Glycine

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  • Identifiers

    CAS number
    56-40-6

    Molecular formula
    C2H5NO2

    SMILES
    C(C(=O)O)N

  • Odor profile

    Fragrance
    Odorless 81.62%
    Sour 23.0%
    Savory 20.23%
    Meaty 18.14%
    Sharp 17.6%
    Cheesy 17.05%
    Sulfurous 14.95%
    Fishy 14.81%
    Cooked 14.78%
    Caramellic 14.77%

     

    Flavor
    Odorless 70.93%
    Sour 41.61%
    Acidic 32.47%
    Pungent 26.5%
    Mild 26.35%
    Vinegar 25.07%
    Yeast 23.02%
    Bland 22.25%
    Soy 22.02%
    Rancid 21.94%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.2

    pKa est.
    6.08 (neutral)

    Molecular weight
    75.07 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    230°C

    Melting point expt.

    • 451 °F (NTP, 1992)
    • 262 dec °C
    • 290 °C decomposes
    • MP: 189 °C /(C2H5NO2)2.HCL/
    • 262.2 °C

    Flash point

    • 119.72 ˚C est.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 64 °F (NTP, 1992)
    • 249000 mg/L (at 25 °C)
    • Insoluble in ethanol, ethyl ether, slightly soluble in acetone; very soluble in water
    • Solubility in 100 ml water @ 25 °C: 25.0 g; @ 50 °C: 39.1 g; @ 75 °C: 54.4 g; @ 100 °C: 67.2 g
    • 100 g of abs alc dissolve about 0.06 g. Sol in 164 parts pyridine. Almost insol in ether.
    • water solubility = 2.49X10+5 mg/l @ 25 °C
    • 249.0 mg/mL
    • Soluble in water; Slightly soluble in ether
    • Slightly soluble (in ethanol)

  • Synonyms

    • glycine
    • 56-40-6
    • 2-Aminoacetic acid
    • aminoacetic acid
    • Glycocoll
    • Aminoethanoic acid
    • Glycolixir
    • H-Gly-OH
    • Glicoamin
    • Glycosthene
    • Aciport
    • Padil
    • Hampshire glycine
    • L-Glycine
    • Amitone
    • Leimzucker
    • Aminoazijnzuur
    • Acetic acid, amino-
    • Glycine, non-medical
    • Sucre de gelatine
    • Glicina
    • Glycinum
    • GLY (IUPAC abbrev)
    • Gyn-hydralin
    • Corilin
    • Glycine [INN]
    • Glyzin
    • FEMA No. 3287
    • Acido aminoacetico
    • Glycinum [INN-Latin]
    • Acide aminoacetique
    • Glicina [INN-Spanish]
    • Acidum aminoaceticum
    • gly
    • Glykokoll
    • Aminoessigsaeure
    • Hgly
    • CCRIS 5915
    • HSDB 495
    • Acide aminoacetique [INN-French]
    • Acido aminoacetico [INN-Spanish]
    • Acidum aminoaceticum [INN-Latin]
    • 25718-94-9
    • AI3-04085
    • MFCD00008131
    • NSC 25936
    • GLYCINE 1.5% IN PLASTIC CONTAINER
    • H2N-CH2-COOH
    • amino-Acetic acid
    • EINECS 200-272-2
    • UNII-TE7660XO1C
    • NSC-25936
    • [14C]glycine
    • TE7660XO1C
    • DTXSID9020667
    • CHEBI:15428
    • Glycine [USP:INN]
    • NSC25936
    • CHEMBL773
    • DTXCID90667
    • Glycine iron sulphate (1:1)
    • EC 200-272-2
    • aminoacetate
    • Athenon
    • 2-aminoacetate
    • Glycine (USP:INN)
    • NCGC00024503-01
    • Glycinum (INN-Latin)
    • Glicina (INN-Spanish)
    • GLYCINE (II)
    • GLYCINE [II]
    • GLYCINE (MART.)
    • GLYCINE [MART.]
    • Glycine, free base
    • GLYCINE (USP-RS)
    • GLYCINE [USP-RS]
    • GLYCINE (EP MONOGRAPH)
    • GLYCINE [EP MONOGRAPH]
    • GLYCINE (USP MONOGRAPH)
    • GLYCINE [USP MONOGRAPH]
    • Acide aminoacetique (INN-French)
    • Acido aminoacetico (INN-Spanish)
    • Acidum aminoaceticum (INN-Latin)
    • CAS-56-40-6
    • Glycine, labeled with carbon-14
    • AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER
    • Aminoessigsaure
    • Aminoethanoate
    • 18875-39-3
    • amino-Acetate
    • 2-aminoaceticacid
    • [3H]glycine
    • Glycine USP grade
    • Glycine (Standard)
    • Glycine - EP
    • Glycine, EP/USP
    • H-Gly
    • L-Gly
    • Gly-CO
    • Gly-OH
    • [14C]-glycine
    • Corilin (Salt/Mix)
    • Tocris-0219
    • Glycine (H-Gly-OH)
    • GLYCINE [VANDF]
    • NH2CH2COOH
    • GLYCINE [FHFI]
    • GLYCINE [HSDB]
    • Glycine, technical grade
    • GLYCINE [FCC]
    • GLYCINE [JAN]
    • GLYCINE [MI]
    • Glycine (JP18/USP)
    • Glycine, 99%, FCC
    • GLYCINE [WHO-DD]
    • Biomol-NT_000195
    • bmse000089
    • bmse000977
    • WLN: Z1VQ
    • Gly-253
    • GLYCINE [GREEN BOOK]
    • GTPL727
    • AB-131/40217813
    • GLYCINE [ORANGE BOOK]
    • Treating Gingivitis Toothpaste
    • Glycine, Electrophoresis Grade
    • BPBio1_001222
    • GTPL4084

  • Applications

    Glycine (CAS 56-40-6), the simplest amino acid, enjoys broad applications: in the food industry it functions as a mild sweetener, pH buffer and flavour enhancer in soy sauce, dried seafood, meat marinades and sports beverages; in pharmaceuticals it is incorporated into parenteral nutrition solutions, stabilises proteins and peptides, features in antacid, heavy-metal antidote and gastrointestinal anti-inflammatory formulations; in agriculture it is the main intermediate for synthesising the herbicide glyphosate, serves as a micronutrient chelating agent to improve plant uptake, and acts as a feed additive that boosts weight gain, immunity and palatability in livestock; in analytical chemistry and biotechnology glycine is an essential biological buffer for SDS-PAGE electrophoresis, cell culture media, protein purification, tissue preservation and acts as a complexing agent for metal surface protection, electroplating finishing and corrosion inhibition; additionally, it appears in cosmetics as a moisturizing, skin-balancing, irritation-reducing ingredient and as a solvent for active substances in personal-care formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.23
    methanol 3.67
    isopropanol 0.54
    water 275.99
    ethyl acetate 0.18
    n-propanol 0.75
    acetone 0.6
    n-butanol 0.73
    acetonitrile 0.55
    DMF 13.64
    toluene 0.11
    isobutanol 0.55
    1,4-dioxane 0.73
    methyl acetate 0.26
    THF 0.75
    2-butanone 0.35
    n-pentanol 0.44
    sec-butanol 0.56
    n-hexane 0.13
    ethylene glycol 7.61
    NMP 14.03
    cyclohexane 0.16
    DMSO 12.8
    n-butyl acetate 0.18
    n-octanol 0.21
    chloroform 0.15
    n-propyl acetate 0.14
    acetic acid 8.31
    dichloromethane 0.23
    cyclohexanone 0.81
    propylene glycol 3.86
    isopropyl acetate 0.14
    DMAc 7.96
    2-ethoxyethanol 1.67
    isopentanol 0.64
    n-heptane 0.15
    ethyl formate 1.05
    1,2-dichloroethane 0.2
    n-hexanol 0.35
    2-methoxyethanol 4.7
    isobutyl acetate 0.07
    tetrachloromethane 0.16
    n-pentyl acetate 0.22
    transcutol 2.46
    n-heptanol 0.37
    ethylbenzene 0.08
    MIBK 0.22
    2-propoxyethanol 1.17
    tert-butanol 0.76
    MTBE 0.25
    2-butoxyethanol 1.37
    propionic acid 1.66
    o-xylene 0.2
    formic acid 43.59
    diethyl ether 0.19
    m-xylene 0.12
    p-xylene 0.13
    chlorobenzene 0.08
    dimethyl carbonate 0.46
    n-octane 0.07
    formamide 24.73
    cyclopentanone 1.08
    2-pentanone 0.29
    anisole 0.16
    cyclopentyl methyl ether 0.39
    gamma-butyrolactone 1.55
    1-methoxy-2-propanol 1.99
    pyridine 0.53
    3-pentanone 0.26
    furfural 3.85
    n-dodecane 0.03
    diethylene glycol 3.72
    diisopropyl ether 0.09
    tert-amyl alcohol 0.89
    acetylacetone 0.46
    n-hexadecane 0.03
    acetophenone 0.29
    methyl propionate 0.29
    isopentyl acetate 0.17
    trichloroethylene 0.27
    n-nonanol 0.21
    cyclohexanol 0.67
    benzyl alcohol 0.43
    2-ethylhexanol 0.24
    isooctanol 0.3
    dipropyl ether 0.2
    1,2-dichlorobenzene 0.11
    ethyl lactate 0.48
    propylene carbonate 0.91
    n-methylformamide 6.42
    2-pentanol 0.37
    n-pentane 0.11
    1-propoxy-2-propanol 0.78
    1-methoxy-2-propyl acetate 0.32
    2-(2-methoxypropoxy) propanol 1.57
    mesitylene 0.13
    ε-caprolactone 0.87
    p-cymene 0.13
    epichlorohydrin 0.6
    1,1,1-trichloroethane 0.1
    2-aminoethanol 5.69
    morpholine-4-carbaldehyde 7.75
    sulfolane 6.17
    2,2,4-trimethylpentane 0.07
    2-methyltetrahydrofuran 0.45
    n-hexyl acetate 0.21
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 1.71
    sec-butyl acetate 0.09
    tert-butyl acetate 0.19
    decalin 0.07
    glycerin 14.88
    diglyme 2.62
    acrylic acid 3.23
    isopropyl myristate 0.1
    n-butyric acid 1.42
    acetyl acetate 0.23
    di(2-ethylhexyl) phthalate 0.34
    ethyl propionate 0.14
    nitromethane 4.98
    1,2-diethoxyethane 0.28
    benzonitrile 0.25
    trioctyl phosphate 0.26
    1-bromopropane 0.1
    gamma-valerolactone 2.99
    n-decanol 0.17
    triethyl phosphate 0.26
    4-methyl-2-pentanol 0.26
    propionitrile 0.29
    vinylene carbonate 1.0
    1,1,2-trichlorotrifluoroethane 2.85
    DMS 0.25
    cumene 0.1
    2-octanol 0.21
    2-hexanone 0.19
    octyl acetate 0.15
    limonene 0.16
    1,2-dimethoxyethane 1.66
    ethyl orthosilicate 0.26
    tributyl phosphate 0.27
    diacetone alcohol 0.89
    N,N-dimethylaniline 0.36
    acrylonitrile 0.56
    aniline 0.32
    1,3-propanediol 4.02
    bromobenzene 0.05
    dibromomethane 0.15
    1,1,2,2-tetrachloroethane 0.28
    2-methyl-cyclohexyl acetate 0.19
    tetrabutyl urea 0.56
    diisobutyl methanol 0.2
    2-phenylethanol 0.31
    styrene 0.08
    dioctyl adipate 0.21
    dimethyl sulfate 1.6
    ethyl butyrate 0.18
    methyl lactate 1.41
    butyl lactate 0.72
    diethyl carbonate 0.14
    propanediol butyl ether 1.97
    triethyl orthoformate 0.26
    p-tert-butyltoluene 0.13
    methyl 4-tert-butylbenzoate 0.79
    morpholine 1.08
    tert-butylamine 0.4
    n-dodecanol 0.14
    dimethoxymethane 1.34
    ethylene carbonate 0.67
    cyrene 2.25
    2-ethoxyethyl acetate 0.33
    2-ethylhexyl acetate 0.14
    1,2,4-trichlorobenzene 0.12
    4-methylpyridine 0.48
    dibutyl ether 0.13
    2,6-dimethyl-4-heptanol 0.2
    DEF 1.51
    dimethyl isosorbide 1.67
    tetrachloroethylene 0.42
    eugenol 1.18
    triacetin 0.42
    span 80 1.32
    1,4-butanediol 1.79
    1,1-dichloroethane 0.09
    2-methyl-1-pentanol 0.43
    methyl formate 4.04
    2-methyl-1-butanol 0.71
    n-decane 0.05
    butyronitrile 0.36
    3,7-dimethyl-1-octanol 0.18
    1-chlorooctane 0.06
    1-chlorotetradecane 0.04
    n-nonane 0.05
    undecane 0.04
    tert-butylcyclohexane 0.05
    cyclooctane 0.1
    cyclopentanol 0.87
    tetrahydropyran 0.33
    tert-amyl methyl ether 0.32
    2,5,8-trioxanonane 2.66
    1-hexene 0.15
    2-isopropoxyethanol 0.75
    2,2,2-trifluoroethanol 5.4
    methyl butyrate 0.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction