Glyceryl Glycyrrhetinate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    108916-85-4

    Molecular formula
    C33H52O6

    SMILES
    C[C@]12CC[C@](C[C@@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C(C5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)OCC(CO)O

    Safety labels

  • Odor profile

    Fragrance
    Woody 77.79%
    Amber 51.54%
    Cedar 47.75%
    Dry 45.31%
    Musk 39.98%
    Balsamic 35.14%
    Sandalwood 32.81%
    Vetiver 31.03%
    Spicy 30.03%
    Camphoreous 29.84%

     

    Flavor
    Bitter 62.24%
    Woody 38.25%
    Pine 34.54%
    Camphor 32.81%
    Balsam 29.56%
    Herbal 25.99%
    Fir 23.65%
    Patchouli 22.89%
    Cedarleaf 22.85%
    Ripe apricot 22.61%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.4

    pKa est.
    5.86 (weak acid)

    Molecular weight
    544.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    142°C

    Flash point

    • 285.82 ˚C est.

  • Synonyms

    • glyceryl glycyrrhetinate
    • 108916-85-4
    • RefChem:663529
    • DTXSID201021841
    • SCHEMBL8605154
    • NNYMAFQJECSMTN-YZADGDQXSA-N
    • 108916-85-4

  • Applications

    Glyceryl Glycyrrhetinate (CAS 108916-85-4) is an ester of glycerol with glycyrrhetinic acid and is commonly used in cosmetics and personal care as an emollient and skin-conditioning agent, helping to hydrate and impart a soft feel; it can also function as a nonionic surfactant and an emulsifier in various formulations. In fragrance and perfumery, it may serve as a solvent or solubilizer for fragrance ingredients. In industrial coatings and polymers, it can act as a plasticizer or processing aid to improve flexibility and handling. In pharmaceuticals and topical dosage forms, it may be used as an excipient/solubilizer and skin-conditioning component in formulations. Applications depend on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 23.4
    methanol 29.97
    isopropanol 8.09
    water 0.01
    ethyl acetate 5.1
    n-propanol 16.75
    acetone 11.12
    n-butanol 7.25
    acetonitrile 2.11
    DMF 112.42
    toluene 3.37
    isobutanol 5.93
    1,4-dioxane 46.01
    methyl acetate 5.69
    THF 104.84
    2-butanone 9.93
    n-pentanol 6.18
    sec-butanol 4.01
    n-hexane 0.13
    ethylene glycol 2.75
    NMP 62.11
    cyclohexane 0.15
    DMSO 39.33
    n-butyl acetate 3.7
    n-octanol 2.51
    chloroform 14.81
    n-propyl acetate 3.44
    acetic acid 17.55
    dichloromethane 9.38
    cyclohexanone 15.18
    propylene glycol 7.88
    isopropyl acetate 4.16
    DMAc 59.9
    2-ethoxyethanol 34.0
    isopentanol 3.72
    n-heptane 0.12
    ethyl formate 4.61
    1,2-dichloroethane 5.04
    n-hexanol 5.08
    2-methoxyethanol 70.84
    isobutyl acetate 2.65
    tetrachloromethane 1.45
    n-pentyl acetate 6.23
    transcutol 45.83
    n-heptanol 4.37
    ethylbenzene 1.51
    MIBK 4.52
    2-propoxyethanol 52.47
    tert-butanol 4.24
    MTBE 3.53
    2-butoxyethanol 24.46
    propionic acid 7.28
    o-xylene 1.77
    formic acid 9.59
    diethyl ether 5.63
    m-xylene 2.02
    p-xylene 1.48
    chlorobenzene 3.4
    dimethyl carbonate 8.41
    n-octane 0.06
    formamide 11.56
    cyclopentanone 34.77
    2-pentanone 7.58
    anisole 6.62
    cyclopentyl methyl ether 13.34
    gamma-butyrolactone 33.11
    1-methoxy-2-propanol 49.81
    pyridine 23.03
    3-pentanone 5.1
    furfural 25.63
    n-dodecane 0.03
    diethylene glycol 28.47
    diisopropyl ether 0.9
    tert-amyl alcohol 2.96
    acetylacetone 11.45
    n-hexadecane 0.04
    acetophenone 6.56
    methyl propionate 8.83
    isopentyl acetate 3.72
    trichloroethylene 14.91
    n-nonanol 2.77
    cyclohexanol 3.18
    benzyl alcohol 9.38
    2-ethylhexanol 1.69
    isooctanol 3.04
    dipropyl ether 3.2
    1,2-dichlorobenzene 3.01
    ethyl lactate 4.81
    propylene carbonate 9.71
    n-methylformamide 31.29
    2-pentanol 2.41
    n-pentane 0.13
    1-propoxy-2-propanol 22.74
    1-methoxy-2-propyl acetate 13.14
    2-(2-methoxypropoxy) propanol 12.69
    mesitylene 0.98
    ε-caprolactone 15.13
    p-cymene 0.85
    epichlorohydrin 40.98
    1,1,1-trichloroethane 3.06
    2-aminoethanol 13.69
    morpholine-4-carbaldehyde 92.45
    sulfolane 42.09
    2,2,4-trimethylpentane 0.08
    2-methyltetrahydrofuran 16.14
    n-hexyl acetate 6.22
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 21.51
    sec-butyl acetate 2.21
    tert-butyl acetate 4.88
    decalin 0.13
    glycerin 14.58
    diglyme 38.07
    acrylic acid 8.72
    isopropyl myristate 1.34
    n-butyric acid 9.58
    acetyl acetate 4.05
    di(2-ethylhexyl) phthalate 3.36
    ethyl propionate 3.04
    nitromethane 20.73
    1,2-diethoxyethane 8.2
    benzonitrile 4.11
    trioctyl phosphate 2.13
    1-bromopropane 2.02
    gamma-valerolactone 80.44
    n-decanol 1.31
    triethyl phosphate 2.14
    4-methyl-2-pentanol 1.58
    propionitrile 2.81
    vinylene carbonate 11.07
    1,1,2-trichlorotrifluoroethane 32.28
    DMS 6.31
    cumene 0.93
    2-octanol 1.69
    2-hexanone 4.77
    octyl acetate 2.42
    limonene 0.99
    1,2-dimethoxyethane 35.21
    ethyl orthosilicate 2.19
    tributyl phosphate 1.76
    diacetone alcohol 10.12
    N,N-dimethylaniline 4.92
    acrylonitrile 5.12
    aniline 6.23
    1,3-propanediol 20.38
    bromobenzene 2.83
    dibromomethane 4.88
    1,1,2,2-tetrachloroethane 11.68
    2-methyl-cyclohexyl acetate 3.57
    tetrabutyl urea 3.01
    diisobutyl methanol 0.92
    2-phenylethanol 8.68
    styrene 1.82
    dioctyl adipate 3.28
    dimethyl sulfate 14.24
    ethyl butyrate 2.81
    methyl lactate 12.02
    butyl lactate 8.56
    diethyl carbonate 1.76
    propanediol butyl ether 20.78
    triethyl orthoformate 3.52
    p-tert-butyltoluene 0.94
    methyl 4-tert-butylbenzoate 9.94
    morpholine 72.82
    tert-butylamine 1.21
    n-dodecanol 0.63
    dimethoxymethane 68.38
    ethylene carbonate 7.86
    cyrene 19.46
    2-ethoxyethyl acetate 14.03
    2-ethylhexyl acetate 2.66
    1,2,4-trichlorobenzene 4.99
    4-methylpyridine 12.96
    dibutyl ether 1.36
    2,6-dimethyl-4-heptanol 0.92
    DEF 13.1
    dimethyl isosorbide 21.79
    tetrachloroethylene 8.75
    eugenol 11.14
    triacetin 8.85
    span 80 12.27
    1,4-butanediol 6.49
    1,1-dichloroethane 3.53
    2-methyl-1-pentanol 3.2
    methyl formate 16.74
    2-methyl-1-butanol 3.58
    n-decane 0.09
    butyronitrile 2.63
    3,7-dimethyl-1-octanol 1.72
    1-chlorooctane 0.6
    1-chlorotetradecane 0.13
    n-nonane 0.07
    undecane 0.05
    tert-butylcyclohexane 0.12
    cyclooctane 0.08
    cyclopentanol 7.33
    tetrahydropyran 16.51
    tert-amyl methyl ether 2.57
    2,5,8-trioxanonane 19.44
    1-hexene 0.64
    2-isopropoxyethanol 15.41
    2,2,2-trifluoroethanol 5.22
    methyl butyrate 4.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction