Ginsenoside Rh2

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  • Identifiers

    CAS number
    78214-33-2

    Molecular formula
    C36H62O8

    SMILES
    CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C)C)O)C)O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Woody 71.28%
    Sweet 48.03%
    Balsamic 45.29%
    Amber 43.53%
    Sandalwood 41.33%
    Spicy 37.58%
    Dry 35.32%
    Mint 34.73%
    Herbal 32.35%
    Cedar 31.81%

     

    Flavor
    Herbal 43.04%
    Woody 42.79%
    Sweet 41.72%
    Balsam 36.41%
    Pine 36.07%
    Earthy 31.01%
    Minty 30.96%
    Bitter 29.83%
    Camphor 27.11%
    Fresh 26.89%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.6

    pKa est.
    5.54 (weak acid)

    Molecular weight
    622.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    230°C

    Flash point

    • 268.12 ˚C est.

  • Synonyms

    • Ginsenoside Rh2
    • 78214-33-2
    • 20(S)-Ginsenoside Rh2
    • (20S)-ginsenoside Rh2
    • Ginsenoside-Rh2
    • 0JU44A5KWG
    • CHEBI:77147
    • DTXSID70999457
    • (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
    • beta-D-Glucopyranoside, (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl
    • (2R,3R,4S,5S,6R)-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-((2S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-3-yl)oxy)-6-(hydroxymethyl)oxane-3,4,5-triol
    • RefChem:483868
    • DTXCID401426429
    • MFCD00800712
    • (20R)-Ginsenoside Rh2
    • C36H62O8
    • 67400-17-3
    • GinsenosideRh2
    • (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-D-glucopyranoside
    • 112246-15-8
    • 20S-GinsenosideRh2
    • 20(S)-Ginsenoside
    • 20S-Ginsenoside Rh2
    • (20R)Ginsenoside Rh2
    • UNII-0JU44A5KWG
    • GINSENOSIDE RH2(S)
    • Ginsenoside Rh2 (Standard)
    • 20(S)- Ginsenoside Rh2
    • GINSENOSIDE 20-RH2
    • orb1304799
    • (S)-(3b,12b)-12,20-Dihydroxydammar-24-en-3-yl beta-D-glucopyranoside
    • CHEMBL1783834
    • SCHEMBL24209709
    • HY-N0605R
    • 20(S)-Rh2
    • HY-N0605
    • BDBM50023457
    • Ginsenoside Rh2, analytical standard
    • MSK156862
    • s9023
    • s9036
    • AKOS037514675
    • CCG-270259
    • CCG-270261
    • CS-3835
    • EBC-618429
    • FG65764
    • OG09293
    • (2R,3R,4S,5S,6R)-2-{[(1S,3aR,3bR,5aR,7S,9aR,9bR,11R,11aR)-11-hydroxy-1-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-3a,3b,6,6,9a-pentamethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
    • AC-33940
    • Ginsenoside Rh2; 20(s)-Ginsenoside Rh2
    • C22128
    • 20S-protopanaxdiol-3-O-beta-D- glucopyranoside
    • 214G332
    • Q27146703
    • 3-O-.BETA.-D-GLUCOPYRANOSYL-20(S)-PROTOPANAXADIOL
    • (3?,12?)-12,20-Dihydroxydammar-24-en-3-yl ?-D-glucopyranoside
    • 12beta,20-Dihydroxydammar-24-en-3beta-yl beta-D-glucopyranoside
    • 3beta-(beta-D-glucopyranosyloxy)dammar-24-ene-3beta,20beta-diol
    • .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-12,20-DIHYDROXYDAMMAR-24-EN-3-YL
    • (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(1S)-1-hydroxy-1,5-dimethyl-hex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
    • 8YG
    • 78214-33-2

  • Applications

    Ginsenoside Rh2 (CAS 78214-33-2) is a natural ginsenoside saponin derived from Panax species and is used in several industrial contexts as a phytochemical of interest. In cosmetics/personal care, it is evaluated as a botanical active ingredient for skin formulations, reflecting potential anti-inflammatory and antioxidant activities studied in preclinical work. In pharmaceutical research, it is investigated as a bioactive phytochemical and used as a reference standard for analytical methods (e.g., HPLC/LC-MS) to support ginsenoside analyses. In nutraceuticals and functional foods, it is considered for inclusion in dietary supplement formulations as a phytochemical ingredient. In analytical and quality-control workflows, it serves as a reference material to support identification and quantification of ginsenosides in complex natural product matrices.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.2
    methanol 16.45
    isopropanol 1.01
    water 0.05
    ethyl acetate 2.07
    n-propanol 2.44
    acetone 5.7
    n-butanol 1.14
    acetonitrile 1.06
    DMF 27.69
    toluene 1.08
    isobutanol 1.03
    1,4-dioxane 13.36
    methyl acetate 2.18
    THF 37.3
    2-butanone 3.33
    n-pentanol 1.3
    sec-butanol 0.64
    n-hexane 0.06
    ethylene glycol 1.81
    NMP 32.96
    cyclohexane 0.08
    DMSO 31.89
    n-butyl acetate 1.47
    n-octanol 1.38
    chloroform 4.6
    n-propyl acetate 1.46
    acetic acid 15.0
    dichloromethane 3.63
    cyclohexanone 6.25
    propylene glycol 2.12
    isopropyl acetate 1.67
    DMAc 25.95
    2-ethoxyethanol 11.36
    isopentanol 0.8
    n-heptane 0.08
    ethyl formate 2.28
    1,2-dichloroethane 1.95
    n-hexanol 1.22
    2-methoxyethanol 20.52
    isobutyl acetate 1.15
    tetrachloromethane 0.72
    n-pentyl acetate 3.13
    transcutol 19.51
    n-heptanol 1.89
    ethylbenzene 0.58
    MIBK 1.85
    2-propoxyethanol 14.82
    tert-butanol 0.84
    MTBE 1.01
    2-butoxyethanol 11.75
    propionic acid 2.78
    o-xylene 0.7
    formic acid 10.65
    diethyl ether 1.42
    m-xylene 0.84
    p-xylene 0.67
    chlorobenzene 1.26
    dimethyl carbonate 4.0
    n-octane 0.05
    formamide 9.6
    cyclopentanone 14.18
    2-pentanone 2.73
    anisole 2.59
    cyclopentyl methyl ether 4.73
    gamma-butyrolactone 15.18
    1-methoxy-2-propanol 10.51
    pyridine 7.46
    3-pentanone 2.15
    furfural 14.44
    n-dodecane 0.03
    diethylene glycol 11.12
    diisopropyl ether 0.35
    tert-amyl alcohol 0.7
    acetylacetone 6.75
    n-hexadecane 0.03
    acetophenone 3.34
    methyl propionate 3.13
    isopentyl acetate 1.61
    trichloroethylene 5.97
    n-nonanol 1.51
    cyclohexanol 0.88
    benzyl alcohol 3.13
    2-ethylhexanol 0.69
    isooctanol 1.36
    dipropyl ether 1.35
    1,2-dichlorobenzene 1.28
    ethyl lactate 2.12
    propylene carbonate 4.59
    n-methylformamide 10.86
    2-pentanol 0.46
    n-pentane 0.06
    1-propoxy-2-propanol 6.31
    1-methoxy-2-propyl acetate 5.4
    2-(2-methoxypropoxy) propanol 6.71
    mesitylene 0.46
    ε-caprolactone 6.31
    p-cymene 0.47
    epichlorohydrin 15.51
    1,1,1-trichloroethane 1.16
    2-aminoethanol 4.73
    morpholine-4-carbaldehyde 36.19
    sulfolane 28.35
    2,2,4-trimethylpentane 0.04
    2-methyltetrahydrofuran 5.12
    n-hexyl acetate 3.19
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 10.81
    sec-butyl acetate 0.94
    tert-butyl acetate 2.22
    decalin 0.07
    glycerin 6.46
    diglyme 19.66
    acrylic acid 4.74
    isopropyl myristate 0.76
    n-butyric acid 3.26
    acetyl acetate 2.66
    di(2-ethylhexyl) phthalate 1.81
    ethyl propionate 1.33
    nitromethane 16.66
    1,2-diethoxyethane 3.49
    benzonitrile 1.52
    trioctyl phosphate 1.17
    1-bromopropane 0.64
    gamma-valerolactone 35.78
    n-decanol 0.78
    triethyl phosphate 1.1
    4-methyl-2-pentanol 0.44
    propionitrile 0.89
    vinylene carbonate 5.49
    1,1,2-trichlorotrifluoroethane 18.08
    DMS 2.78
    cumene 0.44
    2-octanol 0.8
    2-hexanone 1.92
    octyl acetate 1.39
    limonene 0.56
    1,2-dimethoxyethane 12.76
    ethyl orthosilicate 1.13
    tributyl phosphate 0.89
    diacetone alcohol 4.35
    N,N-dimethylaniline 2.17
    acrylonitrile 1.84
    aniline 1.72
    1,3-propanediol 4.97
    bromobenzene 1.17
    dibromomethane 1.84
    1,1,2,2-tetrachloroethane 4.04
    2-methyl-cyclohexyl acetate 1.93
    tetrabutyl urea 1.65
    diisobutyl methanol 0.4
    2-phenylethanol 3.27
    styrene 0.62
    dioctyl adipate 1.8
    dimethyl sulfate 8.8
    ethyl butyrate 1.38
    methyl lactate 5.06
    butyl lactate 3.84
    diethyl carbonate 0.85
    propanediol butyl ether 9.67
    triethyl orthoformate 1.68
    p-tert-butyltoluene 0.49
    methyl 4-tert-butylbenzoate 5.68
    morpholine 15.21
    tert-butylamine 0.28
    n-dodecanol 0.4
    dimethoxymethane 20.62
    ethylene carbonate 3.73
    cyrene 11.79
    2-ethoxyethyl acetate 6.96
    2-ethylhexyl acetate 1.24
    1,2,4-trichlorobenzene 1.99
    4-methylpyridine 3.88
    dibutyl ether 0.71
    2,6-dimethyl-4-heptanol 0.4
    DEF 4.6
    dimethyl isosorbide 11.91
    tetrachloroethylene 3.64
    eugenol 6.38
    triacetin 5.48
    span 80 6.29
    1,4-butanediol 2.08
    1,1-dichloroethane 1.05
    2-methyl-1-pentanol 0.91
    methyl formate 8.34
    2-methyl-1-butanol 0.78
    n-decane 0.07
    butyronitrile 0.73
    3,7-dimethyl-1-octanol 0.85
    1-chlorooctane 0.39
    1-chlorotetradecane 0.1
    n-nonane 0.06
    undecane 0.04
    tert-butylcyclohexane 0.06
    cyclooctane 0.05
    cyclopentanol 1.82
    tetrahydropyran 4.02
    tert-amyl methyl ether 0.88
    2,5,8-trioxanonane 11.55
    1-hexene 0.22
    2-isopropoxyethanol 5.36
    2,2,2-trifluoroethanol 4.7
    methyl butyrate 1.8

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction