Glyceryl Isostearate

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  • Identifiers

    CAS number
    66085-00-5

    Molecular formula
    C21H42O4

    SMILES
    CC(C)CCCCCCCCCCCCCCC(=O)OCC(CO)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 69.11%
    Fatty 53.65%
    Odorless 40.53%
    Oily 39.29%
    Creamy 22.91%
    Milky 20.53%
    Buttery 19.86%
    Alcoholic 19.46%
    Sweet 19.46%
    Clean 17.38%

     

    Flavor
    Waxy 49.74%
    Mild 43.27%
    Fatty 41.02%
    Oily 40.92%
    Bland 36.44%
    Odorless 30.18%
    Faint 29.23%
    Soapy 29.03%
    Fat 25.11%
    Slightly waxy 24.1%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    7.1

    pKa est.
    7.29 (neutral)

    Molecular weight
    358.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    449°C

    Flash point

    • 199.81 ˚C est.

  • Synonyms

    • Glyceryl monoisostearate
    • GLYCERYL ISOSTEARATE
    • Glycerol monoisostearate
    • 66085-00-5
    • HYE7O27HAO
    • NIKKOL MGIS
    • glycerin monoisostearate
    • GLYCEROISOSTEARATE
    • Isooctadecanoic acid, monoester with 1,2,3-propanetriol
    • EINECS 266-124-4
    • PRISORINE 2040
    • Isostearic acid, 1,2,3-propaneriol ester (1:1)
    • PRISORINE GMIS 2040
    • Isooctadecanoic acid, monoester with glycerol
    • GLYCERYL ISOSTEARATE [II]
    • EC 266-124-4
    • ISOSTEARIC ACID MONOGLYCERIDE
    • GLYCERYL ISOSTEARATE (II)
    • RefChem:663536
    • DTXSID40894465
    • GLYCERYL ISOSTEARATE [INCI]
    • 266-124-4
    • 608-698-4
    • 2,3-Dihydroxypropyl 16-methylheptadecanoate
    • 50486-18-5
    • 67938-24-3
    • AKD-2A
    • 2,3-Dihydroxypropyl isooctadecanoate
    • UNII-HYE7O27HAO
    • EINECS 256-603-6
    • EINECS 267-822-1
    • MGIS
    • SCHEMBL2516961
    • DTXSID70867203
    • glycerol monoisostearate, AldrichCPR
    • 2,3-Dihydroxypropyl16-methylheptadecanoate
    • DS-016296
    • NS00004917
    • Q27280163
    • 66085-00-5

  • Applications

    Glyceryl Isostearate (CAS 66085-00-5) is widely used in cosmetics and personal care as an emollient and conditioning agent, providing slip and improving spreadability in creams, lotions, and hair- and skin-care products. It also acts as a surfactant/emulsifier, helping stabilize oil-in-water emulsions in formulations. It may serve as a solvent or carrier for fragrances and active ingredients in perfumery and skin-care products. In formulations, it can function as a thickener or texture enhancer for emulsions and gels. In some polymer, coating, and ink systems, it may act as a plasticizer or lubricating additive. Additionally, it can be used as an intermediate in the synthesis of other ester compounds.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.38
    methanol 15.69
    isopropanol 7.59
    water 0.05
    ethyl acetate 34.61
    n-propanol 9.6
    acetone 27.9
    n-butanol 11.85
    acetonitrile 8.07
    DMF 56.75
    toluene 11.51
    isobutanol 10.08
    1,4-dioxane 48.76
    methyl acetate 24.73
    THF 173.75
    2-butanone 37.32
    n-pentanol 13.66
    sec-butanol 12.52
    n-hexane 1.97
    ethylene glycol 1.38
    NMP 168.31
    cyclohexane 9.08
    DMSO 134.99
    n-butyl acetate 52.47
    n-octanol 25.39
    chloroform 101.3
    n-propyl acetate 70.03
    acetic acid 27.16
    dichloromethane 103.03
    cyclohexanone 146.14
    propylene glycol 4.8
    isopropyl acetate 47.05
    DMAc 155.34
    2-ethoxyethanol 50.97
    isopentanol 20.49
    n-heptane 2.87
    ethyl formate 21.73
    1,2-dichloroethane 69.76
    n-hexanol 12.66
    2-methoxyethanol 44.41
    isobutyl acetate 48.53
    tetrachloromethane 22.07
    n-pentyl acetate 107.76
    transcutol 401.92
    n-heptanol 22.43
    ethylbenzene 13.48
    MIBK 54.97
    2-propoxyethanol 46.94
    tert-butanol 26.44
    MTBE 37.21
    2-butoxyethanol 82.14
    propionic acid 20.66
    o-xylene 16.95
    formic acid 8.38
    diethyl ether 15.74
    m-xylene 13.35
    p-xylene 19.19
    chlorobenzene 23.41
    dimethyl carbonate 13.85
    n-octane 2.01
    formamide 16.59
    cyclopentanone 146.36
    2-pentanone 42.36
    anisole 34.64
    cyclopentyl methyl ether 73.46
    gamma-butyrolactone 133.13
    1-methoxy-2-propanol 53.24
    pyridine 41.07
    3-pentanone 35.91
    furfural 107.81
    n-dodecane 1.41
    diethylene glycol 23.0
    diisopropyl ether 12.32
    tert-amyl alcohol 33.96
    acetylacetone 77.56
    n-hexadecane 1.68
    acetophenone 60.07
    methyl propionate 30.19
    isopentyl acetate 65.78
    trichloroethylene 135.89
    n-nonanol 26.06
    cyclohexanol 34.34
    benzyl alcohol 25.34
    2-ethylhexanol 18.12
    isooctanol 27.08
    dipropyl ether 28.33
    1,2-dichlorobenzene 37.91
    ethyl lactate 34.87
    propylene carbonate 81.94
    n-methylformamide 19.18
    2-pentanol 11.24
    n-pentane 1.14
    1-propoxy-2-propanol 57.68
    1-methoxy-2-propyl acetate 74.83
    2-(2-methoxypropoxy) propanol 80.95
    mesitylene 12.71
    ε-caprolactone 139.63
    p-cymene 14.3
    epichlorohydrin 138.4
    1,1,1-trichloroethane 77.21
    2-aminoethanol 5.68
    morpholine-4-carbaldehyde 126.56
    sulfolane 321.83
    2,2,4-trimethylpentane 3.44
    2-methyltetrahydrofuran 95.06
    n-hexyl acetate 95.67
    isooctane 1.95
    2-(2-butoxyethoxy)ethanol 113.62
    sec-butyl acetate 57.76
    tert-butyl acetate 95.48
    decalin 6.29
    glycerin 12.12
    diglyme 255.67
    acrylic acid 15.63
    isopropyl myristate 28.04
    n-butyric acid 50.33
    acetyl acetate 32.15
    di(2-ethylhexyl) phthalate 28.13
    ethyl propionate 49.11
    nitromethane 58.9
    1,2-diethoxyethane 86.77
    benzonitrile 26.93
    trioctyl phosphate 21.08
    1-bromopropane 27.75
    gamma-valerolactone 227.47
    n-decanol 15.44
    triethyl phosphate 41.44
    4-methyl-2-pentanol 14.04
    propionitrile 10.23
    vinylene carbonate 55.96
    1,1,2-trichlorotrifluoroethane 129.62
    DMS 43.49
    cumene 12.96
    2-octanol 20.85
    2-hexanone 55.61
    octyl acetate 35.1
    limonene 24.93
    1,2-dimethoxyethane 117.83
    ethyl orthosilicate 42.82
    tributyl phosphate 29.21
    diacetone alcohol 110.57
    N,N-dimethylaniline 31.51
    acrylonitrile 11.85
    aniline 15.11
    1,3-propanediol 13.58
    bromobenzene 27.26
    dibromomethane 57.99
    1,1,2,2-tetrachloroethane 151.89
    2-methyl-cyclohexyl acetate 65.37
    tetrabutyl urea 45.55
    diisobutyl methanol 17.58
    2-phenylethanol 24.71
    styrene 13.41
    dioctyl adipate 57.67
    dimethyl sulfate 47.29
    ethyl butyrate 61.08
    methyl lactate 24.73
    butyl lactate 82.79
    diethyl carbonate 32.57
    propanediol butyl ether 73.87
    triethyl orthoformate 58.79
    p-tert-butyltoluene 14.59
    methyl 4-tert-butylbenzoate 93.34
    morpholine 75.26
    tert-butylamine 14.71
    n-dodecanol 10.0
    dimethoxymethane 38.22
    ethylene carbonate 50.14
    cyrene 84.29
    2-ethoxyethyl acetate 121.06
    2-ethylhexyl acetate 53.54
    1,2,4-trichlorobenzene 51.0
    4-methylpyridine 38.9
    dibutyl ether 43.2
    2,6-dimethyl-4-heptanol 17.58
    DEF 72.36
    dimethyl isosorbide 171.72
    tetrachloroethylene 92.82
    eugenol 75.63
    triacetin 125.88
    span 80 70.99
    1,4-butanediol 6.92
    1,1-dichloroethane 47.65
    2-methyl-1-pentanol 22.01
    methyl formate 15.06
    2-methyl-1-butanol 17.82
    n-decane 3.35
    butyronitrile 14.41
    3,7-dimethyl-1-octanol 29.11
    1-chlorooctane 20.72
    1-chlorotetradecane 5.45
    n-nonane 3.04
    undecane 2.0
    tert-butylcyclohexane 4.99
    cyclooctane 2.85
    cyclopentanol 32.93
    tetrahydropyran 65.87
    tert-amyl methyl ether 41.19
    2,5,8-trioxanonane 143.08
    1-hexene 6.83
    2-isopropoxyethanol 46.46
    2,2,2-trifluoroethanol 18.37
    methyl butyrate 82.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction