTXSID601133444
    • HY-N8656
    • LMPK12111995
    • AKOS040761791
    • CS-0148852
    • 2 inverted exclamation marka,3 inverted exclamation marka-Dihydro-3,3 inverted exclamation marka,5,7-tetrahydroxy-2 inverted exclamation marka,2 inverted exclamation marka-dimethyl[2,6 inverted exclamation marka-bi-4H-1-benzopyran]-4-one
    • 2-(3,4-Dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
    • 2a(2),3a(2)-Dihydro-3,3a(2),5,7-tetrahydroxy-2a(2),2a(2)-dimethyl[2,6a(2)-bi-4H-1-benzopyran]-4-one
    • 3,3',5,7-Tetrahydroxy-2',2'-dimethyl-3',4'-dihydro-2'H,4H-[2,6'-bi-1-benzopyran]-4-one
    • 197304-01-1

  • Applications

    Glycyrrhiza flavonol A (CAS 197304-01-1) is a flavonol derived from Glycyrrhiza species. In industry, it is evaluated as an antioxidant and stabilizer additive for cosmetics and personal care, helping protect formulations from oxidation and extend shelf life. It is also studied as a fragrance ingredient or fragrance precursor for perfumery applications. With its stabilizing and potential chelating properties, it may be used as a stabilizer/antioxidant additive in polymers and coatings, and in inks. Additionally, Glycyrrhiza flavonol A can serve as a synthetic intermediate for other licorice-related compounds, or be evaluated as a starting material for broader industrial applications, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.96
    methanol 7.08
    isopropanol 6.13
    water 0.0
    ethyl acetate 1.87
    n-propanol 8.09
    acetone 9.01
    n-butanol 5.16
    acetonitrile 1.39
    DMF 62.64
    toluene 0.19
    isobutanol 3.87
    1,4-dioxane 9.58
    methyl acetate 3.29
    THF 72.9
    2-butanone 12.5
    n-pentanol 2.79
    sec-butanol 5.86
    n-hexane 0.01
    ethylene glycol 4.1
    NMP 24.08
    cyclohexane 0.01
    DMSO 230.11
    n-butyl acetate 1.66
    n-octanol 1.78
    chloroform 0.26
    n-propyl acetate 1.94
    acetic acid 10.55
    dichloromethane 0.28
    cyclohexanone 11.02
    propylene glycol 6.22
    isopropyl acetate 1.61
    DMAc 62.97
    2-ethoxyethanol 27.61
    isopentanol 3.66
    n-heptane 0.02
    ethyl formate 2.44
    1,2-dichloroethane 0.49
    n-hexanol 1.4
    2-methoxyethanol 75.54
    isobutyl acetate 1.04
    tetrachloromethane 0.04
    n-pentyl acetate 2.41
    transcutol 32.25
    n-heptanol 1.96
    ethylbenzene 0.11
    MIBK 2.78
    2-propoxyethanol 23.25
    tert-butanol 5.02
    MTBE 1.5
    2-butoxyethanol 11.21
    propionic acid 4.56
    o-xylene 0.16
    formic acid 7.03
    diethyl ether 1.1
    m-xylene 0.17
    p-xylene 0.17
    chlorobenzene 0.13
    dimethyl carbonate 2.26
    n-octane 0.02
    formamide 13.94
    cyclopentanone 27.79
    2-pentanone 6.12
    anisole 0.97
    cyclopentyl methyl ether 3.54
    gamma-butyrolactone 21.75
    1-methoxy-2-propanol 44.22
    pyridine 4.46
    3-pentanone 2.44
    furfural 11.57
    n-dodecane 0.02
    diethylene glycol 22.97
    diisopropyl ether 0.21
    tert-amyl alcohol 4.54
    acetylacetone 7.27
    n-hexadecane 0.03
    acetophenone 1.78
    methyl propionate 3.61
    isopentyl acetate 2.07
    trichloroethylene 1.14
    n-nonanol 2.09
    cyclohexanol 2.36
    benzyl alcohol 2.01
    2-ethylhexanol 0.85
    isooctanol 1.63
    dipropyl ether 1.09
    1,2-dichlorobenzene 0.14
    ethyl lactate 3.43
    propylene carbonate 3.47
    n-methylformamide 20.01
    2-pentanol 2.09
    n-pentane 0.01
    1-propoxy-2-propanol 13.05
    1-methoxy-2-propyl acetate 5.57
    2-(2-methoxypropoxy) propanol 10.88
    mesitylene 0.09
    ε-caprolactone 7.48
    p-cymene 0.18
    epichlorohydrin 24.85
    1,1,1-trichloroethane 0.22
    2-aminoethanol 9.35
    morpholine-4-carbaldehyde 33.71
    sulfolane 49.83
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 9.17
    n-hexyl acetate 3.35
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 14.94
    sec-butyl acetate 1.13
    tert-butyl acetate 2.33
    decalin 0.01
    glycerin 18.19
    diglyme 27.2
    acrylic acid 4.62
    isopropyl myristate 1.22
    n-butyric acid 5.31
    acetyl acetate 0.92
    di(2-ethylhexyl) phthalate 1.84
    ethyl propionate 1.52
    nitromethane 21.45
    1,2-diethoxyethane 4.97
    benzonitrile 0.99
    trioctyl phosphate 1.59
    1-bromopropane 0.26
    gamma-valerolactone 55.53
    n-decanol 1.36
    triethyl phosphate 1.25
    4-methyl-2-pentanol 1.16
    propionitrile 1.94
    vinylene carbonate 2.49
    1,1,2-trichlorotrifluoroethane 17.95
    DMS 2.3
    cumene 0.09
    2-octanol 1.22
    2-hexanone 3.96
    octyl acetate 2.05
    limonene 0.28
    1,2-dimethoxyethane 32.6
    ethyl orthosilicate 1.15
    tributyl phosphate 1.59
    diacetone alcohol 11.39
    N,N-dimethylaniline 0.77
    acrylonitrile 3.5
    aniline 1.12
    1,3-propanediol 19.02
    bromobenzene 0.08
    dibromomethane 0.14
    1,1,2,2-tetrachloroethane 1.27
    2-methyl-cyclohexyl acetate 1.62
    tetrabutyl urea 3.19
    diisobutyl methanol 0.68
    2-phenylethanol 1.94
    styrene 0.1
    dioctyl adipate 2.52
    dimethyl sulfate 6.83
    ethyl butyrate 1.42
    methyl lactate 8.31
    butyl lactate 4.14
    diethyl carbonate 0.83
    propanediol butyl ether 9.44
    triethyl orthoformate 1.79
    p-tert-butyltoluene 0.19
    methyl 4-tert-butylbenzoate 3.97
    morpholine 26.09
    tert-butylamine 0.78
    n-dodecanol 0.87
    dimethoxymethane 26.06
    ethylene carbonate 2.08
    cyrene 10.12
    2-ethoxyethyl acetate 5.13
    2-ethylhexyl acetate 1.25
    1,2,4-trichlorobenzene 0.34
    4-methylpyridine 2.76
    dibutyl ether 1.33
    2,6-dimethyl-4-heptanol 0.68
    DEF 7.91
    dimethyl isosorbide 14.8
    tetrachloroethylene 0.59
    eugenol 5.26
    triacetin 4.59
    span 80 6.84
    1,4-butanediol 4.31
    1,1-dichloroethane 0.28
    2-methyl-1-pentanol 2.15
    methyl formate 10.11
    2-methyl-1-butanol 3.74
    n-decane 0.05
    butyronitrile 1.79
    3,7-dimethyl-1-octanol 1.52
    1-chlorooctane 0.31
    1-chlorotetradecane 0.12
    n-nonane 0.03
    undecane 0.03
    tert-butylcyclohexane 0.01
    cyclooctane 0.01
    cyclopentanol 4.91
    tetrahydropyran 4.68
    tert-amyl methyl ether 1.58
    2,5,8-trioxanonane 18.37
    1-hexene 0.09
    2-isopropoxyethanol 11.26
    2,2,2-trifluoroethanol 2.39
    methyl butyrate 3.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction