Glycylglycine

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  • Identifiers

    CAS number
    556-50-3

    Molecular formula
    C4H8N2O3

    SMILES
    C(C(=O)NCC(=O)O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 72.81%
    Savory 33.2%
    Sweet 27.75%
    Meaty 24.01%
    Fishy 23.24%
    Cooked 18.97%
    Cocoa 15.48%
    Pungent 15.17%
    Milky 14.49%
    Buttery 13.89%

     

    Flavor
    Odorless 68.5%
    Mild 33.1%
    Very mild 29.09%
    Bland 26.18%
    Yeast 24.48%
    Faint 23.19%
    Sour 22.91%
    Sweet-like 21.87%
    Cooked 21.15%
    Nutty 20.92%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.9

    pKa est.
    6.19 (neutral)

    Molecular weight
    132.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    345°C

    Melting point expt.

    • 215 °C

    Flash point

    • 199.08 ˚C est.

    Solubility expt.

    • 166 mg/mL at 21 °C

  • Synonyms

    • Glycylglycine
    • 556-50-3
    • Diglycine
    • N-GLYCYLGLYCINE
    • Glycine, glycyl-
    • Glycine dipeptide
    • Glycyl-glycine
    • 2-(Aminoacetamido)acetic acid
    • 2-[(2-aminoacetyl)amino]acetic acid
    • Gly2
    • Glycyl Glycine
    • NSC-49346
    • 10525P22U0
    • CHEBI:17201
    • DTXSID90862194
    • 2-((2-aminoacetyl)amino)acetic acid
    • N Glycylglycine
    • RefChem:663940
    • Hydrochloride, Glycylglycine
    • Monohydrochloride, Glycylglycine
    • DTXCID80197700
    • 2-((2-azaniumylacetyl)amino)acetate
    • 2-(glycylamino)acetic acid;hydrochloride
    • 209-127-8
    • Gly-Gly
    • 2-(2-Aminoacetamido)Acetic Acid
    • H-Gly-Gly-OH
    • Glycine, N-glycyl-
    • Gly-Gly-OH
    • alpha-Glycylglycine
    • Dipeptide-15
    • Diglycine (VAN)
    • MFCD00008130
    • Glycylgycine
    • [(Aminoacetyl)amino]acetic acid
    • CHEMBL292467
    • [(ammonioacetyl)amino]acetate
    • 2-(2-azanylethanoylamino)ethanoic acid
    • ((aminoacetyl)amino)acetic acid
    • Glycylglyine
    • 2-(2-aminoacetylamino)acetic acid
    • 2-[(2-Aminoacetyl)amino]acetic Acid (Diglycine; N-Glycylglycine)
    • UNII-10525P22U0
    • GG0
    • EINECS 209-127-8
    • H-Gly-Gly
    • Glycylglycine, DL-
    • NSC 49346
    • .alpha.-Glycylglycine
    • n-GLYCYL- Glycine
    • AI3-62521
    • Glycylglycine (Standard)
    • Glycylglycine, Free Base
    • Gly-Gly, 98%
    • GLYCYLGLYCINE [MI]
    • DIGLYCINE [USP-RS]
    • SCHEMBL14934
    • orb1301921
    • SCHEMBL2305997
    • 2-(2-Aminoacetamido)AceticAcid
    • HY-D0889R
    • Gly-Gly, >=99% (titration)
    • [(Aminoacetyl)amino]acetic acid #
    • BB_NC-03236
    • HY-D0889
    • NSC49346
    • BBL018705
    • BDBM50169222
    • EBC-44071
    • MSK001339
    • s4810
    • SBB067231
    • STL194277
    • AKOS001045997
    • 3-Azapentanoic acid, 5-amino-4-oxo-
    • CCG-231053
    • FG40134
    • Gly-Gly, BioXtra, >=99.0% (NT)
    • AS-14771
    • BP-31104
    • Gly-Gly, BioUltra, >=99.5% (NT)
    • ST099026
    • SY018005
    • Gly-Gly, Vetec(TM) reagent grade, 99%
    • DB-002742
    • Glycylglycine(Discontinued,SeeCPTD788380)
    • CS-0015211
    • G0124
    • NS00013721
    • EN300-34095
    • C02037
    • F17229
    • G-6001
    • 556G503
    • F047801
    • Q665455
    • Glycyl-glycine; N-Glycylglycine; Diglycine; Gly-Gly
    • 2-(2-Aminoacetamido)Acetic Acid; Glycine EP Impurity H
    • F2191-0195
    • 33903968-DDB2-47F2-9B6C-7C232D1962DA
    • Dyglycine, United States Pharmacopeia (USP) Reference Standard
    • Gly-Gly, BioPerformance Certified, cell culture tested, >=99%
    • InChI=1/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9
    • 556-50-3

  • Applications

    Glycylglycine, CAS 556-50-3, is primarily used as a dipeptide building block and intermediate in peptide synthesis for pharmaceutical and biotech research; it also serves as a component in biochemical buffers and analytical workflows to support sample stability and pH control in measurement methods; as a precursor for the synthesis of more complex peptides in laboratory settings; in chromatographic and protein quantification methods, glycylglycine can be used as a reference standard; it may be considered as an intermediate additive evaluated for research and development formulations, subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.63
    methanol 10.43
    isopropanol 2.59
    water 62.64
    ethyl acetate 0.68
    n-propanol 2.96
    acetone 2.87
    n-butanol 2.63
    acetonitrile 1.7
    DMF 132.81
    toluene 0.35
    isobutanol 1.72
    1,4-dioxane 11.6
    methyl acetate 1.06
    THF 5.91
    2-butanone 1.47
    n-pentanol 1.38
    sec-butanol 1.76
    n-hexane 0.43
    ethylene glycol 12.31
    NMP 75.96
    cyclohexane 0.91
    DMSO 87.4
    n-butyl acetate 0.63
    n-octanol 0.67
    chloroform 0.28
    n-propyl acetate 0.47
    acetic acid 9.87
    dichloromethane 0.8
    cyclohexanone 4.87
    propylene glycol 7.59
    isopropyl acetate 0.44
    DMAc 62.58
    2-ethoxyethanol 7.32
    isopentanol 1.74
    n-heptane 0.5
    ethyl formate 3.8
    1,2-dichloroethane 0.95
    n-hexanol 1.13
    2-methoxyethanol 22.93
    isobutyl acetate 0.22
    tetrachloromethane 0.16
    n-pentyl acetate 0.54
    transcutol 7.39
    n-heptanol 0.88
    ethylbenzene 0.33
    MIBK 0.52
    2-propoxyethanol 4.67
    tert-butanol 2.4
    MTBE 1.02
    2-butoxyethanol 3.99
    propionic acid 3.1
    o-xylene 0.77
    formic acid 44.32
    diethyl ether 1.25
    m-xylene 0.35
    p-xylene 0.56
    chlorobenzene 0.25
    dimethyl carbonate 1.6
    n-octane 0.21
    formamide 35.89
    cyclopentanone 4.79
    2-pentanone 1.03
    anisole 0.77
    cyclopentyl methyl ether 2.01
    gamma-butyrolactone 6.98
    1-methoxy-2-propanol 8.19
    pyridine 3.21
    3-pentanone 1.09
    furfural 14.86
    n-dodecane 0.09
    diethylene glycol 10.35
    diisopropyl ether 0.29
    tert-amyl alcohol 1.93
    acetylacetone 1.55
    n-hexadecane 0.1
    acetophenone 1.13
    methyl propionate 1.26
    isopentyl acetate 0.54
    trichloroethylene 0.65
    n-nonanol 0.68
    cyclohexanol 2.65
    benzyl alcohol 1.44
    2-ethylhexanol 0.66
    isooctanol 0.63
    dipropyl ether 1.05
    1,2-dichlorobenzene 0.33
    ethyl lactate 1.3
    propylene carbonate 2.86
    n-methylformamide 26.85
    2-pentanol 0.99
    n-pentane 0.4
    1-propoxy-2-propanol 2.54
    1-methoxy-2-propyl acetate 1.21
    2-(2-methoxypropoxy) propanol 4.02
    mesitylene 0.34
    ε-caprolactone 4.58
    p-cymene 0.36
    epichlorohydrin 3.67
    1,1,1-trichloroethane 0.17
    2-aminoethanol 12.63
    morpholine-4-carbaldehyde 54.61
    sulfolane 23.02
    2,2,4-trimethylpentane 0.12
    2-methyltetrahydrofuran 2.95
    n-hexyl acetate 0.64
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 4.99
    sec-butyl acetate 0.27
    tert-butyl acetate 0.49
    decalin 0.2
    glycerin 24.99
    diglyme 10.42
    acrylic acid 5.14
    isopropyl myristate 0.3
    n-butyric acid 2.91
    acetyl acetate 0.58
    di(2-ethylhexyl) phthalate 0.88
    ethyl propionate 0.58
    nitromethane 10.64
    1,2-diethoxyethane 1.48
    benzonitrile 1.07
    trioctyl phosphate 0.58
    1-bromopropane 0.5
    gamma-valerolactone 19.02
    n-decanol 0.53
    triethyl phosphate 0.97
    4-methyl-2-pentanol 0.48
    propionitrile 1.11
    vinylene carbonate 3.45
    1,1,2-trichlorotrifluoroethane 6.67
    DMS 0.94
    cumene 0.31
    2-octanol 0.48
    2-hexanone 0.61
    octyl acetate 0.47
    limonene 0.52
    1,2-dimethoxyethane 12.47
    ethyl orthosilicate 0.9
    tributyl phosphate 0.63
    diacetone alcohol 1.8
    N,N-dimethylaniline 1.46
    acrylonitrile 2.15
    aniline 1.14
    1,3-propanediol 11.41
    bromobenzene 0.18
    dibromomethane 0.47
    1,1,2,2-tetrachloroethane 0.79
    2-methyl-cyclohexyl acetate 0.75
    tetrabutyl urea 1.62
    diisobutyl methanol 0.45
    2-phenylethanol 1.02
    styrene 0.3
    dioctyl adipate 0.7
    dimethyl sulfate 5.65
    ethyl butyrate 0.77
    methyl lactate 3.87
    butyl lactate 1.39
    diethyl carbonate 0.65
    propanediol butyl ether 3.97
    triethyl orthoformate 1.12
    p-tert-butyltoluene 0.33
    methyl 4-tert-butylbenzoate 1.81
    morpholine 14.43
    tert-butylamine 1.18
    n-dodecanol 0.43
    dimethoxymethane 10.48
    ethylene carbonate 2.64
    cyrene 7.25
    2-ethoxyethyl acetate 1.03
    2-ethylhexyl acetate 0.47
    1,2,4-trichlorobenzene 0.41
    4-methylpyridine 2.66
    dibutyl ether 0.57
    2,6-dimethyl-4-heptanol 0.45
    DEF 8.73
    dimethyl isosorbide 5.03
    tetrachloroethylene 0.72
    eugenol 2.76
    triacetin 1.09
    span 80 3.03
    1,4-butanediol 4.89
    1,1-dichloroethane 0.27
    2-methyl-1-pentanol 1.06
    methyl formate 14.84
    2-methyl-1-butanol 1.79
    n-decane 0.16
    butyronitrile 1.36
    3,7-dimethyl-1-octanol 0.47
    1-chlorooctane 0.22
    1-chlorotetradecane 0.12
    n-nonane 0.17
    undecane 0.12
    tert-butylcyclohexane 0.11
    cyclooctane 0.39
    cyclopentanol 3.17
    tetrahydropyran 3.21
    tert-amyl methyl ether 1.03
    2,5,8-trioxanonane 8.46
    1-hexene 0.55
    2-isopropoxyethanol 2.68
    2,2,2-trifluoroethanol 5.67
    methyl butyrate 1.19

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction