Glycidol

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  • Identifiers

    CAS number
    556-52-5

    Molecular formula
    C3H6O2

    SMILES
    C1C(O1)CO

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Alcoholic 42.0%
    Odorless 41.65%
    Fruity 37.29%
    Ethereal 36.78%
    Caramellic 30.65%
    Solvent 30.33%
    Oily 29.59%
    Sweet 27.74%
    Fermented 26.82%
    Buttery 25.21%

     

    Flavor
    Sweet 51.72%
    Caramel 41.37%
    Oily 37.62%
    Bitter 37.21%
    Odorless 36.59%
    Vegetable 34.49%
    Fatty 33.08%
    Cauliflower 27.89%
    Alcoholic 26.62%
    Sweet-like 26.36%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.9

    pKa est.
    4.61 (weak acid)

    Molecular weight
    74.08 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Melting point expt.

    • -49 °F (NTP, 1992)
    • -45 °C
    • -49 °F

    Boiling point

    • 333 °F at 760 mmHg (with decomposition) (NTP, 1992)
    • 167 °C decomposes; 66 °C at 2.5 mm Hg
    • 320 °F (decomposes)
    • 320 °F (Decomposes)

    Flash point

    • 65.42 ˚C est.
    • 162 °F (NTP, 1992)
    • 162 °F
    • 73 °C (closed cup)
    • 72 °C c.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 64 °F (NTP, 1992)
    • Soluble in water, alcohol, and ether
    • Miscible with water /1.0X10+6 mg/L/
    • Solubility in water: miscible
    • Miscible

  • Synonyms

    • GLYCIDOL
    • 556-52-5
    • oxiran-2-ylmethanol
    • Oxiranemethanol
    • 1-Propanol, 2,3-epoxy-
    • 2,3-Epoxy-1-propanol
    • Glycide
    • Oxiranylmethanol
    • Epihydrin alcohol
    • 3-Hydroxypropylene oxide
    • 2-(Hydroxymethyl)oxirane
    • 2,3-Epoxypropanol
    • Glycidyl alcohol
    • 2-Oxiranemethanol
    • Epoxypropyl alcohol
    • Allyl alcohol oxide
    • Monoepoxide glycidol
    • Methanol, oxiranyl-
    • 2,3-Epoxypropan-1-ol
    • 3-Hydroxy-1,2-epoxypropane
    • 1,2-Epoxy-3-hydroxypropane
    • 1-Hydroxy-2,3-epoxypropane
    • (S)-Oxiranemethanol
    • 2-Hydroxymethyloxiran
    • Hydroxymethyl ethylene oxide
    • (+/-)-Glycidol
    • NCI-C55549
    • (RS)-Glycidol
    • (RS)-3-hydroxy-1,2-epoxypropane
    • NSC 46096
    • CCRIS 1052
    • Oxiranemethanol, (R)-
    • Oxiranemethanol, (S)-
    • HSDB 1819
    • EINECS 209-128-3
    • S54CF1DV9A
    • BRN 0383562
    • DTXSID4020666
    • CHEBI:30966
    • AI3-50540
    • (oxiran-2-yl)methanol
    • D-L-GLYCIDOL
    • GLYCIDOL [HSDB]
    • GLYCIDOL [IARC]
    • GLYCIDOL [MI]
    • NSC-46096
    • R-2,3-epoxy-1-propanol
    • (+/-)-Oxirane-2-methanol
    • DTXCID60666
    • GLYCIDOL [EP IMPURITY]
    • EC 209-128-3
    • NSC46096
    • C3H6O2
    • Glycidol (~90%)
    • GLYCIDOL (IARC)
    • LEVODROPROPIZINE IMPURITY C [EP IMPURITY]
    • 5-17-03-00009 (Beilstein Handbook Reference)
    • GLYCIDOL (EP IMPURITY)
    • Glycerolglycide
    • 2-Oxiranylmethanol #
    • CAS-556-52-5
    • 2-Hydroxymethyl oxiran
    • 2,3-Epoxypropanol-1
    • LEVODROPROPIZINE IMPURITY C (EP IMPURITY)
    • UNII-S54CF1DV9A
    • Glycerol glycid
    • glycerol glycide
    • CCRIS 6389
    • CCRIS 6390
    • Oxirane methanol
    • oxiranyl-methanol
    • 2,3Epoxypropanol
    • 2-Oxiranylmethanol
    • Hydroxymethyloxirane
    • Methanol, oxiranyl
    • 2Hydroxymethyloxiran
    • Glycidol; Oxiran-2-ylmethanol; [(2RS)-Oxiran-2-yl]methanol; Levodropropizine EP impurity C; 2,3-epoxypropan-1-ol
    • 2,3Epoxy1propanol
    • Glycidol, 96%
    • (RS)-Oxiranemethanol
    • DL-GLYCIDOL
    • BRN 0079782
    • BRN 0079783
    • 3Hydroxypropylene oxide
    • EPIOL OH
    • 1-Propanol,3-epoxy-
    • 1Propanol, 2,3epoxy
    • Oxyranyl Methyl Alcohol
    • 2(Hydroxymethyl)oxirane
    • 1,2Epoxy3hydroxypropane
    • 1Hydroxy2,3epoxypropane
    • 3Hydroxy1,2epoxypropane
    • Glycidol (ACGIH:OSHA)
    • WLN: T3OTJ B1Q
    • MLS002174255
    • CHEMBL1530150
    • (+/-)-2-(hydroxymethyl)oxirane
    • HMS3039K06
    • HY-Y1010
    • STR01325
    • Tox21_201309
    • Tox21_300301
    • MFCD00005147
    • MFCD00074873
    • STL483075
    • (+/-)-Glycidol, analytical standard
    • AKOS009031473
    • FG23681
    • PB43085
    • SB40756
    • SB44653
    • 2,3-Epoxy-1-propanol (ACGIH:OSHA)
    • NCGC00090738-01
    • NCGC00090738-02
    • NCGC00090738-03
    • NCGC00090738-04
    • NCGC00253997-01
    • NCGC00258861-01
    • SMR001261426
    • SY013955
    • SY031944
    • CS-0016001
    • NS00006946
    • EN300-19950
    • A10767
    • EC 404-660-4
    • Glycidol Epoxypropyl alcohol 2,3-Epoxy-1-propanol
    • Q418265

  • Applications

    Glycidol is an industrial chemical intermediate used to make glycidyl ethers and polyglycerol derivatives. Glycidyl ethers are common precursors for epoxy resins and epoxy-containing formulations used in coatings, adhesives, and electronics; polyglycerol derivatives produced from glycidol function as nonionic surfactants and emulsifiers in cosmetics, personal care, and some food-processing applications. Through ring-opening polymerization, glycidol provides polyether polyols used as building blocks for polyurethane foams and coatings. Overall, glycidol serves as a versatile monomer in epoxy and polymer chemistries and as a basis for formulation additives in coatings and personal care products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 195.53
    methanol 490.61
    isopropanol 68.54
    water 319.87
    ethyl acetate 21.19
    n-propanol 90.14
    acetone 44.62
    n-butanol 66.11
    acetonitrile 64.08
    DMF 225.57
    toluene 2.64
    isobutanol 45.41
    1,4-dioxane 45.85
    methyl acetate 30.3
    THF 52.83
    2-butanone 22.79
    n-pentanol 31.93
    sec-butanol 41.86
    n-hexane 0.66
    ethylene glycol 251.34
    NMP 100.08
    cyclohexane 2.14
    DMSO 294.93
    n-butyl acetate 8.16
    n-octanol 8.72
    chloroform 31.65
    n-propyl acetate 10.6
    acetic acid 554.05
    dichloromethane 36.97
    cyclohexanone 26.3
    propylene glycol 141.49
    isopropyl acetate 10.3
    DMAc 126.17
    2-ethoxyethanol 125.59
    isopentanol 40.72
    n-heptane 1.52
    ethyl formate 45.89
    1,2-dichloroethane 17.87
    n-hexanol 16.55
    2-methoxyethanol 286.51
    isobutyl acetate 5.62
    tetrachloromethane 8.69
    n-pentyl acetate 6.81
    transcutol 154.24
    n-heptanol 11.35
    ethylbenzene 1.57
    MIBK 10.25
    2-propoxyethanol 54.33
    tert-butanol 51.34
    MTBE 11.79
    2-butoxyethanol 41.59
    propionic acid 127.34
    o-xylene 3.18
    formic acid 1041.64
    diethyl ether 13.12
    m-xylene 2.48
    p-xylene 2.19
    chlorobenzene 4.83
    dimethyl carbonate 14.3
    n-octane 0.59
    formamide 904.7
    cyclopentanone 39.94
    2-pentanone 16.65
    anisole 7.9
    cyclopentyl methyl ether 14.57
    gamma-butyrolactone 64.6
    1-methoxy-2-propanol 106.06
    pyridine 37.4
    3-pentanone 10.82
    furfural 92.56
    n-dodecane 0.48
    diethylene glycol 110.35
    diisopropyl ether 3.12
    tert-amyl alcohol 35.96
    acetylacetone 22.01
    n-hexadecane 0.49
    acetophenone 10.93
    methyl propionate 22.24
    isopentyl acetate 6.95
    trichloroethylene 35.02
    n-nonanol 7.65
    cyclohexanol 29.46
    benzyl alcohol 21.42
    2-ethylhexanol 7.59
    isooctanol 9.37
    dipropyl ether 6.99
    1,2-dichlorobenzene 5.79
    ethyl lactate 17.5
    propylene carbonate 28.91
    n-methylformamide 240.78
    2-pentanol 23.27
    n-pentane 1.33
    1-propoxy-2-propanol 29.54
    1-methoxy-2-propyl acetate 13.46
    2-(2-methoxypropoxy) propanol 31.44
    mesitylene 2.05
    ε-caprolactone 30.38
    p-cymene 2.27
    epichlorohydrin 54.4
    1,1,1-trichloroethane 10.01
    2-aminoethanol 288.56
    morpholine-4-carbaldehyde 108.9
    sulfolane 81.89
    2,2,4-trimethylpentane 0.96
    2-methyltetrahydrofuran 26.43
    n-hexyl acetate 7.84
    isooctane 0.64
    2-(2-butoxyethoxy)ethanol 48.27
    sec-butyl acetate 5.67
    tert-butyl acetate 10.04
    decalin 0.73
    glycerin 272.79
    diglyme 81.82
    acrylic acid 174.6
    isopropyl myristate 3.48
    n-butyric acid 102.37
    acetyl acetate 17.07
    di(2-ethylhexyl) phthalate 7.04
    ethyl propionate 8.52
    nitromethane 341.43
    1,2-diethoxyethane 14.77
    benzonitrile 13.99
    trioctyl phosphate 4.79
    1-bromopropane 6.24
    gamma-valerolactone 78.53
    n-decanol 5.6
    triethyl phosphate 6.26
    4-methyl-2-pentanol 12.31
    propionitrile 28.65
    vinylene carbonate 33.89
    1,1,2-trichlorotrifluoroethane 121.45
    DMS 7.72
    cumene 1.7
    2-octanol 5.36
    2-hexanone 8.55
    octyl acetate 5.09
    limonene 3.42
    1,2-dimethoxyethane 70.21
    ethyl orthosilicate 6.31
    tributyl phosphate 5.29
    diacetone alcohol 31.64
    N,N-dimethylaniline 7.62
    acrylonitrile 54.54
    aniline 19.09
    1,3-propanediol 238.17
    bromobenzene 3.09
    dibromomethane 17.12
    1,1,2,2-tetrachloroethane 24.35
    2-methyl-cyclohexyl acetate 7.01
    tetrabutyl urea 7.98
    diisobutyl methanol 5.59
    2-phenylethanol 12.82
    styrene 2.13
    dioctyl adipate 7.5
    dimethyl sulfate 29.17
    ethyl butyrate 9.17
    methyl lactate 39.04
    butyl lactate 12.69
    diethyl carbonate 6.56
    propanediol butyl ether 40.89
    triethyl orthoformate 8.47
    p-tert-butyltoluene 2.18
    methyl 4-tert-butylbenzoate 13.95
    morpholine 81.96
    tert-butylamine 21.42
    n-dodecanol 4.28
    dimethoxymethane 52.32
    ethylene carbonate 24.71
    cyrene 34.9
    2-ethoxyethyl acetate 12.57
    2-ethylhexyl acetate 4.75
    1,2,4-trichlorobenzene 7.62
    4-methylpyridine 18.71
    dibutyl ether 4.91
    2,6-dimethyl-4-heptanol 5.59
    DEF 42.46
    dimethyl isosorbide 30.99
    tetrachloroethylene 27.7
    eugenol 18.91
    triacetin 14.46
    span 80 26.23
    1,4-butanediol 89.01
    1,1-dichloroethane 10.97
    2-methyl-1-pentanol 21.73
    methyl formate 121.73
    2-methyl-1-butanol 39.54
    n-decane 0.68
    butyronitrile 27.14
    3,7-dimethyl-1-octanol 8.38
    1-chlorooctane 2.03
    1-chlorotetradecane 1.04
    n-nonane 0.62
    undecane 0.55
    tert-butylcyclohexane 0.64
    cyclooctane 0.86
    cyclopentanol 41.84
    tetrahydropyran 21.18
    tert-amyl methyl ether 9.99
    2,5,8-trioxanonane 58.73
    1-hexene 2.06
    2-isopropoxyethanol 50.94
    2,2,2-trifluoroethanol 236.54
    methyl butyrate 15.47

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction