Ginsenoside Rg2

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  • Identifiers

    CAS number
    52286-74-5

    Molecular formula
    C42H72O13

    SMILES
    C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2O[C@H]3C[C@@]4([C@H](C[C@H]([C@H]5[C@]4(CC[C@@H]5[C@](C)(CCC=C(C)C)O)C)O)[C@@]6([C@@H]3C([C@H](CC6)O)(C)C)C)C)CO)O)O)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Woody 48.16%
    Odorless 44.38%
    Sweet 39.07%
    Spicy 33.85%
    Mint 33.19%
    Cooling 30.87%
    Balsamic 30.85%
    Amber 27.98%
    Sandalwood 25.33%
    Dry 24.8%

     

    Flavor
    Bitter 44.85%
    Sweet 34.21%
    Herbal 29.25%
    Odorless 26.99%
    Fatty 26.96%
    Minty 25.87%
    Sweet-like 24.31%
    Pine 23.62%
    Balsam 22.12%
    Cedarleaf 22.08%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    4.61 (weak acid)

    Molecular weight
    785.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    1255°C

    Flash point

    • 225.17 ˚C est.

  • Synonyms

    • Ginsenoside RG2
    • 52286-74-5
    • Chikusetsusaponin I
    • Prosapogenin C2
    • 5R89LAS235
    • DTXSID901317065
    • GF VI
    • Ginsenoside-Rg2
    • Panaxoside Rg2
    • CHEBI:77151
    • (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-methyloxane-3,4,5-triol
    • (2S,3R,4R,5R,6S)-2-((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-((2S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl)oxy-6-methyloxane-3,4,5-triol
    • RefChem:143223
    • DTXCID301746882
    • BETA-D-GLUCOPYRANOSIDE, (3BETA,6ALPHA,12BETA)-3,12,20-TRIHYDROXYDAMMAR-24-EN-6-YL 2-O-(6-DEOXY-ALPHA-L-MANNOPYRANOSYL)-
    • ginsenoside Rg2s
    • Chikusetsusaponin I;Panaxoside Rg2;Prosapogenin C2
    • (20S)Ginsenoside Rg2
    • S-GINSENOSIDE RG2
    • Ginsenoside Rg2 (Standard)
    • GINSENOSIDE 20-RG2
    • UNII-5R89LAS235
    • CHEMBL505747
    • SCHEMBL29349516
    • HY-N0602R
    • WLZ4723
    • (3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
    • HY-N0602
    • MSK40332
    • Ginsenoside Rg2, analytical standard
    • s9117
    • AKOS037514673
    • CCG-270475
    • CS-3833
    • EBC-618427
    • OG09290
    • BRN 6627213
    • (2S,3R,4R,5R,6S)-2-{[(2R,3R,4S,5S,6R)-2-{[(1S,3aR,3bR,5S,5aR,7S,9aR,9bR,11R,11aR)-7,11-dihydroxy-1-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-3a,3b,6,6,9a-pentamethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-5-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-6-methyloxane-3,4,5-triol
    • (3b,6a,12b)-3,12,20-Trihydroxydammar-24-en-6-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranoside
    • 286G745
    • Q27146707
    • (6)-(alpha-L-Rhamnopyranosyl(1-rham-2-glu)-beta-D-glucopyranosyl)-20S-protopanaxatriol
    • (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
    • (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(1S)-1-hydroxy-1,5-dimethyl-hex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-6-methyl-tetrahydropyran-3,4,5-triol
    • (3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside
    • .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-3,12,20-TRIHYDROXYDAMMAR-24-EN-6-YL 2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-
    • 3beta,12beta,20-Trihydroxydammar-24-en-6alpha-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
    • beta-D-Glucopyranoside, (3-beta,6-alpha,12-beta)-3,12,20-trihydroxydammar-24-en-6-yl-2-O-(6-deoxy-alpha-L-mannopyranosyl)-
    • GINSENOSIDE RG2 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]
    • 52286-74-5

  • Applications

    Ginsenoside Rg2 (CAS 52286-74-5) is a dammarane-type saponin from ginseng used in pharmaceutical research as a natural product component with biological activity, often considered a lead compound or reagent in drug discovery. In cosmetics/personal care, it can be incorporated as a ginseng-derived active ingredient in topical formulations or finished products. In the dietary supplement sector, it is included in herbal extract formulations and botanical blends. In analytical chemistry and research, Rg2 serves as a reference compound for method development and quality control of ginsenosides, for example in LC-MS analysis. It can also function as a starting material or intermediate in semi-synthetic routes to generate related saponins or derivatives. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.02
    methanol 27.53
    isopropanol 0.73
    water 0.09
    ethyl acetate 1.83
    n-propanol 1.62
    acetone 5.12
    n-butanol 0.65
    acetonitrile 1.35
    DMF 38.87
    toluene 0.54
    isobutanol 0.6
    1,4-dioxane 10.19
    methyl acetate 2.39
    THF 19.55
    2-butanone 2.67
    n-pentanol 0.66
    sec-butanol 0.45
    n-hexane 0.02
    ethylene glycol 4.48
    NMP 38.2
    cyclohexane 0.04
    DMSO 52.9
    n-butyl acetate 1.0
    n-octanol 0.89
    chloroform 4.44
    n-propyl acetate 1.07
    acetic acid 27.4
    dichloromethane 4.19
    cyclohexanone 4.16
    propylene glycol 3.39
    isopropyl acetate 1.14
    DMAc 29.46
    2-ethoxyethanol 9.84
    isopentanol 0.4
    n-heptane 0.04
    ethyl formate 2.58
    1,2-dichloroethane 1.8
    n-hexanol 0.62
    2-methoxyethanol 21.33
    isobutyl acetate 0.67
    tetrachloromethane 0.52
    n-pentyl acetate 2.1
    transcutol 15.68
    n-heptanol 1.1
    ethylbenzene 0.26
    MIBK 1.08
    2-propoxyethanol 10.84
    tert-butanol 0.54
    MTBE 0.52
    2-butoxyethanol 7.81
    propionic acid 3.29
    o-xylene 0.37
    formic acid 32.2
    diethyl ether 0.91
    m-xylene 0.4
    p-xylene 0.32
    chlorobenzene 0.78
    dimethyl carbonate 4.79
    n-octane 0.03
    formamide 21.3
    cyclopentanone 10.1
    2-pentanone 1.81
    anisole 1.46
    cyclopentyl methyl ether 2.46
    gamma-butyrolactone 14.47
    1-methoxy-2-propanol 8.97
    pyridine 5.49
    3-pentanone 1.55
    furfural 17.43
    n-dodecane 0.02
    diethylene glycol 13.22
    diisopropyl ether 0.18
    tert-amyl alcohol 0.45
    acetylacetone 6.2
    n-hexadecane 0.02
    acetophenone 2.28
    methyl propionate 2.9
    isopentyl acetate 0.94
    trichloroethylene 6.23
    n-nonanol 0.92
    cyclohexanol 0.5
    benzyl alcohol 2.02
    2-ethylhexanol 0.34
    isooctanol 0.72
    dipropyl ether 0.77
    1,2-dichlorobenzene 0.87
    ethyl lactate 2.02
    propylene carbonate 4.73
    n-methylformamide 17.37
    2-pentanol 0.26
    n-pentane 0.03
    1-propoxy-2-propanol 4.38
    1-methoxy-2-propyl acetate 4.2
    2-(2-methoxypropoxy) propanol 5.17
    mesitylene 0.22
    ε-caprolactone 4.67
    p-cymene 0.24
    epichlorohydrin 13.74
    1,1,1-trichloroethane 0.94
    2-aminoethanol 6.18
    morpholine-4-carbaldehyde 39.48
    sulfolane 34.96
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 2.72
    n-hexyl acetate 2.09
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 7.71
    sec-butyl acetate 0.58
    tert-butyl acetate 1.33
    decalin 0.03
    glycerin 12.51
    diglyme 15.95
    acrylic acid 7.2
    isopropyl myristate 0.47
    n-butyric acid 2.74
    acetyl acetate 2.72
    di(2-ethylhexyl) phthalate 1.26
    ethyl propionate 1.0
    nitromethane 33.41
    1,2-diethoxyethane 2.52
    benzonitrile 1.25
    trioctyl phosphate 0.76
    1-bromopropane 0.42
    gamma-valerolactone 34.76
    n-decanol 0.48
    triethyl phosphate 0.78
    4-methyl-2-pentanol 0.22
    propionitrile 0.82
    vinylene carbonate 6.2
    1,1,2-trichlorotrifluoroethane 26.08
    DMS 2.66
    cumene 0.19
    2-octanol 0.49
    2-hexanone 1.13
    octyl acetate 0.93
    limonene 0.29
    1,2-dimethoxyethane 10.72
    ethyl orthosilicate 0.72
    tributyl phosphate 0.61
    diacetone alcohol 3.28
    N,N-dimethylaniline 1.22
    acrylonitrile 2.22
    aniline 1.07
    1,3-propanediol 4.75
    bromobenzene 0.68
    dibromomethane 1.63
    1,1,2,2-tetrachloroethane 3.94
    2-methyl-cyclohexyl acetate 1.09
    tetrabutyl urea 1.16
    diisobutyl methanol 0.2
    2-phenylethanol 2.02
    styrene 0.31
    dioctyl adipate 1.27
    dimethyl sulfate 12.41
    ethyl butyrate 0.9
    methyl lactate 6.31
    butyl lactate 2.81
    diethyl carbonate 0.62
    propanediol butyl ether 7.51
    triethyl orthoformate 1.08
    p-tert-butyltoluene 0.25
    methyl 4-tert-butylbenzoate 4.17
    morpholine 10.14
    tert-butylamine 0.16
    n-dodecanol 0.26
    dimethoxymethane 19.42
    ethylene carbonate 3.6
    cyrene 10.91
    2-ethoxyethyl acetate 5.7
    2-ethylhexyl acetate 0.71
    1,2,4-trichlorobenzene 1.45
    4-methylpyridine 2.56
    dibutyl ether 0.42
    2,6-dimethyl-4-heptanol 0.2
    DEF 3.91
    dimethyl isosorbide 9.95
    tetrachloroethylene 3.35
    eugenol 4.66
    triacetin 5.18
    span 80 4.82
    1,4-butanediol 2.12
    1,1-dichloroethane 0.86
    2-methyl-1-pentanol 0.42
    methyl formate 15.25
    2-methyl-1-butanol 0.42
    n-decane 0.04
    butyronitrile 0.55
    3,7-dimethyl-1-octanol 0.46
    1-chlorooctane 0.24
    1-chlorotetradecane 0.07
    n-nonane 0.04
    undecane 0.03
    tert-butylcyclohexane 0.02
    cyclooctane 0.02
    cyclopentanol 1.1
    tetrahydropyran 2.16
    tert-amyl methyl ether 0.48
    2,5,8-trioxanonane 9.67
    1-hexene 0.1
    2-isopropoxyethanol 4.04
    2,2,2-trifluoroethanol 9.55
    methyl butyrate 1.36

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction