Glutamic Acid Hydrochloride

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  • Identifiers

    CAS number
    138-15-8

    Molecular formula
    C5H10ClNO4

    SMILES
    C(CC(=O)O)[C@@H](C(=O)O)N.Cl

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Odorless 72.25%
    Savory 34.05%
    Meaty 29.54%
    Sweet 26.6%
    Sour 23.91%
    Milky 19.79%
    Cooked 19.63%
    Sulfurous 18.11%
    Buttery 17.73%
    Cheesy 16.66%

     

    Flavor
    Odorless 75.68%
    Mild 37.48%
    Sour 32.48%
    Very mild 30.83%
    Bland 26.88%
    Yeast 26.41%
    Faint 24.74%
    Acidic 23.8%
    Sweet-like 22.28%
    Soy 20.24%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.34 (weak acid)

    Molecular weight
    183.59 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    346°C

    Flash point

    • 194.27 ˚C est.

    Solubility expt.

    • >27.5 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • L-Glutamic acid hydrochloride
    • 138-15-8
    • (S)-2-Aminopentanedioic acid hydrochloride
    • GLUTAMIC ACID HYDROCHLORIDE
    • Acidogen
    • Glutamidin
    • Glutamic acid HCl
    • L-(+)-Glutamic acid hydrochloride
    • Acigluminum
    • Glutamidine
    • Acidalin
    • Acidothyn
    • Aciglumin
    • Antalka
    • Feracid
    • Flamithin
    • Flanithin
    • Glusatin
    • Glutasin
    • Hydrionic
    • Pepsdol
    • Aclor
    • L-Glutamic acid HCl
    • Glutan hcl
    • Glutan-HCl
    • Glutan hydrochloride
    • L-Glutamic acid monohydrochloride
    • UNII-M0C2SP444T
    • Acidulin
    • Gastuloric
    • Hypochylin
    • Clorhidrato de acido glutamico
    • Glutamic acid hydrogen chloride
    • M0C2SP444T
    • DTXSID6047155
    • Glutamic acid, hydrochloride, L-
    • Glutamic acid, L-, hydrochloride
    • (2S)-2-aminopentanedioic acid;hydrochloride
    • NSC 9239
    • NSC-9239
    • EINECS 205-315-9
    • L-Glutamic acid, hydrochloride [NF]
    • MFCD00012619
    • Glutamic acid, hydrochloride
    • Acidoride
    • Muriamic
    • DTXCID4027155
    • alpha-Aminopentanedioic acid, hydrochloride, L-
    • L-Glutamic acid, hydrochloride
    • GLUTAMIC ACID HYDROCHLORIDE [II]
    • GLUTAMIC ACID HYDROCHLORIDE [MI]
    • GLUTAMIC ACID HYDROCHLORIDE [HSDB]
    • GLUTAMIC ACID HYDROCHLORIDE [MART.]
    • L-GLUTAMIC ACID HYDROCHLORIDE [FCC]
    • GLUTAMIC ACID HYDROCHLORIDE [WHO-DD]
    • L-GLUTAMIC ACID HYDROCHLORIDE [USP-RS]
    • GLUTAMIC ACID HYDROCHLORIDE (II)
    • Glu HCl
    • GLUTAMIC ACID HYDROCHLORIDE (MART.)
    • L-GLUTAMIC ACID HYDROCHLORIDE (USP-RS)
    • (S)-1,3-dicarboxypropanaminium chloride
    • (S)-2-Aminoglutaric acid
    • Muripsin
    • Hypochylin (TN)
    • H-Glu-OH.HCl
    • L-(+)-Glutamic acid HCl
    • MLS002153490
    • glutamic acid monohydrochloride
    • SCHEMBL176819
    • glutamic acid hydrochloride salt
    • CHEMBL1255943
    • REGID_for_CID_2723891
    • Tox21_302652
    • Tox21_500529
    • AKOS016003580
    • CCG-221833
    • CS-W017035
    • FG35420
    • HY-W016319
    • L-Glutamic acid, hydrochloride (1:1)
    • LP00529
    • (S)-2-Aminopentanedioicacidhydrochloride
    • NCGC00093922-01
    • NCGC00256673-01
    • NCGC00261214-01
    • CAS-138-15-8
    • SMR001230835
    • EU-0100529
    • G0060
    • D07539
    • G 2128
    • L-Glutamic acid hydrochloride, >=99% (HPLC)
    • L-2-Aminoglutaric acid hydrochloride H-Glu-OH.HCl
    • Q27283300
    • S(+)-1-Aminopropane-1,3-dicarboxylic acid hydrochloride
    • L-Glutamic acid hydrochloride, United States Pharmacopeia (USP) Reference Standard
    • 205-315-9

  • Applications

    Glutamic Acid Hydrochloride, CAS 138-15-8, is commonly used as a building block in pharmaceutical synthesis, including peptide synthesis and as an intermediate in the production of active pharmaceutical ingredients; it can function as an acidic salt and pH-buffering agent in various chemical formulations; it also serves as a source of L-glutamate for microbial culture media and fermentation processes; in the cosmetics and personal care sector, it is used as an amino acid source in skin- and hair-care formulations and may contribute to buffering stability in formulations; in analytical chemistry and research, it is used as a reagent for synthesizing more complex molecules and as a reference standard in analytical methods.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.94
    methanol 2.55
    isopropanol 1.57
    water 12.66
    ethyl acetate 0.95
    n-propanol 1.24
    acetone 3.11
    n-butanol 1.41
    acetonitrile 0.83
    DMF 82.65
    toluene 0.42
    isobutanol 0.92
    1,4-dioxane 12.91
    methyl acetate 0.64
    THF 5.57
    2-butanone 1.21
    n-pentanol 0.8
    sec-butanol 1.01
    n-hexane 0.64
    ethylene glycol 11.55
    NMP 83.1
    cyclohexane 0.82
    DMSO 67.08
    n-butyl acetate 0.65
    n-octanol 1.07
    chloroform 0.1
    n-propyl acetate 0.44
    acetic acid 7.03
    dichloromethane 0.3
    cyclohexanone 4.46
    propylene glycol 6.22
    isopropyl acetate 0.81
    DMAc 53.67
    2-ethoxyethanol 7.12
    isopentanol 1.23
    n-heptane 0.9
    ethyl formate 1.38
    1,2-dichloroethane 0.55
    n-hexanol 1.19
    2-methoxyethanol 19.21
    isobutyl acetate 0.19
    tetrachloromethane 0.07
    n-pentyl acetate 0.75
    transcutol 12.69
    n-heptanol 1.47
    ethylbenzene 0.4
    MIBK 1.0
    2-propoxyethanol 6.76
    tert-butanol 1.98
    MTBE 0.97
    2-butoxyethanol 5.89
    propionic acid 2.15
    o-xylene 1.04
    formic acid 29.22
    diethyl ether 1.38
    m-xylene 0.59
    p-xylene 0.57
    chlorobenzene 0.16
    dimethyl carbonate 1.96
    n-octane 0.39
    formamide 23.89
    cyclopentanone 4.81
    2-pentanone 1.64
    anisole 0.8
    cyclopentyl methyl ether 3.07
    gamma-butyrolactone 6.92
    1-methoxy-2-propanol 11.02
    pyridine 2.32
    3-pentanone 1.48
    furfural 9.69
    n-dodecane 0.18
    diethylene glycol 14.48
    diisopropyl ether 0.61
    tert-amyl alcohol 1.48
    acetylacetone 3.39
    n-hexadecane 0.2
    acetophenone 1.32
    methyl propionate 1.63
    isopentyl acetate 0.55
    trichloroethylene 0.38
    n-nonanol 1.15
    cyclohexanol 2.36
    benzyl alcohol 1.18
    2-ethylhexanol 0.85
    isooctanol 1.05
    dipropyl ether 1.67
    1,2-dichlorobenzene 0.26
    ethyl lactate 1.29
    propylene carbonate 2.52
    n-methylformamide 12.58
    2-pentanol 1.01
    n-pentane 0.45
    1-propoxy-2-propanol 3.93
    1-methoxy-2-propyl acetate 2.02
    2-(2-methoxypropoxy) propanol 6.18
    mesitylene 0.65
    ε-caprolactone 4.51
    p-cymene 0.58
    epichlorohydrin 3.19
    1,1,1-trichloroethane 0.09
    2-aminoethanol 8.69
    morpholine-4-carbaldehyde 60.75
    sulfolane 24.53
    2,2,4-trimethylpentane 0.16
    2-methyltetrahydrofuran 2.89
    n-hexyl acetate 1.01
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 9.33
    sec-butyl acetate 0.32
    tert-butyl acetate 1.03
    decalin 0.32
    glycerin 29.04
    diglyme 14.25
    acrylic acid 3.98
    isopropyl myristate 0.53
    n-butyric acid 2.25
    acetyl acetate 0.73
    di(2-ethylhexyl) phthalate 1.08
    ethyl propionate 0.72
    nitromethane 8.28
    1,2-diethoxyethane 1.95
    benzonitrile 0.64
    trioctyl phosphate 0.9
    1-bromopropane 0.24
    gamma-valerolactone 20.36
    n-decanol 0.97
    triethyl phosphate 0.84
    4-methyl-2-pentanol 0.67
    propionitrile 0.41
    vinylene carbonate 2.24
    1,1,2-trichlorotrifluoroethane 6.56
    DMS 1.29
    cumene 0.44
    2-octanol 0.83
    2-hexanone 0.65
    octyl acetate 0.81
    limonene 0.88
    1,2-dimethoxyethane 8.84
    ethyl orthosilicate 0.84
    tributyl phosphate 0.68
    diacetone alcohol 3.61
    N,N-dimethylaniline 1.81
    acrylonitrile 0.89
    aniline 1.04
    1,3-propanediol 8.5
    bromobenzene 0.12
    dibromomethane 0.19
    1,1,2,2-tetrachloroethane 0.56
    2-methyl-cyclohexyl acetate 0.72
    tetrabutyl urea 2.14
    diisobutyl methanol 0.7
    2-phenylethanol 1.18
    styrene 0.3
    dioctyl adipate 0.92
    dimethyl sulfate 7.35
    ethyl butyrate 0.8
    methyl lactate 5.26
    butyl lactate 1.83
    diethyl carbonate 0.48
    propanediol butyl ether 6.49
    triethyl orthoformate 1.01
    p-tert-butyltoluene 0.55
    methyl 4-tert-butylbenzoate 3.42
    morpholine 12.46
    tert-butylamine 0.9
    n-dodecanol 0.79
    dimethoxymethane 12.1
    ethylene carbonate 1.78
    cyrene 10.13
    2-ethoxyethyl acetate 1.53
    2-ethylhexyl acetate 0.49
    1,2,4-trichlorobenzene 0.35
    4-methylpyridine 1.87
    dibutyl ether 0.82
    2,6-dimethyl-4-heptanol 0.7
    DEF 9.59
    dimethyl isosorbide 7.52
    tetrachloroethylene 0.5
    eugenol 4.02
    triacetin 1.89
    span 80 6.03
    1,4-butanediol 3.22
    1,1-dichloroethane 0.14
    2-methyl-1-pentanol 0.72
    methyl formate 6.35
    2-methyl-1-butanol 1.12
    n-decane 0.3
    butyronitrile 0.59
    3,7-dimethyl-1-octanol 0.68
    1-chlorooctane 0.38
    1-chlorotetradecane 0.23
    n-nonane 0.33
    undecane 0.22
    tert-butylcyclohexane 0.17
    cyclooctane 0.58
    cyclopentanol 2.54
    tetrahydropyran 2.74
    tert-amyl methyl ether 1.29
    2,5,8-trioxanonane 13.26
    1-hexene 0.59
    2-isopropoxyethanol 3.06
    2,2,2-trifluoroethanol 4.17
    methyl butyrate 1.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction