Glycyrrhetinyl Stearate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    4827-59-2

    Molecular formula
    C48H80O5

    SMILES
    CCCCCCCCCCCCCCCCCC(=O)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]3([C@@H]2C(=O)C=C4[C@]3(CC[C@@]5([C@H]4C[C@@](CC5)(C)C(=O)O)C)C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 74.45%
    Amber 45.67%
    Waxy 40.64%
    Sandalwood 39.47%
    Dry 37.84%
    Balsamic 36.15%
    Cedar 33.17%
    Animal 31.81%
    Musk 30.83%
    Fatty 30.49%

     

    Flavor
    Woody 38.76%
    Waxy 28.18%
    Mild 27.19%
    Balsam 23.96%
    Sandalwood 22.08%
    Herbal 22.0%
    Bland 21.67%
    Cedarleaf 21.43%
    Slightly waxy 20.99%
    Oily 20.57%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    15.4

    pKa est.
    -182.31 (strong acid)

    Molecular weight
    737.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    721°C

    Flash point

    • -821.21 ˚C est.

  • Synonyms

    • Glycyrrhetinyl stearate
    • 4827-59-2
    • 3-Stearoyloxy glycyrrhetinic acid
    • UNII-R63V8Q8M4R
    • R63V8Q8M4R
    • Olean-12-en-30-oic acid, 3beta-hydroxy-11-oxo-, stearate
    • DTXSID10197470
    • Stearic acid, ester with 3beta-hydroxy-11-oxoolean-12-en-30-oic acid
    • Olean-12-en-29-oic acid, 11-oxo-3-((1-oxooctadecyl)oxy)-, (3beta,20beta)-
    • OLEAN-12-EN-30-OIC ACID, 3.BETA.-HYDROXY-11-OXO-, STEARATE
    • OLEAN-12-EN-29-OIC ACID, 11-OXO-3-((1-OXOOCTADECYL)OXY)-, (3.BETA.,20.BETA.)-
    • STEARIC ACID, ESTER WITH 3.BETA.-HYDROXY-11-OXOOLEAN-12-EN-30-OIC ACID
    • RefChem:144011
    • DTXCID20119961
    • GLYCYRRHETINYL STEARATE [INCI]
    • Sgs
    • (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-10-octadecanoyloxy-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
    • SCHEMBL29401871
    • NZGKLLOWEPXNDG-SSCMEWPNSA-N
    • Q27287838
    • 3beta-(Octadecanoyloxy)-11-oxoolean-12-en-30-oic acid
    • 4827-59-2

  • Applications

    Glycyrrhetinyl Stearate (CAS 4827-59-2) is primarily used in cosmetics and personal care as a lipophilic emollient and skin-conditioning agent, improving slip and texture in lotions, creams, and oils. It can also serve as a processing aid or intermediate in pharmaceutical and polymer formulations, where its ester functionality enhances formulation compatibility. In coatings and inks, it may act as a plasticizer or compatibility additive to improve flexibility and dispersion of lipophilic components. Additionally, it may be used as an excipient or carrier in topical pharmaceutical and cosmetic formulations, depending on local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 32.61
    methanol 15.54
    isopropanol 37.03
    water 0.01
    ethyl acetate 41.4
    n-propanol 60.27
    acetone 42.74
    n-butanol 49.74
    acetonitrile 9.81
    DMF 135.56
    toluene 55.38
    isobutanol 41.69
    1,4-dioxane 111.0
    methyl acetate 35.99
    THF 289.52
    2-butanone 72.86
    n-pentanol 48.6
    sec-butanol 49.23
    n-hexane 4.5
    ethylene glycol 2.2
    NMP 230.05
    cyclohexane 5.08
    DMSO 54.4
    n-butyl acetate 39.16
    n-octanol 15.31
    chloroform 115.3
    n-propyl acetate 31.57
    acetic acid 34.01
    dichloromethane 75.45
    cyclohexanone 118.62
    propylene glycol 9.74
    isopropyl acetate 34.67
    DMAc 196.33
    2-ethoxyethanol 63.13
    isopentanol 34.07
    n-heptane 2.6
    ethyl formate 20.54
    1,2-dichloroethane 49.76
    n-hexanol 40.67
    2-methoxyethanol 65.51
    isobutyl acetate 25.24
    tetrachloromethane 21.21
    n-pentyl acetate 46.56
    transcutol 107.32
    n-heptanol 25.46
    ethylbenzene 27.22
    MIBK 33.59
    2-propoxyethanol 105.14
    tert-butanol 27.75
    MTBE 38.36
    2-butoxyethanol 65.29
    propionic acid 35.33
    o-xylene 32.01
    formic acid 7.79
    diethyl ether 54.53
    m-xylene 30.98
    p-xylene 26.97
    chlorobenzene 48.0
    dimethyl carbonate 30.33
    n-octane 1.03
    formamide 11.65
    cyclopentanone 155.16
    2-pentanone 62.51
    anisole 42.41
    cyclopentyl methyl ether 103.69
    gamma-butyrolactone 143.02
    1-methoxy-2-propanol 85.41
    pyridine 110.96
    3-pentanone 56.01
    furfural 83.05
    n-dodecane 0.5
    diethylene glycol 32.37
    diisopropyl ether 12.82
    tert-amyl alcohol 33.92
    acetylacetone 49.0
    n-hexadecane 0.61
    acetophenone 43.81
    methyl propionate 55.94
    isopentyl acetate 36.17
    trichloroethylene 107.49
    n-nonanol 17.22
    cyclohexanol 45.97
    benzyl alcohol 43.67
    2-ethylhexanol 19.15
    isooctanol 18.8
    dipropyl ether 29.69
    1,2-dichlorobenzene 39.26
    ethyl lactate 22.91
    propylene carbonate 59.32
    n-methylformamide 40.17
    2-pentanol 34.5
    n-pentane 4.59
    1-propoxy-2-propanol 75.57
    1-methoxy-2-propyl acetate 64.13
    2-(2-methoxypropoxy) propanol 43.36
    mesitylene 14.38
    ε-caprolactone 118.94
    p-cymene 11.26
    epichlorohydrin 149.56
    1,1,1-trichloroethane 50.77
    2-aminoethanol 13.81
    morpholine-4-carbaldehyde 179.97
    sulfolane 162.47
    2,2,4-trimethylpentane 2.55
    2-methyltetrahydrofuran 139.57
    n-hexyl acetate 46.67
    isooctane 1.48
    2-(2-butoxyethoxy)ethanol 57.91
    sec-butyl acetate 26.7
    tert-butyl acetate 35.4
    decalin 3.57
    glycerin 14.1
    diglyme 96.04
    acrylic acid 28.83
    isopropyl myristate 12.94
    n-butyric acid 57.38
    acetyl acetate 25.32
    di(2-ethylhexyl) phthalate 20.3
    ethyl propionate 31.66
    nitromethane 42.08
    1,2-diethoxyethane 45.1
    benzonitrile 26.91
    trioctyl phosphate 14.05
    1-bromopropane 47.33
    gamma-valerolactone 218.42
    n-decanol 9.84
    triethyl phosphate 18.09
    4-methyl-2-pentanol 17.3
    propionitrile 22.83
    vinylene carbonate 58.08
    1,1,2-trichlorotrifluoroethane 79.26
    DMS 36.1
    cumene 14.59
    2-octanol 15.16
    2-hexanone 46.39
    octyl acetate 19.43
    limonene 15.39
    1,2-dimethoxyethane 83.08
    ethyl orthosilicate 19.28
    tributyl phosphate 14.14
    diacetone alcohol 43.96
    N,N-dimethylaniline 34.34
    acrylonitrile 22.29
    aniline 56.7
    1,3-propanediol 28.96
    bromobenzene 50.43
    dibromomethane 57.5
    1,1,2,2-tetrachloroethane 94.81
    2-methyl-cyclohexyl acetate 31.26
    tetrabutyl urea 23.23
    diisobutyl methanol 9.32
    2-phenylethanol 43.26
    styrene 28.45
    dioctyl adipate 23.63
    dimethyl sulfate 52.62
    ethyl butyrate 28.85
    methyl lactate 33.82
    butyl lactate 40.75
    diethyl carbonate 16.29
    propanediol butyl ether 43.53
    triethyl orthoformate 28.32
    p-tert-butyltoluene 11.36
    methyl 4-tert-butylbenzoate 49.63
    morpholine 178.97
    tert-butylamine 16.28
    n-dodecanol 5.82
    dimethoxymethane 100.25
    ethylene carbonate 48.44
    cyrene 61.15
    2-ethoxyethyl acetate 62.65
    2-ethylhexyl acetate 31.92
    1,2,4-trichlorobenzene 57.57
    4-methylpyridine 98.11
    dibutyl ether 15.34
    2,6-dimethyl-4-heptanol 9.32
    DEF 83.58
    dimethyl isosorbide 74.27
    tetrachloroethylene 61.32
    eugenol 43.49
    triacetin 45.01
    span 80 43.11
    1,4-butanediol 13.06
    1,1-dichloroethane 50.5
    2-methyl-1-pentanol 34.39
    methyl formate 23.74
    2-methyl-1-butanol 41.71
    n-decane 1.34
    butyronitrile 25.58
    3,7-dimethyl-1-octanol 12.89
    1-chlorooctane 8.23
    1-chlorotetradecane 2.16
    n-nonane 1.13
    undecane 0.76
    tert-butylcyclohexane 2.95
    cyclooctane 2.15
    cyclopentanol 63.71
    tetrahydropyran 133.8
    tert-amyl methyl ether 37.39
    2,5,8-trioxanonane 52.45
    1-hexene 19.81
    2-isopropoxyethanol 47.83
    2,2,2-trifluoroethanol 15.49
    methyl butyrate 38.36

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction