Glutamic Acid

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  • Identifiers

    CAS number
    56-86-0

    Molecular formula
    C5H9NO4

    SMILES
    C(CC(=O)O)[C@@H](C(=O)O)N

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Odorless 72.25%
    Savory 34.05%
    Meaty 29.54%
    Sweet 26.6%
    Sour 23.91%
    Milky 19.79%
    Cooked 19.63%
    Sulfurous 18.11%
    Buttery 17.73%
    Cheesy 16.66%

     

    Flavor
    Odorless 75.68%
    Mild 37.48%
    Sour 32.48%
    Very mild 30.83%
    Bland 26.88%
    Yeast 26.41%
    Faint 24.74%
    Acidic 23.8%
    Sweet-like 22.28%
    Soy 20.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.7

    pKa est.
    5.34 (weak acid)

    Molecular weight
    147.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 224 dec °C
    • 213 °C (OECD Guideline 102 (Melting point / Melting Range))

    Boiling point

    • Sublimes at 175 °C

    Flash point

    • 194.27 ˚C est.

    Solubility expt.

    • 8570 mg/L (at 25 °C)
    • Sparingly soluble in water; practically insoluble in ethanol or ether
    • In water, 8570 mg/L at 25 °C
    • Insoluble in methanol, ethanol, ether, acetone, cols glacial acetic acid and common neutral solvents.
    • 8.57 mg/mL
    • Slight soluble in water and ether
    • Insoluble (in ethanol)

  • Synonyms

    • L-glutamic acid
    • GLUTAMIC ACID
    • 56-86-0
    • (2S)-2-Aminopentanedioic acid
    • L-glutamate
    • H-Glu-OH
    • Glutamidex
    • (S)-2-Aminopentanedioic acid
    • Glutaminol
    • glutacid
    • Glutamicol
    • Glutaton
    • Aciglut
    • L-Glutaminic acid
    • glutaminic acid
    • Glusate
    • (S)-Glutamic acid
    • L-glu
    • Acidum glutamicum
    • Acido glutamico
    • D-Glutamiensuur
    • L-(+)-glutamic acid
    • Acide glutamique
    • alpha-aminoglutaric acid
    • Glutamic acid, L-
    • (S)-(+)-Glutamic acid
    • Acidum glutaminicum
    • 1-Aminopropane-1,3-dicarboxylic acid
    • FEMA No. 3285
    • Glutamic acid (H-3)
    • alpha-Glutamic acid
    • glut
    • glutamate
    • L-alpha-Aminoglutaric acid
    • 25513-46-6
    • Glutamic acid, (S)-
    • CCRIS 7314
    • 2-Aminoglutaric acid
    • Pentanedioic acid, 2-amino-, (S)-
    • glu
    • AI3-18472
    • Acide glutamique [INN-French]
    • Acido glutamico [INN-Spanish]
    • Acidum glutamicum [INN-Latin]
    • EPA Pesticide Chemical Code 374350
    • NSC 143503
    • Glutamic Acid (L-glutamic acid)
    • 2-Aminopentanedioic acid, (S)-
    • L-2-Aminoglutaric acid
    • aminoglutaric acid
    • EINECS 200-293-7
    • UNII-3KX376GY7L
    • MFCD00002634
    • Glutamic acid (VAN)
    • 3KX376GY7L
    • INS NO.620
    • DTXSID5020659
    • Glutaminic acid (VAN)
    • CHEBI:16015
    • Gamma-L-Glutamic Acid
    • INS-620
    • Glutamate, L-
    • Glutamic Acid [USAN:INN]
    • NSC-143503
    • L-2-amino-pentanedioic acid
    • E620
    • DTXCID30659
    • alpha-Aminoglutaric acid (VAN)
    • HSDB 490
    • E 620
    • E-620
    • EC 200-293-7
    • NCGC00024502-03
    • a-Glutamic acid
    • (S)-2-AMINO-1,5-PENTANEDIOIC ACID
    • a-Aminoglutaric acid
    • L-Glutamic acid-13C5,15N
    • Acide glutamique (INN-French)
    • Acido glutamico (INN-Spanish)
    • Acidum glutamicum (INN-Latin)
    • GLUTAMIC ACID (USP-RS)
    • GLUTAMIC ACID [USP-RS]
    • L-a-Aminoglutaric acid
    • GLUTAMIC ACID (EP MONOGRAPH)
    • GLUTAMIC ACID [EP MONOGRAPH]
    • L-Glutaminsaeure
    • L-Acido glutamico
    • .alpha.-Glutamic acid
    • Polyglutamic acid(PGA)
    • 6899-05-4
    • glt
    • 2-Amino-pentanedioic acid
    • 2-aminopentanedioate
    • 1-amino-propane-1,3-dicarboxylic acid
    • GLUTAMIC ACID [USAN]
    • L-Glutamic acid (9CI)
    • aminoglutarate
    • alpha-Glutamate
    • a-Glutamate
    • L-gluatmate
    • a-Aminoglutarate
    • L-glutamic-acid
    • NSC143503
    • L-Glutamic adid
    • 2-Aminoglutarate
    • 1ftj
    • 1xff
    • (S)-glutamate
    • L-a-Aminoglutarate
    • 208106-41-6
    • alpha-Aminoglutarate
    • GGL
    • (L)-glutamic acid
    • H-Glu
    • L-(+)-Glutamate
    • L-alpha-Aminoglutarate
    • Glutamic acid (USP)
    • Tocris-0218
    • [3h]-l-glutamic acid
    • 1ii5
    • L-Glutamic acid polymer
    • (S)-(+)-Glutamate
    • (S)-Glu
    • L-[14C(U)]glutamate
    • (S)-2-Aminopentanedioate
    • Biomol-NT_000170
    • GLUTAMIC ACID [MI]
    • L-Glutamic acid (JP18)

  • Applications

    L-Glutamic acid (CAS 56-86-0) is a naturally occurring amino acid whose spectrum of applications spans food technology, pharmaceuticals, cosmetics, animal nutrition, agriculture and green chemistry; in the food sector it is the biosynthetic precursor of monosodium glutamate that enriches umami taste, balances saltiness and functions as a buffering agent in fermented beverages; in pharmaceuticals it enters parenteral nutrition formulas, anti-ulcer drugs, neuroprotective research and serves as a precursor for the neurotransmitter GABA; cosmetic formulators exploit its humectant power, pH-modulating capacity and skin-barrier strengthening effect; feed manufacturers add it to improve palatability, stimulate digestive enzyme secretion and promote weight gain; farmers use glutamic acid as a chelating agent for trace elements and as a biostimulant that enhances microbial nitrogen fixation; in sustainable chemistry it is a chiral building block for biodegradable poly(γ-glutamic acid), specialty peptides, biosurfactants and cell-culture media, thus linking renewable fermentation-based production with a wide array of high-value downstream products.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.94
    methanol 2.55
    isopropanol 1.57
    water 12.66
    ethyl acetate 0.95
    n-propanol 1.24
    acetone 3.11
    n-butanol 1.41
    acetonitrile 0.83
    DMF 82.65
    toluene 0.42
    isobutanol 0.92
    1,4-dioxane 12.91
    methyl acetate 0.64
    THF 5.57
    2-butanone 1.21
    n-pentanol 0.8
    sec-butanol 1.01
    n-hexane 0.64
    ethylene glycol 11.55
    NMP 83.1
    cyclohexane 0.82
    DMSO 67.08
    n-butyl acetate 0.65
    n-octanol 1.07
    chloroform 0.1
    n-propyl acetate 0.44
    acetic acid 7.03
    dichloromethane 0.3
    cyclohexanone 4.46
    propylene glycol 6.22
    isopropyl acetate 0.81
    DMAc 53.67
    2-ethoxyethanol 7.12
    isopentanol 1.23
    n-heptane 0.9
    ethyl formate 1.38
    1,2-dichloroethane 0.55
    n-hexanol 1.19
    2-methoxyethanol 19.21
    isobutyl acetate 0.19
    tetrachloromethane 0.07
    n-pentyl acetate 0.75
    transcutol 12.69
    n-heptanol 1.47
    ethylbenzene 0.4
    MIBK 1.0
    2-propoxyethanol 6.76
    tert-butanol 1.98
    MTBE 0.97
    2-butoxyethanol 5.89
    propionic acid 2.15
    o-xylene 1.04
    formic acid 29.22
    diethyl ether 1.38
    m-xylene 0.59
    p-xylene 0.57
    chlorobenzene 0.16
    dimethyl carbonate 1.96
    n-octane 0.39
    formamide 23.89
    cyclopentanone 4.81
    2-pentanone 1.64
    anisole 0.8
    cyclopentyl methyl ether 3.07
    gamma-butyrolactone 6.92
    1-methoxy-2-propanol 11.02
    pyridine 2.32
    3-pentanone 1.48
    furfural 9.69
    n-dodecane 0.18
    diethylene glycol 14.48
    diisopropyl ether 0.61
    tert-amyl alcohol 1.48
    acetylacetone 3.39
    n-hexadecane 0.2
    acetophenone 1.32
    methyl propionate 1.63
    isopentyl acetate 0.55
    trichloroethylene 0.38
    n-nonanol 1.15
    cyclohexanol 2.36
    benzyl alcohol 1.18
    2-ethylhexanol 0.85
    isooctanol 1.05
    dipropyl ether 1.67
    1,2-dichlorobenzene 0.26
    ethyl lactate 1.29
    propylene carbonate 2.52
    n-methylformamide 12.58
    2-pentanol 1.01
    n-pentane 0.45
    1-propoxy-2-propanol 3.93
    1-methoxy-2-propyl acetate 2.02
    2-(2-methoxypropoxy) propanol 6.18
    mesitylene 0.65
    ε-caprolactone 4.51
    p-cymene 0.58
    epichlorohydrin 3.19
    1,1,1-trichloroethane 0.09
    2-aminoethanol 8.69
    morpholine-4-carbaldehyde 60.75
    sulfolane 24.53
    2,2,4-trimethylpentane 0.16
    2-methyltetrahydrofuran 2.89
    n-hexyl acetate 1.01
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 9.33
    sec-butyl acetate 0.32
    tert-butyl acetate 1.03
    decalin 0.32
    glycerin 29.04
    diglyme 14.25
    acrylic acid 3.98
    isopropyl myristate 0.53
    n-butyric acid 2.25
    acetyl acetate 0.73
    di(2-ethylhexyl) phthalate 1.08
    ethyl propionate 0.72
    nitromethane 8.28
    1,2-diethoxyethane 1.95
    benzonitrile 0.64
    trioctyl phosphate 0.9
    1-bromopropane 0.24
    gamma-valerolactone 20.36
    n-decanol 0.97
    triethyl phosphate 0.84
    4-methyl-2-pentanol 0.67
    propionitrile 0.41
    vinylene carbonate 2.24
    1,1,2-trichlorotrifluoroethane 6.56
    DMS 1.29
    cumene 0.44
    2-octanol 0.83
    2-hexanone 0.65
    octyl acetate 0.81
    limonene 0.88
    1,2-dimethoxyethane 8.84
    ethyl orthosilicate 0.84
    tributyl phosphate 0.68
    diacetone alcohol 3.61
    N,N-dimethylaniline 1.81
    acrylonitrile 0.89
    aniline 1.04
    1,3-propanediol 8.5
    bromobenzene 0.12
    dibromomethane 0.19
    1,1,2,2-tetrachloroethane 0.56
    2-methyl-cyclohexyl acetate 0.72
    tetrabutyl urea 2.14
    diisobutyl methanol 0.7
    2-phenylethanol 1.18
    styrene 0.3
    dioctyl adipate 0.92
    dimethyl sulfate 7.35
    ethyl butyrate 0.8
    methyl lactate 5.26
    butyl lactate 1.83
    diethyl carbonate 0.48
    propanediol butyl ether 6.49
    triethyl orthoformate 1.01
    p-tert-butyltoluene 0.55
    methyl 4-tert-butylbenzoate 3.42
    morpholine 12.46
    tert-butylamine 0.9
    n-dodecanol 0.79
    dimethoxymethane 12.1
    ethylene carbonate 1.78
    cyrene 10.13
    2-ethoxyethyl acetate 1.53
    2-ethylhexyl acetate 0.49
    1,2,4-trichlorobenzene 0.35
    4-methylpyridine 1.87
    dibutyl ether 0.82
    2,6-dimethyl-4-heptanol 0.7
    DEF 9.59
    dimethyl isosorbide 7.52
    tetrachloroethylene 0.5
    eugenol 4.02
    triacetin 1.89
    span 80 6.03
    1,4-butanediol 3.22
    1,1-dichloroethane 0.14
    2-methyl-1-pentanol 0.72
    methyl formate 6.35
    2-methyl-1-butanol 1.12
    n-decane 0.3
    butyronitrile 0.59
    3,7-dimethyl-1-octanol 0.68
    1-chlorooctane 0.38
    1-chlorotetradecane 0.23
    n-nonane 0.33
    undecane 0.22
    tert-butylcyclohexane 0.17
    cyclooctane 0.58
    cyclopentanol 2.54
    tetrahydropyran 2.74
    tert-amyl methyl ether 1.29
    2,5,8-trioxanonane 13.26
    1-hexene 0.59
    2-isopropoxyethanol 3.06
    2,2,2-trifluoroethanol 4.17
    methyl butyrate 1.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction